Abstract：
:Simulations are useful to study the heart's ability to generate flow and the interaction between contractility and loading conditions. The left ventricular pressure-volume (PV) relation has been shown to be nonlinear, but it is unknown whether a linear model is accurate enough for simulations. Six models were fitted to the PV-data measured in five sheep and the estimated parameters were used to simulate PV-loops. Simulated and measured PV-loops were compared with the Akaike information criterion (AIC) and the Hamming distance, a measure for geometric shape similarity. The compared models were: a time-varying elastance model with fixed volume intercept (LinFix); a time-varying elastance model with varying volume intercept (LinFree); a Langewouter's pressure-dependent elasticity model (Langew); a sigmoidal model (Sigm); a time-varying elastance model with a systolic flow-dependent resistance (Shroff) and a model with a linear systolic and an exponential diastolic relation (Burkh). Overall, the best model is LinFree (lowest AIC), closely followed by Langew. The remaining models rank: Sigm, Shroff, LinFix and Burkh. If only the shape of the PV-loops is important, all models perform nearly identically (Hamming distance between 20 and 23%). For realistic simulation of the instantaneous PV-relation a linear model suffices.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Lankhaar JW,Rövekamp FA,Steendijk P,Faes TJ,Westerhof BE,Kind T,Vonk-Noordegraaf A,Westerhof Ndoi
10.1007/s10439-009-9742-xsubject
Has Abstractpub_date
2009-09-01 00:00:00pages
1710-26issue
9eissn
0090-6964issn
1573-9686journal_volume
37pub_type
杂志文章abstract：:We describe a system for real-time control of biological and other experiments. This device, based around the Real-Time Linux operating system, was tested specifically in the context of dynamic clamping, a demanding real-time task in which a computational system mimics the effects of nonlinear membrane conductances in...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.1408929
更新日期：2001-10-01 00:00:00
abstract：:While considerable efforts have been expended to develop snore-driven markers for detecting obstructive sleep apnea (OSA), there is little emphasis on the relationship between the human upper airway (UA) dimensions and the attributes of snores. This paper aims to investigate the acoustical and perceptual impacts of ch...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-009-9745-7
更新日期：2009-09-01 00:00:00
abstract：:In this paper, an intelligent proportional-integral-derivative (PID) control method is introduced to the robotic testing system for the biomechanical study of human musculoskeletal joints. For the testing system, the robot is a highly nonlinear and heavily coupled complicated system, and the human spinal specimen also...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1023/b:abme.0000030759.80354.e8
更新日期：2004-06-01 00:00:00
abstract：:A comparison was made between turbulence calculated by subtracting an ensemble average from the instantaneous velocity and calculations made with a high pass digital filter. Velocity was measured with a laser Doppler anemometer in vitro in the region of a normal porcine aortic valve and in patients with a hot film ane...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02584215
更新日期：1983-01-01 00:00:00
abstract：:In order to obtain the first quantitative measurements of the in vivo stresses in early-stage amphibian embryos, we developed a novel instrument that uses a pair of parallel wires that are glued to the surface of an embryo normal to the direction in which the stress is to be determined. When a slit is made parallel to...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-006-9250-1
更新日期：2007-04-01 00:00:00
abstract：:Vibration under shear flow causes the reduction of flow resistance for shear-thinning fluids. The present study investigates the effect of vibration on the flow resistance of a nonaggregating red blood cell (RBC) suspension with a newly designed pressure-scanning capillary viscometer (PSCV). The PSCV was originally de...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.1603751
更新日期：2003-10-01 00:00:00
abstract：:Overexpressed receptors, characteristic of many cancers, have been targeted by various researchers to achieve a more specific treatment for cancer. A common approach is to use the natural ligand for the overexpressed receptor as a cancer-targeting agent which can deliver a chemically or genetically conjugated toxic mo...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1007/s10439-011-0280-y
更新日期：2011-04-01 00:00:00
