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Does Immediate Breast Reconstruction after Mastectomy affect the Initiation of Adjuvant Chemotherapy?

Abstract：

PURPOSE:The frequency of immediate breast reconstruction (IBR) is increasing, and the types of reconstruction used are diverse. Adjuvant chemotherapy is a life-saving intervention in selected high-risk breast cancer patients. The aim of our study was to determine how IBR and type of reconstruction affect the timing of the initiation of chemotherapy. METHODS:We obtained data from female breast cancer patients treated by mastectomy with IBR (IBR group) and without IBR (mastectomy only group) who received adjuvant chemotherapy between January 1, 2008, and December 31, 2010. We retrospectively collected data including patient characteristics, disease characteristics, treatment details, and treatment outcomes from our institutional electronic patient database and medical treatment records. The reconstruction types were categorized as deep inferior epigastric perforator (DIEP) flap, latissimus dorsi (LD) flap and tissue expander/implant (TEI). RESULTS:In total, 595 patients were included in this study. Of these patients, 43 underwent mastectomy with IBR (IBR group) and 552 patients did not undergo reconstruction (mastectomy only group). There was significant difference in the timing of the initiation of chemotherapy between the two groups (p<0.0001). There were no cases of delays of more than 12 weeks. In the IBR group, 20 patients received TEI, 9 patients were treated by the insertion DIEP flaps, and 14 patients were treated by LD flaps. There were no significant differences in the timing of chemotherapy according to the type of reconstruction (p=0.095). CONCLUSION:IBR delays the initiation of chemotherapy, but does not lead to omission or significant clinical delay in chemotherapy. Further, the type of reconstruction does not affect the timing of chemotherapy.

journal_name

J Breast Cancer

journal_title

Journal of breast cancer

authors

Lee J,Lee SK,Kim S,Koo MY,Choi MY,Bae SY,Cho DH,Kim J,Jung SP,Choe JH,Kim JH,Kim JS,Lee JE,Yang JH,Nam SJ

doi

10.4048/jbc.2011.14.4.322

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

322-7

issue

eissn

1738-6756

issn

2092-9900

journal_volume

pub_type

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Does Immediate Breast Reconstruction after Mastectomy affect the Initiation of Adjuvant Chemotherapy?