Abstract:
:Multiple symmetric lipomatosis (MSL), or Madelung's disease, is a rare disease of unknown etiology. It is characterized by the presence of loose adipose tissue deposits localized in the cervical region and upper body. MSL presenting as bilateral huge gynecomastia is an extremely rare phenomenon. The present report describes a case of MSL in a 66-year-old man. The patients presented with bilateral breast bulging. He had a history of cigarette and alcohol use. His condition was treated with a bilateral nipple-sparing mastectomy. MSL can present as a form of gynecomastia, for its accurate diagnosis and proper treatment of MSL, increasing awareness of the clinical characteristics of the disease is required, especially amongst breast surgeons. Herein, we review the literature and discuss the clinical characteristics, pathology, and surgical treatment of MSL.
journal_name
J Breast Cancerjournal_title
Journal of breast cancerauthors
Jang JH,Lee A,Han SA,Ryu JK,Song JYdoi
10.4048/jbc.2014.17.4.397subject
Has Abstractpub_date
2014-12-01 00:00:00pages
397-400issue
4eissn
1738-6756issn
2092-9900journal_volume
17pub_type
abstract:Purpose:The exact mechanism regulating fibronectin (FN) expression in breast cancer cells has not been fully elucidated. In this study, we investigated the pharmacological mechanism of berberine (BBR) with respect to FN expression in triple-negative breast cancer (TNBC) cells. Methods:The clinical significance of FN m...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2018.21.1.21
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:The MammaPrint™ gene signature, currently used in clinical practice, provides prognostic information regarding the recurrence and potential metastasis in breast cancer patients. However, the prognostic information of the 70 genes included can only be estimated at the RNA expression level. In this study, we inve...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2017.20.3.246
更新日期:2017-09-01 00:00:00
abstract:PURPOSE:MicroRNAs (miRNAs) are a major class of small endogenous RNA molecules that posttranscriptionally regulate the expression of most genes in the human genome. miRNAs are often located in chromosomal fragile sites, which are suscept-ible to amplification or deletion. Chromosomal deletions are frequent events in br...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2016.19.2.148
更新日期:2016-06-01 00:00:00
abstract:Purpose:The benefit of post-mastectomy radiation therapy (PMRT) in patients with breast cancer who achieve ypN0 following neoadjuvant chemotherapy (NAC) has not yet been established. This study aimed to identify the role of PMRT in patients who achieve ypN0 according to molecular subtype. Methods:We identified patient...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2019.22.e25
更新日期:2019-05-13 00:00:00
abstract:PURPOSE:We evaluated the effect of local recurrence (LR) and regional recurrence (RR) on distant metastasis and survival in patients treated with breast conservation therapy (BCT). METHODS:We analyzed 907 patients who were treated for invasive breast cancer between 1993 and 2006. With 53 months of follow-up, 28 patien...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2011.14.3.191
更新日期:2011-09-01 00:00:00
abstract::The prognosis associated with brain metastasis arising from breast cancer is very poor. Eribulin is a microtubule dynamic inhibitor synthesized from halichondrin B, a natural marine product. In a phase III study (EMBRACE), eribulin improved overall survival in patients with heavily pretreated metastatic breast cancers...
journal_title:Journal of breast cancer
pub_type:
doi:10.4048/jbc.2016.19.2.214
更新日期:2016-06-01 00:00:00
abstract:PURPOSE:Surgical clips are used as a target for postoperative breast radiotherapy, and displacement of surgical clips would result in inaccurate delivery of radiation. We investigated the displacement range of surgical clips in the breast during postoperative radiotherapy following breast-conserving surgery. METHODS:A...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2016.19.4.417
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:Transient receptor potential vanilloid 1 (TRPV1) is a nonselective cation channel belonging to the transient receptor potential family, and it is expressed in different neoplastic tissues. Its activation is associated with regulation of cancer growth and progression. The aim of this research was to study the ex...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2014.17.4.332
更新日期:2014-12-01 00:00:00
abstract:PURPOSE:Breast volume assessment is one of the most important steps during implant-based breast reconstruction because it is critical in selecting implant size. According to previous studies, there is a close relationship between the mastectomy specimen weight and resected breast volume. The aim of this study was to ev...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2017.20.1.98
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:Metastasis and local recurrence are the primary causes of treatment failure and patient death in breast cancer. The aim of this study was to validate a metastasis- and local recurrenceassociated biomarker for prognostic evaluation and planning treatment strategies. METHODS:Formalin-fixed, paraffin-embedded tis...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2017.20.2.142
更新日期:2017-06-01 00:00:00
abstract::Malignant melanoma rarely originates from the female nipple. Tumors that develop on the skin of the breast are often subject to a delayed diagnosis. Cytologic examination provides excellent diagnostic capabilities and is a safe procedure with a lower risk of local implantation, compared to needle or incisional biopsy....
