Abstract：
Purpose:This study was aimed at identifying the influence of initial weight and weight change during neoadjuvant chemotherapy (NAC) on pathologic complete response (pCR) and long-term survival in Chinese patients with operable breast cancer. Methods:We conducted a retrospective study using data from 409 female patients who received NAC for stage II or III breast cancer and had complete record of body mass index (BMI) before and after NAC. BMI of < 25 kg/m2 was categorized as normal weight/underweight (NW/UW); 25.0-29.9 kg/m2 was categorized as overweight (OW); ≥30 kg/m2 was categorized as obese (OB). BMI change was defined as the difference in BMI between day 1 of the first cycle of NAC and the day before surgery. A BMI gain or loss of > 2 kg/m2 following NAC was considered to be significant, else was considered stable. The study end points included pCR rates, disease-free survival (DFS), and overall survival (OS). Results:The median follow-up time was 43.2 (8.9-93.6) months. The average BMI was 23.40 ± 3.04 kg/m2 before NAC and 23.66 ± 3.02 kg/m2 after NAC (t = -3.604, p < 0.001). The pCR rate was 25.3% in the NW/UW group and 24.1% in the OW/OB group (p = 0.811), and was similar between the BMI-gain (23.3%) and the BMI-stable/loss (25.1%) groups (p = 0.787). Initial BMI was an independent prognostic factor for DFS (hazard ratio, 1.69; 95% confidence interval [CI], 1.13-2.53; p = 0.011) but not for OS, while BMI-gain was an independent prognostic factor for both DFS (hazard ratio, 2.09; 95% CI, 1.28-3.42; p = 0.003) and OS (hazard ratio, 1.97; 95% CI, 1.04-3.74; p = 0.039). Conclusion:BMI increased after NAC in Chinese breast cancer patients. Initial BMI and BMI change during NAC were not associated with pCR but were reversely associated with survival.
journal_name
J Breast Cancerjournal_title
Journal of breast cancerauthors
Fang Q,Huang J,Gan L,Shen K,Chen X,Wu Bdoi
10.4048/jbc.2019.22.e37subject
Has Abstractpub_date
2019-08-26 00:00:00pages
399-411issue
3eissn
1738-6756issn
2092-9900journal_volume
22pub_type
杂志文章abstract：Purpose:The benefit of post-mastectomy radiation therapy (PMRT) in patients with breast cancer who achieve ypN0 following neoadjuvant chemotherapy (NAC) has not yet been established. This study aimed to identify the role of PMRT in patients who achieve ypN0 according to molecular subtype. Methods:We identified patient...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2019.22.e25
更新日期：2019-05-13 00:00:00
abstract：:Breast cancer generally develops in older women and its incidence is continuing to increase with increasing age of the population. The pathology and biology of breast cancer seem to be different in the elderly, often resulting in the undertreatment of elderly patients and thus in higher rates of recurrence and mortal-...
journal_title：Journal of breast cancer
pub_type： 杂志文章,评审
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更新日期：2015-09-01 00:00:00
abstract：PURPOSE:Transient receptor potential vanilloid 1 (TRPV1) is a nonselective cation channel belonging to the transient receptor potential family, and it is expressed in different neoplastic tissues. Its activation is associated with regulation of cancer growth and progression. The aim of this research was to study the ex...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2014.17.4.332
更新日期：2014-12-01 00:00:00
abstract：:Malignant melanoma rarely originates from the female nipple. Tumors that develop on the skin of the breast are often subject to a delayed diagnosis. Cytologic examination provides excellent diagnostic capabilities and is a safe procedure with a lower risk of local implantation, compared to needle or incisional biopsy....
journal_title：Journal of breast cancer
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doi：10.4048/jbc.2018.21.1.96
更新日期：2018-03-01 00:00:00
abstract：PURPOSE:Surgical clips are used as a target for postoperative breast radiotherapy, and displacement of surgical clips would result in inaccurate delivery of radiation. We investigated the displacement range of surgical clips in the breast during postoperative radiotherapy following breast-conserving surgery. METHODS:A...
