The effect of strain rate on the viscoelastic response of aortic valve tissue: a direct-fit approach.

abstract：:In this paper, a novel cell stretcher design that mimics the real-time stretch of the heart wall is introduced. By culturing cells under stretched conditions that mimics the mechanical aspects of the native cardiac environment, better understanding on the role of biomechanical signaling on cell development can be achi...

journal_title：Annals of biomedical engineering

authors： Lau JJ,Wang RM,Black LD 3rd

更新日期：2014-05-01 00:00:00

abstract：:We have developed a method for quantifying the complexity of activation patterns observed during ventricular fibrillation (VF) that is based on our previously reported methodology for decomposing epicardial mapping data into a set of isolated wavefronts. One-half second datasets are acquired from a 21 x 24 array of un...

journal_title：Annals of biomedical engineering

authors： Rogers JM,Usui M,KenKnight BH,Ideker RE,Smith WM

更新日期：1997-09-01 00:00:00

abstract：:Measurement of cell shortening is an important technique for assessment of physiology and pathophysiology of cardiac myocytes. Many types of heart disease are associated with decreased myocyte shortening, which is commonly caused by structural and functional remodeling. Here, we present a new approach for local measur...

journal_title：Annals of biomedical engineering

authors： Lichter J,Li H,Sachse FB

更新日期：2016-10-01 00:00:00

abstract：:Our 3-D model for a junctional complex (JC) in the erythrocyte membrane skeleton proposed that the helical actin protofilament functions as a mechanical axis for three pairs of αβ spectrin (Sp), and each pair wraps around the protofilament in a back-to-back fashion. The distal end of each Sp is further associated with...

journal_title：Annals of biomedical engineering

authors： Sche P,Vera C,Sung LA

更新日期：2011-07-01 00:00:00

abstract：:Twenty-one 3.5-month-old female Sprague-Dawley rats were randomly assigned to three groups: BTX group, in which each rat received a single intramuscular injection of 2 U of Clostridium botulinum toxin (BTX) in the quadriceps femoris muscle of the right hind limb; BTX + SR group, in which each rat received a BTX inject...

journal_title：Annals of biomedical engineering

authors： Sheng ZF,Ma YL,Tong D,Fang DY,Liang QC,Liu LH,Zhang J,Liao EY

更新日期：2012-03-01 00:00:00

abstract：:Intramuscular pressure (IMP), defined as skeletal muscle interstitial fluid pressure, reflects changes in individual muscle tension and may provide crucial insight into musculoskeletal biomechanics and pathologies. IMP may be measured using fiber-optic fluid pressure sensors, provided the sensor is adequately anchored...

journal_title：Annals of biomedical engineering

authors： Go SA,Jensen ER,O'Connor SM,Evertz LQ,Morrow DA,Ward SR,Lieber RL,Kaufman KR

更新日期：2017-03-01 00:00:00

abstract：:Millions of people worldwide are diagnosed each year with valvular heart disease, resulting in hundreds of thousands of valve replacement operations. Prosthetic valve replacements are designed to correct narrowing or backflow through the valvular orifice. Although commonly used, these therapies have serious disadvanta...

journal_title：Annals of biomedical engineering

authors： Berry JL,Steen JA,Koudy Williams J,Jordan JE,Atala A,Yoo JJ

更新日期：2010-11-01 00:00:00

abstract：:A comparison was made between turbulence calculated by subtracting an ensemble average from the instantaneous velocity and calculations made with a high pass digital filter. Velocity was measured with a laser Doppler anemometer in vitro in the region of a normal porcine aortic valve and in patients with a hot film ane...

journal_title：Annals of biomedical engineering

authors： Walburn FJ,Sabbah HN,Stein PD

更新日期：1983-01-01 00:00:00

abstract：:We and others have shown that changing surface characteristics of the spacer implanted during the first Masquelet stage alters some aspects of membrane development. Previously we demonstrated that titanium (TI) spacers create membranes that are better barriers to movement of solutes > 70 kDa in size than polymethyl me...

journal_title：Annals of biomedical engineering

authors： Toth Z,Roi M,Evans E,Watson JT,Nicolaou D,McBride-Gagyi S

更新日期：2019-01-01 00:00:00

abstract：:Mitral valve regurgitation (MVR) is common in patients receiving left ventricular assist device (LVAD) support, however the haemodynamic effect of MVR is not entirely clear. This study evaluated the haemodynamic effect of MVR with LVAD support and the influence of inflow cannulation site and LVAD speed modulation. Lef...

journal_title：Annals of biomedical engineering

authors： Gregory SD,Stevens MC,Wu EL,Pauls JP,Kleinheyer M,Fraser JF

更新日期：2016-09-01 00:00:00

abstract：:Local hemodynamics are an important factor in atherosclerosis, from the development of early lesions, to the assessment of stroke risk, to determining the ultimate fate of a mature plaque. Until recently, our understanding of arterial fluid dynamics and their relationship to atherosclerosis was limited by the use of i...

journal_title：Annals of biomedical engineering

authors： Steinman DA

更新日期：2002-04-01 00:00:00

abstract：:Concussion tolerance and head impact exposure are highly variable among football players. Recent findings highlight that head impact data analyses need to be performed at the subject level. In this paper, we describe a method of characterizing concussion risk between individuals using a new survival analysis technique...

journal_title：Annals of biomedical engineering

authors： Rowson S,Campolettano ET,Duma SM,Stemper B,Shah A,Harezlak J,Riggen L,Mihalik JP,Brooks A,Cameron KL,Svoboda SJ,Houston MN,McAllister T,Broglio S,McCrea M

