Abstract：
:Oxygen is crucial to maintain the homeostasis in aerobic cells. Hypoxia is a condition in which cells are deprived of the oxygen supply necessary for their optimum performance. Whereas oxygen deprivation may occur in normal physiological processes, hypoxia is frequently associated with pathological conditions. It has been identified as a stressor in the tumor microenvironment, acting as a key mediator of cancer development. Numerous pathways are activated in hypoxic cells that affect cell signaling and gene regulation to promote the survival of these cells by stimulating angiogenesis, switching cellular metabolism, slowing their growth rate, and preventing apoptosis. The induction of dysregulated metabolism in cancer cells by hypoxia results in aggressive tumor phenotypes that are characterized by rapid progression, treatment resistance, and poor prognosis. A non-invasive assessment of hypoxia-induced metabolic and architectural changes in tumors is advisable to fully improve breast cancer (BC) patient management, by potentially reducing the need for invasive biopsy procedures and evaluating tumor response to treatment. This review provides a comprehensive overview of the molecular changes in breast tumors secondary to hypoxia and the non-invasive imaging alternatives to evaluate oxygen deprivation, with an emphasis on their application in BC and the advantages and limitations of the currently available techniques.
journal_name
J Breast Cancerjournal_title
Journal of breast cancerauthors
Daimiel Idoi
10.4048/jbc.2019.22.e26subject
Has Abstractpub_date
2019-05-13 00:00:00pages
155-171issue
2eissn
1738-6756issn
2092-9900journal_volume
22pub_type
杂志文章,评审abstract：Purpose:Triple-negative breast cancer (TNBC) is associated with poor prognosis with limited treatment options. Angiogenesis is known to be involved in the progression of TNBC, and targeting this pathway results in modest clinical benefits. In this study, we analyzed the role of tumor microvascular endothelial Notch1 (E...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2019.22.e56
更新日期：2019-12-12 00:00:00
abstract：PURPOSE:We investigated the relationship between BRCA mutations, pathological findings, and magnetic resonance imaging (MRI) features in patients with breast cancer at risk for the mutation. METHODS:Genetic testing for BRCA mutations was performed in 275 breast cancer patients with at least one risk factor for the mut...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2013.16.3.308
更新日期：2013-09-01 00:00:00
abstract：PURPOSE:We investigated the feasibility of using surgical clips as markers for tumor localization and their effect on the imaging evaluation of treatment responses after neoadjuvant chemotherapy (NAC). METHODS:A total of 16 breast cancers confirmed by needle biopsy in 15 patients were included in this study from Octob...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2015.18.1.44
更新日期：2015-03-01 00:00:00
abstract：Purpose:BRCA1/2 mutations are associated with risks of breast and ovarian cancer. In Korea, incidences of BRCA1/2 genetic testing and risk-reducing surgery (RRS) have increased with insurance coverage and the Angelina Jolie effect. The aim of this study was to identify trends in RRS performed in Korean women with the B...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2020.23.e61
更新日期：2020-12-03 00:00:00
abstract：PURPOSE:The MammaPrint™ gene signature, currently used in clinical practice, provides prognostic information regarding the recurrence and potential metastasis in breast cancer patients. However, the prognostic information of the 70 genes included can only be estimated at the RNA expression level. In this study, we inve...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2017.20.3.246
更新日期：2017-09-01 00:00:00
abstract：PURPOSE:To investigate the significance of the cortex-hilum (CH) area ratio and longitudinal-transverse (LT) axis ratio and the blood flow pattern for diagnosis of metastatic axillary lymph nodes by ultrasound in breast cancer patients. METHODS:From October 2005 to July 2006, we prospectively evaluated axillary nodes ...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2012.15.1.65
更新日期：2012-03-01 00:00:00
abstract：PURPOSE:In our previous studies we showed that upregulating claudin-6 (CLDN6) expression may contribute to preventing breast cancer, and that 17β-estradiol induces a concentration- and time-related effect on CLDN6 mRNA and protein expression in MCF-7 cells. However, the mechanisms of 17β-estradiol regulation of CLDN6 a...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2011.14.1.20
更新日期：2011-03-01 00:00:00
abstract：PURPOSE:The reliability of the quantitative measurement of breast density with a semi-automated thresholding method (Cumulus™) has mainly been investigated with film mammograms. This study aimed to evaluate the intrarater reproducibility of percent density (PD) by Cumulus™ with digital mammograms. METHODS:This study i...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2014.17.2.174
更新日期：2014-06-01 00:00:00
abstract：:Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis belong to a severe dermatopathic spectrum that includes frequently fatal mucocutaneous manifestations consisting of whole epidermal necrosis and sloughing with bullous transformation, blistering, and further skin detachment. Notably, cancer patients are at ...
