Tumor anti-angiogenic gene therapy with microencapsulated recombinant CHO cells.

abstract：:The objective of this study was to develop a ferrocene mediated glucose biosensor for reverse iontophoresis. An amperometric ferrocene mediated glucose biosensor based on a three electrodes planar configuration was constructed using screen printing technique. Different combinations of glucose oxidase and ferrocene loa...

journal_title：Annals of biomedical engineering

authors： Ching CT,Sun TP,Huang SH,Shieh HL,Chen CY

更新日期：2010-04-01 00:00:00

abstract：:The appropriateness of integrated information systems to the description of integrated biological systems is discussed. An integrated information system in the physiology of the regulation of respiration is argued to be a structural mathematical model of the system and the relational data base, which it can compute. I...

journal_title：Annals of biomedical engineering

authors： Yamamoto WS

更新日期：1983-01-01 00:00:00

abstract：:Measurement of the instantaneous pressure-volume relationship of the left ventricle is fundamental to the study of ventricular mechanics. In order to effectively investigate this relationship, it is necessary to vary and control the time course of ventricular volume change in a variety of prescribed manners. In the pa...

journal_title：Annals of biomedical engineering

authors： Sunagawa K,Lim KO,Burkhoff D,Sagawa K

更新日期：1982-01-01 00:00:00

abstract：:A lumped parameter compartmental model for the nonsteady flow of the cerebrovascular fluid is constructed. The model assumes constant resistances that relate fluid flux to pressure gradients, and compliances between compartments that relate fluid accumulation to rate of pressure changes. Resistances are evaluated by u...

journal_title：Annals of biomedical engineering

authors： Sorek S,Bear J,Karni Z

更新日期：1989-01-01 00:00:00

abstract：:Correct development of neuronal tracts requires the coordination of multiple permissive and inhibitory signals. By generating an in vitro microenvironment using soft lithography and microfluidic techniques, multiple guidance cues can be presented in a spatially defined way. Here we evaluated how neurites of dorsal roo...

journal_title：Annals of biomedical engineering

authors： Li GN,Liu J,Hoffman-Kim D

更新日期：2008-06-01 00:00:00

abstract：:This study was undertaken to investigate the possible origin of some cutaneously recorded higher frequency electrogastrographic signals. Computer modeling of gastric electrical uncoupling was performed using previously described conoidal dipole model. Cutaneous electrogastrograms were simulated after uncoupling was in...

journal_title：Annals of biomedical engineering

authors： Mintchev MP,Bowes KL

更新日期：1997-11-01 00:00:00

abstract：:Conventional histologic methods provide valuable information regarding the physical nature of damage in fatigue-loaded tendons, limited to thin, two-dimensional sections. We introduce an imaging method that characterizes tendon microstructure three-dimensionally and develop quantitative, spatial measures of damage for...

journal_title：Annals of biomedical engineering

authors： Fung DT,Sereysky JB,Basta-Pljakic J,Laudier DM,Huq R,Jepsen KJ,Schaffler MB,Flatow EL

更新日期：2010-05-01 00:00:00

abstract：:In this paper, we aim to establish a new mathematical model that relates pulse wave velocity (PWV) to blood pressure (BP) for continuous and noninvasive BP measurement. For the first time, we derive an ordinary differential equation (ODE) expressing the fundamental relation between BP, elastic modulus G and PWV. The g...

journal_title：Annals of biomedical engineering

authors： Chen Y,Wen C,Tao G,Bi M,Li G

更新日期：2009-11-01 00:00:00

abstract：:Phenotype transformation of vascular smooth muscle cells (VSMCs) has been reported to be directly influenced by the frequency of mechanical strain. This study explored the effects of different frequencies of mechanical strain on expression of phenotype marker h1-calponin and the possible mechanism. VSMCs were subjecte...

journal_title：Annals of biomedical engineering

authors： Qu MJ,Liu B,Qi YX,Jiang ZL

更新日期：2008-09-01 00:00:00

abstract：:Hemodynamic forces are known to be able to induce an inflammatory phenotype in endothelial cells (ECs). The EC glycocalyx (GCX) is a dynamic structure which is regulated in response to different stimuli and hypothesized as an important contributor to the mechanotransduction of wall shear stresses (WSS). In this work, ...

