Influence of autoregressive model parameter uncertainty on spectral estimates of heart rate dynamics.

Abstract:

:Linear autoregressive (AR) model-based heart rate (HR) spectral analysis has been widely used to study HR dynamics. Owing to system and measurement noise, the parameters of an AR model have intrinsic statistical uncertainty. In this study, we evaluate how this AR parameter uncertainty can translate to uncertainty in HR power spectra. HR time series, obtained from seven subjects in supine and standing positions, were fitted to AR models by least squares minimization via singular value decomposition. Spectral uncertainty due to inexact parameter estimation was assessed through a Monte Carlo study in which the AR model parameters were varied randomly according to their Gaussian distributions. Histogram techniques were used to evaluate the distribution of 50,000 AR spectral estimates of each HR time series. These Monte Carlo uncertainties were found to exceed those predicted by previous theoretical approximations. It was determined that the uncertainty of AR HR spectral estimates, particularly the locations and magnitudes of spectral peaks, can often be large. The same Monte Carlo analysis was applied to synthetic AR time series and found levels of spectral uncertainty similar to that of the HR data, thus suggesting that the results of this study are not specific to experimental HR data. Therefore, AR spectra may be unreliable, and one must be careful in assigning pathophysiological origins to specific spectral features of any one spectrum.

journal_name

Ann Biomed Eng

authors

Christini DJ,Kulkarni A,Rao S,Stutman ER,Bennett FM,Hausdorff JM,Oriol N,Lutchen KR

doi

10.1007/BF02368320

subject

Has Abstract

pub_date

1995-03-01 00:00:00

pages

127-34

issue

2

eissn

0090-6964

issn

1573-9686

journal_volume

23

pub_type

杂志文章
  • Biomechanical properties of esophagus during systemic treatment with epidermal growth factor in rats.

    abstract::The epidermal growth factor (EGF) is a growth factor with effects on many cell types and tissue. Morphometric and passive biomechanical properties were studied in isolated segments of the esophagus in 22 EGF-treated rats and 12 control rats. The rats were divided into groups with EGF treatment for 2, 4, 7, and 14 days...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1114/1.1575758

    authors: Zhao J,Yang J,Vinter-Jensen L,Zhuang F,Gregersen H

    更新日期:2003-06-01 00:00:00

  • Prediction of Post-Concussive Behavioral Changes in a Rodent Model Based on Head Rotational Acceleration Characteristics.

    abstract::Quantifying injury tolerance for concussion is complicated by variability in the type, severity, and time course of post-injury physiological and behavioral changes. The current study outlined acute and chronic changes in behavioral metrics following rotational acceleration-induced concussion in rats. The Medical Coll...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-016-1647-x

    authors: Stemper BD,Shah AS,Chiariello R,Olsen CM,Budde MD,Glavaski-Joksimovic A,McCrea M,Kurpad SN,Pintar FA

    更新日期:2016-11-01 00:00:00

  • The effect of strain rate on the viscoelastic response of aortic valve tissue: a direct-fit approach.

    abstract::Knowledge of strain-rate sensitivity of soft tissue viscoelastic and nonlinear elastic properties is important for accurate predictions of biomechanical behavior and for quantitative assessment of the effects of disease or surgical/pharmaceutical intervention. Soft tissues are known to exhibit mild rate sensitivity, b...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1023/b:abme.0000012742.01261.b0

    authors: Doehring TC,Carew EO,Vesely I

    更新日期:2004-02-01 00:00:00

  • Length-Change Patterns of the Collateral Ligaments During Functional Activities After Total Knee Arthroplasty.

    abstract::This study aimed to quantify the elongation patterns of the collateral ligaments following TKA during functional activities of daily living. Using mobile video-fluoroscopy to capture radiographic images of the knee in a group of six patients, each with an ultra-congruent knee implant, tibiofemoral kinematics were reco...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-020-02459-3

    authors: Hosseini Nasab SH,Smith CR,Schütz P,Damm P,Trepczynski A,List R,Taylor WR

    更新日期:2020-04-01 00:00:00

  • Through the microcirculatory maze with machete, molecule, and minicomputer (1986 Alza lecture).

    abstract::This is a personal historical essay on meanderings through the jungle of the microcirculatory swamp. Because one pretends that the wandering was purposefully exploratory, a few guideposts are placed at positions where one could discern blaze-marks from earlier wanderers, and the path cut a little wider along some of t...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章,评审

    doi:10.1007/BF02363568

    authors: Bassingthwaighte JB

    更新日期:1987-01-01 00:00:00

  • Optical vibrocardiography: a novel tool for the optical monitoring of cardiac activity.