abstract：:Rupture of abdominal aortic aneurysm (AAA) is associated with high mortality rates. Risk of rupture is multi-factorial involving AAA geometric configuration, vessel tortuosity, and the presence of intraluminal pathology. Fluid structure interaction (FSI) simulations were conducted in patient based computed tomography ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-014-1224-0
更新日期：2015-01-01 00:00:00
abstract：:Pathologic vascular adaptation following local injury is the primary driver for accelerated intimal hyperplasia and an occlusive phenotype. Smooth muscle cell (SMC) proliferation within the wall, and migration into the developing intima, is a major component of this remodeling response. The primary objective in the cu...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-016-1725-0
更新日期：2017-03-01 00:00:00
abstract：:Lung cancer is a leading cause of death worldwide. Radiation therapy (RT) is one method to treat this disease. A common side effect of RT for lung cancer is radiation-induced lung damage (RILD) which leads to loss of lung function. RILD often compounds pre-existing smoking-related regional lung function impairment. It...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-020-02697-5
更新日期：2020-11-30 00:00:00
abstract：:Magnetic (eddy-current) stimulation of the inspiratory motor nerves in the neck of the anesthetized dog was achieved. Using a 10-turn coil wound around the base of the neck and a train of pulses (25/s), inspiration was produced by tetanic contraction of the inspiratory muscles. The volume of air inspired increased wit...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02368176
更新日期：1993-05-01 00:00:00
abstract：:A kinematic analysis of the temporomandibular joint (TMJ) is developed to determine the range of motion of the mandible during normal opening and during special motions required for arthroscopic surgery. The translation of the mandible is restricted by the constraint of the ligaments. By accounting for the maximum all...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02368648
更新日期：1993-11-01 00:00:00
abstract：:This article presents a computer-aided detection system for capsule endoscopy (CE) images using contourlet-based color textural features to recognize tumors in the digestive tract. As tumor exhibits rich information in color texture, a novel color texture feature based on contourlet transform is proposed to describe c...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-011-0380-8
更新日期：2011-12-01 00:00:00
abstract：:Registration of bone structures is a common problem in medical research as well as in clinical applications. Intrasubject rigid 3D monomodality registration of segmented bone structures of CT images and multimodality registration of muMR and segmented muCT bone images were performed with the multiresolution intensity-...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-010-9981-x
更新日期：2010-07-01 00:00:00
abstract：:3D bioprinting technology is a promising approach for corneal stromal tissue regeneration. In this study, gelatin methacrylate (GelMA) mixed with corneal stromal cells was used as a bioink. The visible light-based stereolithography (SLA) 3D bioprinting method was utilized to print the anatomically similar dome-shaped ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-020-02537-6
更新日期：2020-07-01 00:00:00
abstract：:Cellular engineering applies the principles and methods of engineering to the problems of cell and molecular biology of both a basic and applied nature. As biomedical engineering has shifted from the organ and tissue level to the cellular and sub-cellular level, cellular engineering has emerged as a new area. A corner...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1007/BF02367396
更新日期：1991-01-01 00:00:00
abstract：:A progressive reduction in muscle fiber conduction velocity is typically observed during fatiguing muscle contraction. Although the exact causes of the conduction velocity decrease have not yet been fully established, increasing evidence suggests that changes in extracellular potassium concentration may be largely res...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-009-9756-4
更新日期：2009-10-01 00:00:00
abstract：:Current efforts to evaluate the performance of laparoscopic arterial fusion devices are limited to costly, time consuming, empirical studies. Thus, a finite element (FE) model, with the ability to predict device performance would improve device design and reduce development time and costs. This study introduces a mode...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-016-1588-4
更新日期：2016-11-01 00:00:00
abstract：:In previous shoulder impact studies, the 50th-percentile male GHBMC human body finite-element model was shown to have good biofidelity regarding impact force, but under-predicted shoulder deflection by 80% compared to those observed in the experiment. The goal of this study was to validate the response of the GHBMC M5...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-015-1546-6
