Abstract:
:This study presents a new steady-state visual evoked potential (SSVEP)-based brain computer interface (BCI). SSVEPs, induced by phase-tagged flashes in eight light emitting diodes (LEDs), were used to control four cursor movements (up, right, down, and left) and four button functions (on, off, right-, and left-clicks) on a screen menu. EEG signals were measured by one EEG electrode placed at Oz position, referring to the international EEG 10-20 system. Since SSVEPs are time-locked and phase-locked to the onsets of SSVEP flashes, EEG signals were bandpass-filtered and segmented into epochs, and then averaged across a number of epochs to sharpen the recorded SSVEPs. Phase lags between the measured SSVEPs and a reference SSVEP were measured, and targets were recognized based on these phase lags. The current design used eight LEDs to flicker at 31.25 Hz with 45 degrees phase margin between any two adjacent SSVEP flickers. The SSVEP responses were filtered within 29.25-33.25 Hz and then averaged over 60 epochs. Owing to the utilization of high-frequency flickers, the induced SSVEPs were away from low-frequency noises, 60 Hz electricity noise, and eye movement artifacts. As a consequence, we achieved a simple architecture that did not require eye movement monitoring or other artifact detection and removal. The high-frequency design also achieved a flicker fusion effect for better visualization. Seven subjects were recruited in this study to sequentially input a command sequence, consisting of a sequence of eight cursor functions, repeated three times. The accuracy and information transfer rate (mean +/- SD) over the seven subjects were 93.14 +/- 5.73% and 28.29 +/- 12.19 bits/min, respectively. The proposed system can provide a reliable channel for severely disabled patients to communicate with external environments.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Lee PL,Sie JJ,Liu YJ,Wu CH,Lee MH,Shu CH,Li PH,Sun CW,Shyu KKdoi
10.1007/s10439-010-9964-ysubject
Has Abstractpub_date
2010-07-01 00:00:00pages
2383-97issue
7eissn
0090-6964issn
1573-9686journal_volume
38pub_type
杂志文章abstract::While bone mineral density has been traditionally used to quantify fracture risk for individuals with spinal cord injuries, recent studies are including engineering measurements such as section modulus and cross sectional moment of inertia. These are almost exclusively calculated by peripheral QCT scanners which, unli...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-017-1796-6
更新日期:2017-05-01 00:00:00
abstract::Gas transfer through hollow fiber membranes (HFMs) can be increased via fiber oscillation. Prior work, however, does not directly translate to present-day, full-scale artificial lungs. This in vitro study characterized the effects of HFM oscillations on oxygenation and hemolysis for a pediatric-sized HFM bundle. Effec...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-018-1995-9
更新日期:2018-05-01 00:00:00
abstract::For an optimal guidance of the rehabilitation therapy of stroke patients in an in-home setting, objective, and patient-specific performance assessment of arm movements is needed. In this study, metrics of hand movement relative to the pelvis and the sternum were estimated in 13 stroke subjects using a full body ambula...
journal_title:Annals of biomedical engineering
pub_type: 临床试验,杂志文章
doi:10.1007/s10439-014-1198-y
更新日期:2015-02-01 00:00:00
abstract::Microfluidic devices aim at miniaturizing, automating, and lowering the cost of chemical and biological sample manipulation and detection, hence creating new opportunities for lab-on-a-chip platforms. Recently, optofluidic devices have also emerged where optics is used to enhance the functionality and the performance ...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章,评审
doi:10.1007/s10439-011-0385-3
更新日期:2012-02-01 00:00:00
abstract::Cerebral blood flow (CBF) increases as arterial oxygen content falls with hypoxic (low PO2), anemic (low hemoglobin) and carbon monoxide (CO) (high carboxyhemoglobin) hypoxia. Despite a higher arterial PO2, CO hypoxia provokes a greater increase in CBF than hypoxic hypoxia. We analyzed published data using a compartme...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.50
更新日期:1998-01-01 00:00:00
abstract::The emerging field of micro-technology has opened up new possibilities for exploring cellular chemotaxis in real space and time, and at single cell resolution. Chemotactic cells sense and move in response to chemical gradients and play important roles in a number of physiological and pathological processes, including ...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章,评审
doi:10.1007/s10439-011-0489-9
更新日期:2012-06-01 00:00:00
abstract::A recent analytical solution of the three-dimensional Stokes flow through a bumpy tube predicts that for a given bump area, there exists an optimal circumferential wavenumber which minimizes flow resistance. This study uses measurements of microvessel endothelial cell morphology to test whether this prediction holds i...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-008-9467-2
更新日期:2008-04-01 00:00:00
abstract::A model predictive control strategy to simultaneously regulate hemodynamic and anesthetic variables in critical care patients is presented. A nonlinear canine circulatory model, which has been used to study the effect of inotropic and vasoactive drugs on hemodynamic variables, has been extended to include propofol pha...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.255
