Abstract:
:One of the major functions of the cardiovascular system is to deliver blood to the microcirculation where exchange of mass and energy can take place. In the present article, we will provide an overview of the state-of-the-art computational methods for modeling of red blood cell (RBC) rheology and dynamics in the microcirculation. While significant progress has been made in simulation of single-file motion of deformable RBCs in capillaries and of diluted sheared suspensions of RBCs in infinite domains, detailed understanding of the mechanics of blood flow in intermediate diameter microvessels (8-1,000 microm) has presented formidable challenges. The difficulties are largely due to modeling the motion of multiple, interacting, highly deformable particles. The current computational tools consist mainly of three-dimensional (3D) boundary-integral methods for single RBC dynamics and deformation; and for rheology of large systems of droplets at large volume fractions using periodic boundary conditions and novel adaptive computational meshes. Further advances will result from combination of these tools to produce new algorithms capable of describing the motion and deformation of large systems of RBCs in microvessels at physiologically relevant volume fractions.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Cristini V,Kassab GSdoi
10.1007/s10439-005-8776-ysubject
Has Abstractpub_date
2005-12-01 00:00:00pages
1724-7issue
12eissn
0090-6964issn
1573-9686journal_volume
33pub_type
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