Abstract：
PURPOSE:In our previous studies we showed that upregulating claudin-6 (CLDN6) expression may contribute to preventing breast cancer, and that 17β-estradiol induces a concentration- and time-related effect on CLDN6 mRNA and protein expression in MCF-7 cells. However, the mechanisms of 17β-estradiol regulation of CLDN6 are still unclear. We determined the role of estrogen receptors in the regulation of CLDN6 expression in human breast cancer tissues and a cell line. METHODS:CLDN6, estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) expression in breast cancer tissues were examined using immunohistochemistry. The human breast cancer cell line, MCF-7, which expresses ERα but not ERβ was used. CLDN6 and ERα expression were measured by reverse transcriptase-PCR, Western blotting and immunofluorescent staining. Treatments with propyl pyrazole triol (PPT) and ICI 182, 780 (ICI) were performed. RESULTS:The results revealed that CLDN6 expression was related to ERα in breast cancer tissues (p=0.033). PPT, an ERα-selective ligand, upregulated CLDN6 expression at 10(-5) mol/L after 24 hours. The effect of PPT on regulating CLDN6 expression in MCF-7 cells was blocked by ICI. CONCLUSION:These findings suggest that Erα reulates CLDN6 expression in breast cancer tissues and that 17β-estradiol induces CLDN6 expression through an ERα pathway in MCF-7 cells.
journal_name
J Breast Cancerjournal_title
Journal of breast cancerauthors
Yafang L,Qiong W,Yue R,Xiaoming X,Lina Y,Mingzi Z,Ting Z,Yulin L,Chengshi Qdoi
10.4048/jbc.2011.14.1.20subject
Has Abstractpub_date
2011-03-01 00:00:00pages
20-7issue
1eissn
1738-6756issn
2092-9900journal_volume
14pub_type
杂志文章abstract：PURPOSE:We investigated the relationship between BRCA mutations, pathological findings, and magnetic resonance imaging (MRI) features in patients with breast cancer at risk for the mutation. METHODS:Genetic testing for BRCA mutations was performed in 275 breast cancer patients with at least one risk factor for the mut...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2013.16.3.308
更新日期：2013-09-01 00:00:00
abstract：Purpose:The aim of this study was to investigate the association of telomere length with breast cancer risk. We simultaneously explored the association between telomerase reverse transcriptase gene polymorphisms and telomere length. Methods:We used real-time quantitative polymerase chain reaction to measure relative t...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2018.21.e52
更新日期：2018-12-01 00:00:00
abstract：:[This corrects the article on p. 192 in vol. 20, PMID: 28690656.]. ...
journal_title：Journal of breast cancer
pub_type： 已发布勘误
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更新日期：2017-09-01 00:00:00
abstract：PURPOSE:MicroRNAs (miRNAs) are a major class of small endogenous RNA molecules that posttranscriptionally regulate the expression of most genes in the human genome. miRNAs are often located in chromosomal fragile sites, which are suscept-ible to amplification or deletion. Chromosomal deletions are frequent events in br...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2016.19.2.148
更新日期：2016-06-01 00:00:00
abstract：Purpose:This study was aimed at identifying the influence of initial weight and weight change during neoadjuvant chemotherapy (NAC) on pathologic complete response (pCR) and long-term survival in Chinese patients with operable breast cancer. Methods:We conducted a retrospective study using data from 409 female patient...
journal_title：Journal of breast cancer
pub_type： 杂志文章
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更新日期：2019-08-26 00:00:00
abstract：Purpose:The benefit of post-mastectomy radiation therapy (PMRT) in patients with breast cancer who achieve ypN0 following neoadjuvant chemotherapy (NAC) has not yet been established. This study aimed to identify the role of PMRT in patients who achieve ypN0 according to molecular subtype. Methods:We identified patient...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2019.22.e25
更新日期：2019-05-13 00:00:00
abstract：PURPOSE:The Gail model is one of the most widely used tools to assess the risk of breast cancer. However, it is known to overestimate breast cancer risk for Asian women. Here, we validate the Gail model and the Korean model using Korean data, and subsequently update and revalidate the Korean model using recent data. M...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2014.17.3.226
更新日期：2014-09-01 00:00:00
abstract：PURPOSE:The purpose of this study was to assess the incidence of invasive lobular carcinoma (ILC) and to compare the clinicopathological features and treatment results after breast conserving surgery (BCS) followed by radiotherapy between ILC and invasive ductal carcinoma (IDC). METHODS:A total of 1,071 patients who u...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2015.18.3.285
更新日期：2015-09-01 00:00:00
abstract：:Apocrine encapsulated papillary carcinoma (EPC) of the breast is a rare neoplasm, and only 10 cases have been reported in the literature to date. Although EPC by definition lacks a peripheral myoepithelial layer, all previously published apocrine EPC cases were clinically indolent and lacked a conventional invasive co...
