A review of return to play issues and sports-related concussion.

abstract：:Spike discharge patterns showing intrinsic oscillations (IOs) have been reported in units in the dorsal cochlear nucleus (DCN) of the decerebrate cat. These oscillations are related to the regularity of a unit's discharge rate and may be important for pitch perception. A DCN unit's regularity can be affected by severa...

journal_title：Annals of biomedical engineering

authors： Gdowski GT,Voigt HF

更新日期：1998-05-01 00:00:00

abstract：:Measurement of cell shortening is an important technique for assessment of physiology and pathophysiology of cardiac myocytes. Many types of heart disease are associated with decreased myocyte shortening, which is commonly caused by structural and functional remodeling. Here, we present a new approach for local measur...

journal_title：Annals of biomedical engineering

authors： Lichter J,Li H,Sachse FB

更新日期：2016-10-01 00:00:00

abstract：:Polycrystalline silicon (poly-Si) micromechanical structures can be made by selectively etching an underlying sacrificial oxide layer. Advantages of this micromachining technique are its simplicity and compatibility with conventional integrated-circuit processing. Compressive internal stress in poly-Si films constrain...

journal_title：Annals of biomedical engineering

authors： Howe RT

更新日期：1986-01-01 00:00:00

abstract：:Lung cancer is a leading cause of death worldwide. Radiation therapy (RT) is one method to treat this disease. A common side effect of RT for lung cancer is radiation-induced lung damage (RILD) which leads to loss of lung function. RILD often compounds pre-existing smoking-related regional lung function impairment. It...

journal_title：Annals of biomedical engineering

authors： Dong Y,Kumar H,Tawhai M,Veiga C,Szmul A,Landau D,McClelland J,Lao L,Burrowes KS

更新日期：2020-11-30 00:00:00

abstract：:Rapid screening of biomarkers, with high specificity and accuracy, is critical for many point-of-care diagnostics. Microfluidics, the use of microscale channels to manipulate small liquid samples and carry reactions in parallel, offers tremendous opportunities to address fundamental questions in biology and provide a ...

journal_title：Annals of biomedical engineering

authors： Ng E,Chen K,Hang A,Syed A,Zhang JX

更新日期：2016-04-01 00:00:00

abstract：:A cable model is formulated to estimate the spatial distribution of intracellular electric potential and current, from the cement line to the lumen of an osteon, as the frequency of the loading and the conductance of the gap junction are altered. The model predicts that the characteristic diffusion time for the spread...

journal_title：Annals of biomedical engineering

authors： Zhang D,Cowin SC,Weinbaum S

更新日期：1997-03-01 00:00:00

abstract：:The temporal and spatial distribution of coronary blood flow, pressure, and volume are determined by the branching pattern and three-dimensional (3-D) geometry of the coronary vasculature, and by the mechanics of heart wall and vascular tone. Consequently, a realistic simulation of coronary blood flow requires, as a f...

journal_title：Annals of biomedical engineering

authors： Kaimovitz B,Lanir Y,Kassab GS

更新日期：2005-11-01 00:00:00

abstract：:Traditionally, measurement of pulmonary O2 uptake uses mass balance of N2 to correct for differences between inspired and expired volume (V) due to temperature (T) and relative humidity (RH). Often during anesthesia, N2 balance cannot be invoked due to high inspired O2 fraction (FIO2) or nonsteady state conditions. Th...

journal_title：Annals of biomedical engineering

authors： Breen PH

更新日期：2000-09-01 00:00:00

abstract：:Computational modeling and simulation has become more common in design and development of bioprosthetic heart valves. To have a reliable computational model, considering accurate mechanical properties of biological soft tissue is one of the most important steps. The goal of this study was to present a non-invasive mat...

journal_title：Annals of biomedical engineering

authors： Abbasi M,Barakat MS,Dvir D,Azadani AN

更新日期：2019-01-01 00:00:00

abstract：:We propose a multiphysical mathematical model by fully coupling lipid deposition, monocytes/macrophages recruitment and angiogenesis to investigate the pathophysiological responses of an atherosclerotic plaque to the dynamic changes in the microenvironment. The time evolutions of cellular (endothelial cells, macrophag...

