Association between BRCA Mutation Status, Pathological Findings, and Magnetic Resonance Imaging Features in Patients with Breast Cancer at Risk for the Mutation.

Abstract:

PURPOSE:We investigated the relationship between BRCA mutations, pathological findings, and magnetic resonance imaging (MRI) features in patients with breast cancer at risk for the mutation. METHODS:Genetic testing for BRCA mutations was performed in 275 breast cancer patients with at least one risk factor for the mutation. Using the breast imaging reporting and data system MR lexicon, morphological and kinetic features were reviewed on MRI scans of 230 tumors in 209 patients. The relationship between BRCA mutations, pathologic findings, and MRI data was examined, and disease recurrence was estimated. RESULTS:BRCA mutations were detected in 48 patients (23.0%), of which 21 (10.0%) were in BRCA1, and 25 (12.0%) in BRCA2. Additionally, two patients (1.0%) had mutations in both genes. Cancers in patients with BRCA1 mutations more frequently showed a higher nuclear grade (p=0.0041), and triple-negative (TN) phenotype (p<0.0001). On MRI scans, the cancers were seen as mass-type in 182 out of 230 lesions (79.1%), and nonmass type in 48 cases (20.9%). Among the features indentified by MRI, rim enhancement was significantly associated with molecular subtypes based on immunohistochemistry (p<0.0001), and nuclear grade (p=0.0387) in multiple logistic regression analysis. Rim enhancement on MRI, along with advanced pathologic N stage, was associated with increased disease recurrence (p=0.0023) based on multivariate analysis. However, the proportion of mass and nonmass tumors, and the distribution of morphological shape, margin, internal enhancement, and kinetic features assessed by MRI were not different according to BRCA mutation status. CONCLUSION:BRCA1 mutations were associated with aggressive pathological characteristics, and the TN phenotype. Rim enhancement was frequently seen on MRI scans of high-grade cancers and in the TN phenotype. And it was a significant predictor of disease recurrence. However, a direct association with BRCA mutations was not observed.

journal_name

J Breast Cancer

journal_title

Journal of breast cancer

authors

Noh JM,Han BK,Choi DH,Rhee SJ,Cho EY,Huh SJ,Park W,Park H,Nam SJ,Lee JE,Kil WH

doi

10.4048/jbc.2013.16.3.308

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

308-14

issue

3

eissn

1738-6756

issn

2092-9900

journal_volume

16

pub_type

杂志文章
  • Oncoplastic surgical techniques for personalized breast conserving surgery in breast cancer patient with small to moderate sized breast.

    abstract::Oncoplastic surgery has revolutionized the field of breast conserving surgery (BCS). The final aims of this technique are to obtain an adequate resection margin that will reduce the rate of local recurrence while simultaneously improving cosmetic outcomes. To obtain successful results after oncoplastic surgery, it is ...

    journal_title:Journal of breast cancer

    pub_type: 杂志文章

    doi:10.4048/jbc.2011.14.4.253

    authors: Yang JD,Lee JW,Kim WW,Jung JH,Park HY

    更新日期:2011-12-01 00:00:00

  • Validation of risk assessment models for predicting the incidence of breast cancer in korean women.

    abstract:PURPOSE:The Gail model is one of the most widely used tools to assess the risk of breast cancer. However, it is known to overestimate breast cancer risk for Asian women. Here, we validate the Gail model and the Korean model using Korean data, and subsequently update and revalidate the Korean model using recent data. M...

    journal_title:Journal of breast cancer

    pub_type: 杂志文章

    doi:10.4048/jbc.2014.17.3.226

    authors: Min JW,Chang MC,Lee HK,Hur MH,Noh DY,Yoon JH,Jung Y,Yang JH,Korean Breast Cancer Society.

