Abstract：
:The toxic or therapeutic effect of an inhaled aerosol is highly dependent upon the site and extent of deposition in the lung. A novel MRI-based method was used to quantify the spatial distribution of particles in the rat lung. Rats were exposed to 0.95 μm-diameter iron oxide particles in a controlled manner (N = 6) or to particle-free air (N = 6). Lungs were fixed in 3% glutaraldehyde by vascular perfusion, excised and imaged in a 3T scanner using a gradient-echo imaging protocol. The signal decay rate, R2*, was measured in each voxel of the entire left lung (1 mm thick slices). R2* was significantly higher in exposed animals (0.0065 ± 0.0006 ms(-1)) than in controls (0.0050 ± 0.0003 ms(-1), p < 0.001). A calibration curve between R2* and concentration of deposited particles (C(part)) was obtained by imaging gel samples with known particle concentrations. Regional deposition was assessed by comparing C(part) between the outer (C(part,peripheral)) and inner (C(part,central)) areas on each transaxial slice, and expressed as the c/p ratio. C(part,peripheral) (1.54 ± 0.70 μg/mL) was significantly higher than C(part,central) (1.00 ± 0.39 μg/mL, p<0.05), resulting in a c/p ratio of 0.65. This method may be used in future studies to quantify spatial distribution of deposited particles in healthy and diseased lungs.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Oakes JM,Scadeng M,Breen EC,Prisk GK,Darquenne Cdoi
10.1007/s10439-013-0745-2subject
Has Abstractpub_date
2013-05-01 00:00:00pages
967-78issue
5eissn
0090-6964issn
1573-9686journal_volume
41pub_type
杂志文章abstract：:High density particle image velocimetry, with spatial resolution of O(1 mm), was used to measure the effect of occluder rebound on the flow field near a Bjork-Shiley Monostrut tilting-disk mitral valve. The ability to measure two velocity components over an entire plane simultaneously provides a very different insight...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.281
更新日期：2000-04-01 00:00:00
abstract：:Although diagnostic testing with auditory evoked potentials (EPs) has become routine, quantitative measurements of signal and noise are still lacking. In this study, current signal, power, noise power, and signal-to-noise ratio (SNR) estimation formulas are reviewed and applied to auditory brainstem response averaging...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02684183
更新日期：1996-11-01 00:00:00
abstract：:Poor prosthetic fit is often the result of heterotopic ossification (HO), a frequent problem following blast injuries for returning service members. Osseointegration technology offers an advantage for individuals with significant HO and poor socket tolerance by using direct skeletal attachment of a prosthesis to the d...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-010-0050-2
更新日期：2010-09-01 00:00:00
abstract：:Presented is a discussion of steps towards the creation of a database of the microcirculation encompassing anatomical and functional experimental data, and conceptual and computational models. The discussion includes issues of database utility, organization, data deposition, and linkage to other databases. The databas...
journal_title：Annals of biomedical engineering
pub_type：
doi：10.1114/1.112
更新日期：1998-11-01 00:00:00
abstract：:Three animal models were evaluated in this study involving head impacts of the rat, including the Marmarou drop-weight and two momentum-exchange techniques. In series 1, 36 Wistar rats were hit on the side of the free-moving head using Marmarou's 450 g impact mass at 4.4, 5.4, and 6.3 m/s. Head acceleration was measur...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-005-2513-4
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journal_title：Annals of biomedical engineering
pub_type： 临床试验,杂志文章
doi：10.1007/BF02770997
更新日期：1996-01-01 00:00:00
abstract：:A number of human head finite element (FE) models have been developed from different research groups over the years to study the mechanisms of traumatic brain injury. These models can vary substantially in model features and parameters, making it important to evaluate whether simulation results from one model are read...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-013-0907-2
更新日期：2014-01-01 00:00:00
abstract：:The ability to predict endothelial cell migration rates may aid in the design of biomaterials that endothelialize following implantation. However, the complexity of the signaling response to migration-promoting stimuli such as sphingosine 1-phosphate (S1P) makes such predictions quite challenging. A number of signalin...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-010-0014-6
更新日期：2010-08-01 00:00:00
abstract：:Optimal treatment of proximal humerus fractures remains controversial. Locking plates offer theoretical advantages but are associated with complications in the clinic. This study aimed to perform parametric design optimisation of proximal humerus plates to enhance their mechanical performance. A finite element (FE) mo...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-018-02160-6
更新日期：2019-02-01 00:00:00
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02584479
更新日期：1995-11-01 00:00:00
abstract：:We propose a mathematical model for analyses of the elastic properties of the wall of the outer hair cell (OHC) in the inner ear. The model reflects the properties of the major components of the OHC wall: the subsurface cisternae, the cortical lattice, the plasma membrane, and the radial pillars. The wall is treated a...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.87
更新日期：1998-01-01 00:00:00
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-015-1312-9
更新日期：2015-07-01 00:00:00
abstract：:In the field of fluid flow within the human body, focus has been placed on the transportation of blood in the systemic circulation since the discovery of that system; but, other fluids and fluid flow phenomena pervade the body. Some of the most fascinating fluid flow phenomena within the human body involve fluids othe...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-010-9902-z
更新日期：2010-03-01 00:00:00
abstract：:The unique resource constraints, urgency, and virulence of the coronavirus disease 2019 pandemic has sparked immense innovation in the development of barrier devices to protect healthcare providers from infectious airborne particles generated by patients during airway management interventions. Of the existing devices,...