journal_title：Journal of breast cancer
pub_type：
doi：10.4048/jbc.2019.22.e44
更新日期：2019-09-18 00:00:00
abstract：:On a pathological specimen of breast cancer cells, retraction artifact during histological processing mimics true lymphovascular invasion (LVI). The accurate determination of the presence or absence of LVI is a factor in determining risk of having a positive sentinel node, or having additional positive axillary nodes ...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2012.15.4.478
更新日期：2012-12-01 00:00:00
abstract：PURPOSE:MicroRNAs (miRNAs) are a major class of small endogenous RNA molecules that posttranscriptionally regulate the expression of most genes in the human genome. miRNAs are often located in chromosomal fragile sites, which are suscept-ible to amplification or deletion. Chromosomal deletions are frequent events in br...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2016.19.2.148
更新日期：2016-06-01 00:00:00
abstract：PURPOSE:Patients with recurrent breast cancer usually die of their disease, even after radical surgery and adjuvant therapies which could reduce the odds of dying. Many studies analyzed and compared patients who died of recurrent disease with those that died without recurrent disease. However, less attention has been p...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2012.15.2.218
更新日期：2012-06-01 00:00:00
abstract：PURPOSE:The aim of this study is to explore signal transducer and activator of transcription 3 (STAT3) expression in breast cancer and to analyze the detailed mechanism that STAT3 contributes to the progression of breast cancer. METHODS:We retrospectively analyzed the clinicopathologic characteristics and overall surv...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2013.16.1.40
更新日期：2013-03-01 00:00:00
abstract：:Internationally, breast cancer is the most common female cancer, and is induced by a combination of environmental, genetic, and epigenetic risk factors. Despite the advancement of imaging techniques, invasive sampling of breast epithelial cells is the only definitive diagnostic procedure for patients with breast cance...
journal_title：Journal of breast cancer
pub_type： 杂志文章,评审
doi：10.4048/jbc.2017.20.1.12
更新日期：2017-03-01 00:00:00
abstract：PURPOSE:The objective of this study was to describe the evolution of health-related quality of life (HRQOL) in a cohort of breast cancer patients over 1 year after surgery and to analyse the predictive ability of HRQOL measurement instruments. METHODS:Observational, multicenter and prospective study of a cohort of bre...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2013.16.1.104
更新日期：2013-03-01 00:00:00
abstract：:ESR1 mutation is frequently encountered in hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC), especially after aromatase inhibitor (AI) therapy, as a mechanism of resistance to endocrine therapy. Circulating tumor DNA-based detection of ESR1 mutatio...
journal_title：Journal of breast cancer
pub_type：
doi：10.4048/jbc.2020.23.e4
更新日期：2019-12-19 00:00:00
abstract：PURPOSE:The Gail model is one of the most widely used tools to assess the risk of breast cancer. However, it is known to overestimate breast cancer risk for Asian women. Here, we validate the Gail model and the Korean model using Korean data, and subsequently update and revalidate the Korean model using recent data. M...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2014.17.3.226
更新日期：2014-09-01 00:00:00
abstract：PURPOSE:Somatic mutations of the chromatin remodeling AT-rich interactive domain 1A (SWI-like) gene (ARID1A) have been identified in many human cancers, including breast cancer. The purpose of this study was to evaluate the nuclear expression of ARID1A in breast cancers by immunohistochemistry (IHC) and to correlate th...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2015.18.4.339
更新日期：2015-12-01 00:00:00
abstract：PURPOSE:Breast cancer subtype correlates with response to systemic therapy and overall survival (OS), but its impact on lymphatic spread is incompletely understood. In this study, we used the Surveillance, Epidemiology, and End Results registry to assess whether the subtype can predict the presence of nodal metastasis ...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2015.18.2.143
更新日期：2015-06-01 00:00:00
abstract：PURPOSE:Re-excisions after breast-conserving surgery (BCS) for breast cancer cause delays in the adjuvant treatment, increased morbidity, and leads to poor aesthetic results. Thus, efforts to reduce the re-excision rate are essential. This study aimed to conclusively determine the re-excision rate and the factors assoc...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2012.15.4.412
更新日期：2012-12-01 00:00:00
abstract：:[This corrects the article on p. 192 in vol. 20, PMID: 28690656.]. ...
