Abstract:
:The continuing lack of longitudinal histopathological and biomechanical data for human arteries in health and disease highlights the importance of studying the many genetic, pharmacological, and surgical models that are available in mice. As a result, there has been a significant increase in the number of reports on the biomechanics of murine arteries over the past decade, particularly for the common carotid artery. Whereas most of these studies have focused on wild-type controls or comparing controls vs. a single model of altered hemodynamics or vascular disease, there is a pressing need to compare results across many different models to understand more broadly the effects of genetic mutations, pharmacological treatments, or surgical alterations on the evolving hemodynamics and the microstructure and biomechanical properties of these vessels. This paper represents a first step toward this goal, that is, a biomechanical phenotyping of common carotid arteries from control mice and seven different mouse models that represent alterations in elastic fiber integrity, collagen remodeling, and smooth muscle cell functionality.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Bersi MR,Ferruzzi J,Eberth JF,Gleason RL Jr,Humphrey JDdoi
10.1007/s10439-014-0988-6subject
Has Abstractpub_date
2014-06-01 00:00:00pages
1207-23issue
6eissn
0090-6964issn
1573-9686journal_volume
42pub_type
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