Abstract:
:In this paper, we aim to establish a new mathematical model that relates pulse wave velocity (PWV) to blood pressure (BP) for continuous and noninvasive BP measurement. For the first time, we derive an ordinary differential equation (ODE) expressing the fundamental relation between BP, elastic modulus G and PWV. The general solution of this ODE is the mathematical BP-PWV model. In our model, the elastic modulus G is included in model parameters, unlike the existing theoretical models. This enables us to express the BP-PWV relationship for subjects of different ages and genders. A family of BP-PWV functions for specific age and gender groups can be obtained using statistical methods based on clinical trial data, which serve as the calibrated benchmark models for continuous and noninvasive BP measurement. To illustrate the modeling methodology, we construct benchmark models for people aged 19 and 60 and apply them to continuous diastolic blood pressure (DBP) measurement without individual calibration. The results of clinical tests meet the test standard in ANSI/AAMI SP10, which attests the feasibility of the modeling methodology.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Chen Y,Wen C,Tao G,Bi M,Li Gdoi
10.1007/s10439-009-9759-1subject
Has Abstractpub_date
2009-11-01 00:00:00pages
2222-33issue
11eissn
0090-6964issn
1573-9686journal_volume
37pub_type
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