    abstract::We present an optical non-contact method for heart beat monitoring, based on the measurement of chest wall movements induced by the pumping action of the heart, which is eligible as a surrogate of electrocardiogram (ECG) in assessing both cardiac rate and heart rate variability (HRV). The method is based on the optica...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-006-9202-9

    authors: Morbiducci U,Scalise L,De Melis M,Grigioni M

    更新日期:2007-01-01 00:00:00

  • Determination of mechanical properties of spatially heterogeneous breast tissue specimens using contact mode atomic force microscopy (AFM).

    abstract::This paper outlines a comprehensive parametric approach for quantifying mechanical properties of spatially heterogeneous thin biological specimens such as human breast tissue using contact-mode Atomic Force Microscopy. Using inverse finite element (FE) analysis of spherical nanoindentation, the force response from hyp...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-014-1057-x

    authors: Roy R,Desai JP

    更新日期:2014-09-01 00:00:00

  • Interaction between high frequency jet ventilation and cardiovascular function.

    abstract::We have studied the interaction of high frequency jet ventilation with cardiovascular pressures and flows. Results in dogs show that the amplitude of all intrathoracic pressures and flows fluctuate with a frequency equal to the difference between the heart rate and ventilator rate. The magnitude of this amplitude vari...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/BF02584287

    authors: Mitzner W,Gioia F,Weinmann GG,Robotham JL,Ehrlich W

    更新日期:1987-01-01 00:00:00

  • Continuous and noninvasive blood pressure measurement: a novel modeling methodology of the relationship between blood pressure and pulse wave velocity.

    abstract::In this paper, we aim to establish a new mathematical model that relates pulse wave velocity (PWV) to blood pressure (BP) for continuous and noninvasive BP measurement. For the first time, we derive an ordinary differential equation (ODE) expressing the fundamental relation between BP, elastic modulus G and PWV. The g...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-009-9759-1

    authors: Chen Y,Wen C,Tao G,Bi M,Li G

    更新日期:2009-11-01 00:00:00

  • Mechanical Performance of Two Left Atrial Appendage Occlusion Systems: In Vitro Comparison of Tug Force, Radial Force, Sealing and Deformation.

    abstract::The aim of this study was to establish in vitro bench-tests of left atrial appendage occlusion (LAAo) devices regarding tug force, radial force and sealing capacity. Two LAAo devices, namely the WATCHMAN™ and the Occlutech®, of three different sizes underwent testing in novel dedicated in vitro setups. Radial force wa...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-018-2057-z

    authors: Menne MF,Schrickel JW,Nickenig G,Al-Kassou B,Nelles D,Schmitz-Rode T,Steinseifer U,Sedaghat A

    更新日期:2018-09-01 00:00:00

  • The Role of Synthetic Extracellular Matrices in Endothelial Progenitor Cell Homing for Treatment of Vascular Disease.

    abstract::Poor vascular homeostasis drives many clinical disorders including diabetes, arthritis, atherosclerosis, and peripheral artery disease. Local tissue ischemia resultant of insufficient blood flow is a potent stimulus for recruitment of endothelial progenitor cells (EPCs). This mobilization and homing is a multi-step pr...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章,评审

    doi:10.1007/s10439-015-1400-x

    authors: Williams PA,Silva EA

    更新日期:2015-10-01 00:00:00

  • Therapeutic effects of functional electrical stimulation on gait in individuals post-stroke.

    abstract::Functional electrical stimulation (FES) to lower extremity (LE) muscles is used by individuals post-stroke as an alternative to mechanical orthotic devices during gait or as a training modality during rehabilitation. Technological developments which improve the feasibility, accessibility and effectiveness of FES syste...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章,评审

    doi:10.1007/s10439-014-1148-8

    authors: Kafri M,Laufer Y

    更新日期:2015-02-01 00:00:00

  • Reproducing cardiac restitution properties using the Fenton-Karma membrane model.

    abstract::Modern models of cardiac membranes are often highly complex and computationally expensive, particularly when used in long simulations of spatially extended models of cardiac tissue. Therefore, there is a need for simpler membrane models that preserve the features of the complex models deemed important. This communicat...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-005-3948-3

    authors: Oliver RA,Krassowska W

    更新日期:2005-07-01 00:00:00

  • Nanoparticle deposition onto biofilms.

