Micro-computed tomography based computational fluid dynamics for the determination of shear stresses in scaffolds within a perfusion bioreactor.

abstract：:Upon nerve injury, the body creates an environment consisting of permissive and non-permissive cues that instruct the function of cells involved in nerve repair. Among other roles, the developing extracellular matrix (ECM) acts as an underlying substrate to guide the union of neurites extending from the proximal stump...

journal_title：Annals of biomedical engineering

authors： Man AJ,Leach JK,Bannerman P

更新日期：2014-06-01 00:00:00

abstract：:Thorax injuries mainly due to rib fractures have been associated with high rates of morbidity and mortality in motor vehicle crashes. Thoracic biomechanics has been studied extensively, but there are no robust biomechanical response targets for ribs that consider age, sex, body size, and vulnerability factors. The obj...

journal_title：Annals of biomedical engineering

authors： Kang YS,Kwon HJ,Stammen J,Moorhouse K,Agnew AM

更新日期：2021-02-01 00:00:00

abstract：:Impedance data, e.g., system responses, from perturbing small amplitude applied sinusoid signals of near DC to high kilohertz frequencies, give chemical information. Analysis of frequency-dependent imaginary and real impedance proceeds from equivalent analog circuit elements to chemical and physical significance deter...

journal_title：Annals of biomedical engineering

authors： Buck RP

更新日期：1992-01-01 00:00:00

abstract：:Spine musculoskeletal models used to estimate loads and displacements require many simplifying assumptions. We examined how assumptions about subject size and vertebral positions can affect the model outcomes. Head and neck models were developed to represent 30 subjects (15 males and 15 females) in neutral posture and...

journal_title：Annals of biomedical engineering

authors： Vasavada AN,Hughes E,Nevins DD,Monda SM,Lin DC

更新日期：2018-11-01 00:00:00

abstract：:Computing the numerical solution of the bidomain equations is widely accepted to be a significant computational challenge. In this study we extend a previously published semi-implicit numerical scheme with good stability properties that has been used to solve the bidomain equations (Whiteley, J.P. IEEE Trans. Biomed. ...

journal_title：Annals of biomedical engineering

authors： Whiteley JP

更新日期：2008-08-01 00:00:00

abstract：:Understanding the complex spatiotemporal dynamics of action potential propagation in the heart during arrhythmia is exceedingly difficult. This study applies nonlinear dynamics tools to simplify this task. Using the results of a simulation of an electrical induction of reentry in a sheet of myocardium represented as a...

journal_title：Annals of biomedical engineering

authors： Larson C,Dragnev L,Trayanova N

更新日期：2003-07-01 00:00:00

abstract：:We describe a system for real-time control of biological and other experiments. This device, based around the Real-Time Linux operating system, was tested specifically in the context of dynamic clamping, a demanding real-time task in which a computational system mimics the effects of nonlinear membrane conductances in...

journal_title：Annals of biomedical engineering

authors： Dorval AD,Christini DJ,White JA

更新日期：2001-10-01 00:00:00

abstract：:During defecation, solid, semisolid or liquid stools are eliminated via the anus in a complex physiological process. Up to 25% of the population are affected by anorectal disorders that are poorly recognized and treated. We developed a new bionics device, a simulated stool named Fecobionics, to replace several current...

journal_title：Annals of biomedical engineering

authors： Sun D,Huang Z,Zhuang Z,Ma Z,Man LK,Liao D,Gregersen H

更新日期：2019-02-01 00:00:00

abstract：:This study was undertaken to investigate the possible origin of some cutaneously recorded higher frequency electrogastrographic signals. Computer modeling of gastric electrical uncoupling was performed using previously described conoidal dipole model. Cutaneous electrogastrograms were simulated after uncoupling was in...

journal_title：Annals of biomedical engineering

authors： Mintchev MP,Bowes KL

更新日期：1997-11-01 00:00:00

abstract：:A two-dimensional sheet model was used to study the dynamics of reentry around a zone of functional block. The sheet is a set of parallel, continuous, and uniform cables, transversely interconnected by a brick-wall arrangement of fixed resistors. In accord with experimental observations on cardiac tissue, longitudinal...

journal_title：Annals of biomedical engineering

authors： Leon LJ,Roberge FA,Vinet A

更新日期：1994-11-01 00:00:00

abstract：:Twenty-one 3.5-month-old female Sprague-Dawley rats were randomly assigned to three groups: BTX group, in which each rat received a single intramuscular injection of 2 U of Clostridium botulinum toxin (BTX) in the quadriceps femoris muscle of the right hind limb; BTX + SR group, in which each rat received a BTX inject...