journal_title：Journal of breast cancer
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doi：10.4048/jbc.2016.19.4.417
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abstract：:The Korean Breast Cancer Society (KBCS) has reported a nationwide breast cancer data since 1996. We present a comprehensive report on the facts and trends of breast cancer in Korea in 2013. Data on the newly diagnosed patients in the year 2013 were collected from 99 hospitals by using nationwide questionnaire survey. ...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2016.19.1.1
更新日期：2016-03-01 00:00:00
abstract：Purpose:Whether tamoxifen affects the risk of neurodegenerative disease is controversial. This nationwide population-based study investigated the risk of Parkinson's disease (PD) associated with tamoxifen treatment in female patients with breast cancer using Taiwan's National Health Insurance Research Database. Method...
journal_title：Journal of breast cancer
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abstract：PURPOSE:The Gail model is one of the most widely used tools to assess the risk of breast cancer. However, it is known to overestimate breast cancer risk for Asian women. Here, we validate the Gail model and the Korean model using Korean data, and subsequently update and revalidate the Korean model using recent data. M...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2014.17.3.226
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abstract：PURPOSE:The role of first-line trastuzumab-based therapy has been firmly established in patients with human epidermal growth factor receptor-2 (HER2) positive metastatic breast cancer. In this trial, we evaluated the efficacy and safety of a vinorelbine and trastuzumab combination chemotherapy in patients who were pret...
journal_title：Journal of breast cancer
pub_type： 杂志文章
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更新日期：2011-06-01 00:00:00
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journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2020.23.e31
更新日期：2020-04-29 00:00:00
abstract：Purpose:Breast cancer treatments, including chemotherapy, administered in combination with glucocorticoids can induce hyperglycemia. This study aimed to investigate the effect of hyperglycemia during adjuvant chemotherapy on the prognosis of breast cancer patients without a known history of diabetes. Methods:In this s...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2020.23.e44
更新日期：2020-08-05 00:00:00
abstract：:Breast metastasis from gastric carcinoma is rare. We present a case of right breast mass with microcalcification in which the diagnosis of poorly differentiated adenocarcinoma from the stomach was made after a biopsy. Pleomorphic microcalcification was noted in the ill-defined breast mass, which is a rare feature in b...
journal_title：Journal of breast cancer
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doi：10.4048/jbc.2012.15.3.356
更新日期：2012-09-01 00:00:00
abstract：PURPOSE:The aim of this study is to explore signal transducer and activator of transcription 3 (STAT3) expression in breast cancer and to analyze the detailed mechanism that STAT3 contributes to the progression of breast cancer. METHODS:We retrospectively analyzed the clinicopathologic characteristics and overall surv...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2013.16.1.40
更新日期：2013-03-01 00:00:00
abstract：PURPOSE:Breast cancer subtype correlates with response to systemic therapy and overall survival (OS), but its impact on lymphatic spread is incompletely understood. In this study, we used the Surveillance, Epidemiology, and End Results registry to assess whether the subtype can predict the presence of nodal metastasis ...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2015.18.2.143
更新日期：2015-06-01 00:00:00
abstract：:The median time of brain metastasis from the diagnosis of breast cancer is approximately 3 years. In this case report, a 69-year-old woman demonstrated cerebellar ataxia. Brain magnetic resonance imaging revealed enhanced lesions in bilateral cerebellar hemispheres. She had undergone surgery, radiation, and chemothera...
