Abstract：
:We attempted to estimate in living adherent epithelial alveolar cells, the degree of structural and mechanical heterogeneity by considering two individualized cytoskeleton components, i.e., a submembranous "cortical" cytoskeleton and a "deep" cytoskeleton (CSK). F-actin structure characterizing each CSK component was visualized from spatial reconstructions at low and high density, respectively, especially in a 10-microm-cubic neighborhood including the bead. Specific mechanical properties (Young elastic and viscous modulus E and n) were revealed after partitioning the magnetic twisting cytometry response using a double viscoelastic "solid" model with asymmetric plastic relaxation. Results show that the cortical CSK response is a faster (tau1 < or = 0.7 s), softer (E1: 63-109 Pa), moderately viscous (n1: 7- 18 Pas), slightly tensed, and easily damaged structure compared to the deep CSK structure which appears slower (tau2 approximately 1/2 min), stiffer (E2: 95-204 Pa), highly viscous (n2: 760-1967 Pa s), more tensed, and fully elastic, while exhibiting a larger stress hardening behavior. Adding drug depolymerizing actin filaments decreased predominantly the deep CSK stiffness. By contrast, an agent altering cell-matrix interactions affected essentially the cortical CSK stiffness. We concluded that partitioning the CSK within cortical and deep structures is largely consistent with their respective functional activities.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Laurent VM,Fodil R,Cañadas P,Féréol S,Louis B,Planus E,Isabey Ddoi
10.1114/1.1616932subject
Has Abstractpub_date
2003-11-01 00:00:00pages
1263-78issue
10eissn
0090-6964issn
1573-9686journal_volume
31pub_type
杂志文章abstract：:Fibroblasts are abundant in cardiac tissue. Experimental studies suggested that fibroblasts are electrically coupled to myocytes and this coupling can impact cardiac electrophysiology. In this work, we present a novel approach for mathematical modeling of electrical conduction in cardiac tissue composed of myocytes, f...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-009-9667-4
更新日期：2009-05-01 00:00:00
abstract：:A solid tumor is composed of a population of cells that is expanding as a result of cell division. With dense cell packing, the solid matrix of the interstitial tissue is subject to residual stress. In addition, elevated interstitial fluid pressure (IFP) has been reported by researchers for a number of solid tumors. T...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.1554923
更新日期：2003-03-01 00:00:00
abstract：:The epidermal growth factor (EGF) is a growth factor with effects on many cell types and tissue. Morphometric and passive biomechanical properties were studied in isolated segments of the esophagus in 22 EGF-treated rats and 12 control rats. The rats were divided into groups with EGF treatment for 2, 4, 7, and 14 days...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.1575758
更新日期：2003-06-01 00:00:00
abstract：:Intramuscular pressure (IMP), defined as skeletal muscle interstitial fluid pressure, reflects changes in individual muscle tension and may provide crucial insight into musculoskeletal biomechanics and pathologies. IMP may be measured using fiber-optic fluid pressure sensors, provided the sensor is adequately anchored...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-016-1703-6
更新日期：2017-03-01 00:00:00
abstract：:This study presents a new steady-state visual evoked potential (SSVEP)-based brain computer interface (BCI). SSVEPs, induced by phase-tagged flashes in eight light emitting diodes (LEDs), were used to control four cursor movements (up, right, down, and left) and four button functions (on, off, right-, and left-clicks)...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-010-9964-y
更新日期：2010-07-01 00:00:00
abstract：:For highly diffusive solutes the kinetics of blood-tissue exchange is only poorly represented by a model consisting of sets of independent parallel capillary-tissue units. We constructed a more realistic multicapillary network model conforming statistically to morphometric data. Flows through the tortuous paths in the...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.273
更新日期：2000-03-01 00:00:00
abstract：:Membrane introduction mass spectrometry has been applied to inert gas measurements in blood and tissue, but gases with low blood solubility are associated with reduced sensitivity. Countercurrent extraction of inert gases from a blood sample into a water carrier phase has the potential to extract most of the gas sampl...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02684170
更新日期：1997-09-01 00:00:00
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-010-0108-1
更新日期：2010-12-01 00:00:00
abstract：:This paper presents two related methods for registering an image of an anatomical object with data from sensors arranged on the object. One method is described with reference to a test case involving a rectangular electrode plaque disposed on a heart surface, which is imaged with MRI. Data from the electrodes is fused...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-007-9350-6
更新日期：2007-10-01 00:00:00
abstract：:Auscultation is an important diagnostic indicator for cardiovascular analysis. Heart sound classification and analysis play an important role in the auscultative diagnosis. This study uses a combination of Mel-frequency cepstral coefficient (MFCC) and hidden Markov model (HMM) to efficiently extract the features for p...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-006-9232-3
更新日期：2007-03-01 00:00:00
abstract：:Neuromuscular impairment associated with cerebral palsy (CP) often leads to life-long walking deficits. Our goal was to evaluate the ability of a novel untethered wearable ankle exoskeleton to reduce the severity of gait pathology from CP. In this clinical feasibility study of five individuals with CP, we used instrum...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-019-02237-w
更新日期：2019-06-01 00:00:00
abstract：:For several years, Virginia Tech and other schools have measured the frequency and severity of head impacts sustained by collegiate American football players in real time using the Head Impact Telemetry (HIT) System of helmet-mounted accelerometers. In this study, data from 37,128 head impacts collected at Virginia Te...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-011-0400-8
更新日期：2012-01-01 00:00:00
