Abstract：
:We propose a multiphysical mathematical model by fully coupling lipid deposition, monocytes/macrophages recruitment and angiogenesis to investigate the pathophysiological responses of an atherosclerotic plaque to the dynamic changes in the microenvironment. The time evolutions of cellular (endothelial cells, macrophages, smooth muscle cells, etc.) and acellular components (low density lipoprotein, proinflammatory cytokines, extravascular plasma concentration, etc.) within the plaque microenvironment are assessed quantitatively. The thickening of the intima, the distributions of the lipid and inflammatory factors, and the intraplaque hemorrhage show a qualitative consistency with the MRI and histology data. Models with and without angiogenesis are compared to demonstrate the important role of neovasculature in the accumulation of blood-borne components in the atherosclerotic lesion by extravasation from the leaky vessel wall, leading to the formation of a lipid core and an inflammatory microenvironment, which eventually promotes plaque destabilization. This model can serve as a theoretical platform for the investigation of the pathological mechanisms of plaque progression and may contribute to the optimal design of atherosclerosis treatment strategies, such as lipid-lowering or anti-angiogenetic therapies.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Guo M,Cai Y,He C,Li Zdoi
10.1007/s10439-018-02173-1subject
Has Abstractpub_date
2019-02-01 00:00:00pages
439-452issue
2eissn
0090-6964issn
1573-9686pii
10.1007/s10439-018-02173-1journal_volume
47pub_type
杂志文章abstract：:Baseball players swung very light and very heavy bats through our instrument and the speed of the bat was recorded. These data were used to make mathematical models for each person. Then these models were coupled with equations of physics for bat-ball collisions to compute the Ideal Bat Weight for each individual. How...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02584443
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abstract：:Glaucoma is a common optic neuropathy characterized by retinal ganglion cell death. Elevated intraocular pressure (IOP), a key risk factor for glaucoma, leads to significant biomechanical deformation of optic nerve head (ONH) cells and tissues. ONH astrocytes respond to this deformation by transforming to a reactive, ...
journal_title：Annals of biomedical engineering
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更新日期：2018-02-01 00:00:00
abstract：:Identifying the associations between head impact biomechanics and clinical recovery may inform better head impact monitoring procedures and identify athletes who may benefit from early treatments aimed to enhance recovery. The purpose of this study was to test whether head injury biomechanics are associated with clini...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-020-02658-y
更新日期：2020-11-01 00:00:00
abstract：:This study was aimed at developing a physical model, supported by experimental observations, to describe the formation and growth of microbubbles seen in patients with mitral mechanical heart valves (MHV). This phenomenon, often referred to as high intensity transient signals (HITS), appears as bright, intense, high-v...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.231
更新日期：1999-11-01 00:00:00
abstract：:The complexity of the coronary circulation especially in the deep layers largely evades experimental investigations. Hence, virtual/computational models depicting structure-function relation of the entire coronary vasculature including the deep layer are imperative. In order to interpret such anatomically based models...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-007-9278-x
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abstract：:Recent advances in angioplasty have involved the application of polymer coatings to stent surfaces for purposes of drug delivery. Given the high levels of deformation developed in the plastic hinge of a stent during deployment, the achievement of an intact bond between the coating and the stent presents a significant ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-010-9972-y
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abstract：:We present a method for the localized statistical discrimination of class populations based on the Karhunen-Loève and Fukunaga-Koontz transforms. These transforms provide features that model the variance of a sample distribution. The spatial series of a 196 channel epicardial electrogram recording from an arrythmogeni...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
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abstract：:The objective of this study was to develop a ferrocene mediated glucose biosensor for reverse iontophoresis. An amperometric ferrocene mediated glucose biosensor based on a three electrodes planar configuration was constructed using screen printing technique. Different combinations of glucose oxidase and ferrocene loa...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-010-9918-4
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abstract：:In this work, we propose an analog electrical model of the coronary circulation for patients with obstructive disease undergoing revascularization. In this clinical situation, the collateral circulation to the occluded artery is difficult to ascertain via preoperative measurements and well-developed collaterals might ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-008-9500-5
更新日期：2008-07-01 00:00:00
abstract：:Osteoarthritis (OA) is a progressive, degenerative disease of articulating joints that not only affects the elderly, but also involves younger, more active individuals with prolonged participation in high physical-demand activities. Thus, effective therapies that are easy to adopt clinically are critical in limiting t...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-006-9194-5
更新日期：2006-10-01 00:00:00
abstract：:The ability to predict endothelial cell migration rates may aid in the design of biomaterials that endothelialize following implantation. However, the complexity of the signaling response to migration-promoting stimuli such as sphingosine 1-phosphate (S1P) makes such predictions quite challenging. A number of signalin...
journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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doi：10.1007/s10439-012-0651-z
更新日期：2013-02-01 00:00:00
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1007/s10439-016-1563-0
更新日期：2016-09-01 00:00:00
abstract：:The epidermal growth factor (EGF) is a growth factor with effects on many cell types and tissue. Morphometric and passive biomechanical properties were studied in isolated segments of the esophagus in 22 EGF-treated rats and 12 control rats. The rats were divided into groups with EGF treatment for 2, 4, 7, and 14 days...
journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-011-0369-3
更新日期：2011-11-01 00:00:00
abstract：:Although medical specialties have recognized the importance of using ultrasonic imaging, dentistry is only beginning to discover its benefit. This has particularly been important in the field of periodontics which studies infections in the gum and bone tissues that surround the teeth. This study investigates the feasi...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-010-0089-0
更新日期：2010-11-01 00:00:00
abstract：:Vascular smooth muscle mechanics have been studied in vitro in cylindrical segments of dog carotid artery, human internal mammary artery, and human saphenous vein. Such cylindrical preparations maintain normal vessel geometry and also permit correlation of mechanical phenomena with transmural pressure. These studies s...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02363919
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journal_title：Annals of biomedical engineering
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更新日期：2010-07-01 00:00:00
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
pub_type： 临床试验,杂志文章
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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doi：10.1114/1.1541014
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abstract：:The linear homeomorphic muscle model proposed by Enderle and coworkers for the rectus eye muscle is fitted to reflect the dynamics of muscles in the head-neck complex, specifically in muscles involved in gaze shifts. This parameterization of the model for different muscles in the neck region will serve to drive a 3D d...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
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