Abstract:
:Emerging evidence suggests that ascorbate, the dominant form of vitamin C under physiological pH conditions, influences activity of the genome via regulating epigenomic processes. Ascorbate serves as a cofactor for Ten-eleven translocation (TET) dioxygenases that catalyze the oxidation of 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), and further to 5-formylcytosine (5fC) and to 5-carboxylcytosine (5caC), which are ultimately replaced by unmodified cytosine. The Jumonji C (JmjC)-domain-containing histone demethylases also require ascorbate as a cofactor for histone demethylation. Thus, by primarily participating in the demethylation of both DNA and histones, ascorbate appears to be a mediator of the interface between the genome and environment. Furthermore, redox status has a profound impact on the bioavailability of ascorbate in the nucleus. In order to bridge the gap between redox biology and genomics, we suggest an interdisciplinary research field that can be termed redox genomics to study dynamic redox processes in health and diseases. This review examines the evidence and potential molecular mechanism of ascorbate in the demethylation of the genome, and it highlights potential epigenetic roles of ascorbate in various diseases.
journal_name
Annu Rev Nutrjournal_title
Annual review of nutritionauthors
Young JI,Züchner S,Wang Gdoi
10.1146/annurev-nutr-071714-034228subject
Has Abstractpub_date
2015-01-01 00:00:00pages
545-64eissn
0199-9885issn
1545-4312journal_volume
35pub_type
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journal_title:Annual review of nutrition
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journal_title:Annual review of nutrition
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pub_type: 杂志文章,评审
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journal_title:Annual review of nutrition
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pub_type: 杂志文章,评审
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更新日期:2007-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
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journal_title:Annual review of nutrition
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pub_type: 杂志文章,评审
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
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journal_title:Annual review of nutrition
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journal_title:Annual review of nutrition
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更新日期:2015-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
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更新日期:1999-01-01 00:00:00
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journal_title:Annual review of nutrition
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