Abstract：
:Phospholipids have been identified by thin-layer chromatography in appreciable quantities in pericardial fluid taken from 12 dogs and found to include sphingomyelin and phosphatidylcholines, -ethanolamines, -inositols and -serines--the cholines predominating. The extracts, the synthetic surfactants and a mixture of synthetics simulating the extracts were all found to be good lubricants when tested by a standard method. The phosphatidylcholines were capable of reducing friction between two otherwise hydrophilic surfaces by as much as 100- to 200-fold when deposited as an oriented monolayer. A goniometer was used to measure an average contact angle of 33 degrees for a drop of saline placed upon the internal wall of the pericardium, indicating an appreciably hydrophobic surface anticipated if surfactant were directly adsorbed. The results are consistent with the classical theory of "boundary" lubrication (17) as modified (21) to reflect the almost ideal molecular structure of the identified surfactants for adsorption, film cohesion and interaction of fatty-acid chains during sliding. This model is proposed as an alternative to hydrodynamic lubrication in the pericardium and one compatible with several practical aspects such as pericardial rub and the maintenance of normal heart action after pericardectomy.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Hills BA,Butler BDdoi
10.1007/BF02584258subject
Has Abstractpub_date
1985-01-01 00:00:00pages
573-86issue
6eissn
0090-6964issn
1573-9686journal_volume
13pub_type
杂志文章abstract：:Microfluidic devices fabricated using poly(dimethylsiloxane) (PDMS) polymer are routinely used for in vitro cell culture for a wide range of cellular assays. These assays typically involve the incubation of cultured cells with a drug molecule or a fluorescent marker while monitoring a cellular response. The accuracy o...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-012-0562-z
更新日期：2012-09-01 00:00:00
abstract：:Deformational loading represents a primary component of the chondrocyte physical environment in vivo. This review summarizes our experience with physiologic deformational loading of chondrocyte-seeded agarose hydrogels to promote development of cartilage constructs having mechanical properties matching that of the par...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1023/b:abme.0000007789.99565.42
更新日期：2004-01-01 00:00:00
abstract：:A model predictive control strategy to simultaneously regulate hemodynamic and anesthetic variables in critical care patients is presented. A nonlinear canine circulatory model, which has been used to study the effect of inotropic and vasoactive drugs on hemodynamic variables, has been extended to include propofol pha...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.255
更新日期：2000-01-01 00:00:00
abstract：:In an effort to share best practices in undergraduate engineering design education, we describe the origin, evolution and the current status of the undergraduate biomedical engineering design team program at Johns Hopkins University. Specifically, we describe the program and judge the quality of the pedagogy by relati...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-013-0781-y
更新日期：2013-09-01 00:00:00
abstract：:The strength between the cortical screw and bone following an orthopaedic implant surgery is an important determinant for the success of osteosynthesis. An excessive axial cutting force during drilling produces microcracks in the bone surface, resulting in reduced strength between the screw and bone, resulting in loos...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-020-02565-2
更新日期：2021-01-01 00:00:00
abstract：:Knowledge of strain-rate sensitivity of soft tissue viscoelastic and nonlinear elastic properties is important for accurate predictions of biomechanical behavior and for quantitative assessment of the effects of disease or surgical/pharmaceutical intervention. Soft tissues are known to exhibit mild rate sensitivity, b...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1023/b:abme.0000012742.01261.b0
更新日期：2004-02-01 00:00:00
abstract：:This paper reviews the applications of accelerometers on the detection of physiological acoustic signals such as heart sounds, respiratory sounds, and gastrointestinal sounds. These acoustic signals contain a rich reservoir of vital physiological and pathological information. Accelerometer-based systems enable continu...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1007/s10439-014-1111-8
更新日期：2014-11-01 00:00:00
abstract：:This paper presents two related methods for registering an image of an anatomical object with data from sensors arranged on the object. One method is described with reference to a test case involving a rectangular electrode plaque disposed on a heart surface, which is imaged with MRI. Data from the electrodes is fused...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-007-9350-6
更新日期：2007-10-01 00:00:00
abstract：:Quantifying injury tolerance for concussion is complicated by variability in the type, severity, and time course of post-injury physiological and behavioral changes. The current study outlined acute and chronic changes in behavioral metrics following rotational acceleration-induced concussion in rats. The Medical Coll...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-016-1647-x
更新日期：2016-11-01 00:00:00
abstract：:A comparison was made between turbulence calculated by subtracting an ensemble average from the instantaneous velocity and calculations made with a high pass digital filter. Velocity was measured with a laser Doppler anemometer in vitro in the region of a normal porcine aortic valve and in patients with a hot film ane...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02584215
更新日期：1983-01-01 00:00:00
abstract：:One of the major functions of the cardiovascular system is to deliver blood to the microcirculation where exchange of mass and energy can take place. In the present article, we will provide an overview of the state-of-the-art computational methods for modeling of red blood cell (RBC) rheology and dynamics in the micro...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-005-8776-y
更新日期：2005-12-01 00:00:00
abstract：:We propose a new method for guiding catheter ablation procedures to abolish sites of origin of arrhythmias. This method models both cardiac electrical activity and current pulses delivered from the tip of the ablation catheter with a single equivalent moving dipole (SEMD). The SEMD parameters are obtained from analysi...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.1567281
更新日期：2003-05-01 00:00:00
abstract：:Currently, there are no clinically available tools or applications which could predict osteoarthritis development. Some computational models have been presented to simulate cartilage degeneration, but they are not clinically feasible due to time required to build subject-specific knee models. Therefore, the objective ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-018-02184-y
更新日期：2019-03-01 00:00:00
