Abstract：
:Millions of people worldwide are diagnosed each year with valvular heart disease, resulting in hundreds of thousands of valve replacement operations. Prosthetic valve replacements are designed to correct narrowing or backflow through the valvular orifice. Although commonly used, these therapies have serious disadvantages including morbidity associated with long-term anticoagulation and limited durability necessitating repeat operations. The ideal substitute would be widely available and technically implantable for most cardiac surgeons, have normal hemodynamic performance, low risk for structural degeneration, thrombo-embolism and endocarditis, and growth potential for pediatric patients. Tissue engineered heart valves hold promise as a viable substitute to outperform existing valve replacements. An essential component to the development of tissue engineered heart valves is a bioreactor. It is inside the bioreactor that the scaffold and cells are gradually conditioned to the biochemical and mechanical environment of the valve to be replaced.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Berry JL,Steen JA,Koudy Williams J,Jordan JE,Atala A,Yoo JJdoi
10.1007/s10439-010-0148-6subject
Has Abstractpub_date
2010-11-01 00:00:00pages
3272-9issue
11eissn
0090-6964issn
1573-9686journal_volume
38pub_type
杂志文章,评审abstract：:The most widely implanted prosthetic valve is the mechanical bileaflet. Recent clinical experiences suggest that some designs are more prone to thromboembolic episodes than others. This study evaluated the hinge flow and near-field forward flow of the new St. Jude Medical Regent bileaflet mechanical heart valve. Laser...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.297
更新日期：2000-05-01 00:00:00
abstract：:Defining the constituent regulatory molecules in tendon is critical to understanding the process of tendon repair and instructive to the development of novel treatment modalities. The purpose of this study is to define the structural, expressional, and mechanical changes in the tendon injury response, and elucidate th...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-013-0915-2
更新日期：2014-03-01 00:00:00
abstract：:Continuous flow left ventricular devices (CF-LVADs) support the failing heart at a constant speed and alters the loads on the aortic valve. This may cause insufficiency in the aortic valve under long-term CF-LVAD support. The aim of this study is to assess the aortic valve function under varying speed CF-LVAD support....
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-014-1204-4
更新日期：2015-08-01 00:00:00
abstract：:Although diagnostic testing with auditory evoked potentials (EPs) has become routine, quantitative measurements of signal and noise are still lacking. In this study, current signal, power, noise power, and signal-to-noise ratio (SNR) estimation formulas are reviewed and applied to auditory brainstem response averaging...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02684183
更新日期：1996-11-01 00:00:00
abstract：:When cells and the matrix of a tissue remodel, the mechanical properties of the tissue do change. The mechanical properties are expressed by constitutive equations. In this article the remodeling of the constitutive equation of the pulmonary artery is studied. The remodeling was induced in a rat breathing a gas whose ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.1380417
更新日期：2001-01-01 00:00:00
abstract：:Instrumentation systems for breath-to-breath analysis of respiratory gas exchange have been faulted by phase lags between various flow and composition signals and by difficulties in gathering and processing large amounts of data. The system described here represents an attempt to overcome these problems. Phase delays ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02367493
更新日期：1983-01-01 00:00:00
abstract：:Dendritic cell (DC) migration is required for efficient presentation of antigen to T cells and the initiation of an adaptive immune response. In spite of its importance, many aspects of DC migration have not been characterized. DCs encounter a variety of environments with different stiffness and geometry, but the effe...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-018-2041-7
更新日期：2018-09-01 00:00:00
abstract：:Normalized maximal ventricular power (nPWRmax) is an index of cardiac function which measures the innate blood pumping ability, or contractility, of the left ventricle (LV), and its noninvasive assessment could prove useful in a variety of patients. nPWRmax is defined as the maximum instantaneous product of LV pressur...
journal_title：Annals of biomedical engineering
pub_type： 临床试验,杂志文章
doi：10.1114/1.1415530
更新日期：2001-11-01 00:00:00
abstract：:The impedance of a monopolar electrode immersed in an environmental volume conductor consists of two parts; the impedance of the active electrode-electrolyte interface, and the resistance of the environmental conductor. Two studies were carried out to quantitate these components. First, impedance-frequency data were c...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02368609
更新日期：1992-01-01 00:00:00
abstract：:Calcium phosphate ceramics have been widely used for filling bone defects to aid in the regeneration of new bone tissue. Addition of osteogenic cells to porous ceramic scaffolds may accelerate the bone repair process. This study demonstrates the feasibility of culturing marrow stromal cells (MSCs) on porous biphasic c...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-005-5536-y
更新日期：2005-09-01 00:00:00
abstract：:This study was undertaken to investigate the possible origin of some cutaneously recorded higher frequency electrogastrographic signals. Computer modeling of gastric electrical uncoupling was performed using previously described conoidal dipole model. Cutaneous electrogastrograms were simulated after uncoupling was in...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：
更新日期：1997-11-01 00:00:00
abstract：:The material properties of normal cadaveric human cartilage in the ankle mortice (tibiotalar articulation) were evaluated to determine a possible etiologic mechanism of cartilage injury of the ankle when an obvious traumatic episode is not present. Using an automated indentation apparatus and the biphasic creep indent...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02584467
更新日期：1995-09-01 00:00:00
abstract：:In this paper, a new method for quantification of rigidity in elbow joint of Parkinsonian patients is introduced. One of the most known syndromes in Parkinson's disease (PD) is increased passive stiffness in muscles, which leads to rigidity in joints. Clinical evaluation of stiffness in wrist and/or elbow, commonly us...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-007-9379-6
更新日期：2007-12-01 00:00:00
