Abstract：
:Biomaterial-based tissue engineering strategies hold great promise for osteochondral tissue repair. Yet significant challenges remain in joining highly dissimilar materials to achieve a biomimetic, mechanically robust design for repairing interfaces between soft tissue and bone. This study sought to improve interfacial properties and function in a bi-layer hydrogel interpenetrated with a fibrous collagen scaffold. 'Soft' 10% (w/w) and 'stiff' 30% (w/w) PEGDM was formed into mono- or bi-layer hydrogels possessing a sharp diffusional interface. Hydrogels were evaluated as single-(hydrogel only) or multi-phase (hydrogel + fibrous scaffold penetrating throughout the stiff layer and extending >500 μm into the soft layer). Including a fibrous scaffold into both soft and stiff mono-layer hydrogels significantly increased tangent modulus and toughness and decreased lateral expansion under compressive loading. Finite element simulations predicted substantially reduced stress and strain gradients across the soft-stiff hydrogel interface in multi-phase, bilayer hydrogels. When combining two low moduli constituent materials, composites theory poorly predicts the observed, large modulus increases. These results suggest material structure associated with the fibrous scaffold penetrating within the PEG hydrogel as the major contributor to improved properties and function-the hydrogel bore compressive loads and the 3D fibrous scaffold was loaded in tension thus resisting lateral expansion.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Kinneberg KR,Nelson A,Stender ME,Aziz AH,Mozdzen LC,Harley BA,Bryant SJ,Ferguson VLdoi
10.1007/s10439-015-1337-0subject
Has Abstractpub_date
2015-11-01 00:00:00pages
2618-29issue
11eissn
0090-6964issn
1573-9686pii
10.1007/s10439-015-1337-0journal_volume
43pub_type
杂志文章abstract：:The identification of the insulin minimal model (MM) for the estimation of insulin secretion rate (ISR) and physiological indexes (e.g. beta-cell sensitivity) requires the knowledge of C-peptide (CP) kinetics. The four parameters of the two-compartment model of CP kinetics in a given individual can be derived either f...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1023/b:abme.0000032465.75888.91
更新日期：2004-07-01 00:00:00
abstract：:Recent advances in angioplasty have involved the application of polymer coatings to stent surfaces for purposes of drug delivery. Given the high levels of deformation developed in the plastic hinge of a stent during deployment, the achievement of an intact bond between the coating and the stent presents a significant ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-010-9972-y
更新日期：2010-07-01 00:00:00
abstract：:Articular cartilage is an avascular connective tissue responsible for bearing loads. Cell signaling plays a central role in cartilage homeostasis and tissue engineering by directing chondrocytes to synthesize/degrade the extracellular matrix or promote inflammatory responses. The aim of this paper was to investigate a...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-017-1964-8
更新日期：2018-02-01 00:00:00
abstract：:A nonintrusive method for the visualization of pulsatile flow velocity profiles is described. The method is based on the use of a photochromic dye that is added to the fluid being studied and a nitrogen laser which excites the dye producing a marker "line" whose movement can be photographed. A microcomputer is used as...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02584271
更新日期：1986-01-01 00:00:00
abstract：:This discussion and review article focuses on the possible use of regenerative techniques applied to the interfaces between skin and medical implants. As is widely known, the area of contact between an implant and the skin--the skin-implant interface--is prone to recurrent and persistent problems originated from the l...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1007/s10439-010-9937-1
更新日期：2010-06-01 00:00:00
abstract：:Analysis and classification of esophageal motility records were investigated using signal processing and fuzzy-set pattern recognition techniques. A set of parameters has been extracted from the raw records and has previously been used as characterizing features. Improvements to these procedures were obtained by extra...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02368227
更新日期：1994-01-01 00:00:00
abstract：:The aim of this study was to develop an empirical model of parameter-based gait data, based on an artificial neural network and a genetic algorithm, for the assessment of patients after ankle arthrodesis. Ground reaction force vectors were measured by force platforms during level walking. Nine force parameters express...