journal_title：Annals of biomedical engineering

authors： Guo M,Cai Y,He C,Li Z

更新日期：2019-02-01 00:00:00

abstract：:The appropriateness of integrated information systems to the description of integrated biological systems is discussed. An integrated information system in the physiology of the regulation of respiration is argued to be a structural mathematical model of the system and the relational data base, which it can compute. I...

journal_title：Annals of biomedical engineering

authors： Yamamoto WS

更新日期：1983-01-01 00:00:00

abstract：:Osteoarthritis (OA) is a progressive, degenerative disease of articulating joints that not only affects the elderly, but also involves younger, more active individuals with prolonged participation in high physical-demand activities. Thus, effective therapies that are easy to adopt clinically are critical in limiting t...

journal_title：Annals of biomedical engineering

authors： Holyoak DT,Tian YF,van der Meulen MC,Singh A

更新日期：2016-06-01 00:00:00

abstract：:Intracellular calcium oscillation caused by receptor activator of nuclear factor kappa-B ligand has been demonstrated to promote the differentiation of osteoclasts. Osteoclasts are recruited on the surface of trabeculae, and are exposed to fluid flow caused by the deformation of the bone matrix. However, the roles of ...

journal_title：Annals of biomedical engineering

authors： Li P,Hu M,Sun S,Zhang Y,Gao Y,Long M,Huo B,Zhang D

更新日期：2012-09-01 00:00:00

abstract：:Linear compartmental models are useful, explanatory tools, that have been widely used to represent the dynamic behavior of complex biological systems. This paper addresses the problem of the numerical identification of such models, i.e., the estimation of the parameter values that will generate predictions closest to ...

journal_title：Annals of biomedical engineering

authors： Juillet B,Bos C,Gaudichon C,Tomé D,Fouillet H

更新日期：2009-05-01 00:00:00

abstract：:Abnormal scapular movement is widely believed to be an important factor in clinical pathology of the shoulder joint complex. Validated non-invasive techniques for measuring scapular movement have been developed, but the effect of marker placement on accuracy is unknown. The objective of this study was to determine the...

journal_title：Annals of biomedical engineering

authors： Bourne DA,Choo AM,Regan WD,MacIntyre DL,Oxland TR

更新日期：2011-02-01 00:00:00

abstract：:Cellular engineering applies the principles and methods of engineering to the problems of cell and molecular biology of both a basic and applied nature. As biomedical engineering has shifted from the organ and tissue level to the cellular and sub-cellular level, cellular engineering has emerged as a new area. A corner...

journal_title：Annals of biomedical engineering

authors： Nerem RM

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:This work explores for the first time the effects of temperature increments on the development of high shear stresses between plaque and arterial wall due to their different dilatational properties. Data from the literature report febrile reactions prior to myocardial infarction in patients with normal coron...

journal_title：Annals of biomedical engineering

authors： Guinea GV,Atienza JM,Fantidis P,Rojo FJ,Ortega A,Torres M,Gonzalez P,Elices ML,Hayashi K,Elices M

更新日期：2008-01-01 00:00:00

abstract：:Three animal models were evaluated in this study involving head impacts of the rat, including the Marmarou drop-weight and two momentum-exchange techniques. In series 1, 36 Wistar rats were hit on the side of the free-moving head using Marmarou's 450 g impact mass at 4.4, 5.4, and 6.3 m/s. Head acceleration was measur...

journal_title：Annals of biomedical engineering

authors： Viano DC,Hamberger A,Bolouri H,Säljö A

更新日期：2012-01-01 00:00:00

abstract：:Traumatic falls are a prevalent and costly threat to elderly adults. Accurate risk assessment is necessary for reducing incidence of falls. The objective of this study was to test the feasibility of a balance impairment detection model using tasks of sample categorization and falls risk estimation. Model design includ...

journal_title：Annals of biomedical engineering

authors： Hahn ME,Chou LS

更新日期：2005-06-01 00:00:00

abstract：:In an effort to share best practices in undergraduate engineering design education, we describe the origin, evolution and the current status of the undergraduate biomedical engineering design team program at Johns Hopkins University. Specifically, we describe the program and judge the quality of the pedagogy by relati...

journal_title：Annals of biomedical engineering

authors： Allen RH,Acharya S,Jancuk C,Shoukas AA

更新日期：2013-09-01 00:00:00

abstract：:Thorax injuries mainly due to rib fractures have been associated with high rates of morbidity and mortality in motor vehicle crashes. Thoracic biomechanics has been studied extensively, but there are no robust biomechanical response targets for ribs that consider age, sex, body size, and vulnerability factors. The obj...