    abstract::We develop a mathematical model of nanoparticles depositing onto and penetrating into a biofilm grown in a parallel-plate flow cell. We carry out deposition experiments in a flow cell to support the modeling. The modeling and the experiments are motivated by the potential use of polymer nanoparticles as part of a trea...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-012-0626-0

    authors: Miller JK,Neubig R,Clemons CB,Kreider KL,Wilber JP,Young GW,Ditto AJ,Yun YH,Milsted A,Badawy HT,Panzner MJ,Youngs WJ,Cannon CL

    更新日期:2013-01-01 00:00:00

  • A paradigm for functional tissue engineering of articular cartilage via applied physiologic deformational loading.

    abstract::Deformational loading represents a primary component of the chondrocyte physical environment in vivo. This review summarizes our experience with physiologic deformational loading of chondrocyte-seeded agarose hydrogels to promote development of cartilage constructs having mechanical properties matching that of the par...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章,评审

    doi:10.1023/b:abme.0000007789.99565.42

    authors: Hung CT,Mauck RL,Wang CC,Lima EG,Ateshian GA

    更新日期:2004-01-01 00:00:00

  • Hydrodynamic shear and tethering through E-selectin signals phosphorylation of p38 MAP kinase and adhesion of human neutrophils.

    abstract::Recently, we reported that tethering and rolling of neutrophils in shear flow over a substrate of E-selectin signals activation of beta 2-integrins and firm adhesion via an intracellular signaling pathway involving phosphorylation of p38 MAP kinase. In the current study the objective was to examine the molecular mecha...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1114/1.1511240

    authors: Hentzen E,McDonough D,McIntire L,Smith CW,Goldsmith HL,Simon SI

    更新日期:2002-09-01 00:00:00

  • In vitro characterization of a compliant biodegradable scaffold with a novel bioreactor system.

    abstract::The influence of scaffold compliance on blood vessel tissue engineering remains unclear and compliance mismatch issues are important to an in vivo tissue-engineering approach. We have designed and constructed a modular bioreactor system that is capable of imparting pulsatile fluid flow while simultaneously measuring v...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-007-9304-z

    authors: Webb AR,Macrie BD,Ray AS,Russo JE,Siegel AM,Glucksberg MR,Ameer GA

    更新日期:2007-08-01 00:00:00

  • Bioreactors for development of tissue engineered heart valves.

    abstract::Millions of people worldwide are diagnosed each year with valvular heart disease, resulting in hundreds of thousands of valve replacement operations. Prosthetic valve replacements are designed to correct narrowing or backflow through the valvular orifice. Although commonly used, these therapies have serious disadvanta...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章,评审

    doi:10.1007/s10439-010-0148-6

    authors: Berry JL,Steen JA,Koudy Williams J,Jordan JE,Atala A,Yoo JJ

    更新日期:2010-11-01 00:00:00

  • Tauberian-prony feature extraction technique for esophageal motility patterns.

    abstract::For the esophageal contractile activity recorded during swallowing, a feature extraction scheme has been developed. It recognizes the time, duration, and amplitudes of local peaks for each peristaltic wave. The method is based on the Tauberian approximation for modeling waveforms as a sum of identically shaped pulses ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/BF02367607

    authors: Abou-Chadi FE,Ezzat FA,Gad-Elhak N,Sif el-Din AA

    更新日期:1993-03-01 00:00:00

  • Sensor Anchoring Improves the Correlation Between Intramuscular Pressure and Muscle Tension in a Rabbit Model.

    abstract::Intramuscular pressure (IMP) shows promise for estimating individual muscle tension in vivo. However, previous pressure measurements show high variability during isometric contraction and poor correlation with tension during dynamic contraction. We hypothesized that enhanced sensor anchoring/orientation would improve ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-020-02633-7

    authors: O'Connor SM,Kaufman KR,Ward SR,Lieber RL

    更新日期:2021-02-01 00:00:00

  • Inverse parameter fitting of biological tissues: a response surface approach.

    abstract::In this paper, we present the application of a semi-global inverse method for determining material parameters of biological tissues. The approach is based on the successive response surface method, and is illustrated by fitting constitutive parameters to two nonlinear anisotropic constitutive equations, one for aortic...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-005-8338-3

    authors: Einstein DR,Freed AD,Stander N,Fata B,Vesely I

    更新日期:2005-12-01 00:00:00

  • Effect of cell-cell interactions on the observable strength of adhesion of sheets of cells.

