A review of return to play issues and sports-related concussion.

abstract：:Congenital heart disease is the leading cause of infant death in the United States with over 36,000 newborns affected each year. Despite this growing problem there are few mechanical circulatory support devices designed specifically for pediatric and neonate patients. Previous research has been done investigating pedi...

journal_title：Annals of biomedical engineering

authors： Good BC,Deutsch S,Manning KB

更新日期：2016-04-01 00:00:00

abstract：:For highly diffusive solutes the kinetics of blood-tissue exchange is only poorly represented by a model consisting of sets of independent parallel capillary-tissue units. We constructed a more realistic multicapillary network model conforming statistically to morphometric data. Flows through the tortuous paths in the...

journal_title：Annals of biomedical engineering

authors： Beard DA,Bassingthwaighte JB

更新日期：2000-03-01 00:00:00

abstract：:Currently, autologous cartilage provides the gold standard for auricular reconstruction. However, synthetic biomaterials offer a number of advantages for ear reconstruction including decreased donor site morbidity and earlier surgery. Critical to implant success is the material's mechanical properties as this affects ...

journal_title：Annals of biomedical engineering

authors： Griffin MF,Premakumar Y,Seifalian AM,Szarko M,Butler PE

更新日期：2016-12-01 00:00:00

abstract：:Statistical methods are increasingly used in biomechanics for studying bone geometry, bone density distribution and function in the population. However, relating population-based bone variation to strain during activity is computationally challenging. Here, we describe a new method for calculating strain in a populati...

journal_title：Annals of biomedical engineering

authors： Ziaeipoor H,Taylor M,Martelli S

更新日期：2020-06-01 00:00:00

abstract：:In an effort to share best practices in undergraduate engineering design education, we describe the origin, evolution and the current status of the undergraduate biomedical engineering design team program at Johns Hopkins University. Specifically, we describe the program and judge the quality of the pedagogy by relati...

journal_title：Annals of biomedical engineering

authors： Allen RH,Acharya S,Jancuk C,Shoukas AA

更新日期：2013-09-01 00:00:00

abstract：:The relationship between laboratory and on-field performance of football helmets was assessed for 31 football helmet models selected from those worn by players in the 2015-2019 National Football League (NFL) seasons. Linear impactor tests were conducted with helmets placed on an instrumented Hybrid III head and neck a...

journal_title：Annals of biomedical engineering

authors： Bailey AM,McMurry TL,Cormier JM,Funk JR,Crandall JR,Mack CD,Myers BS,Arbogast KB

更新日期：2020-11-01 00:00:00

abstract：:We propose a multiphysical mathematical model by fully coupling lipid deposition, monocytes/macrophages recruitment and angiogenesis to investigate the pathophysiological responses of an atherosclerotic plaque to the dynamic changes in the microenvironment. The time evolutions of cellular (endothelial cells, macrophag...

journal_title：Annals of biomedical engineering

authors： Guo M,Cai Y,He C,Li Z

更新日期：2019-02-01 00:00:00

abstract：:Mechanical interactions during angiogenesis, i.e., traction applied by neovessels to the extracellular matrix and the corresponding deformation, are important regulators of growth and neovascularization. We have previously designed, implemented, and validated a coupled model of angiogenesis in which a discrete microve...

journal_title：Annals of biomedical engineering

authors： Edgar LT,Hoying JB,Weiss JA

更新日期：2015-07-01 00:00:00

abstract：:Spike discharge patterns showing intrinsic oscillations (IOs) have been reported in units in the dorsal cochlear nucleus (DCN) of the decerebrate cat. These oscillations are related to the regularity of a unit's discharge rate and may be important for pitch perception. A DCN unit's regularity can be affected by severa...

journal_title：Annals of biomedical engineering

authors： Gdowski GT,Voigt HF

更新日期：1998-05-01 00:00:00

abstract：:Recent developments in computational modeling of cochlear implantation are promising to study in silico the performance of the implant before surgery. However, creating a complete computational model of the patient's anatomy while including an external device geometry remains challenging. To address such a challenge, ...

journal_title：Annals of biomedical engineering

authors： Mangado N,Ceresa M,Duchateau N,Kjer HM,Vera S,Dejea Velardo H,Mistrik P,Paulsen RR,Fagertun J,Noailly J,Piella G,González Ballester MÁ

