Abstract:
:Fatty acid-binding proteins (FABPs) are abundant intracellular proteins that bind long-chain fatty acids with high affinity. Nine separate mammalian FABPs have been identified, and their tertiary structures are highly conserved. The FABPs have unique tissue-specific distributions that have long suggested functional differences among them. In the last decade, considerable progress has been made in understanding the specific functions of the FABPs and, in some cases, their mechanisms of action at the molecular level. The FABPs appear to be involved in the extranuclear compartments of the cell by trafficking their ligands within the cytosol via interactions with organelle membranes and specific proteins. Several members of the FABP family have been shown to function directly in the regulation of cognate nuclear transcription factor activity via ligand-dependent translocation to the nucleus. This review will focus on these emerging functions and mechanisms of the FABPs, highlighting the unique functional properties of each as well as the similarities among them.
journal_name
Annu Rev Nutrjournal_title
Annual review of nutritionauthors
Storch J,Corsico Bdoi
10.1146/annurev.nutr.27.061406.093710subject
Has Abstractpub_date
2008-01-01 00:00:00pages
73-95eissn
0199-9885issn
1545-4312journal_volume
28pub_type
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journal_title:Annual review of nutrition
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journal_title:Annual review of nutrition
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journal_title:Annual review of nutrition
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更新日期:1998-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2003-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
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journal_title:Annual review of nutrition
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
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更新日期:1997-01-01 00:00:00
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更新日期:2009-01-01 00:00:00
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更新日期:2009-01-01 00:00:00