journal_title：Annals of biomedical engineering

authors： Kang YS,Kwon HJ,Stammen J,Moorhouse K,Agnew AM

更新日期：2021-02-01 00:00:00

abstract：:We propose a new method for guiding catheter ablation procedures to abolish sites of origin of arrhythmias. This method models both cardiac electrical activity and current pulses delivered from the tip of the ablation catheter with a single equivalent moving dipole (SEMD). The SEMD parameters are obtained from analysi...

journal_title：Annals of biomedical engineering

authors： Armoundas AA,Feldman AB,Mukkamala R,Cohen RJ

更新日期：2003-05-01 00:00:00

abstract：:It is widely recognized that the bacteria sequestered in a biofilm on a medical implant are much more resistant to antibiotics than their planktonic counterparts. Recent studies have shown that application of antibiotic along with low power ultrasound significantly increases the killing of planktonic bacteria by the a...

journal_title：Annals of biomedical engineering

authors： Qian Z,Sagers RD,Pitt WG

更新日期：1997-01-01 00:00:00

abstract：:Glaucoma is a common optic neuropathy characterized by retinal ganglion cell death. Elevated intraocular pressure (IOP), a key risk factor for glaucoma, leads to significant biomechanical deformation of optic nerve head (ONH) cells and tissues. ONH astrocytes respond to this deformation by transforming to a reactive, ...

journal_title：Annals of biomedical engineering

authors： Mulvihill JJE,Raykin J,Snider EJ,Schildmeyer LA,Zaman I,Platt MO,Kelly DJ,Ethier CR

更新日期：2018-02-01 00:00:00

abstract：:The objective of this study was to develop a unique device for applying well-characterized cyclic, strain to cells growing on implant alloys. The device is based on the four-point bending principle and utilizes an electric motor, belt, and cam system to cyclically deflect a commercially pure titanium plate with cell c...

journal_title：Annals of biomedical engineering

authors： Winter LC,Gilbert JA,Elder SH,Bumgardner JD

更新日期：2002-11-01 00:00:00

abstract：:Biochemical stimulation was applied in combination with cyclic mechanical strain to engineered vascular constructs made of isolated smooth muscle cells in a three-dimensional (3D) collagen type 1 matrix. Platelet-derived growth factor (PDGF) and transforming growth factor beta (TGF-beta) were added exogenously to the ...

journal_title：Annals of biomedical engineering

authors： Stegemann JP,Nerem RM

更新日期：2003-04-01 00:00:00

abstract：:Integration of repair tissue is a key indicator of the long-term success of cell-based therapies for cartilage repair. The objective of this study was to compare the in vitro chondrogenic differentiation and integration of agarose hydrogels seeded with either chondrocytes or bone marrow-derived mesenchymal stem cells ...

journal_title：Annals of biomedical engineering

authors： Vinardell T,Thorpe SD,Buckley CT,Kelly DJ

更新日期：2009-12-01 00:00:00

abstract：:During defecation, solid, semisolid or liquid stools are eliminated via the anus in a complex physiological process. Up to 25% of the population are affected by anorectal disorders that are poorly recognized and treated. We developed a new bionics device, a simulated stool named Fecobionics, to replace several current...

journal_title：Annals of biomedical engineering

authors： Sun D,Huang Z,Zhuang Z,Ma Z,Man LK,Liao D,Gregersen H

更新日期：2019-02-01 00:00:00

abstract：:Diabetic retinopathy is the leading cause of blindness in working age individuals in the United States. Breakdown of the blood-retinal barrier is one of the earliest events in the progression of diabetic retinopathy. Ideally, therapeutic measures would be directed at this early stage, but there are few sensitive, quan...

journal_title：Annals of biomedical engineering

authors： Russ PK,Gaylord GM,Haselton FR

更新日期：2001-08-01 00:00:00

abstract：:Continuous gradients exist at osteochondral interfaces, which may be engineered by applying spatially patterned gradients of biological cues. In the present study, a protein-loaded microsphere-based scaffold fabrication strategy was applied to achieve spatially and temporally controlled delivery of bioactive signals i...

journal_title：Annals of biomedical engineering

authors： Dormer NH,Singh M,Wang L,Berkland CJ,Detamore MS

更新日期：2010-06-01 00:00:00