journal_title：Journal of breast cancer
pub_type：
doi：10.4048/jbc.2018.21.2.227
更新日期：2018-06-01 00:00:00
abstract：Purpose:Triple-negative breast cancer (TNBC) is associated with poor prognosis with limited treatment options. Angiogenesis is known to be involved in the progression of TNBC, and targeting this pathway results in modest clinical benefits. In this study, we analyzed the role of tumor microvascular endothelial Notch1 (E...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2019.22.e56
更新日期：2019-12-12 00:00:00
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journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2017.20.2.142
更新日期：2017-06-01 00:00:00
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journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2020.23.e31
更新日期：2020-04-29 00:00:00
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journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2017.20.4.356
更新日期：2017-12-01 00:00:00
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journal_title：Journal of breast cancer
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更新日期：2019-09-18 00:00:00
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journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2020.23.e57
更新日期：2020-10-26 00:00:00
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journal_title：Journal of breast cancer
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更新日期：2018-03-01 00:00:00
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journal_title：Journal of breast cancer
pub_type： 杂志文章,评审
doi：10.4048/jbc.2019.22.e26
更新日期：2019-05-13 00:00:00
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journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2012.15.4.478
更新日期：2012-12-01 00:00:00
abstract：PURPOSE:We aimed to confirm the prognostic and predictive value of p53 expression, particularly in invasive breast cancer patients, according to immunohistochemical hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) status. METHODS:Immunohistochemical data for p53, estrogen receptor, progesteron...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2013.16.4.386
更新日期：2013-12-01 00:00:00
abstract：:Breast metastasis from gastric carcinoma is rare. We present a case of right breast mass with microcalcification in which the diagnosis of poorly differentiated adenocarcinoma from the stomach was made after a biopsy. Pleomorphic microcalcification was noted in the ill-defined breast mass, which is a rare feature in b...
journal_title：Journal of breast cancer
pub_type：
doi：10.4048/jbc.2012.15.3.356
更新日期：2012-09-01 00:00:00
abstract：PURPOSE:As doxorubicin cardiotoxicity is considered irreversible, early detection of cardiotoxicity and prevention of overt heart failure is essential. Although there are monitoring guidelines for cardiotoxicity, optimal timing for early detection of subclinical doxorubicin cardiotoxicity is still obscure. The purpose ...
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更新日期：2013-06-01 00:00:00
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journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2012.15.1.65
更新日期：2012-03-01 00:00:00
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journal_title：Journal of breast cancer
pub_type： 杂志文章,评审
doi：10.4048/jbc.2017.20.1.12
更新日期：2017-03-01 00:00:00
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journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2011.14.4.322
更新日期：2011-12-01 00:00:00
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journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2017.20.1.98
更新日期：2017-03-01 00:00:00
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journal_title：Journal of breast cancer
pub_type：
doi：10.4048/jbc.2012.15.1.128
更新日期：2012-03-01 00:00:00
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journal_title：Journal of breast cancer
pub_type：
doi：10.4048/jbc.2014.17.4.397
更新日期：2014-12-01 00:00:00
abstract：:The median time of brain metastasis from the diagnosis of breast cancer is approximately 3 years. In this case report, a 69-year-old woman demonstrated cerebellar ataxia. Brain magnetic resonance imaging revealed enhanced lesions in bilateral cerebellar hemispheres. She had undergone surgery, radiation, and chemothera...
journal_title：Journal of breast cancer
pub_type：
doi：10.4048/jbc.2017.20.2.212
更新日期：2017-06-01 00:00:00
abstract：PURPOSE:The objective of this study was to describe the evolution of health-related quality of life (HRQOL) in a cohort of breast cancer patients over 1 year after surgery and to analyse the predictive ability of HRQOL measurement instruments. METHODS:Observational, multicenter and prospective study of a cohort of bre...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2013.16.1.104
更新日期：2013-03-01 00:00:00
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journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2019.22.e11
更新日期：2019-02-15 00:00:00
