A numerical analysis of factor X activation in the presence of tissue factor--factor VIIa complex in a flow reactor.

abstract：:Similarities between photoreceptor Kx channels and EAG and KCNQ channels suggest that the Kx channel may be related to one or both of these families of potassium channels. To provide a basis for further comparison of these channels, as well as to reveal the role of zinc (endogenously present in photoreceptors) in Kx c...

journal_title：Annals of biomedical engineering

authors： Kourennyi DE,Liu X,Barnes S

更新日期：2002-01-01 00:00:00

abstract：:Bone loss during long-term space flight is potentially a significant problem. Bone mineral density measurements show that bone is lost at a rate of about 1% per month from the lumbar spine, and 1.5% per month from the hip. Bone density changes are not uniform throughout the skeleton, and there is accumulating evidence...

journal_title：Annals of biomedical engineering

authors： McCarthy ID

更新日期：2005-01-01 00:00:00

abstract：:The purpose of the study was to examine the effects of arterial coculture conditions on the transport properties of several in vitro endothelial cell (EC)-smooth muscle cell (SMC)-porous filter constructs in which SMC were grown to confluence first and then EC were inoculated. This order of culturing simulates the env...

journal_title：Annals of biomedical engineering

authors： Mathura RA,Russell-Puleri S,Cancel LM,Tarbell JM

更新日期：2016-05-01 00:00:00

abstract：:We propose a novel method to reconstruct the hypothetical geometry of the healthy vasculature prior to intracranial aneurysm (IA) formation: a Frenet frame is calculated along the skeletonization of the arterial geometry; upstream and downstream boundaries of the aneurysmal segment are expressed in terms of the local ...

journal_title：Annals of biomedical engineering

authors： Chen H,Selimovic A,Thompson H,Chiarini A,Penrose J,Ventikos Y,Watton PN

更新日期：2013-07-01 00:00:00

abstract：:Microfluidic devices aim at miniaturizing, automating, and lowering the cost of chemical and biological sample manipulation and detection, hence creating new opportunities for lab-on-a-chip platforms. Recently, optofluidic devices have also emerged where optics is used to enhance the functionality and the performance ...

journal_title：Annals of biomedical engineering

authors： Bishara W,Isikman SO,Ozcan A

更新日期：2012-02-01 00:00:00

abstract：:Förster resonance energy transfer (FRET) technology has been widely used in biological and biomedical research and is a very powerful tool in elucidating protein interactions in many cellular processes. Ubiquitination and SUMOylation are multi-step cascade reactions, involving multiple enzymes and protein-protein inte...

journal_title：Annals of biomedical engineering

authors： Song Y,Madahar V,Liao J

更新日期：2011-04-01 00:00:00

abstract：:Wiener static nonlinear system identification was used to study the linear dynamics and static nonlinearities in the response of skin and underlying tissue under indentation in vivo. A device capable of measuring the dynamic mechanical properties of bulk skin tissue was developed and it incorporates a custom-built Lor...

journal_title：Annals of biomedical engineering

authors： Chen Y,Hunter IW

更新日期：2012-10-01 00:00:00

abstract：:A comparison was made between turbulence calculated by subtracting an ensemble average from the instantaneous velocity and calculations made with a high pass digital filter. Velocity was measured with a laser Doppler anemometer in vitro in the region of a normal porcine aortic valve and in patients with a hot film ane...

journal_title：Annals of biomedical engineering

authors： Walburn FJ,Sabbah HN,Stein PD

更新日期：1983-01-01 00:00:00

abstract：:There is a significant clinical need for engineered bone graft substitutes that can quickly, effectively, and safely repair large segmental bone defects. One emerging field of interest involves the growth of engineered bone tissue in vitro within bioreactors, the most promising of which are perfusion bioreactors. Usin...

journal_title：Annals of biomedical engineering

authors： Ball O,Nguyen BB,Placone JK,Fisher JP

更新日期：2016-12-01 00:00:00

abstract：:Cochlear implantation consists in electrically stimulating the auditory nerve by inserting an electrode array inside the cochlea, a bony structure of the inner ear. In the absence of any visual feedback, the insertion results in many cases of damages of the internal structures. This paper presents a feasibility study ...

journal_title：Annals of biomedical engineering

authors： Lavenir L,Zemiti N,Akkari M,Subsol G,Venail F,Poignet P

更新日期：2020-10-30 00:00:00

abstract：:Spine musculoskeletal models used to estimate loads and displacements require many simplifying assumptions. We examined how assumptions about subject size and vertebral positions can affect the model outcomes. Head and neck models were developed to represent 30 subjects (15 males and 15 females) in neutral posture and...