更新日期：2016-08-01 00:00:00

abstract：:Extraction of the cardiac surfaces of interest from multi-detector computed tomographic (MDCT) data is a pre-requisite step for cardiac analysis, as well as for image guidance procedures. Most of the existing methods need manual corrections, which is time-consuming. We present a fully automatic segmentation technique ...

journal_title：Annals of biomedical engineering

authors： Antunes S,Esposito A,Palmisano A,Colantoni C,Cerutti S,Rizzo G

更新日期：2016-05-01 00:00:00

abstract：:Development of increasingly complex integrated cellular systems will be a major challenge for the next decade and beyond, as we apply the knowledge gained from the sub-disciplines of regenerative medicine, synthetic biology, micro-fabrication and nanotechnology, systems biology, and developmental biology. In this pros...

journal_title：Annals of biomedical engineering

authors： Kamm RD,Bashir R

更新日期：2014-02-01 00:00:00

abstract：:The identification of the input to, or kernels of, a system using nonparametric representations and least-squares estimation is becoming increasingly popular. Nonparametric representations avoid making a priori assumptions about the input or having detailed knowledge about the system, and only need to guarantee known ...

journal_title：Annals of biomedical engineering

authors： Verotta D

更新日期：1998-09-01 00:00:00

abstract：:It is widely recognized that the bacteria sequestered in a biofilm on a medical implant are much more resistant to antibiotics than their planktonic counterparts. Recent studies have shown that application of antibiotic along with low power ultrasound significantly increases the killing of planktonic bacteria by the a...

journal_title：Annals of biomedical engineering

authors： Qian Z,Sagers RD,Pitt WG

更新日期：1997-01-01 00:00:00

abstract：:Microfluidic devices fabricated using poly(dimethylsiloxane) (PDMS) polymer are routinely used for in vitro cell culture for a wide range of cellular assays. These assays typically involve the incubation of cultured cells with a drug molecule or a fluorescent marker while monitoring a cellular response. The accuracy o...

journal_title：Annals of biomedical engineering

authors： Wang JD,Douville NJ,Takayama S,ElSayed M

更新日期：2012-09-01 00:00:00

abstract：:Cell migration is a fundamental process that is crucial to a variety of physiological events. While traditional approaches have focused on two-dimensional (2D) systems, recent efforts have shifted to studying migration in three-dimensional (3D) matrices. A major distinction that has emerged is the increased importance...

journal_title：Annals of biomedical engineering

authors： Harjanto D,Zaman MH

更新日期：2010-05-01 00:00:00

abstract：:The purpose of this study is to measure the transmural pressure-cross sectional area relation of micro tubes (240 microns diameter) and to compare the measured perfusion pressure-flow relation with the pressure-flow relation calculated from the experimental pressure-cross sectional area relation. The microtubes are ma...

journal_title：Annals of biomedical engineering

authors： Sipkema P,Westerhof N

更新日期：1989-01-01 00:00:00

abstract：:The influence of scaffold compliance on blood vessel tissue engineering remains unclear and compliance mismatch issues are important to an in vivo tissue-engineering approach. We have designed and constructed a modular bioreactor system that is capable of imparting pulsatile fluid flow while simultaneously measuring v...

journal_title：Annals of biomedical engineering

authors： Webb AR,Macrie BD,Ray AS,Russo JE,Siegel AM,Glucksberg MR,Ameer GA

更新日期：2007-08-01 00:00:00

abstract：:The false vocal folds are believed to be components of the acoustic filter that is responsible for shaping the voice. However, the effects of false vocal folds on the vocal fold vibration and the glottal aerodynamic during phonation remain unclear. This effect has implications for computational modeling of phonation a...

journal_title：Annals of biomedical engineering

authors： Zheng X,Bielamowicz S,Luo H,Mittal R

更新日期：2009-03-01 00:00:00

abstract：:Rapid screening of biomarkers, with high specificity and accuracy, is critical for many point-of-care diagnostics. Microfluidics, the use of microscale channels to manipulate small liquid samples and carry reactions in parallel, offers tremendous opportunities to address fundamental questions in biology and provide a ...