journal_title:Journal of breast cancer
pub_type:
doi:10.4048/jbc.2018.21.1.96
更新日期:2018-03-01 00:00:00
abstract::On a pathological specimen of breast cancer cells, retraction artifact during histological processing mimics true lymphovascular invasion (LVI). The accurate determination of the presence or absence of LVI is a factor in determining risk of having a positive sentinel node, or having additional positive axillary nodes ...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2012.15.4.478
更新日期:2012-12-01 00:00:00
abstract::The combination of luteinizing hormone-releasing hormone analogs (LHRHa) with tamoxifen is used as a standard postoperative adjuvant therapy in patients with hormone receptor-positive/premenopausal breast cancer. Long-acting LHRHa formulations offer advantages in terms of patient convenience. However, data on the effe...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2020.23.e57
更新日期:2020-10-26 00:00:00
abstract:PURPOSE:We investigated the relationship between BRCA mutations and the distribution of familial cancers other than breast or ovary in high-risk breast cancer patients. METHODS:PATIENTS WITH BREAST CANCER WHO HAD AT LEAST ONE OF THE FOLLOWING RISK FACTORS WERE ENROLLED: reported family history of breast or ovarian can...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2012.15.3.283
更新日期:2012-09-01 00:00:00
abstract::The median time of brain metastasis from the diagnosis of breast cancer is approximately 3 years. In this case report, a 69-year-old woman demonstrated cerebellar ataxia. Brain magnetic resonance imaging revealed enhanced lesions in bilateral cerebellar hemispheres. She had undergone surgery, radiation, and chemothera...
journal_title:Journal of breast cancer
pub_type:
doi:10.4048/jbc.2017.20.2.212
更新日期:2017-06-01 00:00:00
abstract:PURPOSE:Re-excisions after breast-conserving surgery (BCS) for breast cancer cause delays in the adjuvant treatment, increased morbidity, and leads to poor aesthetic results. Thus, efforts to reduce the re-excision rate are essential. This study aimed to conclusively determine the re-excision rate and the factors assoc...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2012.15.4.412
更新日期:2012-12-01 00:00:00
abstract:PURPOSE:Somatic mutations of the chromatin remodeling AT-rich interactive domain 1A (SWI-like) gene (ARID1A) have been identified in many human cancers, including breast cancer. The purpose of this study was to evaluate the nuclear expression of ARID1A in breast cancers by immunohistochemistry (IHC) and to correlate th...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2015.18.4.339
更新日期:2015-12-01 00:00:00
abstract::Oncoplastic surgery has revolutionized the field of breast conserving surgery (BCS). The final aims of this technique are to obtain an adequate resection margin that will reduce the rate of local recurrence while simultaneously improving cosmetic outcomes. To obtain successful results after oncoplastic surgery, it is ...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2011.14.4.253
更新日期:2011-12-01 00:00:00
abstract::[This corrects the article on p. 192 in vol. 20, PMID: 28690656.]. ...
journal_title:Journal of breast cancer
pub_type: 已发布勘误
doi:10.4048/jbc.2017.20.3.319
更新日期:2017-09-01 00:00:00
abstract::We describe a patient with breast cancer who relapsed with an extensive pulmonary lymphovascular tumor embolism. A 38-year-old female, who previously received neoadjuvant chemotherapy and curative resection of breast cancer, underwent adjuvant chemotherapy and was referred to the emergency room because of sudden-onset...