abstract：:Functional electrical stimulation (FES) to lower extremity (LE) muscles is used by individuals post-stroke as an alternative to mechanical orthotic devices during gait or as a training modality during rehabilitation. Technological developments which improve the feasibility, accessibility and effectiveness of FES syste...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1007/s10439-014-1148-8
更新日期：2015-02-01 00:00:00
abstract：:The advantages of photoacoustic (PA) imaging, including low cost, non-ionizing operation, and sub-mm spatial resolution at centimeters depth, make it a promising modality to probe nanoparticle-targeted abnormalities in real time at cellular and molecular levels. However, detecting rare cell types in a heterogeneous ba...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1007/s10439-013-0901-8
更新日期：2013-11-01 00:00:00
abstract：:Numerical models of the mitral valve have been used to elucidate mitral valve function and mechanics. These models have evolved from simple two-dimensional approximations to complex three-dimensional fully coupled fluid structure interaction models. However, to date these models lack direct one-to-one experimental val...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-012-0651-z
更新日期：2013-02-01 00:00:00
abstract：:Osteoarthritis (OA) is a progressive, degenerative disease of articulating joints that not only affects the elderly, but also involves younger, more active individuals with prolonged participation in high physical-demand activities. Thus, effective therapies that are easy to adopt clinically are critical in limiting t...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1007/s10439-016-1600-z
更新日期：2016-06-01 00:00:00
abstract：:The objective of this study was to develop a unique device for applying well-characterized cyclic, strain to cells growing on implant alloys. The device is based on the four-point bending principle and utilizes an electric motor, belt, and cam system to cyclically deflect a commercially pure titanium plate with cell c...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.1529195
更新日期：2002-11-01 00:00:00
abstract：:This paper describes a finite volume method for modeling electrical activation in a sample of cardiac tissue using the bidomain equations. Microstructural features to the level of cleavage planes between sheets of myocardial fibers in the tissue are explicitly represented. The key features of this implementation compa...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-005-1434-6
更新日期：2005-05-01 00:00:00
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-009-9689-y
更新日期：2009-06-01 00:00:00
abstract：:Local hemodynamics are an important factor in atherosclerosis, from the development of early lesions, to the assessment of stroke risk, to determining the ultimate fate of a mature plaque. Until recently, our understanding of arterial fluid dynamics and their relationship to atherosclerosis was limited by the use of i...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1114/1.1467679
更新日期：2002-04-01 00:00:00
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-011-0372-8
更新日期：2011-11-01 00:00:00
abstract：:Microstructural characterization of cardiac tissue and its remodeling in disease is a crucial step in many basic research projects. We present a comprehensive approach for three-dimensional characterization of cardiac tissue at the submicrometer scale. We developed a compression-free mounting method as well as labelin...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-015-1465-6
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-015-1282-y
更新日期：2015-10-01 00:00:00
abstract：:A cohesive zone model (CZM) approach is applied to simulate atherosclerotic plaque delamination experiments in mouse abdominal aorta specimens. A three-dimensional finite element model is developed for the experiments. The aortic wall is treated as a fiber-reinforced, highly deformable, incompressible material, and th...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-015-1357-9
更新日期：2015-12-01 00:00:00
abstract：:Cochlear implantation consists in electrically stimulating the auditory nerve by inserting an electrode array inside the cochlea, a bony structure of the inner ear. In the absence of any visual feedback, the insertion results in many cases of damages of the internal structures. This paper presents a feasibility study ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-020-02671-1
更新日期：2020-10-30 00:00:00
abstract：:We developed muscle-tendon models incorporating Hill-type structure and length-dependent coupling between activation and velocity. The models were evaluated in electrically stimulated cat soleus muscles. Dynamic model parameters were estimated by a nonlinear parameter estimation algorithm from input-output data obtain...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.93
更新日期：1998-05-01 00:00:00
abstract：:This work presents a novel methodology for building a three-dimensional patient-specific eyeball model suitable for performing a fully automatic finite element (FE) analysis of the corneal biomechanics. The reconstruction algorithm fits and smooths the patient's corneal surfaces obtained in clinic with corneal topogra...
journal_title：Annals of biomedical engineering
pub_type： 临床试验,杂志文章
doi：10.1007/s10439-015-1426-0
更新日期：2016-05-01 00:00:00
abstract：:Tissue engineering strategies have utilized a wide spectrum of synthetic and naturally-derived scaffold materials. Synthetic scaffolds are better defined and offer the ability to precisely and reproducibly control their properties, while naturally-derived scaffolds typically have inherent biological and structural pro...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1007/s10439-014-1192-4
更新日期：2015-03-01 00:00:00
abstract：:Linear autoregressive (AR) model-based heart rate (HR) spectral analysis has been widely used to study HR dynamics. Owing to system and measurement noise, the parameters of an AR model have intrinsic statistical uncertainty. In this study, we evaluate how this AR parameter uncertainty can translate to uncertainty in H...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02368320
更新日期：1995-03-01 00:00:00
abstract：:This study was aimed at developing a physical model, supported by experimental observations, to describe the formation and growth of microbubbles seen in patients with mitral mechanical heart valves (MHV). This phenomenon, often referred to as high intensity transient signals (HITS), appears as bright, intense, high-v...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.231
更新日期：1999-11-01 00:00:00