journal_title：Annals of biomedical engineering

authors： Vasavada AN,Hughes E,Nevins DD,Monda SM,Lin DC

更新日期：2018-11-01 00:00:00

abstract：:To better understand oxygen utilization by the retina, a mathematical model of oxygen diffusion and consumption in the cat outer, avascular retina was developed by analyzing previously recorded profiles of oxygen tension (PO2) as a function of retinal depth. Simple diffusion modelling of the oxygen distribution throug...

journal_title：Annals of biomedical engineering

authors： Haugh LM,Linsenmeier RA,Goldstick TK

更新日期：1990-01-01 00:00:00

abstract：:Our 3-D model for a junctional complex (JC) in the erythrocyte membrane skeleton proposed that the helical actin protofilament functions as a mechanical axis for three pairs of αβ spectrin (Sp), and each pair wraps around the protofilament in a back-to-back fashion. The distal end of each Sp is further associated with...

journal_title：Annals of biomedical engineering

authors： Sche P,Vera C,Sung LA

更新日期：2011-07-01 00:00:00

abstract：:Identifying the associations between head impact biomechanics and clinical recovery may inform better head impact monitoring procedures and identify athletes who may benefit from early treatments aimed to enhance recovery. The purpose of this study was to test whether head injury biomechanics are associated with clini...

journal_title：Annals of biomedical engineering

authors： Mihalik JP,Chandran A,Powell JR,Roby PR,Guskiewicz KM,Stemper BD,Shah AS,Rowson S,Duma S,Harezlak J,Riggen L,Broglio SP,McAllister TW,McCrea M,CARE Consortium Investigators.

更新日期：2020-11-01 00:00:00

abstract：:Defining the constituent regulatory molecules in tendon is critical to understanding the process of tendon repair and instructive to the development of novel treatment modalities. The purpose of this study is to define the structural, expressional, and mechanical changes in the tendon injury response, and elucidate th...

journal_title：Annals of biomedical engineering

authors： Dunkman AA,Buckley MR,Mienaltowski MJ,Adams SM,Thomas SJ,Satchell L,Kumar A,Pathmanathan L,Beason DP,Iozzo RV,Birk DE,Soslowsky LJ

更新日期：2014-03-01 00:00:00

abstract：:Spike discharge patterns showing intrinsic oscillations (IOs) have been reported in units in the dorsal cochlear nucleus (DCN) of the decerebrate cat. These oscillations are related to the regularity of a unit's discharge rate and may be important for pitch perception. A DCN unit's regularity can be affected by severa...

journal_title：Annals of biomedical engineering

authors： Gdowski GT,Voigt HF

更新日期：1998-05-01 00:00:00

abstract：:There are recent reports of hybrid tissue-fabric materials with good performance-high biocompatibility and high mechanical strength. In this study, we demonstrate the capability of a hybrid material as a long-term filter for blood proteins. Polyester fabrics were implanted into rats to fabricate hybrid tissue-fabric m...

journal_title：Annals of biomedical engineering

authors： Inoue Y,Yokota T,Sekitani T,Kaneko A,Woo T,Kobayashi S,Shibuya T,Tanaka M,Kosukegawa H,Saito I,Isoyama T,Abe Y,Yambe T,Someya T,Sekino M

更新日期：2017-05-01 00:00:00

abstract：:Abdominal aortic aneurysms occur in as much as 2-3% of the population, and their rupture produces a mortality rate of 78-94% (1), causing 15,000 deaths per year in the U.S. alone. As an investigation into the mechanical factors that lead to aneurysm rupture, flow field measurements are presented for steady flow throug...

journal_title：Annals of biomedical engineering

authors： Asbury CL,Ruberti JW,Bluth EI,Peattie RA

更新日期：1995-01-01 00:00:00

abstract：:Quantifying injury tolerance for concussion is complicated by variability in the type, severity, and time course of post-injury physiological and behavioral changes. The current study outlined acute and chronic changes in behavioral metrics following rotational acceleration-induced concussion in rats. The Medical Coll...

journal_title：Annals of biomedical engineering

authors： Stemper BD,Shah AS,Chiariello R,Olsen CM,Budde MD,Glavaski-Joksimovic A,McCrea M,Kurpad SN,Pintar FA

更新日期：2016-11-01 00:00:00

abstract：:There has been considerable debate on the relative importance of biochemical stimuli and mechanical deformation in neutrophil adhesion in lung capillaries, a process observed following bacterial infection in the body. In contrast to venules, where the vessel diameter is larger than the leukocyte diameter (6-9 microm) ...

