Abstract：
PURPOSE:Metastasis and local recurrence are the primary causes of treatment failure and patient death in breast cancer. The aim of this study was to validate a metastasis- and local recurrenceassociated biomarker for prognostic evaluation and planning treatment strategies. METHODS:Formalin-fixed, paraffin-embedded tissues from a cohort of 312 patients (all stage II and III) were used. The prevalence of CD49f+ cells in the patients' tumors was analyzed and correlated with clinical characteristics to determine its prognostic and clinical implications. RESULTS:CD49f+ tumor cells were found in a minority of tumors, with 62.8% of the samples showing not a single cell of this subtype. In the clinical characteristics analysis, which were performed with t-tests, CD49f+ tumors were not associated with age, tumor size, World Health Organization grade, nodal status, human epidermal growth factor receptor 2 status, progesterone receptor status, or estrogen receptor status, although they were significantly associated with disease recurrence (distant metastasis or/and local recurrence). Univariate survival analysis using the Kaplan-Meier method showed that CD49f+ tumors were associated with markedly decreased disease-free survival (DFS); the same result was found using multivariate Cox analysis, even when only chemotherapy-treated patients were analyzed. CONCLUSION:Our results indicated that breast tumors with CD49f+ cancer cells are associated with an increased risk for disease recurrence after initial surgery with poor clinical outcomes (decreased DFS). Therefore, as it requires testing for only one additional protein, adding CD49f testing to conventional surgical pathology is a strategy that has great potential for prognostic and treatment-guidance purposes.
journal_name
J Breast Cancerjournal_title
Journal of breast cancerauthors
Ye F,Zhong X,Qiu Y,Yang L,Wei B,Zhang Z,Bu Hdoi
10.4048/jbc.2017.20.2.142subject
Has Abstractpub_date
2017-06-01 00:00:00pages
142-149issue
2eissn
1738-6756issn
2092-9900journal_volume
20pub_type
杂志文章abstract：PURPOSE:The objective of this study was to describe the evolution of health-related quality of life (HRQOL) in a cohort of breast cancer patients over 1 year after surgery and to analyse the predictive ability of HRQOL measurement instruments. METHODS:Observational, multicenter and prospective study of a cohort of bre...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2013.16.1.104
更新日期：2013-03-01 00:00:00
abstract：Purpose:BRCA1/2 mutations are associated with risks of breast and ovarian cancer. In Korea, incidences of BRCA1/2 genetic testing and risk-reducing surgery (RRS) have increased with insurance coverage and the Angelina Jolie effect. The aim of this study was to identify trends in RRS performed in Korean women with the B...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2020.23.e61
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abstract：PURPOSE:Breast cancer subtype correlates with response to systemic therapy and overall survival (OS), but its impact on lymphatic spread is incompletely understood. In this study, we used the Surveillance, Epidemiology, and End Results registry to assess whether the subtype can predict the presence of nodal metastasis ...
journal_title：Journal of breast cancer
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doi：10.4048/jbc.2015.18.2.143
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abstract：PURPOSE:Somatic mutations of the chromatin remodeling AT-rich interactive domain 1A (SWI-like) gene (ARID1A) have been identified in many human cancers, including breast cancer. The purpose of this study was to evaluate the nuclear expression of ARID1A in breast cancers by immunohistochemistry (IHC) and to correlate th...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2015.18.4.339
更新日期：2015-12-01 00:00:00
abstract：PURPOSE:We aimed to confirm the prognostic and predictive value of p53 expression, particularly in invasive breast cancer patients, according to immunohistochemical hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) status. METHODS:Immunohistochemical data for p53, estrogen receptor, progesteron...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2013.16.4.386
更新日期：2013-12-01 00:00:00
abstract：:The median time of brain metastasis from the diagnosis of breast cancer is approximately 3 years. In this case report, a 69-year-old woman demonstrated cerebellar ataxia. Brain magnetic resonance imaging revealed enhanced lesions in bilateral cerebellar hemispheres. She had undergone surgery, radiation, and chemothera...
