Abstract:
Purpose:Pokemon, also known as ZBTB7A, belongs to the POZ and Krüppel (POK) family of transcription repressors and is implicated in tumor progression as a key proto-oncogene. This present study aimed at determining the mechanism by which Pokemon inhibits transforming growth factor β (TGFβ)-Smad4 pathway-dependent proliferation arrest of breast cancer cells via specificity protein 1 (SP1). Methods:Over-expressing plasmid or small interfering RNA (siRNA) transfection was used to regulate Pokemon levels. The EdU incorporation assay, MTS assay, and clone formation were used to identify the inhibitory effect of Pokemon siRNA on cell proliferation. Quantitative real-time polymerase chain reaction assay confirmed that Pokemon deletion inhibited the expression of proliferation-associated genes. The dual-luciferase reporter assay, electrophoretic mobility shift assay, and co-immunoprecipitation assay were used to analyze binding between Pokemon, Smad4, and SP1. Results:Pokemon deletion induced proliferation arrest of breast cancer cells and inhibited the expression of proliferation-associated genes, especially Smad4. Pokemon bound with SP1 to interdict Smad4 promoter activity. Information on clinical samples was obtained from The Cancer Genome Atlas data, in which the Pokemon mRNA levels showed a negative correlation with Smad4 levels in different subtypes of breast cancer in two independent datasets. Conclusion:We demonstrated that Pokemon binds to SP1 to down-regulate Smad4 expression, thereby promoting proliferation of breast cancer cells. This suggests that Pokemon is a potential TGFβ-signaling participant in breast cancer progression.
journal_name
J Breast Cancerjournal_title
Journal of breast cancerauthors
Chen L,Zhong J,Liu JH,Liao DF,Shen YY,Zhong XL,Xiao X,Ding WJ,Peng XD,Xiong W,Zu XYdoi
10.4048/jbc.2019.22.e11subject
Has Abstractpub_date
2019-02-15 00:00:00pages
15-28issue
1eissn
1738-6756issn
2092-9900journal_volume
22pub_type
杂志文章abstract:Purpose:The 8th edition of the American Joint Committee on Cancer (AJCC) staging manual introduced a new prognostic staging system for breast cancer. This study aimed to evaluate the changes in staging distribution and predictive power of the new staging system. Methods:Of the 12,275 patients with breast cancer identi...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2020.23.e9
更新日期:2020-01-09 00:00:00
abstract:PURPOSE:Breast cancer subtype correlates with response to systemic therapy and overall survival (OS), but its impact on lymphatic spread is incompletely understood. In this study, we used the Surveillance, Epidemiology, and End Results registry to assess whether the subtype can predict the presence of nodal metastasis ...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2015.18.2.143
更新日期:2015-06-01 00:00:00
abstract:Purpose:We aimed to investigate the clinicopathologic factors associated with distant metastasis (DM) and post-recurrence overall survival (OS) after salvage treatments for isolated locoregional recurrence (ILRR) of breast cancer and identify long-term surviving patients for providing a more personalized therapy. Meth...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2020.23.e31
更新日期:2020-04-29 00:00:00
abstract::Since recurrent bilateral breast infection due to nontuberculous mycobacterium (NTM) is rare, its diagnosis is easily overlooked; in addition, complete recovery is often difficult to achieve. We report a case of recurrent bilateral infection in a 35-year-old woman who had completed treatment for NTM. Although various ...
journal_title:Journal of breast cancer
pub_type:
doi:10.4048/jbc.2014.17.3.295
更新日期:2014-09-01 00:00:00
abstract::The prognosis associated with brain metastasis arising from breast cancer is very poor. Eribulin is a microtubule dynamic inhibitor synthesized from halichondrin B, a natural marine product. In a phase III study (EMBRACE), eribulin improved overall survival in patients with heavily pretreated metastatic breast cancers...
journal_title:Journal of breast cancer
pub_type:
doi:10.4048/jbc.2016.19.2.214
更新日期:2016-06-01 00:00:00
abstract:PURPOSE:This study was performed to assess frequency, timings of occurrence, and predictors of radiologic lung damage (RLD) after forward-planned intensity-modulated radiotherapy (FIMRT) for whole breast irradiation. METHODS:We retrospectively reviewed medical records of 157 breast cancer patients and each of their se...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2014.17.1.69
更新日期:2014-03-01 00:00:00
abstract:PURPOSE:The purpose of this study was to assess the incidence of invasive lobular carcinoma (ILC) and to compare the clinicopathological features and treatment results after breast conserving surgery (BCS) followed by radiotherapy between ILC and invasive ductal carcinoma (IDC). METHODS:A total of 1,071 patients who u...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2015.18.3.285
更新日期:2015-09-01 00:00:00
abstract::We describe a patient with breast cancer who relapsed with an extensive pulmonary lymphovascular tumor embolism. A 38-year-old female, who previously received neoadjuvant chemotherapy and curative resection of breast cancer, underwent adjuvant chemotherapy and was referred to the emergency room because of sudden-onset...
