Efficient dielectrophoretic patterning of embryonic stem cells in energy landscapes defined by hydrogel geometries.

abstract：:In order to obtain the first quantitative measurements of the in vivo stresses in early-stage amphibian embryos, we developed a novel instrument that uses a pair of parallel wires that are glued to the surface of an embryo normal to the direction in which the stress is to be determined. When a slit is made parallel to...

journal_title：Annals of biomedical engineering

authors： Benko R,Brodland GW

更新日期：2007-04-01 00:00:00

abstract：:Auscultation is an important diagnostic indicator for cardiovascular analysis. Heart sound classification and analysis play an important role in the auscultative diagnosis. This study uses a combination of Mel-frequency cepstral coefficient (MFCC) and hidden Markov model (HMM) to efficiently extract the features for p...

journal_title：Annals of biomedical engineering

authors： Wang P,Lim CS,Chauhan S,Foo JY,Anantharaman V

更新日期：2007-03-01 00:00:00

abstract：:Continuum-level finite element models (FEMs) of the humerus offer the ability to evaluate joint replacement designs preclinically; however, experimental validation of these models is critical to ensure accuracy. The objective of the current study was to quantify experimental full-field strain magnitudes within osteoar...

journal_title：Annals of biomedical engineering

authors： Kusins J,Knowles N,Columbus M,Oliviero S,Dall'Ara E,Athwal GS,Ferreira LM

更新日期：2020-12-01 00:00:00

abstract：:This study was aimed at developing a physical model, supported by experimental observations, to describe the formation and growth of microbubbles seen in patients with mitral mechanical heart valves (MHV). This phenomenon, often referred to as high intensity transient signals (HITS), appears as bright, intense, high-v...

journal_title：Annals of biomedical engineering

authors： Rambod E,Beizaie M,Shusser M,Milo S,Gharib M

更新日期：1999-11-01 00:00:00

abstract：:A two-dimensional sheet model was used to study the dynamics of reentry around a zone of functional block. The sheet is a set of parallel, continuous, and uniform cables, transversely interconnected by a brick-wall arrangement of fixed resistors. In accord with experimental observations on cardiac tissue, longitudinal...

journal_title：Annals of biomedical engineering

authors： Leon LJ,Roberge FA,Vinet A

更新日期：1994-11-01 00:00:00

abstract：:Platelet thrombosis under arterial conditions remains a large clinical problem. Previous in vitro experiments have concentrated on early adherence without thrombotic occlusion. We have developed a controllable hemodynamic system that creates intravascular thrombosis to occlusion. Lightly heparinized (3.5 USP units/mL)...

journal_title：Annals of biomedical engineering

authors： Para A,Bark D,Lin A,Ku D

更新日期：2011-07-01 00:00:00

abstract：:Registration of bone structures is a common problem in medical research as well as in clinical applications. Intrasubject rigid 3D monomodality registration of segmented bone structures of CT images and multimodality registration of muMR and segmented muCT bone images were performed with the multiresolution intensity-...

journal_title：Annals of biomedical engineering

authors： Museyko O,Eisa F,Hess A,Schett G,Kalender WA,Engelke K

更新日期：2010-07-01 00:00:00

abstract：:Blunt carotid artery injuries occur in 0.3% of blunt injured patients and may lead to devastating neurological consequences. However, arterial mechanics leading to internal layer subfailure have not been quantified. Twenty-two human carotid artery segments and 18 porcine thoracic aorta segments were opened to expose t...

journal_title：Annals of biomedical engineering

authors： Stemper BD,Yoganandan N,Sinson GP,Gennarelli TA,Stineman MR,Pintar FA

更新日期：2007-02-01 00:00:00

abstract：:Intracellular calcium concentration and transmembrane potentials are two important measurements used to study the mechanisms of cardiac activity. Fluorescent dyes have been used to measure these separately but not simultaneously in cardiac tissue. Fluo-3 and Fluo-4 (a recently improved version of Fluo-3) have been use...

journal_title：Annals of biomedical engineering

authors： Johnson PL,Smith W,Baynham TC,Knisley SB

更新日期：1999-07-01 00:00:00

abstract：:Bending stiffness of passive-dynamic ankle-foot orthoses (PD-AFOs) is a functional characteristic thought to restore lost ankle function due to weakened plantar flexors. However, lower extremity impairment profiles of patients are seldom limited to plantar flexion weakness, and PD-AFO characteristics often influence g...

