Second harmonic generation imaging and Fourier transform spectral analysis reveal damage in fatigue-loaded tendons.

abstract：:Despite cellular environments having dynamic characteristics, many laboratories utilized static polyacrylamide hydrogels to study the ECM-cell relationship. To attain a more in vivo like environment, we have developed a dynamic, DNA-crosslinked hydrogel (DNA gel). Through the controlled delivery of DNA, we can tempora...

journal_title：Annals of biomedical engineering

authors： Previtera ML,Trout KL,Verma D,Chippada U,Schloss RS,Langrana NA

更新日期：2012-05-01 00:00:00

abstract：:Normal physiological mechanical forces cause constant tissue renewal in aortic valve leaflets (AVL) while altered mechanical forces incite changes in their structural and biological properties. The current study aims at characterizing the remodeling properties of AVL subjected to cyclic circumferential stretch in a st...

journal_title：Annals of biomedical engineering

authors： Balachandran K,Konduri S,Sucosky P,Jo H,Yoganathan AP

更新日期：2006-11-01 00:00:00

abstract：:Dendritic cells (DCs) are crucial components of the immune response, strategically positioned as immune sentinels. Complex trafficking and accurate positioning of DCs are indispensable for both immunity and tolerance. This is particularly evident for their therapeutic application where an unmet clinical need exists fo...

journal_title：Annals of biomedical engineering

authors： Silva Z,Konstantopoulos K,Videira PA

更新日期：2012-04-01 00:00:00

abstract：:The toxic or therapeutic effect of an inhaled aerosol is highly dependent upon the site and extent of deposition in the lung. A novel MRI-based method was used to quantify the spatial distribution of particles in the rat lung. Rats were exposed to 0.95 μm-diameter iron oxide particles in a controlled manner (N = 6) or...

journal_title：Annals of biomedical engineering

authors： Oakes JM,Scadeng M,Breen EC,Prisk GK,Darquenne C

更新日期：2013-05-01 00:00:00

abstract：:Concussion tolerance and head impact exposure are highly variable among football players. Recent findings highlight that head impact data analyses need to be performed at the subject level. In this paper, we describe a method of characterizing concussion risk between individuals using a new survival analysis technique...

journal_title：Annals of biomedical engineering

authors： Rowson S,Campolettano ET,Duma SM,Stemper B,Shah A,Harezlak J,Riggen L,Mihalik JP,Brooks A,Cameron KL,Svoboda SJ,Houston MN,McAllister T,Broglio S,McCrea M

更新日期：2020-11-01 00:00:00

abstract：:Intracellular calcium concentration and transmembrane potentials are two important measurements used to study the mechanisms of cardiac activity. Fluorescent dyes have been used to measure these separately but not simultaneously in cardiac tissue. Fluo-3 and Fluo-4 (a recently improved version of Fluo-3) have been use...

journal_title：Annals of biomedical engineering

authors： Johnson PL,Smith W,Baynham TC,Knisley SB

更新日期：1999-07-01 00:00:00

abstract：:Phospholipids have been identified by thin-layer chromatography in appreciable quantities in pericardial fluid taken from 12 dogs and found to include sphingomyelin and phosphatidylcholines, -ethanolamines, -inositols and -serines--the cholines predominating. The extracts, the synthetic surfactants and a mixture of sy...

journal_title：Annals of biomedical engineering

authors： Hills BA,Butler BD

更新日期：1985-01-01 00:00:00

abstract：:When cells and the matrix of a tissue remodel, the mechanical properties of the tissue do change. The mechanical properties are expressed by constitutive equations. In this article the remodeling of the constitutive equation of the pulmonary artery is studied. The remodeling was induced in a rat breathing a gas whose ...

journal_title：Annals of biomedical engineering

authors： Huang W,Delgado-West D,Wu JT,Fung YC

更新日期：2001-01-01 00:00:00

abstract：:Defibrillation efficacy testing is a common procedure at defibrillator implantation, with the objective to ensure that each patient receives a system with adequate shock efficacy. In this study, defibrillation shock efficacy as a function of shock energy was modeled by a dose response relationship. The frequency distr...

journal_title：Annals of biomedical engineering

authors： Smits K,Virag N

更新日期：2010-04-01 00:00:00

abstract：:Three animal models were evaluated in this study involving head impacts of the rat, including the Marmarou drop-weight and two momentum-exchange techniques. In series 1, 36 Wistar rats were hit on the side of the free-moving head using Marmarou's 450 g impact mass at 4.4, 5.4, and 6.3 m/s. Head acceleration was measur...

