Abstract:
:Electromechanical reshaping (EMR) of cartilage provides an alternative to the classic surgical techniques of modifying the shape of facial cartilages. The original embodiment of EMR required surface electrodes to be in direct contact with the entire cartilage region being reshaped. This study evaluates the feasibility of using needle electrode systems for EMR of facial cartilage and evaluates the relationships between electrode configuration, voltage, and application time in effecting shape change. Flat rabbit nasal septal cartilage specimens were deformed by a jig into a 90° bend, while a constant electric voltage was applied to needle electrodes that were inserted into the cartilage. The electrode configuration, voltage (0-7.5 V), and application time (1-9 min) were varied systematically to create the most effective shape change. Electric current and temperature were measured during voltage application, and the resulting specimen shape was assessed in terms of retained bend angle. In order to demonstrate the clinical feasibility of EMR, the most effective and practical settings from the septal cartilage experimentation were used to reshape intact rabbit and pig ears ex vivo. Cell viability of the cartilage after EMR was determined using confocal microscopy in conjunction with a live/dead assay. Overall, cartilage reshaping increased with increased voltage and increased application time. For all electrode configurations and application times tested, heat generation was negligible (<1 °C) up to 6 V. At 6 V, with the most effective electrode configuration, the bend angle began to significantly increase after 2 min of application time and began to plateau above 5 min. As a function of voltage at 2 min of application time, significant reshaping occurred at and above 5 V, with no significant increase in the bend angle between 6 and 7.5 V. In conclusion, electromechanical reshaping of cartilage grafts and intact ears can be effectively performed with negligible temperature elevation and spatially limited cell injury using needle electrodes.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Manuel CT,Foulad A,Protsenko DE,Sepehr A,Wong BJdoi
10.1007/s10439-010-0088-1subject
Has Abstractpub_date
2010-11-01 00:00:00pages
3389-97issue
11eissn
0090-6964issn
1573-9686journal_volume
38pub_type
杂志文章abstract::Simulations are useful to study the heart's ability to generate flow and the interaction between contractility and loading conditions. The left ventricular pressure-volume (PV) relation has been shown to be nonlinear, but it is unknown whether a linear model is accurate enough for simulations. Six models were fitted t...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-009-9742-x
更新日期:2009-09-01 00:00:00
abstract::An understanding of the mechanical deformation behavior of the liver under high strain rate loading conditions could aid in the development of vehicle safety measures to reduce the occurrence of blunt liver injury. The purpose of this study was to develop a constitutive model of the stress-strain behavior of the human...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-008-9555-3
更新日期:2008-11-01 00:00:00
abstract::Three animal models were evaluated in this study involving head impacts of the rat, including the Marmarou drop-weight and two momentum-exchange techniques. In series 1, 36 Wistar rats were hit on the side of the free-moving head using Marmarou's 450 g impact mass at 4.4, 5.4, and 6.3 m/s. Head acceleration was measur...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-011-0386-2
更新日期:2012-01-01 00:00:00
abstract::We compare the influence of time-frequency methods on analysis of time-varying renal autoregulation properties. Particularly, we examine if detection probabilities are similar for amplitude and frequency modulation for a modulated simulation signal among five time-frequency approaches, and if time-varying changes in s...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-012-0625-1
更新日期:2013-01-01 00:00:00
abstract::Peripheral nerve injuries present challenges to regeneration. Currently, the gold standard for nerve repair is an autograft that results in another region of the body suffering nerve damage. Previously, bioactive borate glass (BBG) has been studied in clinical trials to treat patients with non-healing wounds, and we h...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-016-1689-0
更新日期:2016-12-01 00:00:00
abstract::The human thorax is commonly injured in motor vehicle crashes, and despite advancements in occupant safety rib fractures are highly prevalent. The objective of this study was to quantify the ability of gross and cross-sectional geometry, separately and in combination, to explain variation of human rib structural prope...