journal_title：Annals of biomedical engineering

authors： Arch ES,Stanhope SJ

更新日期：2015-02-01 00:00:00

abstract：:Peripheral nerve injuries present challenges to regeneration. Currently, the gold standard for nerve repair is an autograft that results in another region of the body suffering nerve damage. Previously, bioactive borate glass (BBG) has been studied in clinical trials to treat patients with non-healing wounds, and we h...

journal_title：Annals of biomedical engineering

authors： Gupta B,Papke JB,Mohammadkhah A,Day DE,Harkins AB

更新日期：2016-12-01 00:00:00

abstract：:Linear autoregressive (AR) model-based heart rate (HR) spectral analysis has been widely used to study HR dynamics. Owing to system and measurement noise, the parameters of an AR model have intrinsic statistical uncertainty. In this study, we evaluate how this AR parameter uncertainty can translate to uncertainty in H...

journal_title：Annals of biomedical engineering

authors： Christini DJ,Kulkarni A,Rao S,Stutman ER,Bennett FM,Hausdorff JM,Oriol N,Lutchen KR

更新日期：1995-03-01 00:00:00

abstract：:Spike discharge patterns showing intrinsic oscillations (IOs) have been reported in units in the dorsal cochlear nucleus (DCN) of the decerebrate cat. These oscillations are related to the regularity of a unit's discharge rate and may be important for pitch perception. A DCN unit's regularity can be affected by severa...

journal_title：Annals of biomedical engineering

authors： Gdowski GT,Voigt HF

更新日期：1998-05-01 00:00:00

abstract：:Dexterity of robots is highly required when it comes to integration for medical applications. Major efforts have been conducted to increase the dexterity at the distal parts of medical robots. This paper reports on developments toward integrating biocompatible conducting polymers (CP) into inherently dexterous concent...

journal_title：Annals of biomedical engineering

authors： Chikhaoui MT,Benouhiba A,Rougeot P,Rabenorosoa K,Ouisse M,Andreff N

更新日期：2018-10-01 00:00:00

abstract：:This study is aimed at refining our understanding of the role of vortex formation at mitral mechanical heart valve (MHV) closure and its association with the high intensity transient signals (HITS) seen in echocardiographic studies with MHV recipients. Previously reported numerical results described a twofold process ...

journal_title：Annals of biomedical engineering

authors： Rambod E,Beizai M,Sahn DJ,Gharib M

更新日期：2007-07-01 00:00:00

abstract：:Measurement of cell shortening is an important technique for assessment of physiology and pathophysiology of cardiac myocytes. Many types of heart disease are associated with decreased myocyte shortening, which is commonly caused by structural and functional remodeling. Here, we present a new approach for local measur...

journal_title：Annals of biomedical engineering

authors： Lichter J,Li H,Sachse FB

更新日期：2016-10-01 00:00:00

abstract：:Organ models are used for planning and simulation of operations, developing new surgical instruments, and training purposes. There is a substantial demand for in vitro organ phantoms, especially in urological surgery. Animal models and existing simulator systems poorly mimic the detailed morphology and the physical pr...

journal_title：Annals of biomedical engineering

authors： Adams F,Qiu T,Mark A,Fritz B,Kramer L,Schlager D,Wetterauer U,Miernik A,Fischer P

更新日期：2017-04-01 00:00:00

abstract：:Analysis and classification of esophageal motility records were investigated using signal processing and fuzzy-set pattern recognition techniques. A set of parameters has been extracted from the raw records and has previously been used as characterizing features. Improvements to these procedures were obtained by extra...

journal_title：Annals of biomedical engineering

authors： Abou-Chadi FE,Ezzat FA,Sif el-Din AA

更新日期：1994-01-01 00:00:00

abstract：:Computational modeling and simulation has become more common in design and development of bioprosthetic heart valves. To have a reliable computational model, considering accurate mechanical properties of biological soft tissue is one of the most important steps. The goal of this study was to present a non-invasive mat...

journal_title：Annals of biomedical engineering

authors： Abbasi M,Barakat MS,Dvir D,Azadani AN

更新日期：2019-01-01 00:00:00

abstract：:We develop a mathematical model of nanoparticles depositing onto and penetrating into a biofilm grown in a parallel-plate flow cell. We carry out deposition experiments in a flow cell to support the modeling. The modeling and the experiments are motivated by the potential use of polymer nanoparticles as part of a trea...

journal_title：Annals of biomedical engineering

authors： Miller JK,Neubig R,Clemons CB,Kreider KL,Wilber JP,Young GW,Ditto AJ,Yun YH,Milsted A,Badawy HT,Panzner MJ,Youngs WJ,Cannon CL

