Abstract：
:Double-exposure holographic interferometry is a contactless whole-field method. Dimensional changes are visualized as a series of interference fringes overlaid on the holographic image of the femur, where each fringe represents 0.316 micron (half the wavelength of the laser light) of motion. Interferograms for intact femora and for femora with identical geometry prostheses were produced. We have shown that the femur bends as a beam under axial load. The position of maximum deflection is a function of the properties of the composite structure. Under a known load the amount of deflection can be calculated and the effect of the prosthesis's modulus can be ascertained. In addition to bending, rotational effects can be perceived. Although data interpretation is complex and holographic production is costly and time-consuming, the technique holds promise for biomechanical applications as well as other biomedical disciplines.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Ovryn B,Manley MT,Stern LSdoi
10.1007/BF02364168subject
Has Abstractpub_date
1987-01-01 00:00:00pages
67-78issue
1eissn
0090-6964issn
1573-9686journal_volume
15pub_type
杂志文章abstract：:The human thorax is commonly injured in motor vehicle crashes, and despite advancements in occupant safety rib fractures are highly prevalent. The objective of this study was to quantify the ability of gross and cross-sectional geometry, separately and in combination, to explain variation of human rib structural prope...
journal_title：Annals of biomedical engineering
pub_type： 临床试验,杂志文章
doi：10.1007/s10439-017-1850-4
更新日期：2017-09-01 00:00:00
abstract：:There are recent reports of hybrid tissue-fabric materials with good performance-high biocompatibility and high mechanical strength. In this study, we demonstrate the capability of a hybrid material as a long-term filter for blood proteins. Polyester fabrics were implanted into rats to fabricate hybrid tissue-fabric m...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-016-1781-5
更新日期：2017-05-01 00:00:00
abstract：:The responses of photoreceptor cells to moving stimuli are crucial to understanding motion detection in visual systems. However, these responses are not well characterized quantitatively because they result from a combination of spatial optical behavior in the lens systems with temporal behavior in the phototransducti...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.58
更新日期：1998-03-01 00:00:00
abstract：:Long-range dependency has been found in most rhythmic motor signals. The origin of this property is unknown and largely debated. There is a controversy on the influence of voluntary control induced by requiring a pre-determined pace such as asking subjects to step to a metronome. We studied the cycle duration variabil...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10439-013-0834-2
更新日期：2013-08-01 00:00:00
abstract：:Intraluminal thrombus (ILT) is a pseudo-tissue that develops from coagulated blood, and is found in most abdominal aortic aneurysms (AAAs) of clinically relevant size. A number of studies have suggested that ILT mechanical characteristics may be related to AAA risk of rupture, even though there is still great controve...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-015-1267-x
更新日期：2015-09-01 00:00:00
abstract：:Analysis and classification of esophageal motility records were investigated using signal processing and fuzzy-set pattern recognition techniques. A set of parameters has been extracted from the raw records and has previously been used as characterizing features. Improvements to these procedures were obtained by extra...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02368227
更新日期：1994-01-01 00:00:00
abstract：:This experimental work focused on the sensor selection for the development of a needle-like instrument to treat small isolated cartilage defects with hydrogels. The aim was to identify the most accurate and sensitive imaging method to determine the location and size of defects compared to a gold standard (µCT). Only i...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-018-2073-z
更新日期：2018-11-01 00:00:00
abstract：:The scarcity of data available on the best approach for pulmonary fetal valve replacement or implantation necessitate an investigation on whether practices using adult transcatheter valves could be translated to fetal applications. The objective of this study is to evaluate the hemodynamic characteristics and the turb...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-020-02475-3
更新日期：2020-06-01 00:00:00
abstract：:The bending stiffness of a phospholipid bilayer (Kc) was measured by forming thin bilayer cylinders (tethers) from giant phospholipid vesicles. Based on the balance of forces, the tether force was expected to be proportional to the square root of the membrane tension, with a constant of proportionality containing Kc. ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02684228
更新日期：1996-09-01 00:00:00
abstract：:A mathematical model has been developed to investigate previously obtained experimental findings relating to the activation of factor X by surface-bound tissue factor--factor VIIa (TF:VIIa) in a tubular flow reactor. In those experiments, factor X was perfused through a microcapillary tube over a range of flow (shear)...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02660888
更新日期：1996-05-01 00:00:00
abstract：:We propose a multiphysical mathematical model by fully coupling lipid deposition, monocytes/macrophages recruitment and angiogenesis to investigate the pathophysiological responses of an atherosclerotic plaque to the dynamic changes in the microenvironment. The time evolutions of cellular (endothelial cells, macrophag...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-018-02173-1
更新日期：2019-02-01 00:00:00
abstract：:As a human grows from birth to adulthood, both airway anatomy and breathing conditions vary, altering the deposition rate and pattern of inhaled aerosols. However, deposition studies have typically focused on adult subjects, results of which may not be readily extrapolated to children. This study numerically evaluated...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-012-0603-7
更新日期：2012-12-01 00:00:00
abstract：:Hemodynamic forces are known to be able to induce an inflammatory phenotype in endothelial cells (ECs). The EC glycocalyx (GCX) is a dynamic structure which is regulated in response to different stimuli and hypothesized as an important contributor to the mechanotransduction of wall shear stresses (WSS). In this work, ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-017-1846-0
更新日期：2017-09-01 00:00:00
abstract：:A mathematical model of heat, water and soluble gas exchange in the airways and alveoli was used to predict the location of soluble gas exchange in the lung. A previously published model of heat, water and soluble gas exchange in the airways was improved by incorporating anatomical data on the airway wall to better de...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.1630600
更新日期：2003-12-01 00:00:00
abstract：:Nanomedicine (a division of nanotechnology) is an interdisciplinary research field incorporating biology, chemistry, engineering and medicine with the intention to improve disease prevention, diagnosis, and treatment. Specifically, there have been great strides made in using nanomedicine to enhance the functions of ce...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1007/s10439-009-9722-1
更新日期：2009-10-01 00:00:00
abstract：:Mechanical ventilation is a life-support therapy for intensive care patients suffering from respiratory failure. To reduce the current rate of ventilator-induced lung injury requires ventilator settings that are patient-, time-, and disease-specific. A common lung protective strategy is to optimise the level of positi...