journal_title：Annals of biomedical engineering

authors： Sheng ZF,Ma YL,Tong D,Fang DY,Liang QC,Liu LH,Zhang J,Liao EY

更新日期：2012-03-01 00:00:00

abstract：:The concept of body force (force per unit volume) is introduced to account for the effect of the force generated in the radial direction by the active state of the myocardium in an elastic model of the left ventricle represented as a thick-walled cylinder contracting symmetrically. Experimental evidence for the validi...

journal_title：Annals of biomedical engineering

authors： Shoucri RM

更新日期：1991-01-01 00:00:00

abstract：:To better understand oxygen utilization by the retina, a mathematical model of oxygen diffusion and consumption in the cat outer, avascular retina was developed by analyzing previously recorded profiles of oxygen tension (PO2) as a function of retinal depth. Simple diffusion modelling of the oxygen distribution throug...

journal_title：Annals of biomedical engineering

authors： Haugh LM,Linsenmeier RA,Goldstick TK

更新日期：1990-01-01 00:00:00

abstract：:Using a three-dimensional propagation model of the human ventricular myocardium, we studied the role of fibrous structure in generating epicardial potential maps. This model represents the myocardium as an anisotropic bidomain with an equal anisotropy ratio, and it incorporates a realistic representation of anatomical...

journal_title：Annals of biomedical engineering

authors： Hren R,Nenonen J,Horácek BM

更新日期：1998-11-01 00:00:00

abstract：:While viscoelastic responses of isolated trunk soft tissues have been characterized in earlier studies, the effects of external loading and flexion rate on these responses in the intact human trunk are largely unknown. Two experiments were conducted to measure trunk viscoelastic behaviors, one involving prolonged flex...

journal_title：Annals of biomedical engineering

authors： Toosizadeh N,Nussbaum MA

更新日期：2013-06-01 00:00:00

abstract：:This paper presents an in vitro temperature mapping study of bovine cardiac tissue during radiofrequency ablation. The objectives were to: (i) develop a technique for measuring the spatial and temporal temperature distribution in the tissue and in the blood during ablation, and (ii) use the temperature measurements to...

journal_title：Annals of biomedical engineering

authors： Jain MK,Wolf PD

更新日期：2000-09-01 00:00:00

abstract：:We have developed a method for quantifying the complexity of activation patterns observed during ventricular fibrillation (VF) that is based on our previously reported methodology for decomposing epicardial mapping data into a set of isolated wavefronts. One-half second datasets are acquired from a 21 x 24 array of un...

journal_title：Annals of biomedical engineering

authors： Rogers JM,Usui M,KenKnight BH,Ideker RE,Smith WM

更新日期：1997-09-01 00:00:00

abstract：:Cerebral blood flow (CBF) increases as arterial oxygen content falls with hypoxic (low PO2), anemic (low hemoglobin) and carbon monoxide (CO) (high carboxyhemoglobin) hypoxia. Despite a higher arterial PO2, CO hypoxia provokes a greater increase in CBF than hypoxic hypoxia. We analyzed published data using a compartme...

journal_title：Annals of biomedical engineering

authors： Sharan M,Popel AS,Hudak ML,Koehler RC,Traystman RJ,Jones MD Jr

更新日期：1998-01-01 00:00:00

abstract：:The effects of facet wiring procedure commonly used for stabilizing cervical spines after laminectomy or bilateral facet dislocation on the motion behavior of whole cervical spines are investigated using a Selspot II system. A fresh human ligamentous intact specimen was potted at T1/T2 vertebra and clinically relevant...

journal_title：Annals of biomedical engineering

authors： Goel VK,Clark CR,Harris KG,Kim YE,Schulte KR

更新日期：1989-01-01 00:00:00

abstract：:We compare the influence of time-frequency methods on analysis of time-varying renal autoregulation properties. Particularly, we examine if detection probabilities are similar for amplitude and frequency modulation for a modulated simulation signal among five time-frequency approaches, and if time-varying changes in s...

