Abstract:
Purpose:Whether tamoxifen affects the risk of neurodegenerative disease is controversial. This nationwide population-based study investigated the risk of Parkinson's disease (PD) associated with tamoxifen treatment in female patients with breast cancer using Taiwan's National Health Insurance Research Database. Methods:A total of 5,185 and 5,592 female patients with breast cancer who did and did not, respectively, receive tamoxifen treatment between 2000 and 2009 were included in the study. Patients who subsequently developed PD were identified. A Cox proportional hazards model was used to compare the risk of PD between the aforementioned groups. Results:Tamoxifen did not significantly increase the crude rate of developing PD in female patients with breast cancer (tamoxifen group, 16/5,169; non-tamoxifen group, 11/5,581; p=0.246). Tamoxifen did not significantly increase the adjusted hazard ratio (aHR) for subsequently developing PD (aHR, 1.310; 95% confidence interval [CI], 0.605-2.837; p=0.494). However, tamoxifen significantly increased the risk of PD among patients followed up for more than 6 years (aHR, 2.435; 95% CI, 1.008-5.882; p=0.048). Conclusion:Tamoxifen treatment may increase the risk of PD in Taiwanese female patients with breast cancer more than 6 years after the initiation of treatment.
journal_name
J Breast Cancerjournal_title
Journal of breast cancerauthors
Hong CT,Chan L,Hu CJ,Lin CM,Hsu CY,Lin MCdoi
10.4048/jbc.2017.20.4.356subject
Has Abstractpub_date
2017-12-01 00:00:00pages
356-360issue
4eissn
1738-6756issn
2092-9900journal_volume
20pub_type
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abstract:Purpose:BRCA1/2 mutations are associated with risks of breast and ovarian cancer. In Korea, incidences of BRCA1/2 genetic testing and risk-reducing surgery (RRS) have increased with insurance coverage and the Angelina Jolie effect. The aim of this study was to identify trends in RRS performed in Korean women with the B...
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journal_title:Journal of breast cancer
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journal_title:Journal of breast cancer
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journal_title:Journal of breast cancer
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journal_title:Journal of breast cancer
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journal_title:Journal of breast cancer
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journal_title:Journal of breast cancer
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journal_title:Journal of breast cancer
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