    更新日期:2014-09-01 00:00:00

  • Shorter Telomere Length Is Associated with Increased Breast Cancer Risk in a Chinese Han Population: A Case-Control Analysis.

    abstract:Purpose:The aim of this study was to investigate the association of telomere length with breast cancer risk. We simultaneously explored the association between telomerase reverse transcriptase gene polymorphisms and telomere length. Methods:We used real-time quantitative polymerase chain reaction to measure relative t...

    journal_title:Journal of breast cancer

    pub_type: 杂志文章

    doi:10.4048/jbc.2018.21.e52

    authors: Wang Z,Zhang Z,Guo Y,Shui H,Liu G,Jin T,Wang H

    更新日期:2018-12-01 00:00:00

  • The educational utility of simulations in teaching history and physical examination skills in diagnosing breast cancer: a review of the literature.

    abstract::This paper is a review of the literature examining the use of medical simulations to teach our future healthcare providers how to diagnose breast cancer. MEDLINE and Embase databases were searched to identify the literature published between 1990 and 2014. In total, 113 articles were retrieved and evaluated for their ...

    journal_title:Journal of breast cancer

    pub_type: 杂志文章,评审

    doi:10.4048/jbc.2014.17.2.107

    authors: Simpson JS

    更新日期:2014-06-01 00:00:00

  • Breast Cancer Subtype as a Predictor of Lymph Node Metastasis according to the SEER Registry.

    abstract:PURPOSE:Breast cancer subtype correlates with response to systemic therapy and overall survival (OS), but its impact on lymphatic spread is incompletely understood. In this study, we used the Surveillance, Epidemiology, and End Results registry to assess whether the subtype can predict the presence of nodal metastasis ...

    journal_title:Journal of breast cancer

    pub_type: 杂志文章

    doi:10.4048/jbc.2015.18.2.143

    authors: Mattes MD,Bhatia JK,Metzger D,Ashamalla H,Katsoulakis E

    更新日期:2015-06-01 00:00:00

  • Early-Stage Breast Cancer in the Elderly: Confronting an Old Clinical Problem.

    abstract::Breast cancer generally develops in older women and its incidence is continuing to increase with increasing age of the population. The pathology and biology of breast cancer seem to be different in the elderly, often resulting in the undertreatment of elderly patients and thus in higher rates of recurrence and mortal-...

    journal_title:Journal of breast cancer

    pub_type: 杂志文章,评审

    doi:10.4048/jbc.2015.18.3.207

    authors: Dimitrakopoulos FI,Kottorou A,Antonacopoulou AG,Makatsoris T,Kalofonos HP

    更新日期:2015-09-01 00:00:00

  • Identifying Long-Term Survival Candidates among Patients with Isolated Locoregionally Recurrent Breast Cancer: Implications of the Use of Systemic Chemotherapy.

    abstract:Purpose:We aimed to investigate the clinicopathologic factors associated with distant metastasis (DM) and post-recurrence overall survival (OS) after salvage treatments for isolated locoregional recurrence (ILRR) of breast cancer and identify long-term surviving patients for providing a more personalized therapy. Meth...

    journal_title:Journal of breast cancer

    pub_type: 杂志文章

    doi:10.4048/jbc.2020.23.e31

    authors: Kim BH,Shin KH,Chie EK,Kim JH,Kim K,Hwang KT,Kim J,Choi IS,Park JH,Kim S

    更新日期:2020-04-29 00:00:00

  • Role of Estrogen Receptor-α in the Regulation of Claudin-6 Expression in Breast Cancer Cells.

    abstract:PURPOSE:In our previous studies we showed that upregulating claudin-6 (CLDN6) expression may contribute to preventing breast cancer, and that 17β-estradiol induces a concentration- and time-related effect on CLDN6 mRNA and protein expression in MCF-7 cells. However, the mechanisms of 17β-estradiol regulation of CLDN6 a...

    journal_title:Journal of breast cancer

    pub_type: 杂志文章

    doi:10.4048/jbc.2011.14.1.20

    authors: Yafang L,Qiong W,Yue R,Xiaoming X,Lina Y,Mingzi Z,Ting Z,Yulin L,Chengshi Q