journal_title：Annals of biomedical engineering

authors： Scully CG,Siu KL,Cupples WA,Braam B,Chon KH

更新日期：2013-01-01 00:00:00

abstract：:Microencapsulation of recombinant cells is a novel promising approach to tumor therapy in which therapeutic protein is sustainable and long-term delivered by microencapsulated cells. The semi-permeable membrane of microcapsule can protect cell from host's immune rejection, increase the chemical stability of therapeuti...

journal_title：Annals of biomedical engineering

authors： Zhang Y,Wang W,Zhou J,Yu W,Zhang X,Guo X,Ma X

更新日期：2007-04-01 00:00:00

abstract：:A coculture of endothelial cells (ECs) and smooth muscle cells (SMCs), which mimics cellular interactions appearing in vivo, has been performed in studies on the relationship between atherogenesis and fluid shear stress conditions. Although healthy arteries in vivo consist of contractile phenotype SMCs, cultured cells...

journal_title：Annals of biomedical engineering

authors： Sakamoto N,Kiuchi T,Sato M

更新日期：2011-11-01 00:00:00

abstract：:In an ovine femur model, proliferative woven bone fills critically sized defects enveloped by periosteum within 2 weeks of treatment with the one-stage bone-transport surgery. We hypothesize that mechanical loading modulates this process. Using high-definition optical strain measurements we determined prevailing perio...

journal_title：Annals of biomedical engineering

authors： McBride SH,Dolejs S,Brianza S,Knothe U,Knothe Tate ML

更新日期：2011-05-01 00:00:00

abstract：:The pulmonary microvasculature offers a heterogeneous barrier to the motion of large solutes as they pass between blood and lymph. While this barrier has been approximated by a few discrete pathways or by statistical ensembles of many pathways, these descriptions only partly capture the structural and functional prope...

journal_title：Annals of biomedical engineering

authors： McNamee JE

更新日期：1990-01-01 00:00:00

abstract：:Crowding can substantially affect the transition of a protein between its native (N) and unfolded (U) states via volume exclusion effects. Also, it influences considerably the aggregation (A) of unfolded proteins. To examine the details, we developed an approach for computing the kinetic rates of the process N <--> U ...

journal_title：Annals of biomedical engineering

authors： Despa F,Orgill DP,Lee RC

更新日期：2005-08-01 00:00:00

abstract：:Current efforts to evaluate the performance of laparoscopic arterial fusion devices are limited to costly, time consuming, empirical studies. Thus, a finite element (FE) model, with the ability to predict device performance would improve device design and reduce development time and costs. This study introduces a mode...

journal_title：Annals of biomedical engineering

authors： Fankell DP,Kramer E,Cezo J,Taylor KD,Ferguson VL,Rentschler ME

更新日期：2016-11-01 00:00:00

abstract：:The bioinspired, microscale tissue engineering approach has emerged in recent years as a promising alternative to preformed scaffolds. Using this approach, complex tissues and organs can be efficiently engineered from microscale modules to replicate the intricate architecture and physiology of vascularized organs and ...

journal_title：Annals of biomedical engineering

authors： Annamalai RT,Matthew HWT

更新日期：2019-05-01 00:00:00

abstract：:The proliferation, migration, and adhesion of vascular smooth muscle cells (VSMCs) and their interactions with extracellular matrix are key features of atherosclerosis and restenosis. Recently, there has been evidence that magnetic fields exert multiple effects on the biological performance of cells and may aid in the...

journal_title：Annals of biomedical engineering

authors： Li Y,Song LQ,Chen MQ,Zhang YM,Li J,Feng XY,Li W,Guo W,Jia G,Wang H,Yu J

更新日期：2012-12-01 00:00:00

abstract：:The longitudinal assessment of joint health is a long-standing issue in the management of musculoskeletal injuries. The acoustic emissions (AEs) produced by joint articulation could serve as a biomarker for joint health assessment, but their use has been limited by a lack of mechanistic understanding of their creation...

journal_title：Annals of biomedical engineering

authors： Whittingslow DC,Jeong HK,Ganti VG,Kirkpatrick NJ,Kogler GF,Inan OT

更新日期：2020-01-01 00:00:00

abstract：:Electromechanical reshaping (EMR) of cartilage provides an alternative to the classic surgical techniques of modifying the shape of facial cartilages. The original embodiment of EMR required surface electrodes to be in direct contact with the entire cartilage region being reshaped. This study evaluates the feasibility...

journal_title：Annals of biomedical engineering

authors： Manuel CT,Foulad A,Protsenko DE,Sepehr A,Wong BJ

更新日期：2010-11-01 00:00:00