更新日期:2000-01-01 00:00:00
abstract::A novel electrocardiogram (ECG) electrode film is developed by mixing carbon black powder and a quaternary salt with a visco-elastic polymeric adhesive. Unlike traditional wet gel-based electrodes, carbon/salt/adhesive (CSA) electrodes should theoretically have an infinite shelf life as they do not dehydrate even afte...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-015-1282-y
更新日期:2015-10-01 00:00:00
abstract::Arteries are composed of multiple constituents that endow the wall with proper structure and function. Many vascular diseases are associated with prominent mechanical and biological alterations in the wall constituents. In this study, planar biaxial tensile test data of elastase-treated porcine aortic tissue (Chow et ...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-012-0733-y
更新日期:2013-07-01 00:00:00
abstract::We compare the influence of time-frequency methods on analysis of time-varying renal autoregulation properties. Particularly, we examine if detection probabilities are similar for amplitude and frequency modulation for a modulated simulation signal among five time-frequency approaches, and if time-varying changes in s...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-012-0625-1
更新日期:2013-01-01 00:00:00
abstract::Additive manufacturing, also known as 3D printing, has emerged over the past 3 decades as a disruptive technology for rapid prototyping and manufacturing. Vat polymerization, powder bed fusion, material extrusion, and binder jetting are distinct technologies of additive manufacturing, which have been used in a wide va...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章,评审
doi:10.1007/s10439-016-1678-3
更新日期:2017-01-01 00:00:00
abstract::The combination of gene therapy and chemotherapy has showed increased therapeutic efficacy in the treatment of cancers, but it is not well investigated about the actual coordination pattern between therapeutic gene and chemical drug. In this work, p53/BPEI-β-CD/AD-dox complex was fabricated and employed to investigate...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-016-1627-1
更新日期:2016-11-01 00:00:00
abstract::The epidermal growth factor (EGF) is a growth factor with effects on many cell types and tissue. Morphometric and passive biomechanical properties were studied in isolated segments of the esophagus in 22 EGF-treated rats and 12 control rats. The rats were divided into groups with EGF treatment for 2, 4, 7, and 14 days...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1575758
更新日期:2003-06-01 00:00:00
abstract::Poor vascular homeostasis drives many clinical disorders including diabetes, arthritis, atherosclerosis, and peripheral artery disease. Local tissue ischemia resultant of insufficient blood flow is a potent stimulus for recruitment of endothelial progenitor cells (EPCs). This mobilization and homing is a multi-step pr...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章,评审
doi:10.1007/s10439-015-1400-x
更新日期:2015-10-01 00:00:00
abstract::Analysis and classification of esophageal motility records were investigated using signal processing and fuzzy-set pattern recognition techniques. A set of parameters has been extracted from the raw records and has previously been used as characterizing features. Improvements to these procedures were obtained by extra...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/BF02368227
更新日期:1994-01-01 00:00:00
abstract::This paper discusses the dynamics of the circus movement around a one-dimensional continuous and uniform loop of model cardiac cells. The membrane ionic currents are represented by a modified Beeler-Reuter formulation. The description of the quasiperiodic regimes initiated in a previous paper is completed and their eq...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1289458
更新日期:2000-07-01 00:00:00
abstract::Elastin is an essential component of arteries which provides structural integrity and instructs smooth muscle cells to adopt a quiescent state. Despite interaction of endothelial cells with elastin in the internal elastic lamina, the potential for exploiting this interaction therapeutically has not been explored in de...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-010-0142-z
更新日期:2011-01-01 00:00:00
abstract::Phospholipids have been identified by thin-layer chromatography in appreciable quantities in pericardial fluid taken from 12 dogs and found to include sphingomyelin and phosphatidylcholines, -ethanolamines, -inositols and -serines--the cholines predominating. The extracts, the synthetic surfactants and a mixture of sy...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/BF02584258
更新日期:1985-01-01 00:00:00
abstract::Correct development of neuronal tracts requires the coordination of multiple permissive and inhibitory signals. By generating an in vitro microenvironment using soft lithography and microfluidic techniques, multiple guidance cues can be presented in a spatially defined way. Here we evaluated how neurites of dorsal roo...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-008-9486-z
更新日期:2008-06-01 00:00:00
abstract::Blood flow simulations are making their way into the clinic, and much attention is given to estimation of fractional flow reserve in coronary arteries. Intracardiac blood flow simulations also show promising results, and here the flow field is expected to depend on the pulmonary venous (PV) flow rates. In the absence ...