journal_title:Annals of biomedical engineering
pub_type: 临床试验,杂志文章
doi:10.1007/s10439-017-1850-4
更新日期:2017-09-01 00:00:00
abstract::Recently, we reported that tethering and rolling of neutrophils in shear flow over a substrate of E-selectin signals activation of beta 2-integrins and firm adhesion via an intracellular signaling pathway involving phosphorylation of p38 MAP kinase. In the current study the objective was to examine the molecular mecha...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1511240
更新日期:2002-09-01 00:00:00
abstract::While bone mineral density has been traditionally used to quantify fracture risk for individuals with spinal cord injuries, recent studies are including engineering measurements such as section modulus and cross sectional moment of inertia. These are almost exclusively calculated by peripheral QCT scanners which, unli...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-017-1796-6
更新日期:2017-05-01 00:00:00
abstract::We hypothesize that variations of body anthropometry, conjointly with the bone strength, determine the risk of hip fracture. To test the hypothesis, we compared, in a simulated sideways fall, the hip impact energy to the energy needed to fracture the femur. Ten femurs from elderly donors were tested using a novel drop...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-020-02682-y
更新日期:2020-11-12 00:00:00
abstract::Proper replacement or repair of damaged tendons or ligaments requires functionally engineered tissue that mimics their native mechanical properties. While tendon structure-function relationships are generally assumed, there exists little quantitative evidence of the roles of distinct tendon components in tendon functi...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1023/b:abme.0000032455.78459.56
更新日期:2004-07-01 00:00:00
abstract::Due to its unique non-invasive microstructure probing capabilities, diffusion tensor imaging (DTI) constitutes a valuable tool in the study of fiber orientation in skeletal muscles. By implementing a DTI sequence with judiciously chosen directional encoding to quantify in vivo the microarchitectural properties in the ...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-009-9783-1
更新日期:2009-12-01 00:00:00
abstract::A mathematical model of heat, water and soluble gas exchange in the airways and alveoli was used to predict the location of soluble gas exchange in the lung. A previously published model of heat, water and soluble gas exchange in the airways was improved by incorporating anatomical data on the airway wall to better de...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1630600
更新日期:2003-12-01 00:00:00
abstract::The effects of tissue hydration and fixed charge density on hydraulic permeability and creep behavior of cartilaginous tissues have been investigated using the triphasic theory and finite element methods. The empirical model for hydraulic permeability of uncharged gels and Mackie and Meares (1955) model for ion diffus...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1615576
更新日期:2003-11-01 00:00:00
abstract::Arteries are composed of multiple constituents that endow the wall with proper structure and function. Many vascular diseases are associated with prominent mechanical and biological alterations in the wall constituents. In this study, planar biaxial tensile test data of elastase-treated porcine aortic tissue (Chow et ...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-012-0733-y
更新日期:2013-07-01 00:00:00
abstract::In vitro stent-induced thromboembolism was altered by the presence of residual stenoses placed upstream or placed upstream and downstream of the stent. Heparinized (3 micro/ml) bovine blood was gravity fed through a conduit with a deployed coronary stent. Embolism was continuously monitored using a light-scattering mi...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.243
更新日期:2000-02-01 00:00:00
abstract::We developed muscle-tendon models incorporating Hill-type structure and length-dependent coupling between activation and velocity. The models were evaluated in electrically stimulated cat soleus muscles. Dynamic model parameters were estimated by a nonlinear parameter estimation algorithm from input-output data obtain...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.93
更新日期:1998-05-01 00:00:00
abstract::A coculture of endothelial cells (ECs) and smooth muscle cells (SMCs), which mimics cellular interactions appearing in vivo, has been performed in studies on the relationship between atherogenesis and fluid shear stress conditions. Although healthy arteries in vivo consist of contractile phenotype SMCs, cultured cells...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-011-0372-8
更新日期:2011-11-01 00:00:00
abstract::Neuromuscular impairment associated with cerebral palsy (CP) often leads to life-long walking deficits. Our goal was to evaluate the ability of a novel untethered wearable ankle exoskeleton to reduce the severity of gait pathology from CP. In this clinical feasibility study of five individuals with CP, we used instrum...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-019-02237-w
