Trends in Risk-Reducing Mastectomy and Risk-Reducing Salpingo-Oophorectomy in Korean Carriers of the BRCA1/2 Mutation.


Purpose:BRCA1/2 mutations are associated with risks of breast and ovarian cancer. In Korea, incidences of BRCA1/2 genetic testing and risk-reducing surgery (RRS) have increased with insurance coverage and the Angelina Jolie effect. The aim of this study was to identify trends in RRS performed in Korean women with the BRCA1/2 mutation. Methods:We retrospectively reviewed the medical records of BRCA1/2 mutation carriers with (affected carriers) and without (unaffected carriers) breast cancer until August 2018 from 25 Korean Hereditary Breast Cancer (KOHBRA)-affiliated hospitals. Results:The numbers of contralateral risk-reducing mastectomy (RRM) and risk-reducing bilateral salpingo-oophorectomy (RRBSO) in affected carriers have increased 5.8- and 3.6-fold, respectively, since 2013. The numbers of RRBSO in unaffected carriers has increased 8-fold since 2013. The number of institutions that perform RRS has increased gradually. The number of hospitals that perform contralateral RRM on affected carriers increased from 3 in 2012 to 11 in 2018, and that of those that perform RRBSO increased from 7 to 17. The number of hospitals that perform bilateral RRM on unaffected carriers increased from 1 in 2012 to 2 in 2018, and that of those that perform RRBSO increased from 1 to 8. However, the hospitals showed differences in the rates of RRM or RRBSO performed. Conclusion:The incidence of RRS increased each year throughout the study period. However, in Korea, the rate of RRS procedures depended on the hospital.


J Breast Cancer


Journal of breast cancer


Jung SM,Ryu JM,Park HS,Park JS,Kang E,Lee S,Lee HB,Youn HJ,Yoo TK,Kim J,Lee JE,Han SA,Kim D,Kim SW,Korean Hereditary Breast Cancer Study Group.




Has Abstract


2020-12-03 00:00:00












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    abstract:PURPOSE:MicroRNAs (miRNAs) are a major class of small endogenous RNA molecules that posttranscriptionally regulate the expression of most genes in the human genome. miRNAs are often located in chromosomal fragile sites, which are suscept-ible to amplification or deletion. Chromosomal deletions are frequent events in br...

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    authors: Damavandi Z,Torkashvand S,Vasei M,Soltani BM,Tavallaei M,Mowla SJ

    更新日期:2016-06-01 00:00:00

  • ESR1 Mutation Detection and Dynamics in Meningeal Carcinomatosis in Breast Cancer.

    abstract::ESR1 mutation is frequently encountered in hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC), especially after aromatase inhibitor (AI) therapy, as a mechanism of resistance to endocrine therapy. Circulating tumor DNA-based detection of ESR1 mutatio...

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    更新日期:2019-12-19 00:00:00

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    pub_type: 杂志文章,评审


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    更新日期:2017-03-01 00:00:00

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    authors: Yang JD,Lee JW,Kim WW,Jung JH,Park HY

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    authors: Nagata Y,Yoshioka M,Uramoto H,Tsurudome Y,Yamada S,Hanagiri T,Tanaka F

    更新日期:2018-03-01 00:00:00

  • Enhanced radiosensitivity and chemosensitivity of breast cancer cells by 2-deoxy-d-glucose in combination therapy.

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    journal_title:Journal of breast cancer

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    authors: Aghaee F,Pirayesh Islamian J,Baradaran B

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    authors: Zaorsky NG,Patil N,Freedman GM,Tuluc M

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    authors: Song SE,Seo BK,Lee SH,Yie A,Lee KY,Cho KR,Woo OH,Cha SH,Kim BH

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    journal_title:Journal of breast cancer

    pub_type: 杂志文章


    authors: Jung W,Kang E,Kim SM,Kim D,Hwang Y,Sun Y,Yom CK,Kim SW

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    journal_title:Journal of breast cancer

    pub_type: 杂志文章


    authors: Noh JM,Han BK,Choi DH,Rhee SJ,Cho EY,Huh SJ,Park W,Park H,Nam SJ,Lee JE,Kil WH

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  • Associations between BRCA Mutations in High-Risk Breast Cancer Patients and Familial Cancers Other than Breast or Ovary.

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    journal_title:Journal of breast cancer

    pub_type: 杂志文章


    authors: Noh JM,Choi DH,Baek H,Nam SJ,Lee JE,Kim JW,Ki CS,Park W,Huh SJ

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    journal_title:Journal of breast cancer



    authors: Byun KD,Ahn SG,Baik HJ,Lee A,Bae KB,An MS,Kim KH,Shin JH,Park HK,Cho H,Jeong J,Kim TH

    更新日期:2016-06-01 00:00:00

  • Effect Modification of Hormonal Therapy by p53 Status in Invasive Breast Cancer.

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    journal_title:Journal of breast cancer

    pub_type: 杂志文章


    authors: Ahn SH,Kim HJ,Han W,Cho J,Gong G,Jung KH,Kim SB,Son BH,Lee JW

    更新日期:2013-12-01 00:00:00