更新日期：2016-08-01 00:00:00
abstract：:One of the major functions of the cardiovascular system is to deliver blood to the microcirculation where exchange of mass and energy can take place. In the present article, we will provide an overview of the state-of-the-art computational methods for modeling of red blood cell (RBC) rheology and dynamics in the micro...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-005-8776-y
更新日期：2005-12-01 00:00:00
abstract：:Adherence of a biological graft to the wound surface is the most important factor influencing the ultimate success of graft viability. A machine has been developed to test the adherence of biological graft materials to a substrate such as a wound surface. The peeling mode, which yields reproducible quantitative measur...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02368164
更新日期：1993-01-01 00:00:00
abstract：:We describe a model for the Compound Action Currents (CACs) and Compound Action Potentials (CAPs) produced by a peripheral nerve bundle in vitro. The Single Fiber Action Currents (SFACs) and the extracellular Single Fiber Action Potentials (SFAPs) are calculated using a generalized volume conduction model. Frequency-d...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02368460
更新日期：1991-01-01 00:00:00
abstract：:The multiphoton fluorescence recovery after photobleaching (MP-FRAP) technique has been developed to measure the three-dimensional (3D) solute diffusion within biological systems. However, current 3D MP-FRAP models are based on isotropic diffusion and spatial domain analysis. The 3D anisotropic diffusion and frequency...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-013-0939-7
更新日期：2014-03-01 00:00:00
abstract：:We hypothesize that variations of body anthropometry, conjointly with the bone strength, determine the risk of hip fracture. To test the hypothesis, we compared, in a simulated sideways fall, the hip impact energy to the energy needed to fracture the femur. Ten femurs from elderly donors were tested using a novel drop...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-020-02682-y
更新日期：2020-11-12 00:00:00
abstract：:Bending stiffness of passive-dynamic ankle-foot orthoses (PD-AFOs) is a functional characteristic thought to restore lost ankle function due to weakened plantar flexors. However, lower extremity impairment profiles of patients are seldom limited to plantar flexion weakness, and PD-AFO characteristics often influence g...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-014-1067-8
更新日期：2015-02-01 00:00:00
abstract：:Currently, autologous cartilage provides the gold standard for auricular reconstruction. However, synthetic biomaterials offer a number of advantages for ear reconstruction including decreased donor site morbidity and earlier surgery. Critical to implant success is the material's mechanical properties as this affects ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-016-1688-1
更新日期：2016-12-01 00:00:00
abstract：:The manner in which energy from an explosion is transmitted into the brain is currently a highly debated topic within the blast injury community. This study was conducted to investigate the injury biomechanics causing blast-related neurotrauma in the rat. Biomechanical responses of the rat head under shock wave loadin...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-011-0343-0
更新日期：2011-10-01 00:00:00
abstract：:There are a number of cell therapies that are either in clinical trials or moving toward clinical trials, particularly for diseases of the retina. One of the challenges with cell therapies is tracking the status of cells over time. Genetic manipulation can facilitate this, but it can limit the clinical application of ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-019-02393-z
更新日期：2020-07-01 00:00:00
abstract：:Further understanding of the mechanical deformation and tear behavior of kidney during suturing helps to enhance surgical task execution that requires fine suture manipulation. This paper aims to develop a model to describe the relationship between the tensile force acting on suture line and the resulted kidney deform...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-012-0722-1
更新日期：2013-04-01 00:00:00
abstract：:Coronary artery bypass graft (CABG) failure has been linked to graft hemodynamics, in particular wall shear stress. This study characterizes the morphology, geometry and wall shear stress patterns in human CABGs. The intimal thickness (IT) in 49 human saphenous vein CABGs was measured by digital light microscopy. The ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-005-1732-z
更新日期：2005-03-01 00:00:00
