Abstract:
:A cable model is formulated to estimate the spatial distribution of intracellular electric potential and current, from the cement line to the lumen of an osteon, as the frequency of the loading and the conductance of the gap junction are altered. The model predicts that the characteristic diffusion time for the spread of current along the membrane of the osteocytic processes, 0.03 sec, is nearly the same as the predicted pore pressure relaxation time in Zeng et al. (Annals of Biomedical Engineering. 1994) for the draining of the bone fluid into the osteonal canal. This approximate equality of characteristic times causes the cable to behave as a high-pass, low-pass filter cascade with a maximum in the spectral response for the intracellular potential at approximately 30 Hz. This behavior could be related to the experiments of Rubin and McLeod (Osteoporosis, Academic Press, 1996) which show that live bone appears to be selectively responsive to mechanical loading in a specific frequency range (15-30 Hz) for several species.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Zhang D,Cowin SC,Weinbaum Sdoi
10.1007/BF02648049subject
Has Abstractpub_date
1997-03-01 00:00:00pages
357-74issue
2eissn
0090-6964issn
1573-9686journal_volume
25pub_type
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