Abstract:
:Breast cancer is the most common malignancy, and it is also the major cause of cancer-related deaths of women worldwide. Breast cancer treatment involves surgery, chemotherapy, radiation therapy, or combination therapy, and novel strategies are needed to boost the oncologic outcome. The non-metabolizable glucose analogue, 2-deoxy-D-glucose (2-DG) which inhibits glucose synthesis and adenosine triphosphate production, is one of the important discoveries involving the disturbances that can be caused to the process of the metabolism. The glucose analogue, 2-DG, is known as a tumor sensitizer to irradiation (IR) and chemotherapy, which help improve the treatment rates. It enhances the cytotoxicity via oxidative stress, which is more redundant in tumor cells than in normal ones. This article provides a brief summary on studies related to 2-DG chemo-/radio-sensitization effects by combination therapy of 2-DG/IR or 2-DG/doxorubicin.
journal_name
J Breast Cancerjournal_title
Journal of breast cancerauthors
Aghaee F,Pirayesh Islamian J,Baradaran Bdoi
10.4048/jbc.2012.15.2.141subject
Has Abstractpub_date
2012-06-01 00:00:00pages
141-7issue
2eissn
1738-6756issn
2092-9900journal_volume
15pub_type
杂志文章abstract:Purpose:Previous oncological studies showed that lymph node ratio (LNR) (ratio of number of lymph nodes that tested positive for metastasis to the total number of lymph nodes examined) is a negative indicator of cancer survival. The American Joint Committee on Cancer (AJCC) staging system incorporates tumor size, lymph...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2018.21.e35
更新日期:2018-09-01 00:00:00
abstract:PURPOSE:Breast volume assessment is one of the most important steps during implant-based breast reconstruction because it is critical in selecting implant size. According to previous studies, there is a close relationship between the mastectomy specimen weight and resected breast volume. The aim of this study was to ev...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2017.20.1.98
更新日期:2017-03-01 00:00:00
abstract::Breast cancer generally develops in older women and its incidence is continuing to increase with increasing age of the population. The pathology and biology of breast cancer seem to be different in the elderly, often resulting in the undertreatment of elderly patients and thus in higher rates of recurrence and mortal-...
journal_title:Journal of breast cancer
pub_type: 杂志文章,评审
doi:10.4048/jbc.2015.18.3.207
更新日期:2015-09-01 00:00:00
abstract::Malignant melanoma rarely originates from the female nipple. Tumors that develop on the skin of the breast are often subject to a delayed diagnosis. Cytologic examination provides excellent diagnostic capabilities and is a safe procedure with a lower risk of local implantation, compared to needle or incisional biopsy....
journal_title:Journal of breast cancer
pub_type:
doi:10.4048/jbc.2018.21.1.96
更新日期:2018-03-01 00:00:00
abstract::Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis belong to a severe dermatopathic spectrum that includes frequently fatal mucocutaneous manifestations consisting of whole epidermal necrosis and sloughing with bullous transformation, blistering, and further skin detachment. Notably, cancer patients are at ...