journal_title：Annals of biomedical engineering

authors： Cooper S,McDonald K,Burkat D,Leask RL

更新日期：2017-09-01 00:00:00

abstract：:The identification of the input to, or kernels of, a system using nonparametric representations and least-squares estimation is becoming increasingly popular. Nonparametric representations avoid making a priori assumptions about the input or having detailed knowledge about the system, and only need to guarantee known ...

journal_title：Annals of biomedical engineering

authors： Verotta D

更新日期：1998-09-01 00:00:00

abstract：:Gap junctions play a fundamental role in intercellular communication in cardiac tissue. Various types of heart disease including hypertrophy and ischemia are associated with alterations of the spatial arrangement of gap junctions. Previous studies applied two-dimensional optical and electron-microscopy to visualize ga...

journal_title：Annals of biomedical engineering

authors： Lackey DP,Carruth ED,Lasher RA,Boenisch J,Sachse FB,Hitchcock RW

更新日期：2011-11-01 00:00:00

abstract：:For an optimal guidance of the rehabilitation therapy of stroke patients in an in-home setting, objective, and patient-specific performance assessment of arm movements is needed. In this study, metrics of hand movement relative to the pelvis and the sternum were estimated in 13 stroke subjects using a full body ambula...

journal_title：Annals of biomedical engineering

authors： van Meulen FB,Reenalda J,Buurke JH,Veltink PH

更新日期：2015-02-01 00:00:00

abstract：:Viscous shear stress and Reynolds stress are often used to predict hemolysis and thrombosis due to flow-induced stress on blood elements in cardiovascular devices. These macroscopic stresses are distinct from the true stress on an individual cell, which is determined by the local microscale flow field. In this paper t...

journal_title：Annals of biomedical engineering

authors： Quinlan NJ,Dooley PN

更新日期：2007-08-01 00:00:00

abstract：:The neutrophil has developed into one of the most efficient vertebrate motile cells. It migrates through tissues, where it encounters multiple chemoattractant signals with complex spatial and temporal characteristics. The directional movement of the neutrophil is signaled by the binding of chemoattractants and chemoki...

journal_title：Annals of biomedical engineering

authors： Zhelev DV,Alteraifi A

更新日期：2002-03-01 00:00:00

abstract：:A search for robust noninvasive methods permitting to discern the respiration subtle peculiarities in mammals is a topical issue. A novel approach called "sorption-enhanced infrared thermography" (SEIRT), helping to solve this problem, is described. Its benefits spring from the integration of the infrared thermography...

journal_title：Annals of biomedical engineering

authors： Vainer BG

更新日期：2018-07-01 00:00:00

abstract：:The toxic or therapeutic effect of an inhaled aerosol is highly dependent upon the site and extent of deposition in the lung. A novel MRI-based method was used to quantify the spatial distribution of particles in the rat lung. Rats were exposed to 0.95 μm-diameter iron oxide particles in a controlled manner (N = 6) or...

journal_title：Annals of biomedical engineering

authors： Oakes JM,Scadeng M,Breen EC,Prisk GK,Darquenne C

更新日期：2013-05-01 00:00:00

abstract：:There are recent reports of hybrid tissue-fabric materials with good performance-high biocompatibility and high mechanical strength. In this study, we demonstrate the capability of a hybrid material as a long-term filter for blood proteins. Polyester fabrics were implanted into rats to fabricate hybrid tissue-fabric m...

journal_title：Annals of biomedical engineering

authors： Inoue Y,Yokota T,Sekitani T,Kaneko A,Woo T,Kobayashi S,Shibuya T,Tanaka M,Kosukegawa H,Saito I,Isoyama T,Abe Y,Yambe T,Someya T,Sekino M

更新日期：2017-05-01 00:00:00

abstract：:To study the effects of compressive straining on muscle cell deformation and damage an in vitro model system was developed. Myoblasts were seeded in agarose constructs and cultured in growth medium for 4 days. Subsequently, the cells were allowed to fuse into multinucleated myotubes for 8 days in differentiation mediu...

journal_title：Annals of biomedical engineering

authors： Bouten CV,Knight MM,Lee DA,Bade DL

更新日期：2001-02-01 00:00:00

abstract：:The human thorax is commonly injured in motor vehicle crashes, and despite advancements in occupant safety rib fractures are highly prevalent. The objective of this study was to quantify the ability of gross and cross-sectional geometry, separately and in combination, to explain variation of human rib structural prope...