    更新日期:2011-03-01 00:00:00

  • Erratum: Imaging Surveillance for Survivors of Breast Cancer: Correlation between Cancer Characteristics and Method of Detection.

    abstract::[This corrects the article on p. 192 in vol. 20, PMID: 28690656.]. ...

    journal_title:Journal of breast cancer

    pub_type: 已发布勘误

    doi:10.4048/jbc.2017.20.3.319

    authors: Chu AJ,Chang JM,Cho N,Moon WK

    更新日期:2017-09-01 00:00:00

  • Comparison of Clinicopathological Features and Treatment Results between Invasive Lobular Carcinoma and Ductal Carcinoma of the Breast.

    abstract:PURPOSE:The purpose of this study was to assess the incidence of invasive lobular carcinoma (ILC) and to compare the clinicopathological features and treatment results after breast conserving surgery (BCS) followed by radiotherapy between ILC and invasive ductal carcinoma (IDC). METHODS:A total of 1,071 patients who u...

    journal_title:Journal of breast cancer

    pub_type: 杂志文章

    doi:10.4048/jbc.2015.18.3.285

    authors: Park JS,Choi DH,Huh SJ,Park W,Kim YI,Nam SJ,Lee JE,Kil WH

    更新日期:2015-09-01 00:00:00

  • An unusual case of gastric cancer presenting with breast metastasis with pleomorphic microcalcifications.

    abstract::Breast metastasis from gastric carcinoma is rare. We present a case of right breast mass with microcalcification in which the diagnosis of poorly differentiated adenocarcinoma from the stomach was made after a biopsy. Pleomorphic microcalcification was noted in the ill-defined breast mass, which is a rare feature in b...

    journal_title:Journal of breast cancer

    pub_type:

    doi:10.4048/jbc.2012.15.3.356

    authors: Luk YS,Ka SY,Lo SS,Chu CY,Ma MW

    更新日期:2012-09-01 00:00:00

  • Factors Associated with Re-excision after Breast-Conserving Surgery for Early-Stage Breast Cancer.

    abstract:PURPOSE:Re-excisions after breast-conserving surgery (BCS) for breast cancer cause delays in the adjuvant treatment, increased morbidity, and leads to poor aesthetic results. Thus, efforts to reduce the re-excision rate are essential. This study aimed to conclusively determine the re-excision rate and the factors assoc...

    journal_title:Journal of breast cancer

    pub_type: 杂志文章

    doi:10.4048/jbc.2012.15.4.412

    authors: Jung W,Kang E,Kim SM,Kim D,Hwang Y,Sun Y,Yom CK,Kim SW

    更新日期:2012-12-01 00:00:00

  • Loss of Tumor Suppressor ARID1A Protein Expression Correlates with Poor Prognosis in Patients with Primary Breast Cancer.

    abstract:PURPOSE:Somatic mutations of the chromatin remodeling AT-rich interactive domain 1A (SWI-like) gene (ARID1A) have been identified in many human cancers, including breast cancer. The purpose of this study was to evaluate the nuclear expression of ARID1A in breast cancers by immunohistochemistry (IHC) and to correlate th...

    journal_title:Journal of breast cancer

    pub_type: 杂志文章

    doi:10.4048/jbc.2015.18.4.339

    authors: Cho HD,Lee JE,Jung HY,Oh MH,Lee JH,Jang SH,Kim KJ,Han SW,Kim SY,Kim HJ,Bae SB,Lee HJ

    更新日期:2015-12-01 00:00:00

  • Notch1 in Tumor Microvascular Endothelial Cells and Tumoral miR-34a as Prognostic Markers in Locally Advanced Triple-Negative Breast Cancer.

    abstract:Purpose:Triple-negative breast cancer (TNBC) is associated with poor prognosis with limited treatment options. Angiogenesis is known to be involved in the progression of TNBC, and targeting this pathway results in modest clinical benefits. In this study, we analyzed the role of tumor microvascular endothelial Notch1 (E...

