Abstract:
Purpose:Previous oncological studies showed that lymph node ratio (LNR) (ratio of number of lymph nodes that tested positive for metastasis to the total number of lymph nodes examined) is a negative indicator of cancer survival. The American Joint Committee on Cancer (AJCC) staging system incorporates tumor size, lymph node involvement, and metastasis in a comprehensive model of cancer progression, but LNR alone has been shown to outperform the AJCC system in prognostic and survival predictions for various types of cancer. The effectiveness of LNR has not been evaluated in breast cancer staging. Evaluating LNR for predicting cancer staging in breast cancer has the potential to improve treatment recommendations. Methods:The Surveillance, Epidemiology, and End Results dataset was used to identify 10,655 breast cancer patients who underwent nodal evaluation from 2010 to 2013, and their LNRs were calculated. Descriptive statistics of lymph node evaluation in the patients are provided. Logistic regression with LNR as the continuous independent variable was conducted to determine whether LNR could predict cancer progression, coded as regional or distant. Analysis was conducted using SPSS version 24. Results:Patient's mean age was 59.43±18.62. Logistic regression analysis revealed that for every 1.3% increase in LNR, the odds of falling into the distant stage of the TNM staging system increased by 13.7% (odds ratio, 14.73; 95% confidence interval, 12.00-18.08). Conclusion:LNR, while correlated with breast cancer staging, serves as a better predictor of survival. Precision staging can influence treatment modality, and improved treatments can significantly improve quality of life. Additional research and diagnostic examinations using LNR as a potential tool for accurate staging in breast cancer patients are warranted.
journal_name
J Breast Cancerjournal_title
Journal of breast cancerauthors
Hung M,Xu J,Nielson D,Bounsanga J,Gu Y,Hansen AR,Voss MWdoi
10.4048/jbc.2018.21.e35subject
Has Abstractpub_date
2018-09-01 00:00:00pages
315-320issue
3eissn
1738-6756issn
2092-9900journal_volume
21pub_type
杂志文章abstract:PURPOSE:We aimed to confirm the prognostic and predictive value of p53 expression, particularly in invasive breast cancer patients, according to immunohistochemical hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) status. METHODS:Immunohistochemical data for p53, estrogen receptor, progesteron...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2013.16.4.386
更新日期:2013-12-01 00:00:00
abstract::Multiple symmetric lipomatosis (MSL), or Madelung's disease, is a rare disease of unknown etiology. It is characterized by the presence of loose adipose tissue deposits localized in the cervical region and upper body. MSL presenting as bilateral huge gynecomastia is an extremely rare phenomenon. The present report des...
journal_title:Journal of breast cancer
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doi:10.4048/jbc.2014.17.4.397
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pub_type: 杂志文章
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更新日期:2019-05-13 00:00:00
abstract::[This corrects the article on p. 192 in vol. 20, PMID: 28690656.]. ...
journal_title:Journal of breast cancer
pub_type: 已发布勘误
doi:10.4048/jbc.2017.20.3.319
更新日期:2017-09-01 00:00:00
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journal_title:Journal of breast cancer
pub_type: 杂志文章,评审
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更新日期:2014-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-12-01 00:00:00
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journal_title:Journal of breast cancer
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更新日期:2019-08-26 00:00:00
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journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2017.20.4.356
更新日期:2017-12-01 00:00:00
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journal_title:Journal of breast cancer
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journal_title:Journal of breast cancer
pub_type: 杂志文章,评审
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journal_title:Journal of breast cancer
pub_type: 杂志文章
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更新日期:2020-04-29 00:00:00
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journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2016.19.4.417
更新日期:2016-12-01 00:00:00
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journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2019.22.e56
更新日期:2019-12-12 00:00:00
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journal_title:Journal of breast cancer
pub_type:
doi:10.4048/jbc.2018.21.1.96
更新日期:2018-03-01 00:00:00
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journal_title:Journal of breast cancer
pub_type:
doi:10.4048/jbc.2019.22.e10
更新日期:2019-02-02 00:00:00
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journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2014.17.2.174
更新日期:2014-06-01 00:00:00
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journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2015.18.2.143
更新日期:2015-06-01 00:00:00
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journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2015.18.4.339
更新日期:2015-12-01 00:00:00
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journal_title:Journal of breast cancer
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journal_title:Journal of breast cancer
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journal_title:Journal of breast cancer
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更新日期:2018-06-01 00:00:00
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journal_title:Journal of breast cancer
pub_type: 杂志文章
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journal_title:Journal of breast cancer
pub_type: 杂志文章
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更新日期:2011-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-03-01 00:00:00