journal_title:Journal of breast cancer
pub_type:
doi:10.4048/jbc.2012.15.1.128
更新日期:2012-03-01 00:00:00
abstract::Breast cancer is the most common malignancy, and it is also the major cause of cancer-related deaths of women worldwide. Breast cancer treatment involves surgery, chemotherapy, radiation therapy, or combination therapy, and novel strategies are needed to boost the oncologic outcome. The non-metabolizable glucose analo...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2012.15.2.141
更新日期:2012-06-01 00:00:00
abstract::Internationally, breast cancer is the most common female cancer, and is induced by a combination of environmental, genetic, and epigenetic risk factors. Despite the advancement of imaging techniques, invasive sampling of breast epithelial cells is the only definitive diagnostic procedure for patients with breast cance...
journal_title:Journal of breast cancer
pub_type: 杂志文章,评审
doi:10.4048/jbc.2017.20.1.12
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:The reliability of the quantitative measurement of breast density with a semi-automated thresholding method (Cumulus™) has mainly been investigated with film mammograms. This study aimed to evaluate the intrarater reproducibility of percent density (PD) by Cumulus™ with digital mammograms. METHODS:This study i...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2014.17.2.174
更新日期:2014-06-01 00:00:00
abstract:PURPOSE:In our previous studies we showed that upregulating claudin-6 (CLDN6) expression may contribute to preventing breast cancer, and that 17β-estradiol induces a concentration- and time-related effect on CLDN6 mRNA and protein expression in MCF-7 cells. However, the mechanisms of 17β-estradiol regulation of CLDN6 a...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2011.14.1.20
更新日期:2011-03-01 00:00:00
abstract:PURPOSE:Patients with recurrent breast cancer usually die of their disease, even after radical surgery and adjuvant therapies which could reduce the odds of dying. Many studies analyzed and compared patients who died of recurrent disease with those that died without recurrent disease. However, less attention has been p...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2012.15.2.218
更新日期:2012-06-01 00:00:00
abstract::Since recurrent bilateral breast infection due to nontuberculous mycobacterium (NTM) is rare, its diagnosis is easily overlooked; in addition, complete recovery is often difficult to achieve. We report a case of recurrent bilateral infection in a 35-year-old woman who had completed treatment for NTM. Although various ...
journal_title:Journal of breast cancer
pub_type:
doi:10.4048/jbc.2014.17.3.295
更新日期:2014-09-01 00:00:00
abstract:Purpose:Whether tamoxifen affects the risk of neurodegenerative disease is controversial. This nationwide population-based study investigated the risk of Parkinson's disease (PD) associated with tamoxifen treatment in female patients with breast cancer using Taiwan's National Health Insurance Research Database. Method...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2017.20.4.356
更新日期:2017-12-01 00:00:00
abstract:PURPOSE:This study assessed the incidence and cancer rate of probably benign lesions detected on bilateral whole-breast screening ultrasound (US), which corresponded to US Breast Imaging Reporting and Data System (BI-RADS) category 3, and evaluated the proper management of those lesions. METHODS:This study was approve...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2016.19.3.301
更新日期:2016-09-01 00:00:00
abstract::When faced with a case of bilateral breast cancer (BBC), understanding how to differentiate bilateral primary breast cancer from contralateral metastatic breast cancer is essential for treatment, but clear identification criteria have not been established to date. Diverse events play different roles in the therapy and...
journal_title:Journal of breast cancer
pub_type:
doi:10.4048/jbc.2019.22.e10
更新日期:2019-02-02 00:00:00
abstract::ESR1 mutation is frequently encountered in hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC), especially after aromatase inhibitor (AI) therapy, as a mechanism of resistance to endocrine therapy. Circulating tumor DNA-based detection of ESR1 mutatio...
journal_title:Journal of breast cancer
pub_type:
doi:10.4048/jbc.2020.23.e4
更新日期:2019-12-19 00:00:00