更新日期：2013-01-01 00:00:00

abstract：:In previous shoulder impact studies, the 50th-percentile male GHBMC human body finite-element model was shown to have good biofidelity regarding impact force, but under-predicted shoulder deflection by 80% compared to those observed in the experiment. The goal of this study was to validate the response of the GHBMC M5...

journal_title：Annals of biomedical engineering

authors： Park G,Kim T,Panzer MB,Crandall JR

更新日期：2016-08-01 00:00:00

abstract：:The advantages of photoacoustic (PA) imaging, including low cost, non-ionizing operation, and sub-mm spatial resolution at centimeters depth, make it a promising modality to probe nanoparticle-targeted abnormalities in real time at cellular and molecular levels. However, detecting rare cell types in a heterogeneous ba...

journal_title：Annals of biomedical engineering

authors： O'Donnell M,Wei CW,Xia J,Pelivanov I,Jia C,Huang SW,Hu X,Gao X

更新日期：2013-11-01 00:00:00

abstract：:In this study various blood rheological assumptions are numerically investigated for the hemodynamic properties of intra-stent flow. Non-newtonian blood properties have never been implemented in blood coronary stented flow investigation, although its effects appear essential for a correct estimation and distribution o...

journal_title：Annals of biomedical engineering

authors： Benard N,Perrault R,Coisne D

更新日期：2006-08-01 00:00:00

abstract：:Understanding the complex spatiotemporal dynamics of action potential propagation in the heart during arrhythmia is exceedingly difficult. This study applies nonlinear dynamics tools to simplify this task. Using the results of a simulation of an electrical induction of reentry in a sheet of myocardium represented as a...

journal_title：Annals of biomedical engineering

authors： Larson C,Dragnev L,Trayanova N

更新日期：2003-07-01 00:00:00

abstract：:Elastin is an essential component of arteries which provides structural integrity and instructs smooth muscle cells to adopt a quiescent state. Despite interaction of endothelial cells with elastin in the internal elastic lamina, the potential for exploiting this interaction therapeutically has not been explored in de...

journal_title：Annals of biomedical engineering

authors： Wilson BD,Gibson CC,Sorensen LK,Guilhermier MY,Clinger M,Kelley LL,Shiu YT,Li DY

更新日期：2011-01-01 00:00:00

abstract：:Gap junctions play a fundamental role in intercellular communication in cardiac tissue. Various types of heart disease including hypertrophy and ischemia are associated with alterations of the spatial arrangement of gap junctions. Previous studies applied two-dimensional optical and electron-microscopy to visualize ga...

journal_title：Annals of biomedical engineering

authors： Lackey DP,Carruth ED,Lasher RA,Boenisch J,Sachse FB,Hitchcock RW

更新日期：2011-11-01 00:00:00

abstract：:Typical inverse dynamics approaches to the calculation of muscle, ligament, and joint contact forces are based on a step-wise solution of the equations of motion. This approach is therefore limited in its ability to provide insight as to the muscular, ligamentous, and articular interactions that create joint stability...

journal_title：Annals of biomedical engineering

authors： Cleather DJ,Bull AM

更新日期：2011-07-01 00:00:00

abstract：:We propose a mathematical model for analyses of the elastic properties of the wall of the outer hair cell (OHC) in the inner ear. The model reflects the properties of the major components of the OHC wall: the subsurface cisternae, the cortical lattice, the plasma membrane, and the radial pillars. The wall is treated a...

journal_title：Annals of biomedical engineering

authors： Spector AA,Brownell WE,Popel AS

更新日期：1998-01-01 00:00:00

abstract：:Maintenance of movement accuracy relies on motor learning, by which prior errors guide future behavior. One aspect of this learning process involves the accurate generation of predictions of movement outcome. These predictions can, for example, drive anticipatory movements during a predictive-saccade task. Predictive ...

journal_title：Annals of biomedical engineering

authors： Wong AL,Shelhamer M

更新日期：2013-08-01 00:00:00

abstract：:Cochlear implantation consists in electrically stimulating the auditory nerve by inserting an electrode array inside the cochlea, a bony structure of the inner ear. In the absence of any visual feedback, the insertion results in many cases of damages of the internal structures. This paper presents a feasibility study ...

journal_title：Annals of biomedical engineering

authors： Lavenir L,Zemiti N,Akkari M,Subsol G,Venail F,Poignet P

更新日期：2020-10-30 00:00:00