Abstract：
:This project was undertaken to establish if the integral circulation had any effects upon the mechanical behavior of bone. The influence of blood flow in the rabbit tibia on the strain induced at the bone surface when under load was assessed. Recordings were taken from three adult and three immature New Zealand White rabbits which had previously had both their tibiae pinned with modified orthopedic pins. Strain readings were obtained from the exposed mid-shaft of the tibia of both hind legs before, during and after blood flow changes. The loading was static and used to maintain a strain of 250 mu strain in adult animals and 180 mu strain in immature animals prior to variation in blood flow. The blood flow was altered by means of a tourniquet inflated to 80 mm Hg and placed medial to the pinned tibia; it was inflated for a specific time (approximately 40 minutes) during the experimental loading. Reducing the blood flow appeared to alter the strain recorded at the bone surface while the applied load across the pins remained constant. An initial effect when there was reduced perfusion was that the strain increased following a reduction in blood flow. The strain then began to decrease in magnitude on the compressive aspect coincident with release of the cuff to a level below the value of the initial normally perfused bone. Upon return of the blood supply to normal levels following the initial hyperaemic phase, the strain value increased to a value comparable with that of normally perfused bone.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
McDonald F,Pitt Ford TRdoi
10.1007/BF02390377subject
Has Abstractpub_date
1994-03-01 00:00:00pages
194-201issue
2eissn
0090-6964issn
1573-9686journal_volume
22pub_type
杂志文章abstract：:We describe the development of experimental platforms to quantify the regeneration of injured central nervous system (CNS) neurons by combining engineering technologies and primary neuronal cultures. Although the regeneration of CNS neurons is an important area of research, there are no currently available methods to ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1007/s10439-012-0515-6
更新日期：2012-06-01 00:00:00
abstract：:The objectives were as follows: (1) estimating mean value of the overall hemoglobin glycation rate constant (k); (2) analyzing inter-individual variability of k; (3) verifying ability of the hemoglobin A1c (HbA1c) formation model to predict changes of HbA1c during red blood cells cultivation in vitro and to reproduce ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-011-0366-6
更新日期：2011-11-01 00:00:00
abstract：:Microencapsulation of recombinant cells is a novel promising approach to tumor therapy in which therapeutic protein is sustainable and long-term delivered by microencapsulated cells. The semi-permeable membrane of microcapsule can protect cell from host's immune rejection, increase the chemical stability of therapeuti...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-007-9255-4
更新日期：2007-04-01 00:00:00
abstract：:High-frequency ventilation (HFV) has not one but several histories. Proceeding along largely independent pathways are techniques using frequencies of 1-5 Hz and techniques using 10-40 Hz, the former being introduced by Sjostrand in 1971, the latter by Lunkenheimer in 1972. It was nearly ten years before it was recogni...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02407779
更新日期：1984-01-01 00:00:00
abstract：:Optimal treatment of proximal humerus fractures remains controversial. Locking plates offer theoretical advantages but are associated with complications in the clinic. This study aimed to perform parametric design optimisation of proximal humerus plates to enhance their mechanical performance. A finite element (FE) mo...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-018-02160-6
更新日期：2019-02-01 00:00:00
abstract：:Changes in fetal magnetocardiographic (fMCG) signals are indicators for fetal body movement. We propose a novel approach to reliably extract fetal body movements based on the field strength of the fMCG signal independent of its frequency. After attenuating the maternal MCG, we use a Hilbert transform approach to ident...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-010-0231-z
更新日期：2011-03-01 00:00:00
abstract：:This study presents a generic numerical model to simulate the coupled solute and solvent transport in tissue sections during addition and removal of chemical additives or cryoprotective agents (CPA; dimethylsulfoxide or DMSO). Osmotic responses of various tissue cells within the artificial tissue are predicted by the ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-005-1511-x
更新日期：2005-05-01 00:00:00
abstract：:The continuing lack of longitudinal histopathological and biomechanical data for human arteries in health and disease highlights the importance of studying the many genetic, pharmacological, and surgical models that are available in mice. As a result, there has been a significant increase in the number of reports on t...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-014-0988-6