journal_title：Annals of biomedical engineering

authors： Pai A,Sundd P,Tees DF

更新日期：2008-04-01 00:00:00

abstract：:The Veterans Health Administration determined that over 250,000 U.S. service members were diagnosed with a traumatic brain injury (TBI) between 2008 and 2018, of which a great proportion were due to blast exposure. Although the penetrating (secondary) and inertia-driven (tertiary) phases of blast-induced TBI (bTBI) ha...

journal_title：Annals of biomedical engineering

authors： Vogel EW 3rd,Panzer MB,Morales FN,Varghese N,Bass CR,Meaney DF,Morrison B 3rd

更新日期：2020-04-01 00:00:00

abstract：:A wide range of length and time scales are relevant to pharmacology, especially in drug development, drug design and drug delivery. Therefore, multiscale computational modeling and simulation methods and paradigms that advance the linkage of phenomena occurring at these multiple scales have become increasingly importa...

journal_title：Annals of biomedical engineering

authors： Clancy CE,An G,Cannon WR,Liu Y,May EE,Ortoleva P,Popel AS,Sluka JP,Su J,Vicini P,Zhou X,Eckmann DM

更新日期：2016-09-01 00:00:00

abstract：:An algorithm to track a rat swimming in a Morris Water Maze has been developed. The system is automatically configured to any pool and relative suitable light conditions. It tracks the rat's position and head pose 10 times per second. The output data is displayed in a bitmap and also in a text file. The system was tes...

journal_title：Annals of biomedical engineering

authors： Hval ES,Barrett SF,Wilcox M,Bailey TA

更新日期：2004-08-01 00:00:00

abstract：:The field of percutaneous coronary intervention has witnessed many progressions over the last few decades, more recently with the advancement of fully degradable bioabsorbable stents. Bioabsorbable materials, such as metallic alloys and aliphatic polyesters, have the potential to yield stents which provide temporary s...

journal_title：Annals of biomedical engineering

authors： Boland EL,Shine R,Kelly N,Sweeney CA,McHugh PE

更新日期：2016-02-01 00:00:00

abstract：:This paper describes the development and use of a direct compression stimulator for culturing explants from the meniscus of the knee and articular cartilage. Following design and fabrication of the instrument along with its data acquisition system, the function of the machine was verified by both mechanical means and ...

journal_title：Annals of biomedical engineering

authors： Aufderheide AC,Athanasiou KA

更新日期：2006-09-01 00:00:00

abstract：:Recent studies suggest that vortex ring formation during left ventricular (LV) rapid filling is an optimized mechanism for blood transport, and that the volume of the vortex ring is an important measure. However, due to lack of quantitative methods, the volume of the vortex ring has not previously been studied. Lagran...

journal_title：Annals of biomedical engineering

authors： Töger J,Kanski M,Carlsson M,Kovács SJ,Söderlind G,Arheden H,Heiberg E

更新日期：2012-12-01 00:00:00

abstract：:Kiani et al. (Kiani, M. F., A. R. Pries, L. L. Hsu, I. H. Sarelius, and G. R. Cokelet, Am. J. Physics. 266: H1822-H1828, 1994) suggested that blood velocity, hematocrit, and nodal pressures can oscillate spontaneously in large microvascular networks in the absence of biological control. This paper presents a model of ...

journal_title：Annals of biomedical engineering

authors： Carr RT,Lacoin M

更新日期：2000-06-01 00:00:00

abstract：:Mechanical cues arising from extracellular matrices greatly affect cellular properties, and hence, are of significance in designing biomaterials. In this study, a DNA crosslinked hydrogel was employed to examine cellular responses of spinal cord neurons to substrate compliances. Using DNA as crosslinkers in polymeric ...

journal_title：Annals of biomedical engineering

authors： Jiang FX,Yurke B,Firestein BL,Langrana NA

更新日期：2008-09-01 00:00:00

abstract：:Measurement of the instantaneous pressure-volume relationship of the left ventricle is fundamental to the study of ventricular mechanics. In order to effectively investigate this relationship, it is necessary to vary and control the time course of ventricular volume change in a variety of prescribed manners. In the pa...

journal_title：Annals of biomedical engineering

authors： Sunagawa K,Lim KO,Burkhoff D,Sagawa K

更新日期：1982-01-01 00:00:00

abstract：:The traditional auscultatory technique and current methodologies for measuring human blood pressure are limited when used in situations where extreme vibration or acoustic noise is present. In this study, human subjects were used to establish the effectiveness of a novel adaptive blood pressure monitoring (ABPM) syste...

journal_title：Annals of biomedical engineering

authors： Pinto L,Dhanantwari A,Wong W,Stergiopoulos S,Maris M

更新日期：2002-05-01 00:00:00