journal_title：Annals of biomedical engineering

authors： Murach MM,Kang YS,Goldman SD,Schafman MA,Schlecht SH,Moorhouse K,Bolte JH 4th,Agnew AM

更新日期：2017-09-01 00:00:00

abstract：:The nose is the front line defender of the respiratory system. Unsteady simulations in three-dimensional models have been developed to study transport patterns in the human nose and its overall air-conditioning capacity. The results suggested that the healthy nose can efficiently provide about 90% of the heat and the ...

journal_title：Annals of biomedical engineering

authors： Naftali S,Rosenfeld M,Wolf M,Elad D

更新日期：2005-04-01 00:00:00

abstract：:Ever-increasing demand for bone grafts necessitates the realization of clinical implementation of bone tissue engineered constructs. The predominant hurdle to implementation remains to be securing FDA approval, based on the lack of viable methods for the rigorous monitoring of said constructs. The study presented here...

journal_title：Annals of biomedical engineering

authors： Simmons AD,Sikavitsas VI

更新日期：2018-01-01 00:00:00

abstract：:One goal of large scale clinical trials is to determine how a drug is processed by, and cleared from, the human body [i.e., its pharmacokinetic (PK) properties] and how these PK properties differ between individuals in a population (i.e., its population PK properties). Due to the high cost of these studies and the lim...

journal_title：Annals of biomedical engineering

authors： Hooker AC,Foracchia M,Dodds MG,Vicini P

更新日期：2003-01-01 00:00:00

abstract：:The concept of body force (force per unit volume) is introduced to account for the effect of the force generated in the radial direction by the active state of the myocardium in an elastic model of the left ventricle represented as a thick-walled cylinder contracting symmetrically. Experimental evidence for the validi...

journal_title：Annals of biomedical engineering

authors： Shoucri RM

更新日期：1991-01-01 00:00:00

abstract：:Traditionally, measurement of pulmonary O2 uptake uses mass balance of N2 to correct for differences between inspired and expired volume (V) due to temperature (T) and relative humidity (RH). Often during anesthesia, N2 balance cannot be invoked due to high inspired O2 fraction (FIO2) or nonsteady state conditions. Th...

journal_title：Annals of biomedical engineering

authors： Breen PH

更新日期：2000-09-01 00:00:00

abstract：:This project was undertaken to establish if the integral circulation had any effects upon the mechanical behavior of bone. The influence of blood flow in the rabbit tibia on the strain induced at the bone surface when under load was assessed. Recordings were taken from three adult and three immature New Zealand White ...

journal_title：Annals of biomedical engineering

authors： McDonald F,Pitt Ford TR

更新日期：1994-03-01 00:00:00

abstract：:The continuing lack of longitudinal histopathological and biomechanical data for human arteries in health and disease highlights the importance of studying the many genetic, pharmacological, and surgical models that are available in mice. As a result, there has been a significant increase in the number of reports on t...

journal_title：Annals of biomedical engineering

authors： Bersi MR,Ferruzzi J,Eberth JF,Gleason RL Jr,Humphrey JD

更新日期：2014-06-01 00:00:00

abstract：:Effects of hyperthermia on transport of low-density lipoprotein (LDL) through a stenosed arterial wall are analyzed comprehensively in the present work. The realistic and pertinent aspects of an arterial wall is represented by a multi-layer model, with a proper representation of the thickened intima region due to the ...

journal_title：Annals of biomedical engineering

authors： Iasiello M,Vafai K,Andreozzi A,Bianco N,Tavakkoli F

更新日期：2015-07-01 00:00:00

abstract：:Disease and injury perturb the balance of processes associated with inflammation and tissue remodeling, resulting in positive feedback loops, exacerbation of disease and compromised tissue repair. Conversely, under homeostatic healthy conditions, these processes are tightly regulated through the expansion and/or recru...

journal_title：Annals of biomedical engineering

authors： Glowacki AJ,Gottardi R,Yoshizawa S,Cavalla F,Garlet GP,Sfeir C,Little SR

更新日期：2015-03-01 00:00:00

abstract：:The field of percutaneous coronary intervention has witnessed many progressions over the last few decades, more recently with the advancement of fully degradable bioabsorbable stents. Bioabsorbable materials, such as metallic alloys and aliphatic polyesters, have the potential to yield stents which provide temporary s...

journal_title：Annals of biomedical engineering

authors： Boland EL,Shine R,Kelly N,Sweeney CA,McHugh PE

更新日期：2016-02-01 00:00:00