journal_title：Journal of breast cancer
pub_type： 已发布勘误
doi：10.4048/jbc.2017.20.3.319
更新日期：2017-09-01 00:00:00
abstract：Purpose:Previous oncological studies showed that lymph node ratio (LNR) (ratio of number of lymph nodes that tested positive for metastasis to the total number of lymph nodes examined) is a negative indicator of cancer survival. The American Joint Committee on Cancer (AJCC) staging system incorporates tumor size, lymph...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2018.21.e35
更新日期：2018-09-01 00:00:00
abstract：PURPOSE:We evaluated the effect of local recurrence (LR) and regional recurrence (RR) on distant metastasis and survival in patients treated with breast conservation therapy (BCT). METHODS:We analyzed 907 patients who were treated for invasive breast cancer between 1993 and 2006. With 53 months of follow-up, 28 patien...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2011.14.3.191
更新日期：2011-09-01 00:00:00
abstract：:Multiple symmetric lipomatosis (MSL), or Madelung's disease, is a rare disease of unknown etiology. It is characterized by the presence of loose adipose tissue deposits localized in the cervical region and upper body. MSL presenting as bilateral huge gynecomastia is an extremely rare phenomenon. The present report des...
journal_title：Journal of breast cancer
pub_type：
doi：10.4048/jbc.2014.17.4.397
更新日期：2014-12-01 00:00:00
abstract：:Apocrine encapsulated papillary carcinoma (EPC) of the breast is a rare neoplasm, and only 10 cases have been reported in the literature to date. Although EPC by definition lacks a peripheral myoepithelial layer, all previously published apocrine EPC cases were clinically indolent and lacked a conventional invasive co...
journal_title：Journal of breast cancer
pub_type：
doi：10.4048/jbc.2018.21.2.227
更新日期：2018-06-01 00:00:00
abstract：Purpose:Breast cancer treatments, including chemotherapy, administered in combination with glucocorticoids can induce hyperglycemia. This study aimed to investigate the effect of hyperglycemia during adjuvant chemotherapy on the prognosis of breast cancer patients without a known history of diabetes. Methods:In this s...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2020.23.e44
更新日期：2020-08-05 00:00:00
abstract：:The prognosis associated with brain metastasis arising from breast cancer is very poor. Eribulin is a microtubule dynamic inhibitor synthesized from halichondrin B, a natural marine product. In a phase III study (EMBRACE), eribulin improved overall survival in patients with heavily pretreated metastatic breast cancers...
journal_title：Journal of breast cancer
pub_type：
doi：10.4048/jbc.2016.19.2.214
更新日期：2016-06-01 00:00:00
abstract：Purpose:The aim of this study was to investigate the association of telomere length with breast cancer risk. We simultaneously explored the association between telomerase reverse transcriptase gene polymorphisms and telomere length. Methods:We used real-time quantitative polymerase chain reaction to measure relative t...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2018.21.e52
更新日期：2018-12-01 00:00:00
abstract：:Breast cancer generally develops in older women and its incidence is continuing to increase with increasing age of the population. The pathology and biology of breast cancer seem to be different in the elderly, often resulting in the undertreatment of elderly patients and thus in higher rates of recurrence and mortal-...
journal_title：Journal of breast cancer
pub_type： 杂志文章,评审
doi：10.4048/jbc.2015.18.3.207
更新日期：2015-09-01 00:00:00
abstract：:Breast cancer is the most common malignancy, and it is also the major cause of cancer-related deaths of women worldwide. Breast cancer treatment involves surgery, chemotherapy, radiation therapy, or combination therapy, and novel strategies are needed to boost the oncologic outcome. The non-metabolizable glucose analo...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2012.15.2.141
更新日期：2012-06-01 00:00:00
