Abstract:
:Parameters of physiological models are commonly associated in an input-output experiment with a specific pattern of the system response. This association is often made on an intuitive basis by traditional sensitivity analysis, i.e., by inspecting the variations of model output trajectories with respect to parameter variations. However, this approach provides limited information since, for instance, it ignores correlation among parameters. The aim of this study is to propose a new set of sensitivity functions, called the generalized sensitivity functions (GSF), for the analysis of input-output identification experiments. GSF are based on information theoretical criteria and provide, as compared to traditional sensitivity analysis, a more accurate picture on the information content of measured outputs on individual model parameters at different times. Case studies are presented on an input-output model and on two structural circulatory and respiratory models. GSF allow the definition of relevant time intervals for the identification of specific parameters and improve the understanding of the role played by specific model parameters in describing experimental data.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Thomaseth K,Cobelli Cdoi
10.1114/1.207subject
Has Abstractpub_date
1999-09-01 00:00:00pages
607-16issue
5eissn
0090-6964issn
1573-9686journal_volume
27pub_type
杂志文章abstract::Wall Shear Stress (WSS) topological skeleton, composed by fixed points and the manifolds linking them, reflects the presence of blood flow features associated to adverse vascular response. However, the influence of WSS topological skeleton on vascular pathophysiology is still underexplored. This study aimed to identif...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-020-02607-9
更新日期:2020-12-01 00:00:00
abstract::Concussion tolerance and head impact exposure are highly variable among football players. Recent findings highlight that head impact data analyses need to be performed at the subject level. In this paper, we describe a method of characterizing concussion risk between individuals using a new survival analysis technique...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
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abstract::Blunt carotid artery injuries occur in 0.3% of blunt injured patients and may lead to devastating neurological consequences. However, arterial mechanics leading to internal layer subfailure have not been quantified. Twenty-two human carotid artery segments and 18 porcine thoracic aorta segments were opened to expose t...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-006-9229-y
更新日期:2007-02-01 00:00:00
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journal_title:Annals of biomedical engineering
pub_type: 杂志文章
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更新日期:2011-07-01 00:00:00
abstract::Computational modeling and simulation has become more common in design and development of bioprosthetic heart valves. To have a reliable computational model, considering accurate mechanical properties of biological soft tissue is one of the most important steps. The goal of this study was to present a non-invasive mat...
journal_title:Annals of biomedical engineering
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doi:10.1007/s10439-018-02129-5
更新日期:2019-01-01 00:00:00
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journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-010-0185-1
更新日期:2011-02-01 00:00:00
abstract::This discussion and review article focuses on the possible use of regenerative techniques applied to the interfaces between skin and medical implants. As is widely known, the area of contact between an implant and the skin--the skin-implant interface--is prone to recurrent and persistent problems originated from the l...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章,评审
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更新日期:2010-06-01 00:00:00
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journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-017-1914-5
更新日期:2017-12-01 00:00:00
abstract::The length-tension (L-T) relationships in rabbit detrusor smooth muscle (DSM) are similar to those in vascular and airway smooth muscles and exhibit short-term length adaptation characterized by L-T curves that shift along the length axis as a function of activation and strain history. In contrast to skeletal muscle, ...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-012-0590-8
更新日期:2012-10-01 00:00:00
abstract::Congenital heart disease is the leading cause of infant death in the United States with over 36,000 newborns affected each year. Despite this growing problem there are few mechanical circulatory support devices designed specifically for pediatric and neonate patients. Previous research has been done investigating pedi...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-015-1370-z
更新日期:2016-04-01 00:00:00
abstract::It is well known that neutrophils take much longer to traverse the pulmonary capillary bed than erythrocytes, and this is likely due to differences in the structure and rheology of the cells. In this study, we simulate the transit of a neutrophil in a capillary using a Newtonian drop model and a viscoelastic drop mode...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
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更新日期:2007-05-01 00:00:00
abstract::Polymeric heart valves have the potential to reduce thrombogenic complications associated with current mechanical valves and overcome fatigue-related problems experienced by bioprosthetic valves. In this paper we characterize the in vitro velocity and Reynolds Shear Stress (RSS) fields inside and downstream of three d...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-006-9117-5
更新日期:2006-06-01 00:00:00
abstract:BACKGROUND:We present a fundamental theoretical framework for analysis of energy dissipation in any component of the circulatory system and formulate the full energy budget for both venous and arterial circulations. New indices allowing disease-specific subject-to-subject comparisons and disease-to-disease hemodynamic ...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-009-9650-0
更新日期:2009-04-01 00:00:00
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journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-008-9437-8
更新日期:2008-04-01 00:00:00
abstract::Additive manufacturing, also known as 3D printing, has emerged over the past 3 decades as a disruptive technology for rapid prototyping and manufacturing. Vat polymerization, powder bed fusion, material extrusion, and binder jetting are distinct technologies of additive manufacturing, which have been used in a wide va...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章,评审
doi:10.1007/s10439-016-1678-3
更新日期:2017-01-01 00:00:00
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journal_title:Annals of biomedical engineering
pub_type: 杂志文章,评审
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更新日期:2006-04-01 00:00:00
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journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/BF02738547
更新日期:1997-01-01 00:00:00
abstract::This paper describes the development and use of a direct compression stimulator for culturing explants from the meniscus of the knee and articular cartilage. Following design and fabrication of the instrument along with its data acquisition system, the function of the machine was verified by both mechanical means and ...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-006-9157-x
更新日期:2006-09-01 00:00:00
abstract::This paper reports the design, manufacturing, and characterization of a new bioreactor dedicated to the development of tissue-engineered heart valve substitutes. First, a comprehensive review of the state of the art in bioreactors is presented and a rigorous classification is put forward. The existing bioreactors foun...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-009-9646-9
更新日期:2009-04-01 00:00:00
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journal_title:Annals of biomedical engineering
pub_type: 杂志文章
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更新日期:1992-01-01 00:00:00
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journal_title:Annals of biomedical engineering
pub_type: 杂志文章
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journal_title:Annals of biomedical engineering
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journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-007-9370-2
更新日期:2007-11-01 00:00:00
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journal_title:Annals of biomedical engineering
pub_type: 杂志文章,评审
doi:10.1007/s10439-012-0567-7
更新日期:2012-07-01 00:00:00
abstract::Recent studies suggest that vortex ring formation during left ventricular (LV) rapid filling is an optimized mechanism for blood transport, and that the volume of the vortex ring is an important measure. However, due to lack of quantitative methods, the volume of the vortex ring has not previously been studied. Lagran...
journal_title:Annals of biomedical engineering
pub_type: 临床试验,杂志文章
doi:10.1007/s10439-012-0615-3
更新日期:2012-12-01 00:00:00
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journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-010-0028-0
更新日期:2010-06-01 00:00:00
abstract::Continuum-level finite element models (FEMs) of the humerus offer the ability to evaluate joint replacement designs preclinically; however, experimental validation of these models is critical to ensure accuracy. The objective of the current study was to quantify experimental full-field strain magnitudes within osteoar...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-020-02549-2
更新日期:2020-12-01 00:00:00
abstract::Registration of bone structures is a common problem in medical research as well as in clinical applications. Intrasubject rigid 3D monomodality registration of segmented bone structures of CT images and multimodality registration of muMR and segmented muCT bone images were performed with the multiresolution intensity-...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-010-9981-x
更新日期:2010-07-01 00:00:00
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journal_title:Annals of biomedical engineering
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更新日期:2013-07-01 00:00:00
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journal_title:Annals of biomedical engineering
pub_type: 杂志文章
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更新日期:2017-03-01 00:00:00