journal_title：Annals of biomedical engineering

authors： Ng E,Chen K,Hang A,Syed A,Zhang JX

更新日期：2016-04-01 00:00:00

abstract：:In this paper, an intelligent proportional-integral-derivative (PID) control method is introduced to the robotic testing system for the biomechanical study of human musculoskeletal joints. For the testing system, the robot is a highly nonlinear and heavily coupled complicated system, and the human spinal specimen also...

journal_title：Annals of biomedical engineering

authors： Tian L

更新日期：2004-06-01 00:00:00

abstract：:Pathologic vascular adaptation following local injury is the primary driver for accelerated intimal hyperplasia and an occlusive phenotype. Smooth muscle cell (SMC) proliferation within the wall, and migration into the developing intima, is a major component of this remodeling response. The primary objective in the cu...

journal_title：Annals of biomedical engineering

authors： Klein B,Destephens A,Dumeny L,Hu Q,He Y,O'Malley K,Jiang Z,Tran-Son-Tay R,Berceli S

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:This work explores for the first time the effects of temperature increments on the development of high shear stresses between plaque and arterial wall due to their different dilatational properties. Data from the literature report febrile reactions prior to myocardial infarction in patients with normal coron...

journal_title：Annals of biomedical engineering

authors： Guinea GV,Atienza JM,Fantidis P,Rojo FJ,Ortega A,Torres M,Gonzalez P,Elices ML,Hayashi K,Elices M

更新日期：2008-01-01 00:00:00

abstract：:Abnormal scapular movement is widely believed to be an important factor in clinical pathology of the shoulder joint complex. Validated non-invasive techniques for measuring scapular movement have been developed, but the effect of marker placement on accuracy is unknown. The objective of this study was to determine the...

journal_title：Annals of biomedical engineering

authors： Bourne DA,Choo AM,Regan WD,MacIntyre DL,Oxland TR

更新日期：2011-02-01 00:00:00

abstract：:In vitro stent-induced thromboembolism was altered by the presence of residual stenoses placed upstream or placed upstream and downstream of the stent. Heparinized (3 micro/ml) bovine blood was gravity fed through a conduit with a deployed coronary stent. Embolism was continuously monitored using a light-scattering mi...

journal_title：Annals of biomedical engineering

authors： Sukavaneshvar S,Rosa GM,Solen KA

更新日期：2000-02-01 00:00:00

abstract：:User preferences need to be taken into account in order to be able to design devices that will gain acceptance both in a clinical and home setting. Sensor systems become redundant if patients or clinicians do not want to work with them. The aim of this systematic review was to determine both patients' and clinicians' ...

journal_title：Annals of biomedical engineering

authors： Bergmann JH,McGregor AH

更新日期：2011-09-01 00:00:00

abstract：:Conventional nanoporous hydrogels often lead to slow cartilage deposition by MSCs in 3D due to physical constraints and requirement for degradation. Our group has recently reported macroporous gelatin microribbon (μRB) hydrogels, which substantially accelerate MSC-based cartilage formation in vitro compared to convent...

journal_title：Annals of biomedical engineering

authors： Barati D,Gegg C,Yang F

更新日期：2020-07-01 00:00:00

abstract：:Accurate assessment of blood platelet function is essential in understanding thrombus formation which plays a central role in cardiovascular disease. Parallel plate flow chambers have been widely used as they allow for platelet adhesion on a collagen surface at physiologically relevant fluid mechanical forces. Standar...

journal_title：Annals of biomedical engineering

authors： Sarvepalli DP,Schmidtke DW,Nollert MU

更新日期：2009-07-01 00:00:00

abstract：:This paper presents two related methods for registering an image of an anatomical object with data from sensors arranged on the object. One method is described with reference to a test case involving a rectangular electrode plaque disposed on a heart surface, which is imaged with MRI. Data from the electrodes is fused...

journal_title：Annals of biomedical engineering

authors： Hopenfeld B,Ashikaga H,McVeigh ER

更新日期：2007-10-01 00:00:00

abstract：:Functional electrical stimulation (FES) to lower extremity (LE) muscles is used by individuals post-stroke as an alternative to mechanical orthotic devices during gait or as a training modality during rehabilitation. Technological developments which improve the feasibility, accessibility and effectiveness of FES syste...

journal_title：Annals of biomedical engineering

authors： Kafri M,Laufer Y

更新日期：2015-02-01 00:00:00