Abstract:
:We propose a novel method to reconstruct the hypothetical geometry of the healthy vasculature prior to intracranial aneurysm (IA) formation: a Frenet frame is calculated along the skeletonization of the arterial geometry; upstream and downstream boundaries of the aneurysmal segment are expressed in terms of the local Frenet frame basis vectors; the hypothetical healthy geometry is then reconstructed by propagating a closed curve along the skeleton using the local Frenet frames so that the upstream boundary is smoothly morphed into the downstream boundary. This methodology takes into account the tortuosity of the arterial vasculature and requires minimal user subjectivity. The method is applied to 22 clinical cases depicting IAs. Computational fluid dynamic simulations of the vasculature without IA are performed and the haemodynamic stimuli in the location of IA formation are examined. We observe that locally elevated wall shear stress (WSS) and gradient oscillatory number (GON) are highly correlated (20/22 for WSS and 19/22 for GON) with regions susceptible to sidewall IA formation whilst haemodynamic indices associated with the oscillation of the WSS vectors have much lower correlations.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Chen H,Selimovic A,Thompson H,Chiarini A,Penrose J,Ventikos Y,Watton PNdoi
10.1007/s10439-013-0794-6subject
Has Abstractpub_date
2013-07-01 00:00:00pages
1492-504issue
7eissn
0090-6964issn
1573-9686journal_volume
41pub_type
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