Abstract:
:ESR1 mutation is frequently encountered in hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC), especially after aromatase inhibitor (AI) therapy, as a mechanism of resistance to endocrine therapy. Circulating tumor DNA-based detection of ESR1 mutation in plasma has been demonstrated as a prognostic and predictive factor for poor outcomes in subsequent AI therapy. In this case report, for the first time, we describe the detection of ESR1 mutation (p.Tyr537Ser) only in the cerebrospinal fluid (CSF) and not in the plasma of a patient with isolated leptomeningeal progression who was treated with AI for HR-positive, HER2-negative MBC (bone metastasis only). Circulating tumor DNA levels also appeared to be correlated with clinical evolution. We suggest that in the presence of isolated leptomeningeal metastasis and when tamoxifen or AI has been prescribed for HR-positive MBC, CSF should be screened for ESR1 mutations to potentially adjust systemic treatment.
journal_name
J Breast Cancerjournal_title
Journal of breast cancerauthors
Carausu M,Melaabi S,Pierga JY,Bidard FC,Cabel Ldoi
10.4048/jbc.2020.23.e4subject
Has Abstractpub_date
2019-12-19 00:00:00pages
218-223issue
2eissn
1738-6756issn
2092-9900journal_volume
23pub_type
abstract:PURPOSE:Transient receptor potential vanilloid 1 (TRPV1) is a nonselective cation channel belonging to the transient receptor potential family, and it is expressed in different neoplastic tissues. Its activation is associated with regulation of cancer growth and progression. The aim of this research was to study the ex...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2014.17.4.332
更新日期:2014-12-01 00:00:00
abstract::On a pathological specimen of breast cancer cells, retraction artifact during histological processing mimics true lymphovascular invasion (LVI). The accurate determination of the presence or absence of LVI is a factor in determining risk of having a positive sentinel node, or having additional positive axillary nodes ...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2012.15.4.478
更新日期:2012-12-01 00:00:00
abstract::The combination of luteinizing hormone-releasing hormone analogs (LHRHa) with tamoxifen is used as a standard postoperative adjuvant therapy in patients with hormone receptor-positive/premenopausal breast cancer. Long-acting LHRHa formulations offer advantages in terms of patient convenience. However, data on the effe...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2020.23.e57
更新日期:2020-10-26 00:00:00
abstract::Breast metastasis from gastric carcinoma is rare. We present a case of right breast mass with microcalcification in which the diagnosis of poorly differentiated adenocarcinoma from the stomach was made after a biopsy. Pleomorphic microcalcification was noted in the ill-defined breast mass, which is a rare feature in b...
journal_title:Journal of breast cancer
pub_type:
doi:10.4048/jbc.2012.15.3.356
更新日期:2012-09-01 00:00:00
abstract:PURPOSE:The frequency of immediate breast reconstruction (IBR) is increasing, and the types of reconstruction used are diverse. Adjuvant chemotherapy is a life-saving intervention in selected high-risk breast cancer patients. The aim of our study was to determine how IBR and type of reconstruction affect the timing of ...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2011.14.4.322
更新日期:2011-12-01 00:00:00
abstract:Purpose:Previous oncological studies showed that lymph node ratio (LNR) (ratio of number of lymph nodes that tested positive for metastasis to the total number of lymph nodes examined) is a negative indicator of cancer survival. The American Joint Committee on Cancer (AJCC) staging system incorporates tumor size, lymph...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2018.21.e35
更新日期:2018-09-01 00:00:00
abstract:PURPOSE:We investigated the relationship between BRCA mutations and the distribution of familial cancers other than breast or ovary in high-risk breast cancer patients. METHODS:PATIENTS WITH BREAST CANCER WHO HAD AT LEAST ONE OF THE FOLLOWING RISK FACTORS WERE ENROLLED: reported family history of breast or ovarian can...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2012.15.3.283
更新日期:2012-09-01 00:00:00
abstract::Since recurrent bilateral breast infection due to nontuberculous mycobacterium (NTM) is rare, its diagnosis is easily overlooked; in addition, complete recovery is often difficult to achieve. We report a case of recurrent bilateral infection in a 35-year-old woman who had completed treatment for NTM. Although various ...
