Abstract:
Purpose:We aimed to investigate the clinicopathologic factors associated with distant metastasis (DM) and post-recurrence overall survival (OS) after salvage treatments for isolated locoregional recurrence (ILRR) of breast cancer and identify long-term surviving patients for providing a more personalized therapy. Methods:We analyzed 125 patients who underwent salvage local treatments for ILRR after initial curative breast surgery. Results:Fifty-two (41.6%) patients experienced secondary recurrence or disease progression, of which 20 (38.5%) experienced a secondary locoregional recurrence and 40 (76.9%) experienced DM as the first site of failure. In multivariate analysis of distant metastasis free survival (DMFS) and post-recurrence OS, the initial pN2-3 stage, a disease-free interval of < 36 months, and non-curative resection for recurrent disease were independently poor prognosticators. The score for patients stratified according to the number of risk factors increased from 0 to 3; the corresponding 5-year DMFS rates were 91.4%, 53.0%, 35.9%, and 0% and the 5-year OS rates were 97.3%, 70.4%, 32.7%, and 25.0%, respectively (p < 0.001). Systemic chemotherapy reduced DM in patients with a score of 2-3, but it did not in those with a score of 0-1. Conclusion:Our collective stratification can help with prognosis prediction for ILRR of breast cancer. Depending on the DM risk of patients, the potential combination of systemic therapy should be discussed further.
journal_name
J Breast Cancerjournal_title
Journal of breast cancerauthors
Kim BH,Shin KH,Chie EK,Kim JH,Kim K,Hwang KT,Kim J,Choi IS,Park JH,Kim Sdoi
10.4048/jbc.2020.23.e31subject
Has Abstractpub_date
2020-04-29 00:00:00pages
279-290issue
3eissn
1738-6756issn
2092-9900journal_volume
23pub_type
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journal_title:Journal of breast cancer
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pub_type: 杂志文章,评审
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