更新日期:2019-06-01 00:00:00
abstract::Tissue engineering strategies have utilized a wide spectrum of synthetic and naturally-derived scaffold materials. Synthetic scaffolds are better defined and offer the ability to precisely and reproducibly control their properties, while naturally-derived scaffolds typically have inherent biological and structural pro...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章,评审
doi:10.1007/s10439-014-1192-4
更新日期:2015-03-01 00:00:00
abstract::A role for mechanical stimulation in the control of cell fate has been proposed and mechanical conditioning of mesenchymal stem cells (MSCs) is of interest in directing MSC behavior for tissue engineering applications. This study investigates strain-induced differentiation and proliferation of MSCs, and investigates t...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-010-9979-4
更新日期:2010-05-01 00:00:00
abstract::Auscultation is an important diagnostic indicator for cardiovascular analysis. Heart sound classification and analysis play an important role in the auscultative diagnosis. This study uses a combination of Mel-frequency cepstral coefficient (MFCC) and hidden Markov model (HMM) to efficiently extract the features for p...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-006-9232-3
更新日期:2007-03-01 00:00:00
abstract::Dynamic occlusal loading during mastication is clinically relevant in the design and functional assessment of dental restorations and removable dentures, and in evaluating temporomandibular joint dysfunction. The aim of this study was to develop a modelling framework to evaluate subject-specific dynamic occlusal loadi...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-020-02688-6
更新日期:2021-01-06 00:00:00
abstract::Zebrafish is an emerging model system for cardiac conduction and regeneration. Zebrafish heart regenerates after 20% ventricular resection within 60 days. Whether cardiac conduction phenotype correlated with cardiomyocyte regeneration remained undefined. Longitudinal monitoring of the adult zebrafish heart (n = 12) wa...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-010-9993-6
更新日期:2010-07-01 00:00:00
abstract::The effects of training on a person's ability to perceive, interpret and utilize information presented via the tactile sense were examined by using a dual-channel electrocutaneous tracking approach. The electrocutaneous code studied was linear pulse rate encoding of information. The stimulus had a pulse width of 200 m...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/BF02367409
更新日期:1986-01-01 00:00:00
abstract::The applicability of a computer model, which relates the transmural mechanical distribution in the left ventricle (LV) to its global function at different loading conditions, was evaluated in patients with normal to near normal LV function undergoing cardiac catheterization. Left ventriculography and measurements of a...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/BF02364159
更新日期:1990-01-01 00:00:00
abstract::Early stage changes in hypertensive arteries have a significant effect on the long-term adaptation of the arteries. Compared to the long-term adaptation, little is known about the early dimensional and functional changes in hypertensive arteries in the first few days of hypertension. To study the early stage changes i...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1376391
更新日期:2001-06-01 00:00:00
abstract::A search for robust noninvasive methods permitting to discern the respiration subtle peculiarities in mammals is a topical issue. A novel approach called "sorption-enhanced infrared thermography" (SEIRT), helping to solve this problem, is described. Its benefits spring from the integration of the infrared thermography...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-018-2018-6
更新日期:2018-07-01 00:00:00
abstract::The nonlinear dynamic properties of action potential encoding were studied in mechanosensory neurons innervating the slits of a slit-sense organ in the tropical wandering spider, Cupiennius salei. The organ contains two types of neurons that are morphologically similar but have different dynamic properties. Type A neu...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1355278
更新日期:2001-03-01 00:00:00
abstract::Alzheimer's disease (AD) is an irreversible brain disorder which represents the most common form of dementia in western countries. An early and accurate diagnosis of AD would enable to develop new strategies for managing the disease; however, nowadays there is no single test that can accurately predict the development...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-010-0155-7
更新日期:2011-01-01 00:00:00
abstract::The relationship between laboratory and on-field performance of football helmets was assessed for 31 football helmet models selected from those worn by players in the 2015-2019 National Football League (NFL) seasons. Linear impactor tests were conducted with helmets placed on an instrumented Hybrid III head and neck a...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-020-02627-5
更新日期:2020-11-01 00:00:00