    journal_title:Journal of breast cancer

    pub_type: 杂志文章

    doi:10.4048/jbc.2019.22.e56

    authors: Kim D,Lee J,Kang J,Kim SH,Yoo TK,Oh S,Lee A

    更新日期:2019-12-12 00:00:00

  • The Basic Facts of Korean Breast Cancer in 2013: Results of a Nationwide Survey and Breast Cancer Registry Database.

    abstract::The Korean Breast Cancer Society (KBCS) has reported a nationwide breast cancer data since 1996. We present a comprehensive report on the facts and trends of breast cancer in Korea in 2013. Data on the newly diagnosed patients in the year 2013 were collected from 99 hospitals by using nationwide questionnaire survey. ...

    journal_title:Journal of breast cancer

    pub_type: 杂志文章

    doi:10.4048/jbc.2016.19.1.1

    authors: Min SY,Kim Z,Hur MH,Yoon CS,Park EH,Jung KW,Korean Breast Cancer Society Consortium.

    更新日期:2016-03-01 00:00:00

  • Associations between BRCA Mutations in High-Risk Breast Cancer Patients and Familial Cancers Other than Breast or Ovary.

    abstract:PURPOSE:We investigated the relationship between BRCA mutations and the distribution of familial cancers other than breast or ovary in high-risk breast cancer patients. METHODS:PATIENTS WITH BREAST CANCER WHO HAD AT LEAST ONE OF THE FOLLOWING RISK FACTORS WERE ENROLLED: reported family history of breast or ovarian can...

    journal_title:Journal of breast cancer

    pub_type: 杂志文章

    doi:10.4048/jbc.2012.15.3.283

    authors: Noh JM,Choi DH,Baek H,Nam SJ,Lee JE,Kim JW,Ki CS,Park W,Huh SJ

    更新日期:2012-09-01 00:00:00

  • Insights into Hypoxia: Non-invasive Assessment through Imaging Modalities and Its Application in Breast Cancer.

    abstract::Oxygen is crucial to maintain the homeostasis in aerobic cells. Hypoxia is a condition in which cells are deprived of the oxygen supply necessary for their optimum performance. Whereas oxygen deprivation may occur in normal physiological processes, hypoxia is frequently associated with pathological conditions. It has ...

    journal_title:Journal of breast cancer

    pub_type: 杂志文章,评审

    doi:10.4048/jbc.2019.22.e26

    authors: Daimiel I

    更新日期:2019-05-13 00:00:00

  • Transient receptor potential vanilloid 1 expression and functionality in mcf-7 cells: a preliminary investigation.

    abstract:PURPOSE:Transient receptor potential vanilloid 1 (TRPV1) is a nonselective cation channel belonging to the transient receptor potential family, and it is expressed in different neoplastic tissues. Its activation is associated with regulation of cancer growth and progression. The aim of this research was to study the ex...

    journal_title:Journal of breast cancer

    pub_type: 杂志文章

    doi:10.4048/jbc.2014.17.4.332

    authors: Vercelli C,Barbero R,Cuniberti B,Racca S,Abbadessa G,Piccione F,Re G

    更新日期:2014-12-01 00:00:00

  • Tamoxifen and the Risk of Parkinson's Disease in Female Patients with Breast Cancer in Asian People: A Nationwide Population-Based Study.

    abstract:Purpose:Whether tamoxifen affects the risk of neurodegenerative disease is controversial. This nationwide population-based study investigated the risk of Parkinson's disease (PD) associated with tamoxifen treatment in female patients with breast cancer using Taiwan's National Health Insurance Research Database. Method...

