Abstract:
PURPOSE:Breast cancer subtype correlates with response to systemic therapy and overall survival (OS), but its impact on lymphatic spread is incompletely understood. In this study, we used the Surveillance, Epidemiology, and End Results registry to assess whether the subtype can predict the presence of nodal metastasis or advanced nodal stage in breast cancer. METHODS:A total of 7,274 eligible patients diagnosed with T1-3 infiltrating ductal carcinoma with known estrogen or progesterone hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) status, who underwent surgical excision of the primary tumor and pathologic lymph node evaluation, were included in this analysis. Patients were categorized into four breast cancer subtypes: HR+/HER2-; HR+/HER2+; HR-/HER2+; and HR-/HER2-. Binary logistic regression analysis was used to determine whether breast cancer subtype, tumor size, tumor grade, patient race, and patient age at diagnosis are independently predictive of lymph node positivity or advanced nodal stage. The Pearson chi-square test was used to determine whether progesterone receptor (PR) status had an impact on the incidence of lymph node positivity in estrogen receptor (ER) positive patients. RESULTS:Independent predictors of nodal positivity included breast cancer subtype (p=0.040), tumor size (p<0.001), tumor grade (p<0.001), and patient age (p<0.001), whereas only tumor size (p<0.001), grade (p=0.001), and patient age (p=0.005) predicted advanced nodal stage. Triple-negative cancers had a significantly lower risk of nodal positivity than the HR+/HER2- subtype (odds ratio, 0.686; p=0.004), but no other significant differences between subtypes were observed. There was also no difference in lymph node positivity between PR+ and PR- tumors amongst ER+/HER2- (p=0.228) or ER+/HER2+ tumors (p=0.713). CONCLUSION:The HR+/HER2-breast cancer subtype has a higher rate of lymph node involvement at diagnosis than the triple-negative subtype. These findings may play a role in guiding regional management considerations if confirmed in further studies.
journal_name
J Breast Cancerjournal_title
Journal of breast cancerauthors
Mattes MD,Bhatia JK,Metzger D,Ashamalla H,Katsoulakis Edoi
10.4048/jbc.2015.18.2.143subject
Has Abstractpub_date
2015-06-01 00:00:00pages
143-8issue
2eissn
1738-6756issn
2092-9900journal_volume
18pub_type
杂志文章abstract:Purpose:The treatment of triple-negative breast cancer (TNBC) remains challenging, due to the absence of estrogen, progesterone, and human epidermal growth factor receptors. This study was designed to evaluate the efficiency and safety of cytokine-induced killer (CIK) cell immunotherapy, following regular chemotherapy,...
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abstract::Apocrine encapsulated papillary carcinoma (EPC) of the breast is a rare neoplasm, and only 10 cases have been reported in the literature to date. Although EPC by definition lacks a peripheral myoepithelial layer, all previously published apocrine EPC cases were clinically indolent and lacked a conventional invasive co...
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journal_title:Journal of breast cancer
pub_type: 杂志文章,评审
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更新日期:2014-06-01 00:00:00
abstract::Internationally, breast cancer is the most common female cancer, and is induced by a combination of environmental, genetic, and epigenetic risk factors. Despite the advancement of imaging techniques, invasive sampling of breast epithelial cells is the only definitive diagnostic procedure for patients with breast cance...
journal_title:Journal of breast cancer
pub_type: 杂志文章,评审
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abstract:PURPOSE:The reliability of the quantitative measurement of breast density with a semi-automated thresholding method (Cumulus™) has mainly been investigated with film mammograms. This study aimed to evaluate the intrarater reproducibility of percent density (PD) by Cumulus™ with digital mammograms. METHODS:This study i...
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journal_title:Journal of breast cancer
pub_type: 杂志文章
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更新日期:2013-03-01 00:00:00
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journal_title:Journal of breast cancer
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doi:10.4048/jbc.2016.19.3.301
更新日期:2016-09-01 00:00:00
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journal_title:Journal of breast cancer
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更新日期:2012-09-01 00:00:00
abstract:Purpose:The benefit of post-mastectomy radiation therapy (PMRT) in patients with breast cancer who achieve ypN0 following neoadjuvant chemotherapy (NAC) has not yet been established. This study aimed to identify the role of PMRT in patients who achieve ypN0 according to molecular subtype. Methods:We identified patient...
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更新日期:2019-05-13 00:00:00
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更新日期:2013-12-01 00:00:00
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journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2011.14.2.140
更新日期:2011-06-01 00:00:00
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journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2012.15.4.478
更新日期:2012-12-01 00:00:00
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journal_title:Journal of breast cancer
pub_type: 已发布勘误
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更新日期:2012-09-01 00:00:00
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更新日期:2016-12-01 00:00:00
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