Abstract:
Purpose:The aim of this study was to investigate the association of telomere length with breast cancer risk. We simultaneously explored the association between telomerase reverse transcriptase gene polymorphisms and telomere length. Methods:We used real-time quantitative polymerase chain reaction to measure relative telomere length (RTL) in genomic DNA extracted from peripheral blood from 183 breast cancer cases and 191 healthy controls. Genotyping was performed using the Sequenom MassARRAY platform. Results:Our results show that breast cancer patients had significantly shorter RTLs than control subjects (p<0.05). When the RTLs were categorized into tertiles, we found that the lowest RTL was significantly associated with increased breast cancer risk compared with the highest RTL (odds ratio [OR], 2.33; 95% confidence interval [CI], 1.40-3.90; p=0.001). Subgroup analyses indicated that risk of breast cancer was also significantly increased in the lowest RTL compared with the highest RTL in age >40 years (OR, 2.41; 95% CI, 1.31-4.43; p=0.005), body mass index ≤24 kg/m2 (OR, 2.81; 95% CI, 1.55-5.10; p=0.001), and postmenopausal women (OR, 3.94; 95% CI, 1.63-9.51; p=0.002), respectively. In addition, individuals with the AA genotype of rs2853677 have longer telomeres than those of breast cancer patients with the AG genotype (p=0.011). Conclusion:Our results suggest that shorter RTL was associated with an increased risk of breast cancer. An association was found between the AA genotype of rs2853677 and longer RTLs in the case group. Functional studies are warranted to validate this association and further investigate our findings.
journal_name
J Breast Cancerjournal_title
Journal of breast cancerauthors
Wang Z,Zhang Z,Guo Y,Shui H,Liu G,Jin T,Wang Hdoi
10.4048/jbc.2018.21.e52subject
Has Abstractpub_date
2018-12-01 00:00:00pages
391-398issue
4eissn
1738-6756issn
2092-9900journal_volume
21pub_type
杂志文章abstract:PURPOSE:Breast cancer subtype correlates with response to systemic therapy and overall survival (OS), but its impact on lymphatic spread is incompletely understood. In this study, we used the Surveillance, Epidemiology, and End Results registry to assess whether the subtype can predict the presence of nodal metastasis ...
journal_title:Journal of breast cancer
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journal_title:Journal of breast cancer
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journal_title:Journal of breast cancer
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journal_title:Journal of breast cancer
pub_type: 杂志文章,评审
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journal_title:Journal of breast cancer
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journal_title:Journal of breast cancer
pub_type: 杂志文章
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更新日期:2019-05-13 00:00:00
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journal_title:Journal of breast cancer
pub_type: 杂志文章
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journal_title:Journal of breast cancer
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更新日期:2016-09-01 00:00:00
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journal_title:Journal of breast cancer
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doi:10.4048/jbc.2018.21.2.227
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journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2020.23.e31
更新日期:2020-04-29 00:00:00
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journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2014.17.4.332
更新日期:2014-12-01 00:00:00
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journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2019.22.e11
更新日期:2019-02-15 00:00:00
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journal_title:Journal of breast cancer
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更新日期:2019-12-12 00:00:00
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journal_title:Journal of breast cancer
pub_type: 杂志文章
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更新日期:2013-03-01 00:00:00
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journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2014.17.3.226
更新日期:2014-09-01 00:00:00
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journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2017.20.4.356
更新日期:2017-12-01 00:00:00
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journal_title:Journal of breast cancer
pub_type:
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journal_title:Journal of breast cancer
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更新日期:2019-08-26 00:00:00
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journal_title:Journal of breast cancer
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journal_title:Journal of breast cancer
pub_type: 杂志文章
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更新日期:2016-03-01 00:00:00
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journal_title:Journal of breast cancer
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doi:10.4048/jbc.2016.19.2.214
更新日期:2016-06-01 00:00:00
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journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2016.19.4.417
更新日期:2016-12-01 00:00:00
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journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2013.16.4.386
更新日期:2013-12-01 00:00:00
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journal_title:Journal of breast cancer
pub_type:
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更新日期:2019-12-19 00:00:00
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journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2011.14.4.322
更新日期:2011-12-01 00:00:00
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journal_title:Journal of breast cancer
pub_type: 杂志文章,评审
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journal_title:Journal of breast cancer
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更新日期:2011-06-01 00:00:00
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journal_title:Journal of breast cancer
pub_type: 杂志文章
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更新日期:2012-12-01 00:00:00