    journal_title:Journal of breast cancer

    pub_type: 杂志文章

    doi:10.4048/jbc.2017.20.4.356

    authors: Hong CT,Chan L,Hu CJ,Lin CM,Hsu CY,Lin MC

    更新日期:2017-12-01 00:00:00

  • The Benefit of Post-Mastectomy Radiotherapy in ypN0 Patients after Neoadjuvant Chemotherapy According to Molecular Subtypes.

    abstract:Purpose:The benefit of post-mastectomy radiation therapy (PMRT) in patients with breast cancer who achieve ypN0 following neoadjuvant chemotherapy (NAC) has not yet been established. This study aimed to identify the role of PMRT in patients who achieve ypN0 according to molecular subtype. Methods:We identified patient...

    journal_title:Journal of breast cancer

    pub_type: 杂志文章

    doi:10.4048/jbc.2019.22.e25

    authors: Cho WK,Park W,Choi DH,Kim YB,Kim JH,Kim SS,Kim K,Kim JH,Ahn SJ,Lee SY,Lee J,Kim SW,Kwon J,Ahn KJ

    更新日期:2019-05-13 00:00:00

  • A case report of breast cancer with extensive pulmonary lymphovascular tumor emboli.

    abstract::We describe a patient with breast cancer who relapsed with an extensive pulmonary lymphovascular tumor embolism. A 38-year-old female, who previously received neoadjuvant chemotherapy and curative resection of breast cancer, underwent adjuvant chemotherapy and was referred to the emergency room because of sudden-onset...

    journal_title:Journal of breast cancer

    pub_type:

    doi:10.4048/jbc.2012.15.1.128

    authors: Yang Y,Choi Y,Beom SH,Kim JW,Joen YK,Kim NJ,Kim JH,Im SA,Lee KH

    更新日期:2012-03-01 00:00:00

  • Breast Imaging Reporting and Data System Category 3 Lesions Detected on Whole-Breast Screening Ultrasound.

    abstract:PURPOSE:This study assessed the incidence and cancer rate of probably benign lesions detected on bilateral whole-breast screening ultrasound (US), which corresponded to US Breast Imaging Reporting and Data System (BI-RADS) category 3, and evaluated the proper management of those lesions. METHODS:This study was approve...

    journal_title:Journal of breast cancer

    pub_type: 杂志文章

    doi:10.4048/jbc.2016.19.3.301

    authors: Nam SY,Ko EY,Han BK,Shin JH,Ko ES,Hahn SY

    更新日期:2016-09-01 00:00:00

  • A Case of Breast Cancer Brain Metastasis with a 16-Year Time Interval without Evidence of Cancer Recurrence.

    abstract::The median time of brain metastasis from the diagnosis of breast cancer is approximately 3 years. In this case report, a 69-year-old woman demonstrated cerebellar ataxia. Brain magnetic resonance imaging revealed enhanced lesions in bilateral cerebellar hemispheres. She had undergone surgery, radiation, and chemothera...

    journal_title:Journal of breast cancer

    pub_type:

    doi:10.4048/jbc.2017.20.2.212

    authors: Yamada SM,Tomita Y,Shibui S,Kurokawa T,Baba Y

    更新日期:2017-06-01 00:00:00

  • Enhanced radiosensitivity and chemosensitivity of breast cancer cells by 2-deoxy-d-glucose in combination therapy.

    abstract::Breast cancer is the most common malignancy, and it is also the major cause of cancer-related deaths of women worldwide. Breast cancer treatment involves surgery, chemotherapy, radiation therapy, or combination therapy, and novel strategies are needed to boost the oncologic outcome. The non-metabolizable glucose analo...

    journal_title:Journal of breast cancer

    pub_type: 杂志文章

    doi:10.4048/jbc.2012.15.2.141

    authors: Aghaee F,Pirayesh Islamian J,Baradaran B

    更新日期:2012-06-01 00:00:00

  • Apocrine Encapsulated Papillary Carcinoma of the Breast: The First Reported Case with an Infiltrative Component.