journal_title:Journal of breast cancer
pub_type:
doi:10.4048/jbc.2019.22.e44
更新日期:2019-09-18 00:00:00
abstract:Purpose:Breast cancer treatments, including chemotherapy, administered in combination with glucocorticoids can induce hyperglycemia. This study aimed to investigate the effect of hyperglycemia during adjuvant chemotherapy on the prognosis of breast cancer patients without a known history of diabetes. Methods:In this s...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2020.23.e44
更新日期:2020-08-05 00:00:00
abstract:Purpose:The benefit of post-mastectomy radiation therapy (PMRT) in patients with breast cancer who achieve ypN0 following neoadjuvant chemotherapy (NAC) has not yet been established. This study aimed to identify the role of PMRT in patients who achieve ypN0 according to molecular subtype. Methods:We identified patient...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2019.22.e25
更新日期:2019-05-13 00:00:00
abstract:PURPOSE:The purpose of this study was to assess the incidence of invasive lobular carcinoma (ILC) and to compare the clinicopathological features and treatment results after breast conserving surgery (BCS) followed by radiotherapy between ILC and invasive ductal carcinoma (IDC). METHODS:A total of 1,071 patients who u...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2015.18.3.285
更新日期:2015-09-01 00:00:00
abstract:Purpose:The treatment of triple-negative breast cancer (TNBC) remains challenging, due to the absence of estrogen, progesterone, and human epidermal growth factor receptors. This study was designed to evaluate the efficiency and safety of cytokine-induced killer (CIK) cell immunotherapy, following regular chemotherapy,...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2018.21.2.150
更新日期:2018-06-01 00:00:00
abstract::On a pathological specimen of breast cancer cells, retraction artifact during histological processing mimics true lymphovascular invasion (LVI). The accurate determination of the presence or absence of LVI is a factor in determining risk of having a positive sentinel node, or having additional positive axillary nodes ...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2012.15.4.478
更新日期:2012-12-01 00:00:00
abstract::The Korean Breast Cancer Society (KBCS) has reported a nationwide breast cancer data since 1996. We present a comprehensive report on the facts and trends of breast cancer in Korea in 2013. Data on the newly diagnosed patients in the year 2013 were collected from 99 hospitals by using nationwide questionnaire survey. ...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2016.19.1.1
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:This study was performed to assess frequency, timings of occurrence, and predictors of radiologic lung damage (RLD) after forward-planned intensity-modulated radiotherapy (FIMRT) for whole breast irradiation. METHODS:We retrospectively reviewed medical records of 157 breast cancer patients and each of their se...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2014.17.1.69
更新日期:2014-03-01 00:00:00
abstract:PURPOSE:In our previous studies we showed that upregulating claudin-6 (CLDN6) expression may contribute to preventing breast cancer, and that 17β-estradiol induces a concentration- and time-related effect on CLDN6 mRNA and protein expression in MCF-7 cells. However, the mechanisms of 17β-estradiol regulation of CLDN6 a...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2011.14.1.20
更新日期:2011-03-01 00:00:00
abstract::The median time of brain metastasis from the diagnosis of breast cancer is approximately 3 years. In this case report, a 69-year-old woman demonstrated cerebellar ataxia. Brain magnetic resonance imaging revealed enhanced lesions in bilateral cerebellar hemispheres. She had undergone surgery, radiation, and chemothera...
journal_title:Journal of breast cancer
pub_type:
doi:10.4048/jbc.2017.20.2.212
更新日期:2017-06-01 00:00:00
abstract:Purpose:This study was aimed at identifying the influence of initial weight and weight change during neoadjuvant chemotherapy (NAC) on pathologic complete response (pCR) and long-term survival in Chinese patients with operable breast cancer. Methods:We conducted a retrospective study using data from 409 female patient...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2019.22.e37
更新日期:2019-08-26 00:00:00
abstract::Oncoplastic surgery has revolutionized the field of breast conserving surgery (BCS). The final aims of this technique are to obtain an adequate resection margin that will reduce the rate of local recurrence while simultaneously improving cosmetic outcomes. To obtain successful results after oncoplastic surgery, it is ...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2011.14.4.253
更新日期:2011-12-01 00:00:00
abstract::ESR1 mutation is frequently encountered in hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC), especially after aromatase inhibitor (AI) therapy, as a mechanism of resistance to endocrine therapy. Circulating tumor DNA-based detection of ESR1 mutatio...
journal_title:Journal of breast cancer
pub_type:
doi:10.4048/jbc.2020.23.e4
更新日期:2019-12-19 00:00:00
abstract::Since recurrent bilateral breast infection due to nontuberculous mycobacterium (NTM) is rare, its diagnosis is easily overlooked; in addition, complete recovery is often difficult to achieve. We report a case of recurrent bilateral infection in a 35-year-old woman who had completed treatment for NTM. Although various ...