journal_title:Journal of breast cancer
pub_type:
doi:10.4048/jbc.2012.15.1.128
更新日期:2012-03-01 00:00:00
abstract::Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis belong to a severe dermatopathic spectrum that includes frequently fatal mucocutaneous manifestations consisting of whole epidermal necrosis and sloughing with bullous transformation, blistering, and further skin detachment. Notably, cancer patients are at ...
journal_title:Journal of breast cancer
pub_type:
doi:10.4048/jbc.2019.22.e44
更新日期:2019-09-18 00:00:00
abstract:PURPOSE:We aimed to confirm the prognostic and predictive value of p53 expression, particularly in invasive breast cancer patients, according to immunohistochemical hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) status. METHODS:Immunohistochemical data for p53, estrogen receptor, progesteron...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2013.16.4.386
更新日期:2013-12-01 00:00:00
abstract::The Korean Breast Cancer Society (KBCS) has reported a nationwide breast cancer data since 1996. We present a comprehensive report on the facts and trends of breast cancer in Korea in 2013. Data on the newly diagnosed patients in the year 2013 were collected from 99 hospitals by using nationwide questionnaire survey. ...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2016.19.1.1
更新日期:2016-03-01 00:00:00
abstract:Purpose:Whether tamoxifen affects the risk of neurodegenerative disease is controversial. This nationwide population-based study investigated the risk of Parkinson's disease (PD) associated with tamoxifen treatment in female patients with breast cancer using Taiwan's National Health Insurance Research Database. Method...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2017.20.4.356
更新日期:2017-12-01 00:00:00
abstract:PURPOSE:Transient receptor potential vanilloid 1 (TRPV1) is a nonselective cation channel belonging to the transient receptor potential family, and it is expressed in different neoplastic tissues. Its activation is associated with regulation of cancer growth and progression. The aim of this research was to study the ex...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2014.17.4.332
更新日期:2014-12-01 00:00:00
abstract::The combination of luteinizing hormone-releasing hormone analogs (LHRHa) with tamoxifen is used as a standard postoperative adjuvant therapy in patients with hormone receptor-positive/premenopausal breast cancer. Long-acting LHRHa formulations offer advantages in terms of patient convenience. However, data on the effe...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2020.23.e57
更新日期:2020-10-26 00:00:00
abstract:PURPOSE:Patients with recurrent breast cancer usually die of their disease, even after radical surgery and adjuvant therapies which could reduce the odds of dying. Many studies analyzed and compared patients who died of recurrent disease with those that died without recurrent disease. However, less attention has been p...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2012.15.2.218
更新日期:2012-06-01 00:00:00
abstract:PURPOSE:The objective of this study was to describe the evolution of health-related quality of life (HRQOL) in a cohort of breast cancer patients over 1 year after surgery and to analyse the predictive ability of HRQOL measurement instruments. METHODS:Observational, multicenter and prospective study of a cohort of bre...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2013.16.1.104
更新日期:2013-03-01 00:00:00
abstract:PURPOSE:The reliability of the quantitative measurement of breast density with a semi-automated thresholding method (Cumulus™) has mainly been investigated with film mammograms. This study aimed to evaluate the intrarater reproducibility of percent density (PD) by Cumulus™ with digital mammograms. METHODS:This study i...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2014.17.2.174
更新日期:2014-06-01 00:00:00
abstract::[This corrects the article on p. 192 in vol. 20, PMID: 28690656.]. ...
journal_title:Journal of breast cancer
pub_type: 已发布勘误
doi:10.4048/jbc.2017.20.3.319
更新日期:2017-09-01 00:00:00
abstract::Multiple symmetric lipomatosis (MSL), or Madelung's disease, is a rare disease of unknown etiology. It is characterized by the presence of loose adipose tissue deposits localized in the cervical region and upper body. MSL presenting as bilateral huge gynecomastia is an extremely rare phenomenon. The present report des...