更新日期：2014-06-01 00:00:00
abstract：:It would often be desirable to obtain the respiratory rate during everyday conditions without obtaining an additional respiratory trace. This study investigates the agreement between respiratory rate assessed from the electrocardiogram (ECG) and the reference respiratory rate derived from a nasal/oral airflow (AF). Na...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-008-9580-2
更新日期：2008-12-01 00:00:00
abstract：:An MR image-based computational model of a murine KHT sarcoma is presented that allows the calculation of plasma fluid and solute transport within tissue. Such image-based models of solid tumors may be used to optimize patient-specific therapies. This model incorporates heterogeneous vasculature and tissue porosity to...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-011-0349-7
更新日期：2011-09-01 00:00:00
abstract：:In this paper, we present the application of a semi-global inverse method for determining material parameters of biological tissues. The approach is based on the successive response surface method, and is illustrated by fitting constitutive parameters to two nonlinear anisotropic constitutive equations, one for aortic...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-005-8338-3
更新日期：2005-12-01 00:00:00
abstract：:For an optimal guidance of the rehabilitation therapy of stroke patients in an in-home setting, objective, and patient-specific performance assessment of arm movements is needed. In this study, metrics of hand movement relative to the pelvis and the sternum were estimated in 13 stroke subjects using a full body ambula...
journal_title：Annals of biomedical engineering
pub_type： 临床试验,杂志文章
doi：10.1007/s10439-014-1198-y
更新日期：2015-02-01 00:00:00
abstract：:Magnetic (eddy-current) stimulation of the inspiratory motor nerves in the neck of the anesthetized dog was achieved. Using a 10-turn coil wound around the base of the neck and a train of pulses (25/s), inspiration was produced by tetanic contraction of the inspiratory muscles. The volume of air inspired increased wit...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02368176
更新日期：1993-05-01 00:00:00
abstract：:The objective of this study was to develop a unique device for applying well-characterized cyclic, strain to cells growing on implant alloys. The device is based on the four-point bending principle and utilizes an electric motor, belt, and cam system to cyclically deflect a commercially pure titanium plate with cell c...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.1529195
更新日期：2002-11-01 00:00:00
abstract：:Pressure ulcer risk assessment might be optimized by incorporating the soft tissue reaction to mechanical loading in the currently used risk assessment scales. Cytokines, like IL-1alpha, IL-1RA, IL-8, and TNF-alpha, might be used to determine this tissue reaction, since they are released after 24 h of mechanical loadi...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-009-9652-y
更新日期：2009-05-01 00:00:00
abstract：:The bending stiffness of a phospholipid bilayer (Kc) was measured by forming thin bilayer cylinders (tethers) from giant phospholipid vesicles. Based on the balance of forces, the tether force was expected to be proportional to the square root of the membrane tension, with a constant of proportionality containing Kc. ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02684228
更新日期：1996-09-01 00:00:00
abstract：:Biodegradable implants have demonstrated clinical success in simple applications (e.g., absorbable sutures) and have shown great potential in many other areas of interventional medicine, such as localized drug delivery, engineered tissue scaffolding, and structural implants. For endovascular stenting and musculoskelet...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-015-1477-2
更新日期：2016-02-01 00:00:00
abstract：:We have studied the interaction of high frequency jet ventilation with cardiovascular pressures and flows. Results in dogs show that the amplitude of all intrathoracic pressures and flows fluctuate with a frequency equal to the difference between the heart rate and ventilator rate. The magnitude of this amplitude vari...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02584287
更新日期：1987-01-01 00:00:00
abstract：:Baseball players swung very light and very heavy bats through our instrument and the speed of the bat was recorded. These data were used to make mathematical models for each person. Then these models were coupled with equations of physics for bat-ball collisions to compute the Ideal Bat Weight for each individual. How...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02584443
更新日期：1995-07-01 00:00:00
abstract：:The development of prevention strategies is critical to address the rising prevalence of sport-related concussions. Visual and sensory performance may influence an individual's ability to interpret environmental cues, anticipate opponents' actions, and create appropriate motor responses limiting the severity of an imp...