abstract：:Overexpressed receptors, characteristic of many cancers, have been targeted by various researchers to achieve a more specific treatment for cancer. A common approach is to use the natural ligand for the overexpressed receptor as a cancer-targeting agent which can deliver a chemically or genetically conjugated toxic mo...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1007/s10439-011-0280-y
更新日期：2011-04-01 00:00:00
abstract：:While viscoelastic responses of isolated trunk soft tissues have been characterized in earlier studies, the effects of external loading and flexion rate on these responses in the intact human trunk are largely unknown. Two experiments were conducted to measure trunk viscoelastic behaviors, one involving prolonged flex...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-013-0797-3
更新日期：2013-06-01 00:00:00
abstract：:Fibroblasts are abundant in cardiac tissue. Experimental studies suggested that fibroblasts are electrically coupled to myocytes and this coupling can impact cardiac electrophysiology. In this work, we present a novel approach for mathematical modeling of electrical conduction in cardiac tissue composed of myocytes, f...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-009-9667-4
更新日期：2009-05-01 00:00:00
abstract：:An algorithm to track a rat swimming in a Morris Water Maze has been developed. The system is automatically configured to any pool and relative suitable light conditions. It tracks the rat's position and head pose 10 times per second. The output data is displayed in a bitmap and also in a text file. The system was tes...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/b:abme.0000036650.32345.b6
更新日期：2004-08-01 00:00:00
abstract：:Despite the clinical effectiveness of coronary artery stenting, percutaneous coronary intervention or "stenting" is not free of complications. Stent malapposition (SM) is a common feature of "stenting" particularly in challenging anatomy, such as that characterized by long, tortuous and bifurcated segments. SM is an i...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-014-1237-8
更新日期：2015-08-01 00:00:00
abstract：:Classically, the primary tool for quantifying the dynamics of vergence and other eye movements has been the main sequence. The main sequence is a plot of peak velocity versus response amplitude and is particularly useful for comparing the dynamics of a large number of eye movements over a range of response amplitudes....
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.162
更新日期：1999-05-01 00:00:00
abstract：:High energy laser has emerged to be an important surgical tool in medical technology. However, the application of laser energy to drill or cut a bone is still in an experimental state. In order to estimate the adequacy of laser heating of bone surface and at the same time minimize the damage to the bone tissue, we dev...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02363565
更新日期：1987-01-01 00:00:00
abstract：:Electrical potentials in mechanically loaded bone have been implicated as signals in the bone remodeling cycle. Recently, interest has grown in exploiting this phenomenon to develop electrically active ceramics for implantation in hard tissue which may induce improved biological responses. Both polarized hydroxyapatit...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1007/s10439-010-9977-6
更新日期：2010-06-01 00:00:00
abstract：:Double-exposure holographic interferometry is a contactless whole-field method. Dimensional changes are visualized as a series of interference fringes overlaid on the holographic image of the femur, where each fringe represents 0.316 micron (half the wavelength of the laser light) of motion. Interferograms for intact ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02364168
更新日期：1987-01-01 00:00:00
abstract：:Arterial restenosis following stent deployment may be influenced by the local flow environment within and around the stent. We have used computational fluid dynamics to investigate the flow field in the vicinity of model stents positioned within straight and curved vessels. Our simulations have revealed the presence o...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-005-2499-y
更新日期：2005-04-01 00:00:00
abstract：:Past literature has provided evidence that a normal mechanical force environment of blood flow may guide normal development while an abnormal environment can lead to congenital malformations, thus warranting further studies on embryonic cardiovascular flow dynamics. In the current study, we developed a non-invasive 4D...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-017-1882-9
更新日期：2017-10-01 00:00:00
abstract：:To study pulsatile pressure-flow rate relationships in the intact pulmonary vascular network of mice, we developed a protocol for measuring pulmonary vascular resistance and impedance in isolated, ventilated, and perfused mouse lungs. We used pulmonary emboli to validate the effect of vascular obstruction on resistanc...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-005-9050-z
更新日期：2006-04-01 00:00:00
abstract：:A major tissue engineering challenge is the creation of multilaminate scaffolds with layer-specific mechanical properties representative of native tissues, such as heart valve leaflets, blood vessels, and cartilage. For this purpose, poly(ethylene glycol) diacrylate (PEGDA) hydrogels are attractive materials due to th...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-012-0666-5
更新日期：2013-02-01 00:00:00
abstract：:The continuing lack of longitudinal histopathological and biomechanical data for human arteries in health and disease highlights the importance of studying the many genetic, pharmacological, and surgical models that are available in mice. As a result, there has been a significant increase in the number of reports on t...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-014-0988-6
更新日期：2014-06-01 00:00:00
abstract：:Dual X-ray absorptiometry (DXA) measures areal bone mineral density (aBMD) by simplifying a complex 3D bone structure to a 2D projection and is not equally effective for explaining fracture strength in women and men. Unlike DXA, subject-specific quantitative computed tomography-based finite element analysis (QCT/FEA) ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-017-1914-5
更新日期：2017-12-01 00:00:00
abstract：:In order to increase the probability of having a successful cataract post-surgery, the customisation of the haptic design of the intraocular lens (IOL) according to the characteristics of the patient is recommended. In this study, we present two prediction models based on deep neural networks (DNNs). One is capable of...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-020-02636-4
更新日期：2020-12-01 00:00:00
abstract：:The objective of this study was to develop a unique device for applying well-characterized cyclic, strain to cells growing on implant alloys. The device is based on the four-point bending principle and utilizes an electric motor, belt, and cam system to cyclically deflect a commercially pure titanium plate with cell c...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.1529195
更新日期：2002-11-01 00:00:00