journal_title：Annals of biomedical engineering
pub_type： 临床试验,杂志文章
doi：10.1007/s10439-019-02253-w
更新日期：2019-07-01 00:00:00
abstract：:This study evaluates the use of artificial neural networks to estimate stroke volume from pre-processed, thoracic impedance plethysmograph signals from 20 healthy subjects. Standard back-propagation was used to train the networks, with Doppler stroke volume estimates as the desired output. The trained networks were th...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.47
更新日期：1998-07-01 00:00:00
abstract：:Naphthalene is a toxicant with unusual species and tissue specificity that has been the subject of in vitro studies. We describe a preliminary physiologically based pharmacokinetic (PBPK) model for naphthalene constructed solely from in vitro data for comparison to animal data without the use of adjustable parameters....
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02667357
更新日期：1996-03-01 00:00:00
abstract：:The objective of this study was to develop a unique device for applying well-characterized cyclic, strain to cells growing on implant alloys. The device is based on the four-point bending principle and utilizes an electric motor, belt, and cam system to cyclically deflect a commercially pure titanium plate with cell c...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.1529195
更新日期：2002-11-01 00:00:00
abstract：:A solid tumor is composed of a population of cells that is expanding as a result of cell division. With dense cell packing, the solid matrix of the interstitial tissue is subject to residual stress. In addition, elevated interstitial fluid pressure (IFP) has been reported by researchers for a number of solid tumors. T...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.1554923
更新日期：2003-03-01 00:00:00
abstract：:Membrane introduction mass spectrometry has been applied to inert gas measurements in blood and tissue, but gases with low blood solubility are associated with reduced sensitivity. Countercurrent extraction of inert gases from a blood sample into a water carrier phase has the potential to extract most of the gas sampl...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02684170
更新日期：1997-09-01 00:00:00
abstract：:This study presents a generic numerical model to simulate the coupled solute and solvent transport in tissue sections during addition and removal of chemical additives or cryoprotective agents (CPA; dimethylsulfoxide or DMSO). Osmotic responses of various tissue cells within the artificial tissue are predicted by the ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-005-1511-x
更新日期：2005-05-01 00:00:00
abstract：:Using a three-dimensional propagation model of the human ventricular myocardium, we studied the role of fibrous structure in generating epicardial potential maps. This model represents the myocardium as an anisotropic bidomain with an equal anisotropy ratio, and it incorporates a realistic representation of anatomical...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.73
更新日期：1998-11-01 00:00:00
abstract：:We have developed poly(L: -lactide-co-glycolide) (PLGA) based composites using sol-gel derived bioactive glasses (S-BG), previously described by our group, as composite components. Two different composite types were manufactured that contained either S2-high content silica S-BG, or A2-high content lime S-BG. The compo...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-011-0307-4
更新日期：2011-08-01 00:00:00
abstract：:Upon nerve injury, the body creates an environment consisting of permissive and non-permissive cues that instruct the function of cells involved in nerve repair. Among other roles, the developing extracellular matrix (ECM) acts as an underlying substrate to guide the union of neurites extending from the proximal stump...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-014-0991-y
更新日期：2014-06-01 00:00:00
abstract：:There are a number of cell therapies that are either in clinical trials or moving toward clinical trials, particularly for diseases of the retina. One of the challenges with cell therapies is tracking the status of cells over time. Genetic manipulation can facilitate this, but it can limit the clinical application of ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-019-02393-z
更新日期：2020-07-01 00:00:00
abstract：:Human stem cells hold significant potential for the treatment of various diseases. However, their use as a therapy is hampered because of limited understanding of the mechanisms by which they respond to environmental stimuli. Efforts to understand extracellular biophysical cues have demonstrated the critical roles of ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-018-2008-8
更新日期：2018-06-01 00:00:00
abstract：:Baseball players swung very light and very heavy bats through our instrument and the speed of the bat was recorded. These data were used to make mathematical models for each person. Then these models were coupled with equations of physics for bat-ball collisions to compute the Ideal Bat Weight for each individual. How...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02584443
更新日期：1995-07-01 00:00:00
abstract：:The compression of blood vessels by surrounding tissue is an important problem in hemodynamics, most prominently in studies relating to the heart. In this study we consider a long tube of elliptic cross section as an idealization of the geometry of a compressed blood vessel. An exact solution of the governing equation...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.106
更新日期：1998-09-01 00:00:00
abstract：:The impedance of a monopolar electrode immersed in an environmental volume conductor consists of two parts; the impedance of the active electrode-electrolyte interface, and the resistance of the environmental conductor. Two studies were carried out to quantitate these components. First, impedance-frequency data were c...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02368609
更新日期：1992-01-01 00:00:00