journal_title：Annals of biomedical engineering
pub_type： 临床试验,杂志文章
doi：10.1114/1.1342053
更新日期：2001-01-01 00:00:00
abstract：:Computing the numerical solution of the bidomain equations is widely accepted to be a significant computational challenge. In this study we extend a previously published semi-implicit numerical scheme with good stability properties that has been used to solve the bidomain equations (Whiteley, J.P. IEEE Trans. Biomed. ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-008-9513-0
更新日期：2008-08-01 00:00:00
abstract：:In physiological conditions, joint function involves continuously moving contact areas over the tissue surface. Such moving contacts play an important role for the durability of the tissue. It is known that in pathological joints these motion paths and contact mechanics change. Nevertheless, limited information exists...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-015-1543-9
更新日期：2016-08-01 00:00:00
abstract：:Cochlear implantation consists in electrically stimulating the auditory nerve by inserting an electrode array inside the cochlea, a bony structure of the inner ear. In the absence of any visual feedback, the insertion results in many cases of damages of the internal structures. This paper presents a feasibility study ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-020-02671-1
更新日期：2020-10-30 00:00:00
abstract：:Electromechanical reshaping (EMR) of cartilage provides an alternative to the classic surgical techniques of modifying the shape of facial cartilages. The original embodiment of EMR required surface electrodes to be in direct contact with the entire cartilage region being reshaped. This study evaluates the feasibility...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-010-0088-1
更新日期：2010-11-01 00:00:00
abstract：:The most widely implanted prosthetic valve is the mechanical bileaflet. Recent clinical experiences suggest that some designs are more prone to thromboembolic episodes than others. This study evaluated the hinge flow and near-field forward flow of the new St. Jude Medical Regent bileaflet mechanical heart valve. Laser...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.297
更新日期：2000-05-01 00:00:00
abstract：:Electrical potentials in mechanically loaded bone have been implicated as signals in the bone remodeling cycle. Recently, interest has grown in exploiting this phenomenon to develop electrically active ceramics for implantation in hard tissue which may induce improved biological responses. Both polarized hydroxyapatit...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1007/s10439-010-9977-6
更新日期：2010-06-01 00:00:00
abstract：:This is a personal historical essay on meanderings through the jungle of the microcirculatory swamp. Because one pretends that the wandering was purposefully exploratory, a few guideposts are placed at positions where one could discern blaze-marks from earlier wanderers, and the path cut a little wider along some of t...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1007/BF02363568
更新日期：1987-01-01 00:00:00
abstract：:Perfusion bioreactors are known to exert shear stresses on cultured cells, leading to cell differentiation and enhanced extracellular matrix deposition on scaffolds. The influence of the scaffold's porous microstructure is investigated for a polycaprolactone (PCL) scaffold with a regular microarchitecture and a silk f...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-014-0981-0
更新日期：2014-05-01 00:00:00
abstract：:For an optimal guidance of the rehabilitation therapy of stroke patients in an in-home setting, objective, and patient-specific performance assessment of arm movements is needed. In this study, metrics of hand movement relative to the pelvis and the sternum were estimated in 13 stroke subjects using a full body ambula...
