Abstract：
:Neuromuscular impairment associated with cerebral palsy (CP) often leads to life-long walking deficits. Our goal was to evaluate the ability of a novel untethered wearable ankle exoskeleton to reduce the severity of gait pathology from CP. In this clinical feasibility study of five individuals with CP, we used instrumented gait analysis to quantify how powered plantar-flexor assistance affected gait mechanics following multi-visit acclimation. Compared to how each participant walked normally, walking with untethered exoskeleton assistance resulted in improved ankle plantar-flexion and knee extension; residual flexion deformity across the lower-extremity improved by a clinically significant 14.4° (p = 0.022). Powered plantar-flexor assistance increased average total positive ankle power by 44% (p = 0.037), and resulted in a 30% reduction in average negative biological ankle power (p = 0.004) and a 29% reduction in average positive hip power (p = 0.009). These findings suggest that powered ankle assistance augmented, rather than simply replaced, biological function to produce a more efficient gait pattern, which was corroborated by a 19% improvement in metabolic cost of transport (p = 0.011). This study provides evidence in support of the continued investigation of ankle assistance in mobility and rehabilitation interventions for this patient population.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Lerner ZF,Harvey TA,Lawson JLdoi
10.1007/s10439-019-02237-wsubject
Has Abstractpub_date
2019-06-01 00:00:00pages
1345-1356issue
6eissn
0090-6964issn
1573-9686pii
10.1007/s10439-019-02237-wjournal_volume
47pub_type
杂志文章abstract：:In an effort to share best practices in undergraduate engineering design education, we describe the origin, evolution and the current status of the undergraduate biomedical engineering design team program at Johns Hopkins University. Specifically, we describe the program and judge the quality of the pedagogy by relati...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-013-0781-y
更新日期：2013-09-01 00:00:00
abstract：:Optimal treatment of proximal humerus fractures remains controversial. Locking plates offer theoretical advantages but are associated with complications in the clinic. This study aimed to perform parametric design optimisation of proximal humerus plates to enhance their mechanical performance. A finite element (FE) mo...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-018-02160-6
更新日期：2019-02-01 00:00:00
abstract：:When cells and the matrix of a tissue remodel, the mechanical properties of the tissue do change. The mechanical properties are expressed by constitutive equations. In this article the remodeling of the constitutive equation of the pulmonary artery is studied. The remodeling was induced in a rat breathing a gas whose ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.1380417
更新日期：2001-01-01 00:00:00
abstract：:Cerebral blood flow (CBF) increases as arterial oxygen content falls with hypoxic (low PO2), anemic (low hemoglobin) and carbon monoxide (CO) (high carboxyhemoglobin) hypoxia. Despite a higher arterial PO2, CO hypoxia provokes a greater increase in CBF than hypoxic hypoxia. We analyzed published data using a compartme...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.50
更新日期：1998-01-01 00:00:00
abstract：:Accurate identification of contracting muscles can help us to understand the muscle function in both physiological and pathological conditions. Conventional electromyography (EMG) have limited access to deep muscles, crosstalk, or instability in the recordings. Accordingly, a novel framework was developed to detect co...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-020-02557-2
更新日期：2021-01-01 00:00:00
abstract：:Opportunities to provide clinical immersion experiences to bioengineering undergraduate students have expanded over the last several years. These programs allow students to observe the clinical environment in order to better understand workflow processes, the context in which medical equipment is used, and identify un...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-020-02508-x
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abstract：:During the fetal-to-neonatal transition, transvalvular pressures (TVPs) on the aortic and pulmonary valves change dramatically-but differently for each valve. We have examined changes in the molecular stability and crosslinking of collagen during this transition. Aortic and pulmonary valves were harvested from fetal a...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-010-0061-z
更新日期：2010-09-01 00:00:00
abstract：:Rapid technological advances have prompted the development of a wide range of telemonitoring systems to enable the prevention, early diagnosis and management, of chronic conditions. Remote monitoring can reduce the amount of recurring admissions to hospital, facilitate more efficient clinical visits with objective res...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1007/s10439-005-9068-2
更新日期：2006-04-01 00:00:00
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-009-9751-9
更新日期：2009-09-01 00:00:00
abstract：:We attempted to estimate in living adherent epithelial alveolar cells, the degree of structural and mechanical heterogeneity by considering two individualized cytoskeleton components, i.e., a submembranous "cortical" cytoskeleton and a "deep" cytoskeleton (CSK). F-actin structure characterizing each CSK component was ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.1616932
更新日期：2003-11-01 00:00:00
abstract：:Therapeutic irradiation is commonly used in the treatment of malignant brain tumors and has the potential to cause severe injury to normal tissues adjacent to a lesion. Computed tomography (CT) can be used not only to visualize tissue damage but to monitor the development of a lesion using advanced quantitative CT tec...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02410288
更新日期：1984-01-01 00:00:00