journal_title：Journal of breast cancer
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doi：10.4048/jbc.2017.20.2.212
更新日期：2017-06-01 00:00:00
abstract：:Oxygen is crucial to maintain the homeostasis in aerobic cells. Hypoxia is a condition in which cells are deprived of the oxygen supply necessary for their optimum performance. Whereas oxygen deprivation may occur in normal physiological processes, hypoxia is frequently associated with pathological conditions. It has ...
journal_title：Journal of breast cancer
pub_type： 杂志文章,评审
doi：10.4048/jbc.2019.22.e26
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abstract：:The combination of luteinizing hormone-releasing hormone analogs (LHRHa) with tamoxifen is used as a standard postoperative adjuvant therapy in patients with hormone receptor-positive/premenopausal breast cancer. Long-acting LHRHa formulations offer advantages in terms of patient convenience. However, data on the effe...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2020.23.e57
更新日期：2020-10-26 00:00:00
abstract：PURPOSE:We investigated the feasibility of using surgical clips as markers for tumor localization and their effect on the imaging evaluation of treatment responses after neoadjuvant chemotherapy (NAC). METHODS:A total of 16 breast cancers confirmed by needle biopsy in 15 patients were included in this study from Octob...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2015.18.1.44
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abstract：:On a pathological specimen of breast cancer cells, retraction artifact during histological processing mimics true lymphovascular invasion (LVI). The accurate determination of the presence or absence of LVI is a factor in determining risk of having a positive sentinel node, or having additional positive axillary nodes ...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2012.15.4.478
更新日期：2012-12-01 00:00:00
abstract：:The prognosis associated with brain metastasis arising from breast cancer is very poor. Eribulin is a microtubule dynamic inhibitor synthesized from halichondrin B, a natural marine product. In a phase III study (EMBRACE), eribulin improved overall survival in patients with heavily pretreated metastatic breast cancers...
journal_title：Journal of breast cancer
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doi：10.4048/jbc.2016.19.2.214
更新日期：2016-06-01 00:00:00
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journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2013.16.1.40
更新日期：2013-03-01 00:00:00
abstract：Purpose:Pokemon, also known as ZBTB7A, belongs to the POZ and Krüppel (POK) family of transcription repressors and is implicated in tumor progression as a key proto-oncogene. This present study aimed at determining the mechanism by which Pokemon inhibits transforming growth factor β (TGFβ)-Smad4 pathway-dependent proli...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2019.22.e11
更新日期：2019-02-15 00:00:00
abstract：PURPOSE:Patients with recurrent breast cancer usually die of their disease, even after radical surgery and adjuvant therapies which could reduce the odds of dying. Many studies analyzed and compared patients who died of recurrent disease with those that died without recurrent disease. However, less attention has been p...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2012.15.2.218
更新日期：2012-06-01 00:00:00
abstract：:ESR1 mutation is frequently encountered in hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC), especially after aromatase inhibitor (AI) therapy, as a mechanism of resistance to endocrine therapy. Circulating tumor DNA-based detection of ESR1 mutatio...
journal_title：Journal of breast cancer
pub_type：
doi：10.4048/jbc.2020.23.e4
更新日期：2019-12-19 00:00:00
abstract：Purpose:We aimed to investigate the clinicopathologic factors associated with distant metastasis (DM) and post-recurrence overall survival (OS) after salvage treatments for isolated locoregional recurrence (ILRR) of breast cancer and identify long-term surviving patients for providing a more personalized therapy. Meth...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2020.23.e31
更新日期：2020-04-29 00:00:00
abstract：PURPOSE:Surgical clips are used as a target for postoperative breast radiotherapy, and displacement of surgical clips would result in inaccurate delivery of radiation. We investigated the displacement range of surgical clips in the breast during postoperative radiotherapy following breast-conserving surgery. METHODS:A...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2016.19.4.417
更新日期：2016-12-01 00:00:00
abstract：PURPOSE:The purpose of this study was to assess the incidence of invasive lobular carcinoma (ILC) and to compare the clinicopathological features and treatment results after breast conserving surgery (BCS) followed by radiotherapy between ILC and invasive ductal carcinoma (IDC). METHODS:A total of 1,071 patients who u...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2015.18.3.285
更新日期：2015-09-01 00:00:00
abstract：:Breast cancer is the most common malignancy, and it is also the major cause of cancer-related deaths of women worldwide. Breast cancer treatment involves surgery, chemotherapy, radiation therapy, or combination therapy, and novel strategies are needed to boost the oncologic outcome. The non-metabolizable glucose analo...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2012.15.2.141
更新日期：2012-06-01 00:00:00
abstract：:Breast metastasis from gastric carcinoma is rare. We present a case of right breast mass with microcalcification in which the diagnosis of poorly differentiated adenocarcinoma from the stomach was made after a biopsy. Pleomorphic microcalcification was noted in the ill-defined breast mass, which is a rare feature in b...