journal_title：Annals of biomedical engineering
pub_type： 临床试验,杂志文章
doi：10.1007/s10439-013-0881-8
更新日期：2014-01-01 00:00:00
abstract：:A major drawback in the operation of mechanical heart valve prostheses is thrombus formation in the near valve region. Detailed flow analysis in this region during the valve closure phase is of interest in understanding the relationship between shear stress and platelet activation. A fixed-grid Cartesian mesh flow sol...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-006-9194-5
更新日期：2006-10-01 00:00:00
abstract：:Measurement of cell shortening is an important technique for assessment of physiology and pathophysiology of cardiac myocytes. Many types of heart disease are associated with decreased myocyte shortening, which is commonly caused by structural and functional remodeling. Here, we present a new approach for local measur...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-016-1593-7
更新日期：2016-10-01 00:00:00
abstract：:A two-dimensional sheet model was used to study the dynamics of reentry around a zone of functional block. The sheet is a set of parallel, continuous, and uniform cables, transversely interconnected by a brick-wall arrangement of fixed resistors. In accord with experimental observations on cardiac tissue, longitudinal...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02368286
更新日期：1994-11-01 00:00:00
abstract：:A novel in vitro culture system of organotypic human skin explants interfacing with external fixator pins is presented. The system was used to observe changes in skin morphology on the skin at the pin interface. To evaluate the performance of this novel system, histological analysis of human skin explants cultured for...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-008-9614-9
更新日期：2009-02-01 00:00:00
abstract：:It is well known that neutrophils take much longer to traverse the pulmonary capillary bed than erythrocytes, and this is likely due to differences in the structure and rheology of the cells. In this study, we simulate the transit of a neutrophil in a capillary using a Newtonian drop model and a viscoelastic drop mode...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-007-9286-x
更新日期：2007-05-01 00:00:00
abstract：:The function of a chamber depends on its hydrodynamic properties: isometric pressures it can exert in the operating range of distensions, compliances in the operating range of distensions, and wall-displacement resistances in the operating range of distensions. Wall-displacement resistance is the departure of pressure...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02368017
更新日期：1988-01-01 00:00:00
abstract：:We present a method for the localized statistical discrimination of class populations based on the Karhunen-Loève and Fukunaga-Koontz transforms. These transforms provide features that model the variance of a sample distribution. The spatial series of a 196 channel epicardial electrogram recording from an arrythmogeni...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02367084
更新日期：1994-09-01 00:00:00
abstract：:The appropriateness of integrated information systems to the description of integrated biological systems is discussed. An integrated information system in the physiology of the regulation of respiration is argued to be a structural mathematical model of the system and the relational data base, which it can compute. I...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02363292
更新日期：1983-01-01 00:00:00
abstract：:Effects of hyperthermia on transport of low-density lipoprotein (LDL) through a stenosed arterial wall are analyzed comprehensively in the present work. The realistic and pertinent aspects of an arterial wall is represented by a multi-layer model, with a proper representation of the thickened intima region due to the ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-014-1196-0
更新日期：2015-07-01 00:00:00
abstract：:Linear autoregressive (AR) model-based heart rate (HR) spectral analysis has been widely used to study HR dynamics. Owing to system and measurement noise, the parameters of an AR model have intrinsic statistical uncertainty. In this study, we evaluate how this AR parameter uncertainty can translate to uncertainty in H...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02368320
更新日期：1995-03-01 00:00:00