journal_title：Annals of biomedical engineering
pub_type： 临床试验,杂志文章
doi：10.1007/s10439-014-1198-y
更新日期：2015-02-01 00:00:00
abstract：:A novel in vitro culture system of organotypic human skin explants interfacing with external fixator pins is presented. The system was used to observe changes in skin morphology on the skin at the pin interface. To evaluate the performance of this novel system, histological analysis of human skin explants cultured for...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-008-9614-9
更新日期：2009-02-01 00:00:00
abstract：:Zebrafish is an emerging model system for cardiac conduction and regeneration. Zebrafish heart regenerates after 20% ventricular resection within 60 days. Whether cardiac conduction phenotype correlated with cardiomyocyte regeneration remained undefined. Longitudinal monitoring of the adult zebrafish heart (n = 12) wa...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-010-9993-6
更新日期：2010-07-01 00:00:00
abstract：:Collagen is known to be a viscoelastic material and therefore is an important source of time dependent behavior in soft tissue. Though there are material models for soft tissue that rely on properties and structure of constituent collagen fibers, such models generally utilize only the elastic properties of collagen, a...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-006-9124-6
更新日期：2006-07-01 00:00:00
abstract：:The objectives were as follows: (1) estimating mean value of the overall hemoglobin glycation rate constant (k); (2) analyzing inter-individual variability of k; (3) verifying ability of the hemoglobin A1c (HbA1c) formation model to predict changes of HbA1c during red blood cells cultivation in vitro and to reproduce ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-011-0366-6
更新日期：2011-11-01 00:00:00
abstract：:This study aimed to quantify the elongation patterns of the collateral ligaments following TKA during functional activities of daily living. Using mobile video-fluoroscopy to capture radiographic images of the knee in a group of six patients, each with an ultra-congruent knee implant, tibiofemoral kinematics were reco...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-020-02459-3
更新日期：2020-04-01 00:00:00
abstract：:Functional electrical stimulation (FES) to lower extremity (LE) muscles is used by individuals post-stroke as an alternative to mechanical orthotic devices during gait or as a training modality during rehabilitation. Technological developments which improve the feasibility, accessibility and effectiveness of FES syste...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1007/s10439-014-1148-8
更新日期：2015-02-01 00:00:00
abstract：:The influence of scaffold compliance on blood vessel tissue engineering remains unclear and compliance mismatch issues are important to an in vivo tissue-engineering approach. We have designed and constructed a modular bioreactor system that is capable of imparting pulsatile fluid flow while simultaneously measuring v...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-007-9304-z
更新日期：2007-08-01 00:00:00
abstract：:The purpose of this study is to measure the transmural pressure-cross sectional area relation of micro tubes (240 microns diameter) and to compare the measured perfusion pressure-flow relation with the pressure-flow relation calculated from the experimental pressure-cross sectional area relation. The microtubes are ma...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02368042
更新日期：1989-01-01 00:00:00
abstract：:Proper replacement or repair of damaged tendons or ligaments requires functionally engineered tissue that mimics their native mechanical properties. While tendon structure-function relationships are generally assumed, there exists little quantitative evidence of the roles of distinct tendon components in tendon functi...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1023/b:abme.0000032455.78459.56
更新日期：2004-07-01 00:00:00
abstract：:The effects of facet wiring procedure commonly used for stabilizing cervical spines after laminectomy or bilateral facet dislocation on the motion behavior of whole cervical spines are investigated using a Selspot II system. A fresh human ligamentous intact specimen was potted at T1/T2 vertebra and clinically relevant...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02368022
更新日期：1989-01-01 00:00:00
abstract：:The geometric and hemodynamic characteristics of the left and right vertebral arteries (LVA, RVA) of six healthy volunteers were investigated for the supine (S) and the prone position (P) a common sleeping posture with head rotation. MRI images were used to reconstruct the subject specific three-dimensional solid mode...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-015-1340-5
更新日期：2015-06-01 00:00:00
abstract：:The unique resource constraints, urgency, and virulence of the coronavirus disease 2019 pandemic has sparked immense innovation in the development of barrier devices to protect healthcare providers from infectious airborne particles generated by patients during airway management interventions. Of the existing devices,...
journal_title：Annals of biomedical engineering
pub_type： 社论
doi：10.1007/s10439-020-02599-6
更新日期：2020-10-01 00:00:00
abstract：:Knowledge of strain-rate sensitivity of soft tissue viscoelastic and nonlinear elastic properties is important for accurate predictions of biomechanical behavior and for quantitative assessment of the effects of disease or surgical/pharmaceutical intervention. Soft tissues are known to exhibit mild rate sensitivity, b...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1023/b:abme.0000012742.01261.b0
更新日期：2004-02-01 00:00:00
abstract：:The human thorax is commonly injured in motor vehicle crashes, and despite advancements in occupant safety rib fractures are highly prevalent. The objective of this study was to quantify the ability of gross and cross-sectional geometry, separately and in combination, to explain variation of human rib structural prope...
journal_title：Annals of biomedical engineering
pub_type： 临床试验,杂志文章
doi：10.1007/s10439-017-1850-4
更新日期：2017-09-01 00:00:00