    abstract::Previous research in cellular adhesion has focused primarily on studying isolated cells under conditions where cells do not interact with each other. However, in vivo cells form sheets where both cell-substratum and cell-cell interactions contribute to the overall adhesive behavior. Our understanding of how cell-cell ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1114/1.178

    authors: Peel MM,DiMilla PA

    更新日期:1999-03-01 00:00:00

  • CareToy: Stimulation and Assessment of Preterm Infant's Activity Using a Novel Sensorized System.

    abstract::Early intervention programs aim at improving cognitive and motor outcomes of preterm infants. Intensive custom-tailored training activities are usually accompanied by assessment procedures, which have shortcomings, such as subjectivity, complex setups, and need for structured environments. A novel sensorized system, c...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-016-1669-4

    authors: Rihar A,Sgandurra G,Beani E,Cecchi F,Pašič J,Cioni G,Dario P,Mihelj M,Munih M

    更新日期:2016-12-01 00:00:00

  • Matrix Stiffness Modulates Mesenchymal Stem Cell Sensitivity to Geometric Asymmetry Signals.

    abstract::Human stem cells hold significant potential for the treatment of various diseases. However, their use as a therapy is hampered because of limited understanding of the mechanisms by which they respond to environmental stimuli. Efforts to understand extracellular biophysical cues have demonstrated the critical roles of ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-018-2008-8

    authors: Piroli ME,Jabbarzadeh E

    更新日期:2018-06-01 00:00:00

  • Shear modulus of elasticity of the esophagus.

    abstract::Experimental and diagnostic procedures like distension of a balloon catheter, bougie, and esophagogastroduodenoscopy can induce shear deformation in the esophageal wall. However, the shear modulus of the esophagus is yet unknown. The aim of this study was to determine the esophageal shear modulus and its dependence on...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1114/b:abme.0000039356.24821.6c

    authors: Yang J,Liao D,Zhao J,Gregersen H

    更新日期:2004-09-01 00:00:00

  • Aortic Valve Function Under Support of a Left Ventricular Assist Device: Continuous vs. Dynamic Speed Support.

    abstract::Continuous flow left ventricular devices (CF-LVADs) support the failing heart at a constant speed and alters the loads on the aortic valve. This may cause insufficiency in the aortic valve under long-term CF-LVAD support. The aim of this study is to assess the aortic valve function under varying speed CF-LVAD support....

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-014-1204-4

    authors: Bozkurt S,van de Vosse FN,Rutten MC

    更新日期:2015-08-01 00:00:00

  • An improved Morris Water Maze tracking algorithm for psychophysical studies.

    abstract::An algorithm to track a rat swimming in a Morris Water Maze has been developed. The system is automatically configured to any pool and relative suitable light conditions. It tracks the rat's position and head pose 10 times per second. The output data is displayed in a bitmap and also in a text file. The system was tes...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1114/b:abme.0000036650.32345.b6

    authors: Hval ES,Barrett SF,Wilcox M,Bailey TA

    更新日期:2004-08-01 00:00:00

  • The effect of visual and sensory performance on head impact biomechanics in college football players.

    abstract::The development of prevention strategies is critical to address the rising prevalence of sport-related concussions. Visual and sensory performance may influence an individual's ability to interpret environmental cues, anticipate opponents' actions, and create appropriate motor responses limiting the severity of an imp...

    journal_title:Annals of biomedical engineering

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10439-013-0881-8

    authors: Harpham JA,Mihalik JP,Littleton AC,Frank BS,Guskiewicz KM

    更新日期:2014-01-01 00:00:00

  • Left-right asymmetry of visual evoked potentials in brain-damaged patients: a mathematical model and experimental results.

    abstract::The left-right asymmetry in the potential amplitude on the scalp was studied in poststroke patients by using flash visual evoked potential (VEP) and a numerical two-dimensional model of the head. The left-right asymmetry of the VEP was measured in three patients after thrombosis, in one after hemorrhage, and in one he...

    journal_title:Annals of biomedical engineering

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF02770997

    authors: Abboud S,Bar L,Rosenfeld M,Ring H,Glass I

    更新日期:1996-01-01 00:00:00

  • Estimating the parameter distributions of defibrillation shock efficacy curves in a large population.

    abstract::Defibrillation efficacy testing is a common procedure at defibrillator implantation, with the objective to ensure that each patient receives a system with adequate shock efficacy. In this study, defibrillation shock efficacy as a function of shock energy was modeled by a dose response relationship. The frequency distr...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-009-9890-z

    authors: Smits K,Virag N

    更新日期:2010-04-01 00:00:00