Abstract：
:The Veterans Health Administration determined that over 250,000 U.S. service members were diagnosed with a traumatic brain injury (TBI) between 2008 and 2018, of which a great proportion were due to blast exposure. Although the penetrating (secondary) and inertia-driven (tertiary) phases of blast-induced TBI (bTBI) have been studied thoroughly and are known to be injurious, primary blast brain injury has been less studied. We investigated the biomechanics of primary bTBI in our previously developed in vitro shock tube model with a fluid-filled sample receiver. Using stereoscopic, high-speed cameras and digital image correlation (DIC), we mapped the deformation of organotypic hippocampal slice cultures (OHSCs) following a range of blast exposures to characterize the induced strains. As blast exposure increased, tissue strain increased, although the levels remained relatively low (maximum < 9%), with strains rates between 25 and 85 s-1. Both strain magnitude and rate were highly correlated with the in-air blast impulse and in-fluid peak pressure parameters. Comparing biomechanical parameters to previously reported blast-induced electrophysiological dysfunction, a threshold for deficits in long-term potentiation (LTP) was observed for strains between 3.7 and 6.7% and strain rates between 25 and 33 s-1. This is the first study to experimentally determine primary blast-induced strain and strain rates in hippocampal tissue.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Vogel EW 3rd,Panzer MB,Morales FN,Varghese N,Bass CR,Meaney DF,Morrison B 3rddoi
10.1007/s10439-019-02437-4subject
Has Abstractpub_date
2020-04-01 00:00:00pages
1196-1206issue
4eissn
0090-6964issn
1573-9686pii
10.1007/s10439-019-02437-4journal_volume
48pub_type
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