journal_title:Journal of breast cancer
pub_type:
doi:10.4048/jbc.2014.17.3.295
更新日期:2014-09-01 00:00:00
abstract:PURPOSE:Patients with recurrent breast cancer usually die of their disease, even after radical surgery and adjuvant therapies which could reduce the odds of dying. Many studies analyzed and compared patients who died of recurrent disease with those that died without recurrent disease. However, less attention has been p...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2012.15.2.218
更新日期:2012-06-01 00:00:00
abstract:Purpose:BRCA1/2 mutations are associated with risks of breast and ovarian cancer. In Korea, incidences of BRCA1/2 genetic testing and risk-reducing surgery (RRS) have increased with insurance coverage and the Angelina Jolie effect. The aim of this study was to identify trends in RRS performed in Korean women with the B...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2020.23.e61
更新日期:2020-12-03 00:00:00
abstract::We describe a patient with breast cancer who relapsed with an extensive pulmonary lymphovascular tumor embolism. A 38-year-old female, who previously received neoadjuvant chemotherapy and curative resection of breast cancer, underwent adjuvant chemotherapy and was referred to the emergency room because of sudden-onset...
journal_title:Journal of breast cancer
pub_type:
doi:10.4048/jbc.2012.15.1.128
更新日期:2012-03-01 00:00:00
abstract:PURPOSE:The frequency of immediate breast reconstruction (IBR) is increasing, and the types of reconstruction used are diverse. Adjuvant chemotherapy is a life-saving intervention in selected high-risk breast cancer patients. The aim of our study was to determine how IBR and type of reconstruction affect the timing of ...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2011.14.4.322
更新日期:2011-12-01 00:00:00
abstract::The prognosis associated with brain metastasis arising from breast cancer is very poor. Eribulin is a microtubule dynamic inhibitor synthesized from halichondrin B, a natural marine product. In a phase III study (EMBRACE), eribulin improved overall survival in patients with heavily pretreated metastatic breast cancers...
journal_title:Journal of breast cancer
pub_type:
doi:10.4048/jbc.2016.19.2.214
更新日期:2016-06-01 00:00:00
abstract:PURPOSE:Re-excisions after breast-conserving surgery (BCS) for breast cancer cause delays in the adjuvant treatment, increased morbidity, and leads to poor aesthetic results. Thus, efforts to reduce the re-excision rate are essential. This study aimed to conclusively determine the re-excision rate and the factors assoc...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2012.15.4.412
更新日期:2012-12-01 00:00:00
abstract:Purpose:Triple-negative breast cancer (TNBC) is associated with poor prognosis with limited treatment options. Angiogenesis is known to be involved in the progression of TNBC, and targeting this pathway results in modest clinical benefits. In this study, we analyzed the role of tumor microvascular endothelial Notch1 (E...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2019.22.e56
更新日期:2019-12-12 00:00:00
abstract:PURPOSE:The aim of this study is to explore signal transducer and activator of transcription 3 (STAT3) expression in breast cancer and to analyze the detailed mechanism that STAT3 contributes to the progression of breast cancer. METHODS:We retrospectively analyzed the clinicopathologic characteristics and overall surv...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2013.16.1.40
更新日期:2013-03-01 00:00:00
abstract:PURPOSE:We investigated the relationship between BRCA mutations and the distribution of familial cancers other than breast or ovary in high-risk breast cancer patients. METHODS:PATIENTS WITH BREAST CANCER WHO HAD AT LEAST ONE OF THE FOLLOWING RISK FACTORS WERE ENROLLED: reported family history of breast or ovarian can...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2012.15.3.283
更新日期:2012-09-01 00:00:00
abstract::This paper is a review of the literature examining the use of medical simulations to teach our future healthcare providers how to diagnose breast cancer. MEDLINE and Embase databases were searched to identify the literature published between 1990 and 2014. In total, 113 articles were retrieved and evaluated for their ...
journal_title:Journal of breast cancer
pub_type: 杂志文章,评审
doi:10.4048/jbc.2014.17.2.107
更新日期:2014-06-01 00:00:00
abstract:PURPOSE:We evaluated the effect of local recurrence (LR) and regional recurrence (RR) on distant metastasis and survival in patients treated with breast conservation therapy (BCT). METHODS:We analyzed 907 patients who were treated for invasive breast cancer between 1993 and 2006. With 53 months of follow-up, 28 patien...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2011.14.3.191
更新日期:2011-09-01 00:00:00
abstract::[This corrects the article on p. 192 in vol. 20, PMID: 28690656.]. ...
journal_title:Journal of breast cancer
pub_type: 已发布勘误
doi:10.4048/jbc.2017.20.3.319
更新日期:2017-09-01 00:00:00