journal_title:Journal of breast cancer
pub_type:
doi:10.4048/jbc.2014.17.3.295
更新日期:2014-09-01 00:00:00
abstract:Purpose:BRCA1/2 mutations are associated with risks of breast and ovarian cancer. In Korea, incidences of BRCA1/2 genetic testing and risk-reducing surgery (RRS) have increased with insurance coverage and the Angelina Jolie effect. The aim of this study was to identify trends in RRS performed in Korean women with the B...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2020.23.e61
更新日期:2020-12-03 00:00:00
abstract::This paper is a review of the literature examining the use of medical simulations to teach our future healthcare providers how to diagnose breast cancer. MEDLINE and Embase databases were searched to identify the literature published between 1990 and 2014. In total, 113 articles were retrieved and evaluated for their ...
journal_title:Journal of breast cancer
pub_type: 杂志文章,评审
doi:10.4048/jbc.2014.17.2.107
更新日期:2014-06-01 00:00:00
abstract:PURPOSE:The role of first-line trastuzumab-based therapy has been firmly established in patients with human epidermal growth factor receptor-2 (HER2) positive metastatic breast cancer. In this trial, we evaluated the efficacy and safety of a vinorelbine and trastuzumab combination chemotherapy in patients who were pret...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2011.14.2.140
更新日期:2011-06-01 00:00:00
abstract:PURPOSE:This study assessed the incidence and cancer rate of probably benign lesions detected on bilateral whole-breast screening ultrasound (US), which corresponded to US Breast Imaging Reporting and Data System (BI-RADS) category 3, and evaluated the proper management of those lesions. METHODS:This study was approve...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2016.19.3.301
更新日期:2016-09-01 00:00:00
abstract:Purpose:The exact mechanism regulating fibronectin (FN) expression in breast cancer cells has not been fully elucidated. In this study, we investigated the pharmacological mechanism of berberine (BBR) with respect to FN expression in triple-negative breast cancer (TNBC) cells. Methods:The clinical significance of FN m...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2018.21.1.21
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:The objective of this study was to describe the evolution of health-related quality of life (HRQOL) in a cohort of breast cancer patients over 1 year after surgery and to analyse the predictive ability of HRQOL measurement instruments. METHODS:Observational, multicenter and prospective study of a cohort of bre...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2013.16.1.104
更新日期:2013-03-01 00:00:00
abstract::Multiple symmetric lipomatosis (MSL), or Madelung's disease, is a rare disease of unknown etiology. It is characterized by the presence of loose adipose tissue deposits localized in the cervical region and upper body. MSL presenting as bilateral huge gynecomastia is an extremely rare phenomenon. The present report des...
journal_title:Journal of breast cancer
pub_type:
doi:10.4048/jbc.2014.17.4.397
更新日期:2014-12-01 00:00:00
abstract:Purpose:This study was aimed at identifying the influence of initial weight and weight change during neoadjuvant chemotherapy (NAC) on pathologic complete response (pCR) and long-term survival in Chinese patients with operable breast cancer. Methods:We conducted a retrospective study using data from 409 female patient...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2019.22.e37
更新日期:2019-08-26 00:00:00
abstract:PURPOSE:In our previous studies we showed that upregulating claudin-6 (CLDN6) expression may contribute to preventing breast cancer, and that 17β-estradiol induces a concentration- and time-related effect on CLDN6 mRNA and protein expression in MCF-7 cells. However, the mechanisms of 17β-estradiol regulation of CLDN6 a...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2011.14.1.20
更新日期:2011-03-01 00:00:00
abstract:PURPOSE:Patients with recurrent breast cancer usually die of their disease, even after radical surgery and adjuvant therapies which could reduce the odds of dying. Many studies analyzed and compared patients who died of recurrent disease with those that died without recurrent disease. However, less attention has been p...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2012.15.2.218
更新日期:2012-06-01 00:00:00
abstract:PURPOSE:To investigate the significance of the cortex-hilum (CH) area ratio and longitudinal-transverse (LT) axis ratio and the blood flow pattern for diagnosis of metastatic axillary lymph nodes by ultrasound in breast cancer patients. METHODS:From October 2005 to July 2006, we prospectively evaluated axillary nodes ...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2012.15.1.65
更新日期:2012-03-01 00:00:00
abstract::When faced with a case of bilateral breast cancer (BBC), understanding how to differentiate bilateral primary breast cancer from contralateral metastatic breast cancer is essential for treatment, but clear identification criteria have not been established to date. Diverse events play different roles in the therapy and...