journal_title:Annals of biomedical engineering
pub_type: 临床试验,杂志文章
doi:10.1007/s10439-018-02153-5
更新日期:2019-02-01 00:00:00
abstract::This work presents a novel methodology for building a three-dimensional patient-specific eyeball model suitable for performing a fully automatic finite element (FE) analysis of the corneal biomechanics. The reconstruction algorithm fits and smooths the patient's corneal surfaces obtained in clinic with corneal topogra...
journal_title:Annals of biomedical engineering
pub_type: 临床试验,杂志文章
doi:10.1007/s10439-015-1426-0
更新日期:2016-05-01 00:00:00
abstract::The false vocal folds are believed to be components of the acoustic filter that is responsible for shaping the voice. However, the effects of false vocal folds on the vocal fold vibration and the glottal aerodynamic during phonation remain unclear. This effect has implications for computational modeling of phonation a...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-008-9630-9
更新日期:2009-03-01 00:00:00
abstract::The function of a chamber depends on its hydrodynamic properties: isometric pressures it can exert in the operating range of distensions, compliances in the operating range of distensions, and wall-displacement resistances in the operating range of distensions. Wall-displacement resistance is the departure of pressure...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/BF02368017
更新日期:1988-01-01 00:00:00
abstract::3D bioprinting technology is a promising approach for corneal stromal tissue regeneration. In this study, gelatin methacrylate (GelMA) mixed with corneal stromal cells was used as a bioink. The visible light-based stereolithography (SLA) 3D bioprinting method was utilized to print the anatomically similar dome-shaped ...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-020-02537-6
更新日期:2020-07-01 00:00:00
abstract::Gap junctions play a fundamental role in intercellular communication in cardiac tissue. Various types of heart disease including hypertrophy and ischemia are associated with alterations of the spatial arrangement of gap junctions. Previous studies applied two-dimensional optical and electron-microscopy to visualize ga...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-011-0369-3
更新日期:2011-11-01 00:00:00
abstract::Polycrystalline silicon (poly-Si) micromechanical structures can be made by selectively etching an underlying sacrificial oxide layer. Advantages of this micromachining technique are its simplicity and compatibility with conventional integrated-circuit processing. Compressive internal stress in poly-Si films constrain...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/BF02584269
更新日期:1986-01-01 00:00:00
abstract::Most non-invasive blood pressure measurements are based on either the auscultatory or the oscillometric technique. In this study, we performed an extensive analysis of the signals, i.e., responses of a microphone implanted in the cuff and pressure changes in the cuff, which can be recorded during such measurements. We...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-009-9853-4
更新日期:2010-03-01 00:00:00
abstract::In this paper, a new method for quantification of rigidity in elbow joint of Parkinsonian patients is introduced. One of the most known syndromes in Parkinson's disease (PD) is increased passive stiffness in muscles, which leads to rigidity in joints. Clinical evaluation of stiffness in wrist and/or elbow, commonly us...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-007-9379-6
更新日期:2007-12-01 00:00:00
abstract::A major drawback in the operation of mechanical heart valve prostheses is thrombus formation in the near valve region. Detailed flow analysis in this region during the valve closure phase is of interest in understanding the relationship between shear stress and platelet activation. A fixed-grid Cartesian mesh flow sol...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-006-9194-5
更新日期:2006-10-01 00:00:00