journal_title：Journal of breast cancer
pub_type：
doi：10.4048/jbc.2012.15.3.356
更新日期：2012-09-01 00:00:00
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journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2014.17.4.332
更新日期：2014-12-01 00:00:00
abstract：:The Korean Breast Cancer Society (KBCS) has reported a nationwide breast cancer data since 1996. We present a comprehensive report on the facts and trends of breast cancer in Korea in 2013. Data on the newly diagnosed patients in the year 2013 were collected from 99 hospitals by using nationwide questionnaire survey. ...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2016.19.1.1
更新日期：2016-03-01 00:00:00
abstract：PURPOSE:Re-excisions after breast-conserving surgery (BCS) for breast cancer cause delays in the adjuvant treatment, increased morbidity, and leads to poor aesthetic results. Thus, efforts to reduce the re-excision rate are essential. This study aimed to conclusively determine the re-excision rate and the factors assoc...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2012.15.4.412
更新日期：2012-12-01 00:00:00
abstract：PURPOSE:We evaluated the effect of local recurrence (LR) and regional recurrence (RR) on distant metastasis and survival in patients treated with breast conservation therapy (BCT). METHODS:We analyzed 907 patients who were treated for invasive breast cancer between 1993 and 2006. With 53 months of follow-up, 28 patien...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2011.14.3.191
更新日期：2011-09-01 00:00:00
abstract：PURPOSE:The MammaPrint™ gene signature, currently used in clinical practice, provides prognostic information regarding the recurrence and potential metastasis in breast cancer patients. However, the prognostic information of the 70 genes included can only be estimated at the RNA expression level. In this study, we inve...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2017.20.3.246
更新日期：2017-09-01 00:00:00
abstract：:Breast cancer generally develops in older women and its incidence is continuing to increase with increasing age of the population. The pathology and biology of breast cancer seem to be different in the elderly, often resulting in the undertreatment of elderly patients and thus in higher rates of recurrence and mortal-...
journal_title：Journal of breast cancer
pub_type： 杂志文章,评审
doi：10.4048/jbc.2015.18.3.207
更新日期：2015-09-01 00:00:00
abstract：PURPOSE:The Gail model is one of the most widely used tools to assess the risk of breast cancer. However, it is known to overestimate breast cancer risk for Asian women. Here, we validate the Gail model and the Korean model using Korean data, and subsequently update and revalidate the Korean model using recent data. M...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2014.17.3.226
更新日期：2014-09-01 00:00:00
abstract：Purpose:The benefit of post-mastectomy radiation therapy (PMRT) in patients with breast cancer who achieve ypN0 following neoadjuvant chemotherapy (NAC) has not yet been established. This study aimed to identify the role of PMRT in patients who achieve ypN0 according to molecular subtype. Methods:We identified patient...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2019.22.e25
更新日期：2019-05-13 00:00:00
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journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2017.20.1.98
更新日期：2017-03-01 00:00:00
abstract：:Since recurrent bilateral breast infection due to nontuberculous mycobacterium (NTM) is rare, its diagnosis is easily overlooked; in addition, complete recovery is often difficult to achieve. We report a case of recurrent bilateral infection in a 35-year-old woman who had completed treatment for NTM. Although various ...
journal_title：Journal of breast cancer
pub_type：
doi：10.4048/jbc.2014.17.3.295
更新日期：2014-09-01 00:00:00