    abstract::Apocrine encapsulated papillary carcinoma (EPC) of the breast is a rare neoplasm, and only 10 cases have been reported in the literature to date. Although EPC by definition lacks a peripheral myoepithelial layer, all previously published apocrine EPC cases were clinically indolent and lacked a conventional invasive co...

    journal_title:Journal of breast cancer

    pub_type:

    doi:10.4048/jbc.2018.21.2.227

    authors: Kővári B,Ormándi K,Simonka Z,Vörös A,Cserni G

    更新日期:2018-06-01 00:00:00

  • Weight Gain during Neoadjuvant Chemotherapy is Associated with Worse Outcome among the Patients with Operable Breast Cancer.

    abstract:Purpose:This study was aimed at identifying the influence of initial weight and weight change during neoadjuvant chemotherapy (NAC) on pathologic complete response (pCR) and long-term survival in Chinese patients with operable breast cancer. Methods:We conducted a retrospective study using data from 409 female patient...

    journal_title:Journal of breast cancer

    pub_type: 杂志文章

    doi:10.4048/jbc.2019.22.e37

    authors: Fang Q,Huang J,Gan L,Shen K,Chen X,Wu B

    更新日期:2019-08-26 00:00:00

  • Effect Modification of Hormonal Therapy by p53 Status in Invasive Breast Cancer.

    abstract:PURPOSE:We aimed to confirm the prognostic and predictive value of p53 expression, particularly in invasive breast cancer patients, according to immunohistochemical hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) status. METHODS:Immunohistochemical data for p53, estrogen receptor, progesteron...

    journal_title:Journal of breast cancer

    pub_type: 杂志文章

    doi:10.4048/jbc.2013.16.4.386

    authors: Ahn SH,Kim HJ,Han W,Cho J,Gong G,Jung KH,Kim SB,Son BH,Lee JW

    更新日期:2013-12-01 00:00:00

  • Whole Exome Sequencing in the Accurate Diagnosis of Bilateral Breast Cancer: a Case Study.

    abstract::When faced with a case of bilateral breast cancer (BBC), understanding how to differentiate bilateral primary breast cancer from contralateral metastatic breast cancer is essential for treatment, but clear identification criteria have not been established to date. Diverse events play different roles in the therapy and...

    journal_title:Journal of breast cancer

    pub_type:

    doi:10.4048/jbc.2019.22.e10

    authors: Li X,Yang M,Zhang Q,Fan Y,Zhu T,Chen F,Wang K

    更新日期:2019-02-02 00:00:00

  • Pokemon Inhibits Transforming Growth Factor β-Smad4-Related Cell Proliferation Arrest in Breast Cancer through Specificity Protein 1.

    abstract:Purpose:Pokemon, also known as ZBTB7A, belongs to the POZ and Krüppel (POK) family of transcription repressors and is implicated in tumor progression as a key proto-oncogene. This present study aimed at determining the mechanism by which Pokemon inhibits transforming growth factor β (TGFβ)-Smad4 pathway-dependent proli...

    journal_title:Journal of breast cancer

    pub_type: 杂志文章

    doi:10.4048/jbc.2019.22.e11

    authors: Chen L,Zhong J,Liu JH,Liao DF,Shen YY,Zhong XL,Xiao X,Ding WJ,Peng XD,Xiong W,Zu XY

    更新日期:2019-02-15 00:00:00

  • Patient Satisfaction with Implant Based Breast Reconstruction Associated with Implant Volume and Mastectomy Specimen Weight Ratio.

    abstract:PURPOSE:Breast volume assessment is one of the most important steps during implant-based breast reconstruction because it is critical in selecting implant size. According to previous studies, there is a close relationship between the mastectomy specimen weight and resected breast volume. The aim of this study was to ev...

    journal_title:Journal of breast cancer

    pub_type: 杂志文章

    doi:10.4048/jbc.2017.20.1.98

    authors: Baek WY,Byun IH,Kim YS,Lew DH,Jeong J,Roh TS

    更新日期:2017-03-01 00:00:00