journal_title：Annals of biomedical engineering
pub_type： 社论
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更新日期：2020-10-01 00:00:00
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-016-1781-5
更新日期：2017-05-01 00:00:00
abstract：:Tumor vasculature damage induced by various thermal treatments has been studied in vivo via laser confocal microscopy. Murine mammary carcinoma 4T1 was implanted in the nude mice dorsal skin fold window chamber. The implanted tumor was treated by alternate cooling and heating. Results showed that the treatment was muc...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-008-9511-2
更新日期：2008-08-01 00:00:00
abstract：:Recent evidence suggests that energy substrate metabolism forms the link between gene expression and contractile function of the heart. This hypothesis draws on three seemingly unconnected observations, made in 1941 by three different investigators. The first gave rise to the concept of the dynamic nature of body cons...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1114/1.1312187
更新日期：2000-08-01 00:00:00
abstract：:Interstitial fluid flow, critical for macromolecular transport, was recently shown to drive fibroblast differentiation and perpendicular cell and matrix alignment in 3D collagen cultures. Here we explore the mechanisms underlying this flow-induced cell and collagen alignment. Cell and matrix alignment was assessed fro...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-005-9067-3
更新日期：2006-03-01 00:00:00
abstract：:A numerical single path model of respiratory gas exchange with distributed alveolar gas sources was used to estimate the anatomical changes in small peripheral airways such as occur in chronic obstructive pulmonary diseases (COPD). A previous sensitivity analysis of the single path model showed that decreasing total a...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02368236
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
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abstract：:Validation is a critical step in finite element model (FEM) development. This study focuses on the validation of the Global Human Body Models Consortium full body average male occupant FEM in five localized loading regimes-a chest impact, a shoulder impact, a thoracoabdominal impact, an abdominal impact, and a pelvic ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-015-1286-7
更新日期：2015-09-01 00:00:00
abstract：:Twenty-one 3.5-month-old female Sprague-Dawley rats were randomly assigned to three groups: BTX group, in which each rat received a single intramuscular injection of 2 U of Clostridium botulinum toxin (BTX) in the quadriceps femoris muscle of the right hind limb; BTX + SR group, in which each rat received a BTX inject...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
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更新日期：2012-03-01 00:00:00
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1007/BF02363568
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02390377
更新日期：1994-03-01 00:00:00
abstract：:Left ventricular (LV) diastolic filling is limited by the constraining effects exerted by the pericardium (PE) and the lung/chest wall. The aim of the present study was to assess the validity of various estimates of external cardiac constraint, compared to pericardial surface pressure (Ppe) measured lateral to the LV ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02584288
更新日期：1987-01-01 00:00:00
abstract：:In vitro stent-induced thromboembolism was altered by the presence of residual stenoses placed upstream or placed upstream and downstream of the stent. Heparinized (3 micro/ml) bovine blood was gravity fed through a conduit with a deployed coronary stent. Embolism was continuously monitored using a light-scattering mi...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
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更新日期：2000-02-01 00:00:00
abstract：:This paper reports the design, manufacturing, and characterization of a new bioreactor dedicated to the development of tissue-engineered heart valve substitutes. First, a comprehensive review of the state of the art in bioreactors is presented and a rigorous classification is put forward. The existing bioreactors foun...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-009-9646-9
更新日期：2009-04-01 00:00:00
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-012-0700-7
更新日期：2013-03-01 00:00:00
abstract：:Potential human and environmental hazards resulting from the exposure of living organisms to silver nanoparticles (Ag NPs) have been the subject of intensive discussion in the last decade. Despite the growing use of Ag NPs in biomedical applications, a quantification of the toxic effects as a function of the total sil...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-020-02449-5
更新日期：2020-04-01 00:00:00