journal_title:Journal of breast cancer
pub_type:
doi:10.4048/jbc.2019.22.e10
更新日期:2019-02-02 00:00:00
abstract:PURPOSE:This study was performed to assess frequency, timings of occurrence, and predictors of radiologic lung damage (RLD) after forward-planned intensity-modulated radiotherapy (FIMRT) for whole breast irradiation. METHODS:We retrospectively reviewed medical records of 157 breast cancer patients and each of their se...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2014.17.1.69
更新日期:2014-03-01 00:00:00
abstract:PURPOSE:Somatic mutations of the chromatin remodeling AT-rich interactive domain 1A (SWI-like) gene (ARID1A) have been identified in many human cancers, including breast cancer. The purpose of this study was to evaluate the nuclear expression of ARID1A in breast cancers by immunohistochemistry (IHC) and to correlate th...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2015.18.4.339
更新日期:2015-12-01 00:00:00
abstract:PURPOSE:Surgical clips are used as a target for postoperative breast radiotherapy, and displacement of surgical clips would result in inaccurate delivery of radiation. We investigated the displacement range of surgical clips in the breast during postoperative radiotherapy following breast-conserving surgery. METHODS:A...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2016.19.4.417
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:Re-excisions after breast-conserving surgery (BCS) for breast cancer cause delays in the adjuvant treatment, increased morbidity, and leads to poor aesthetic results. Thus, efforts to reduce the re-excision rate are essential. This study aimed to conclusively determine the re-excision rate and the factors assoc...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2012.15.4.412
更新日期:2012-12-01 00:00:00
abstract::The Korean Breast Cancer Society (KBCS) has reported a nationwide breast cancer data since 1996. We present a comprehensive report on the facts and trends of breast cancer in Korea in 2013. Data on the newly diagnosed patients in the year 2013 were collected from 99 hospitals by using nationwide questionnaire survey. ...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2016.19.1.1
更新日期:2016-03-01 00:00:00
abstract::Oncoplastic surgery has revolutionized the field of breast conserving surgery (BCS). The final aims of this technique are to obtain an adequate resection margin that will reduce the rate of local recurrence while simultaneously improving cosmetic outcomes. To obtain successful results after oncoplastic surgery, it is ...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2011.14.4.253
更新日期:2011-12-01 00:00:00
abstract:PURPOSE:Breast volume assessment is one of the most important steps during implant-based breast reconstruction because it is critical in selecting implant size. According to previous studies, there is a close relationship between the mastectomy specimen weight and resected breast volume. The aim of this study was to ev...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2017.20.1.98
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:The MammaPrint™ gene signature, currently used in clinical practice, provides prognostic information regarding the recurrence and potential metastasis in breast cancer patients. However, the prognostic information of the 70 genes included can only be estimated at the RNA expression level. In this study, we inve...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2017.20.3.246
更新日期:2017-09-01 00:00:00
abstract::Oxygen is crucial to maintain the homeostasis in aerobic cells. Hypoxia is a condition in which cells are deprived of the oxygen supply necessary for their optimum performance. Whereas oxygen deprivation may occur in normal physiological processes, hypoxia is frequently associated with pathological conditions. It has ...
journal_title:Journal of breast cancer
pub_type: 杂志文章,评审
doi:10.4048/jbc.2019.22.e26
更新日期:2019-05-13 00:00:00
abstract:PURPOSE:We investigated the relationship between BRCA mutations, pathological findings, and magnetic resonance imaging (MRI) features in patients with breast cancer at risk for the mutation. METHODS:Genetic testing for BRCA mutations was performed in 275 breast cancer patients with at least one risk factor for the mut...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2013.16.3.308
更新日期:2013-09-01 00:00:00