journal_title：Journal of breast cancer
pub_type：
doi：10.4048/jbc.2017.20.2.212
更新日期：2017-06-01 00:00:00
abstract：:The combination of luteinizing hormone-releasing hormone analogs (LHRHa) with tamoxifen is used as a standard postoperative adjuvant therapy in patients with hormone receptor-positive/premenopausal breast cancer. Long-acting LHRHa formulations offer advantages in terms of patient convenience. However, data on the effe...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2020.23.e57
更新日期：2020-10-26 00:00:00
abstract：PURPOSE:As doxorubicin cardiotoxicity is considered irreversible, early detection of cardiotoxicity and prevention of overt heart failure is essential. Although there are monitoring guidelines for cardiotoxicity, optimal timing for early detection of subclinical doxorubicin cardiotoxicity is still obscure. The purpose ...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2013.16.2.178
更新日期：2013-06-01 00:00:00
abstract：PURPOSE:The MammaPrint™ gene signature, currently used in clinical practice, provides prognostic information regarding the recurrence and potential metastasis in breast cancer patients. However, the prognostic information of the 70 genes included can only be estimated at the RNA expression level. In this study, we inve...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2017.20.3.246
更新日期：2017-09-01 00:00:00
abstract：:Apocrine encapsulated papillary carcinoma (EPC) of the breast is a rare neoplasm, and only 10 cases have been reported in the literature to date. Although EPC by definition lacks a peripheral myoepithelial layer, all previously published apocrine EPC cases were clinically indolent and lacked a conventional invasive co...
journal_title：Journal of breast cancer
pub_type：
doi：10.4048/jbc.2018.21.2.227
更新日期：2018-06-01 00:00:00
abstract：PURPOSE:MicroRNAs (miRNAs) are a major class of small endogenous RNA molecules that posttranscriptionally regulate the expression of most genes in the human genome. miRNAs are often located in chromosomal fragile sites, which are suscept-ible to amplification or deletion. Chromosomal deletions are frequent events in br...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2016.19.2.148
更新日期：2016-06-01 00:00:00
abstract：Purpose:BRCA1/2 mutations are associated with risks of breast and ovarian cancer. In Korea, incidences of BRCA1/2 genetic testing and risk-reducing surgery (RRS) have increased with insurance coverage and the Angelina Jolie effect. The aim of this study was to identify trends in RRS performed in Korean women with the B...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2020.23.e61
更新日期：2020-12-03 00:00:00
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journal_title：Journal of breast cancer
pub_type： 杂志文章,评审
doi：10.4048/jbc.2014.17.2.107
更新日期：2014-06-01 00:00:00
abstract：:ESR1 mutation is frequently encountered in hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC), especially after aromatase inhibitor (AI) therapy, as a mechanism of resistance to endocrine therapy. Circulating tumor DNA-based detection of ESR1 mutatio...
journal_title：Journal of breast cancer
pub_type：
doi：10.4048/jbc.2020.23.e4
更新日期：2019-12-19 00:00:00
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journal_title：Journal of breast cancer
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doi：10.4048/jbc.2012.15.1.128
更新日期：2012-03-01 00:00:00
abstract：PURPOSE:We evaluated the effect of local recurrence (LR) and regional recurrence (RR) on distant metastasis and survival in patients treated with breast conservation therapy (BCT). METHODS:We analyzed 907 patients who were treated for invasive breast cancer between 1993 and 2006. With 53 months of follow-up, 28 patien...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2011.14.3.191
更新日期：2011-09-01 00:00:00
abstract：PURPOSE:Metastasis and local recurrence are the primary causes of treatment failure and patient death in breast cancer. The aim of this study was to validate a metastasis- and local recurrenceassociated biomarker for prognostic evaluation and planning treatment strategies. METHODS:Formalin-fixed, paraffin-embedded tis...
journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2017.20.2.142
更新日期：2017-06-01 00:00:00
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journal_title：Journal of breast cancer
pub_type： 杂志文章
doi：10.4048/jbc.2013.16.3.308
更新日期：2013-09-01 00:00:00
abstract：Purpose:Pokemon, also known as ZBTB7A, belongs to the POZ and Krüppel (POK) family of transcription repressors and is implicated in tumor progression as a key proto-oncogene. This present study aimed at determining the mechanism by which Pokemon inhibits transforming growth factor β (TGFβ)-Smad4 pathway-dependent proli...
journal_title：Journal of breast cancer
pub_type： 杂志文章
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更新日期：2019-02-15 00:00:00
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更新日期：2015-09-01 00:00:00
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journal_title：Journal of breast cancer
pub_type：
doi：10.4048/jbc.2019.22.e44
更新日期：2019-09-18 00:00:00