abstract：:We attempted to estimate in living adherent epithelial alveolar cells, the degree of structural and mechanical heterogeneity by considering two individualized cytoskeleton components, i.e., a submembranous "cortical" cytoskeleton and a "deep" cytoskeleton (CSK). F-actin structure characterizing each CSK component was ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.1616932
更新日期：2003-11-01 00:00:00
abstract：:In vitro and in vivo studies were conducted on omega-3 fatty acid-derived biomaterials to determine their utility as an implantable material for adhesion prevention following soft tissue hernia repair and as a means to allow for the local delivery of antimicrobial or antibiofilm agents. Naturally derived biomaterials ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-015-1489-y
更新日期：2016-03-01 00:00:00
abstract：:The material properties of normal cadaveric human cartilage in the ankle mortice (tibiotalar articulation) were evaluated to determine a possible etiologic mechanism of cartilage injury of the ankle when an obvious traumatic episode is not present. Using an automated indentation apparatus and the biphasic creep indent...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02584467
更新日期：1995-09-01 00:00:00
abstract：:Continuous measurement of arterial blood density after bolus injection of fluids of different density into the right atrium has been used to measure cardiac output and mean transit time through the central circulation. The transit time distribution for density, however, differs from that for plasma-phase tracers such ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02368628
更新日期：1993-07-01 00:00:00
abstract：:The measurement of CO2 volume exhaled per breath (VCO2.br) can be determined during anesthesia by the multiplication and integration of tidal flow (V) and PCO2. During side-stream capnometry, PCO2 must be advanced in time by transport delay (TD), the time to suction gas through the sampling tube. During ventilation, T...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02738547
更新日期：1997-01-01 00:00:00
abstract：:Double-exposure holographic interferometry is a contactless whole-field method. Dimensional changes are visualized as a series of interference fringes overlaid on the holographic image of the femur, where each fringe represents 0.316 micron (half the wavelength of the laser light) of motion. Interferograms for intact ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02364168
更新日期：1987-01-01 00:00:00
abstract：:Static and dynamic components of the stretch reflex were studied in elbow flexors of 13 hemiparetic brain-injured individuals. Constant-velocity joint rotations were applied to the elbow, and the resulting stretch reflex torque and electromyographic responses were recorded in the biceps brachii and brachioradialis mus...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.1359496
更新日期：2001-04-01 00:00:00
abstract：:Femoral neck fractures are a relevant clinical and social problem. The aim of this study was to improve the prediction of patients at-risk of femoral neck fracture with respect to the current densitometric-based methods. In particular, finite element models were used to assess the prediction accuracy obtained by combi...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.1495866
更新日期：2002-06-01 00:00:00
abstract：:In this study, we have developed an integrated microfluidic platform for actively patterning mammalian cells, where poly(ethylene glycol) (PEG) hydrogels play two important roles as a non-fouling layer and a dielectric structure. The developed system has an embedded array of PEG microwells fabricated on a planar indiu...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-010-0108-1
更新日期：2010-12-01 00:00:00
abstract：:Past literature has provided evidence that a normal mechanical force environment of blood flow may guide normal development while an abnormal environment can lead to congenital malformations, thus warranting further studies on embryonic cardiovascular flow dynamics. In the current study, we developed a non-invasive 4D...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-017-1882-9
更新日期：2017-10-01 00:00:00
abstract：:Potential human and environmental hazards resulting from the exposure of living organisms to silver nanoparticles (Ag NPs) have been the subject of intensive discussion in the last decade. Despite the growing use of Ag NPs in biomedical applications, a quantification of the toxic effects as a function of the total sil...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-020-02449-5
更新日期：2020-04-01 00:00:00
abstract：:Mechanical properties of the cardiac tissue play an important role in normal heart function. The goal of this study was to determine the passive mechanical properties of all heart chambers through a paired comparison study in an ovine model. Ovine heart was used due its physiological and anatomical similarities to hum...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-016-1658-7
更新日期：2016-11-01 00:00:00
abstract：:We have developed a method for quantifying the complexity of activation patterns observed during ventricular fibrillation (VF) that is based on our previously reported methodology for decomposing epicardial mapping data into a set of isolated wavefronts. One-half second datasets are acquired from a 21 x 24 array of un...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02684160
更新日期：1997-09-01 00:00:00
abstract：:A progressive reduction in muscle fiber conduction velocity is typically observed during fatiguing muscle contraction. Although the exact causes of the conduction velocity decrease have not yet been fully established, increasing evidence suggests that changes in extracellular potassium concentration may be largely res...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-009-9756-4
更新日期：2009-10-01 00:00:00
abstract：:A vaccine that induces broadly neutralizing antibodies (bnAbs) against the human immunodeficiency virus (HIV) would be instrumental in controlling the disease. The membrane proximal external region (MPER) peptide is an appealing antigen candidate since it is conserved and is the target of several human bnAbs, such as ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-019-02398-8
更新日期：2020-07-01 00:00:00
abstract：:Conventional nanoporous hydrogels often lead to slow cartilage deposition by MSCs in 3D due to physical constraints and requirement for degradation. Our group has recently reported macroporous gelatin microribbon (μRB) hydrogels, which substantially accelerate MSC-based cartilage formation in vitro compared to convent...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-020-02522-z
更新日期：2020-07-01 00:00:00
abstract：:We present a method for the localized statistical discrimination of class populations based on the Karhunen-Loève and Fukunaga-Koontz transforms. These transforms provide features that model the variance of a sample distribution. The spatial series of a 196 channel epicardial electrogram recording from an arrythmogeni...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02367084
更新日期：1994-09-01 00:00:00