journal_title：Annals of biomedical engineering

authors： Viano DC,Hamberger A,Bolouri H,Säljö A

更新日期：2012-01-01 00:00:00

abstract：:Rupture of abdominal aortic aneurysm (AAA) is associated with high mortality rates. Risk of rupture is multi-factorial involving AAA geometric configuration, vessel tortuosity, and the presence of intraluminal pathology. Fluid structure interaction (FSI) simulations were conducted in patient based computed tomography ...

journal_title：Annals of biomedical engineering

authors： Xenos M,Labropoulos N,Rambhia S,Alemu Y,Einav S,Tassiopoulos A,Sakalihasan N,Bluestein D

更新日期：2015-01-01 00:00:00

abstract：:This study evaluates the use of artificial neural networks to estimate stroke volume from pre-processed, thoracic impedance plethysmograph signals from 20 healthy subjects. Standard back-propagation was used to train the networks, with Doppler stroke volume estimates as the desired output. The trained networks were th...

journal_title：Annals of biomedical engineering

authors： Mulavara AP,Timmons WD,Nair MS,Gupta V,Kumar AA,Taylor BC

更新日期：1998-07-01 00:00:00

abstract：:A two-dimensional sheet model was used to study the dynamics of reentry around a zone of functional block. The sheet is a set of parallel, continuous, and uniform cables, transversely interconnected by a brick-wall arrangement of fixed resistors. In accord with experimental observations on cardiac tissue, longitudinal...

journal_title：Annals of biomedical engineering

authors： Leon LJ,Roberge FA,Vinet A

更新日期：1994-11-01 00:00:00

abstract：:To meet demands of vascular reconstruction, there is a need for prosthetic alternatives to natural blood vessels. Here we explored a new conduit fabrication approach. Macroporous, gelatin microcarriers laden with human umbilical vein endothelial cells and aortic smooth muscle cells were dispensed into tubular agarose ...

journal_title：Annals of biomedical engineering

authors： Twal WO,Klatt SC,Harikrishnan K,Gerges E,Cooley MA,Trusk TC,Zhou B,Gabr MG,Shazly T,Lessner SM,Markwald RR,Argraves WS

更新日期：2014-07-01 00:00:00

abstract：:Opportunities to provide clinical immersion experiences to bioengineering undergraduate students have expanded over the last several years. These programs allow students to observe the clinical environment in order to better understand workflow processes, the context in which medical equipment is used, and identify un...

journal_title：Annals of biomedical engineering

authors： Kotche M,Felder AE,Wilkens K,Stirling S

更新日期：2020-09-01 00:00:00

abstract：:Depending on the duration of exposure to supraphysiological temperatures, cellular proteins and organelles can suffer from structural alternations and irreversible denaturation, which may induce cell death. The thermotolerance of three human urinary bladder carcinoma cell lines, TSGH-8301, J82 and TCC-SUP (cytological...

journal_title：Annals of biomedical engineering

authors： Jen CP,Huang CT,Tsai CH

更新日期：2009-11-01 00:00:00

abstract：:This study was aimed at developing a physical model, supported by experimental observations, to describe the formation and growth of microbubbles seen in patients with mitral mechanical heart valves (MHV). This phenomenon, often referred to as high intensity transient signals (HITS), appears as bright, intense, high-v...

journal_title：Annals of biomedical engineering

authors： Rambod E,Beizaie M,Shusser M,Milo S,Gharib M

更新日期：1999-11-01 00:00:00

abstract：:During the fetal-to-neonatal transition, transvalvular pressures (TVPs) on the aortic and pulmonary valves change dramatically-but differently for each valve. We have examined changes in the molecular stability and crosslinking of collagen during this transition. Aortic and pulmonary valves were harvested from fetal a...

journal_title：Annals of biomedical engineering

authors： Aldous IG,Lee JM,Wells SM

更新日期：2010-09-01 00:00:00

abstract：:Numerical models of the mitral valve have been used to elucidate mitral valve function and mechanics. These models have evolved from simple two-dimensional approximations to complex three-dimensional fully coupled fluid structure interaction models. However, to date these models lack direct one-to-one experimental val...

journal_title：Annals of biomedical engineering

authors： Rabbah JP,Saikrishnan N,Yoganathan AP

更新日期：2013-02-01 00:00:00

abstract：:The great success of stents in treating cardiovascular disease is actually undermined by their long-term fatigue failure. The high variability of stent failure incidence suggests that it is due to several correlated aspects, such as loading conditions, material properties, component design, surgical procedure, and pat...