journal_title:Journal of breast cancer
pub_type:
doi:10.4048/jbc.2014.17.4.397
更新日期:2014-12-01 00:00:00
abstract:Purpose:The treatment of triple-negative breast cancer (TNBC) remains challenging, due to the absence of estrogen, progesterone, and human epidermal growth factor receptors. This study was designed to evaluate the efficiency and safety of cytokine-induced killer (CIK) cell immunotherapy, following regular chemotherapy,...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2018.21.2.150
更新日期:2018-06-01 00:00:00
abstract:PURPOSE:The role of first-line trastuzumab-based therapy has been firmly established in patients with human epidermal growth factor receptor-2 (HER2) positive metastatic breast cancer. In this trial, we evaluated the efficacy and safety of a vinorelbine and trastuzumab combination chemotherapy in patients who were pret...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2011.14.2.140
更新日期:2011-06-01 00:00:00
abstract::This paper is a review of the literature examining the use of medical simulations to teach our future healthcare providers how to diagnose breast cancer. MEDLINE and Embase databases were searched to identify the literature published between 1990 and 2014. In total, 113 articles were retrieved and evaluated for their ...
journal_title:Journal of breast cancer
pub_type: 杂志文章,评审
doi:10.4048/jbc.2014.17.2.107
更新日期:2014-06-01 00:00:00
abstract:PURPOSE:We investigated the relationship between BRCA mutations and the distribution of familial cancers other than breast or ovary in high-risk breast cancer patients. METHODS:PATIENTS WITH BREAST CANCER WHO HAD AT LEAST ONE OF THE FOLLOWING RISK FACTORS WERE ENROLLED: reported family history of breast or ovarian can...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2012.15.3.283
更新日期:2012-09-01 00:00:00
abstract:PURPOSE:We evaluated the effect of local recurrence (LR) and regional recurrence (RR) on distant metastasis and survival in patients treated with breast conservation therapy (BCT). METHODS:We analyzed 907 patients who were treated for invasive breast cancer between 1993 and 2006. With 53 months of follow-up, 28 patien...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2011.14.3.191
更新日期:2011-09-01 00:00:00
abstract::Apocrine encapsulated papillary carcinoma (EPC) of the breast is a rare neoplasm, and only 10 cases have been reported in the literature to date. Although EPC by definition lacks a peripheral myoepithelial layer, all previously published apocrine EPC cases were clinically indolent and lacked a conventional invasive co...
journal_title:Journal of breast cancer
pub_type:
doi:10.4048/jbc.2018.21.2.227
更新日期:2018-06-01 00:00:00
abstract:PURPOSE:We investigated the feasibility of using surgical clips as markers for tumor localization and their effect on the imaging evaluation of treatment responses after neoadjuvant chemotherapy (NAC). METHODS:A total of 16 breast cancers confirmed by needle biopsy in 15 patients were included in this study from Octob...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2015.18.1.44
更新日期:2015-03-01 00:00:00
abstract:PURPOSE:MicroRNAs (miRNAs) are a major class of small endogenous RNA molecules that posttranscriptionally regulate the expression of most genes in the human genome. miRNAs are often located in chromosomal fragile sites, which are suscept-ible to amplification or deletion. Chromosomal deletions are frequent events in br...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2016.19.2.148
更新日期:2016-06-01 00:00:00
abstract:PURPOSE:The aim of this study is to explore signal transducer and activator of transcription 3 (STAT3) expression in breast cancer and to analyze the detailed mechanism that STAT3 contributes to the progression of breast cancer. METHODS:We retrospectively analyzed the clinicopathologic characteristics and overall surv...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2013.16.1.40
更新日期:2013-03-01 00:00:00
abstract:Purpose:BRCA1/2 mutations are associated with risks of breast and ovarian cancer. In Korea, incidences of BRCA1/2 genetic testing and risk-reducing surgery (RRS) have increased with insurance coverage and the Angelina Jolie effect. The aim of this study was to identify trends in RRS performed in Korean women with the B...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2020.23.e61
更新日期:2020-12-03 00:00:00
abstract:PURPOSE:Somatic mutations of the chromatin remodeling AT-rich interactive domain 1A (SWI-like) gene (ARID1A) have been identified in many human cancers, including breast cancer. The purpose of this study was to evaluate the nuclear expression of ARID1A in breast cancers by immunohistochemistry (IHC) and to correlate th...
journal_title:Journal of breast cancer
pub_type: 杂志文章
doi:10.4048/jbc.2015.18.4.339
更新日期:2015-12-01 00:00:00