abstract：:The nonlinear diffusion-reaction equations describing the nonequilibrium transport of CO2 through flat layers of complex but homogeneous aqueous media were solved by an approximate analytical method called the "Combined Damköhler Number" (CDN) technique. Unlike other approximate analytical solutions, the CDN technique...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02484468
更新日期：1986-01-01 00:00:00
abstract：:This study presents a new steady-state visual evoked potential (SSVEP)-based brain computer interface (BCI). SSVEPs, induced by phase-tagged flashes in eight light emitting diodes (LEDs), were used to control four cursor movements (up, right, down, and left) and four button functions (on, off, right-, and left-clicks)...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-010-9964-y
更新日期：2010-07-01 00:00:00
abstract：:Typical inverse dynamics approaches to the calculation of muscle, ligament, and joint contact forces are based on a step-wise solution of the equations of motion. This approach is therefore limited in its ability to provide insight as to the muscular, ligamentous, and articular interactions that create joint stability...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-011-0303-8
更新日期：2011-07-01 00:00:00
abstract：:Radiation applied for therapy and diagnostics damages molecular/atomic couples of biotissues, bones being among them. As a result, electron peculiarities and mechanical behavior of the latter are altered. Correlation between strength of the irradiated bone and its electron features explored due to photo- and exoelectr...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1114/1.1424911
更新日期：2001-12-01 00:00:00
abstract：:This study is aimed at refining our understanding of the role of vortex formation at mitral mechanical heart valve (MHV) closure and its association with the high intensity transient signals (HITS) seen in echocardiographic studies with MHV recipients. Previously reported numerical results described a twofold process ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-007-9293-y
更新日期：2007-07-01 00:00:00
abstract：:The proliferation, migration, and adhesion of vascular smooth muscle cells (VSMCs) and their interactions with extracellular matrix are key features of atherosclerosis and restenosis. Recently, there has been evidence that magnetic fields exert multiple effects on the biological performance of cells and may aid in the...
journal_title：Annals of biomedical engineering
pub_type： 临床试验,杂志文章
doi：10.1007/s10439-012-0602-8
更新日期：2012-12-01 00:00:00
abstract：:The bioinspired, microscale tissue engineering approach has emerged in recent years as a promising alternative to preformed scaffolds. Using this approach, complex tissues and organs can be efficiently engineered from microscale modules to replicate the intricate architecture and physiology of vascularized organs and ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-018-02192-y
更新日期：2019-05-01 00:00:00
abstract：:Modern models of cardiac membranes are often highly complex and computationally expensive, particularly when used in long simulations of spatially extended models of cardiac tissue. Therefore, there is a need for simpler membrane models that preserve the features of the complex models deemed important. This communicat...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-005-3948-3
更新日期：2005-07-01 00:00:00
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-006-9097-5
更新日期：2006-06-01 00:00:00
abstract：:Articular cartilage is an avascular connective tissue responsible for bearing loads. Cell signaling plays a central role in cartilage homeostasis and tissue engineering by directing chondrocytes to synthesize/degrade the extracellular matrix or promote inflammatory responses. The aim of this paper was to investigate a...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
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更新日期：2018-02-01 00:00:00
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02584427
更新日期：1995-05-01 00:00:00
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journal_title：Annals of biomedical engineering
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doi：10.1007/s10439-018-2073-z
更新日期：2018-11-01 00:00:00
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-005-5536-y
更新日期：2005-09-01 00:00:00
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-005-1742-x
更新日期：2005-03-01 00:00:00
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.1630600
更新日期：2003-12-01 00:00:00
abstract：:Arterial restenosis following stent deployment may be influenced by the local flow environment within and around the stent. We have used computational fluid dynamics to investigate the flow field in the vicinity of model stents positioned within straight and curved vessels. Our simulations have revealed the presence o...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-005-2499-y
更新日期：2005-04-01 00:00:00
abstract：:Three-dimensional (3D) measurement of the spine can provide important information for functional, developmental, diagnostic, and treatment-effect evaluations. However, existing measurement techniques are either 2-dimensional, highly invasive, or involve a high radiation dose, prohibiting their widespread and repeated ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-016-1599-1
更新日期：2016-10-01 00:00:00
abstract：:Cellular engineering applies the principles and methods of engineering to the problems of cell and molecular biology of both a basic and applied nature. As biomedical engineering has shifted from the organ and tissue level to the cellular and sub-cellular level, cellular engineering has emerged as a new area. A corner...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1007/BF02367396
更新日期：1991-01-01 00:00:00
abstract：:Pathologic vascular adaptation following local injury is the primary driver for accelerated intimal hyperplasia and an occlusive phenotype. Smooth muscle cell (SMC) proliferation within the wall, and migration into the developing intima, is a major component of this remodeling response. The primary objective in the cu...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-016-1725-0
更新日期：2017-03-01 00:00:00