journal_title：Annals of biomedical engineering

authors： Auricchio F,Constantinescu A,Conti M,Scalet G

更新日期：2016-02-01 00:00:00

abstract：:Biomaterial-based tissue engineering strategies hold great promise for osteochondral tissue repair. Yet significant challenges remain in joining highly dissimilar materials to achieve a biomimetic, mechanically robust design for repairing interfaces between soft tissue and bone. This study sought to improve interfacia...

journal_title：Annals of biomedical engineering

authors： Kinneberg KR,Nelson A,Stender ME,Aziz AH,Mozdzen LC,Harley BA,Bryant SJ,Ferguson VL

更新日期：2015-11-01 00:00:00

abstract：:A role for mechanical stimulation in the control of cell fate has been proposed and mechanical conditioning of mesenchymal stem cells (MSCs) is of interest in directing MSC behavior for tissue engineering applications. This study investigates strain-induced differentiation and proliferation of MSCs, and investigates t...

journal_title：Annals of biomedical engineering

authors： Kearney EM,Farrell E,Prendergast PJ,Campbell VA

更新日期：2010-05-01 00:00:00

abstract：:We examine the influence of the added mass effect (fluid inertia) on mitral valve leaflet stress during isovolumetric phases. To study this effect, oscillating flow is applied to a flexible membrane at various frequencies to control inertia. Resulting membrane strain is calculated through a three-dimensional reconstru...

journal_title：Annals of biomedical engineering

authors： Bark DL Jr,Dasi LP

更新日期：2016-05-01 00:00:00

abstract：:A mathematical model of heat, water and soluble gas exchange in the airways and alveoli was used to predict the location of soluble gas exchange in the lung. A previously published model of heat, water and soluble gas exchange in the airways was improved by incorporating anatomical data on the airway wall to better de...

journal_title：Annals of biomedical engineering

authors： Anderson JC,Babb AL,Hlastala MP

更新日期：2003-12-01 00:00:00

abstract：:Bone loss during long-term space flight is potentially a significant problem. Bone mineral density measurements show that bone is lost at a rate of about 1% per month from the lumbar spine, and 1.5% per month from the hip. Bone density changes are not uniform throughout the skeleton, and there is accumulating evidence...

journal_title：Annals of biomedical engineering

authors： McCarthy ID

更新日期：2005-01-01 00:00:00

abstract：:Recent studies suggest that vortex ring formation during left ventricular (LV) rapid filling is an optimized mechanism for blood transport, and that the volume of the vortex ring is an important measure. However, due to lack of quantitative methods, the volume of the vortex ring has not previously been studied. Lagran...

journal_title：Annals of biomedical engineering

authors： Töger J,Kanski M,Carlsson M,Kovács SJ,Söderlind G,Arheden H,Heiberg E

更新日期：2012-12-01 00:00:00

abstract：:Phenotype transformation of vascular smooth muscle cells (VSMCs) has been reported to be directly influenced by the frequency of mechanical strain. This study explored the effects of different frequencies of mechanical strain on expression of phenotype marker h1-calponin and the possible mechanism. VSMCs were subjecte...

journal_title：Annals of biomedical engineering

authors： Qu MJ,Liu B,Qi YX,Jiang ZL

更新日期：2008-09-01 00:00:00

abstract：:Skeletal muscles can be injured by their own contractions. Such contraction-induced injury, often accompanied by delayed onset of muscle soreness, is a leading cause of the loss of mobility in the rapidly increasing population of elderly people. Unlike other types of muscle injuries which hurt almost exclusively those...

journal_title：Annals of biomedical engineering

authors： Givli S

更新日期：2015-02-01 00:00:00

abstract：:Cochlear implantation consists in electrically stimulating the auditory nerve by inserting an electrode array inside the cochlea, a bony structure of the inner ear. In the absence of any visual feedback, the insertion results in many cases of damages of the internal structures. This paper presents a feasibility study ...

journal_title：Annals of biomedical engineering

authors： Lavenir L,Zemiti N,Akkari M,Subsol G,Venail F,Poignet P

更新日期：2020-10-30 00:00:00

abstract：:Continuum-level finite element models (FEMs) of the humerus offer the ability to evaluate joint replacement designs preclinically; however, experimental validation of these models is critical to ensure accuracy. The objective of the current study was to quantify experimental full-field strain magnitudes within osteoar...

journal_title：Annals of biomedical engineering

authors： Kusins J,Knowles N,Columbus M,Oliviero S,Dall'Ara E,Athwal GS,Ferreira LM

更新日期：2020-12-01 00:00:00