Continuous and noninvasive blood pressure measurement: a novel modeling methodology of the relationship between blood pressure and pulse wave velocity.

Abstract:

:In this paper, we aim to establish a new mathematical model that relates pulse wave velocity (PWV) to blood pressure (BP) for continuous and noninvasive BP measurement. For the first time, we derive an ordinary differential equation (ODE) expressing the fundamental relation between BP, elastic modulus G and PWV. The general solution of this ODE is the mathematical BP-PWV model. In our model, the elastic modulus G is included in model parameters, unlike the existing theoretical models. This enables us to express the BP-PWV relationship for subjects of different ages and genders. A family of BP-PWV functions for specific age and gender groups can be obtained using statistical methods based on clinical trial data, which serve as the calibrated benchmark models for continuous and noninvasive BP measurement. To illustrate the modeling methodology, we construct benchmark models for people aged 19 and 60 and apply them to continuous diastolic blood pressure (DBP) measurement without individual calibration. The results of clinical tests meet the test standard in ANSI/AAMI SP10, which attests the feasibility of the modeling methodology.

journal_name

Ann Biomed Eng

authors

Chen Y,Wen C,Tao G,Bi M,Li G

doi

10.1007/s10439-009-9759-1

subject

Has Abstract

pub_date

2009-11-01 00:00:00

pages

2222-33

issue

11

eissn

0090-6964

issn

1573-9686

journal_volume

37

pub_type

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