更新日期：2020-11-01 00:00:00

abstract：:To better understand oxygen utilization by the retina, a mathematical model of oxygen diffusion and consumption in the cat outer, avascular retina was developed by analyzing previously recorded profiles of oxygen tension (PO2) as a function of retinal depth. Simple diffusion modelling of the oxygen distribution throug...

journal_title：Annals of biomedical engineering

authors： Haugh LM,Linsenmeier RA,Goldstick TK

更新日期：1990-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is an irreversible brain disorder which represents the most common form of dementia in western countries. An early and accurate diagnosis of AD would enable to develop new strategies for managing the disease; however, nowadays there is no single test that can accurately predict the development...

journal_title：Annals of biomedical engineering

authors： Alonso JF,Poza J,Mañanas MA,Romero S,Fernández A,Hornero R

更新日期：2011-01-01 00:00:00

abstract：:Point cathodal stimulation of cardiac tissue was shown previously to produce both a dog-bone shaped virtual cathode transverse to the muscle fibers and two longitudinal virtual anodes. We hypothesize that virtual anodes can cause a region of delayed activation, separating two regions of early activation caused by the ...

journal_title：Annals of biomedical engineering

authors： Wu J,Roden DM,Wikswo JP Jr

更新日期：2000-11-01 00:00:00

abstract：:Mild traumatic brain injury in sports has become a significant public health concern which has not only received the general public's attention through multiple news media stories involving athletic concussions, but has also resulted in local, state, and national legislative efforts to improve recognition and manageme...

journal_title：Annals of biomedical engineering

authors： Doolan AW,Day DD,Maerlender AC,Goforth M,Gunnar Brolinson P

更新日期：2012-01-01 00:00:00

abstract：:We develop a mathematical model of nanoparticles depositing onto and penetrating into a biofilm grown in a parallel-plate flow cell. We carry out deposition experiments in a flow cell to support the modeling. The modeling and the experiments are motivated by the potential use of polymer nanoparticles as part of a trea...

journal_title：Annals of biomedical engineering

authors： Miller JK,Neubig R,Clemons CB,Kreider KL,Wilber JP,Young GW,Ditto AJ,Yun YH,Milsted A,Badawy HT,Panzner MJ,Youngs WJ,Cannon CL

更新日期：2013-01-01 00:00:00

abstract：:A number of human head finite element (FE) models have been developed from different research groups over the years to study the mechanisms of traumatic brain injury. These models can vary substantially in model features and parameters, making it important to evaluate whether simulation results from one model are read...

journal_title：Annals of biomedical engineering

authors： Ji S,Ghadyani H,Bolander RP,Beckwith JG,Ford JC,McAllister TW,Flashman LA,Paulsen KD,Ernstrom K,Jain S,Raman R,Zhang L,Greenwald RM

更新日期：2014-01-01 00:00:00

abstract：:Neuromuscular impairment associated with cerebral palsy (CP) often leads to life-long walking deficits. Our goal was to evaluate the ability of a novel untethered wearable ankle exoskeleton to reduce the severity of gait pathology from CP. In this clinical feasibility study of five individuals with CP, we used instrum...

journal_title：Annals of biomedical engineering

authors： Lerner ZF,Harvey TA,Lawson JL

更新日期：2019-06-01 00:00:00

abstract：:Effects of hyperthermia on transport of low-density lipoprotein (LDL) through a stenosed arterial wall are analyzed comprehensively in the present work. The realistic and pertinent aspects of an arterial wall is represented by a multi-layer model, with a proper representation of the thickened intima region due to the ...

journal_title：Annals of biomedical engineering

authors： Iasiello M,Vafai K,Andreozzi A,Bianco N,Tavakkoli F

更新日期：2015-07-01 00:00:00

abstract：:Interstitial fluid flow, critical for macromolecular transport, was recently shown to drive fibroblast differentiation and perpendicular cell and matrix alignment in 3D collagen cultures. Here we explore the mechanisms underlying this flow-induced cell and collagen alignment. Cell and matrix alignment was assessed fro...

journal_title：Annals of biomedical engineering

authors： Ng CP,Swartz MA

更新日期：2006-03-01 00:00:00

abstract：:Intramuscular pressure (IMP) shows promise for estimating individual muscle tension in vivo. However, previous pressure measurements show high variability during isometric contraction and poor correlation with tension during dynamic contraction. We hypothesized that enhanced sensor anchoring/orientation would improve ...

journal_title：Annals of biomedical engineering

authors： O'Connor SM,Kaufman KR,Ward SR,Lieber RL

更新日期：2021-02-01 00:00:00

abstract：:Arterial responses to diverse pathologies and insults likely occur via similar mechanisms. For example, many studies suggest that the natural process of aging and isolated systolic hypertension share many characteristics in arteries, including loss of functional elastin, decreased smooth muscle tone, and altered rates...

journal_title：Annals of biomedical engineering

authors： Valentín A,Humphrey JD,Holzapfel GA

更新日期：2011-07-01 00:00:00

abstract：:Radiation applied for therapy and diagnostics damages molecular/atomic couples of biotissues, bones being among them. As a result, electron peculiarities and mechanical behavior of the latter are altered. Correlation between strength of the irradiated bone and its electron features explored due to photo- and exoelectr...

journal_title：Annals of biomedical engineering

authors： Dekhtyar Y

更新日期：2001-12-01 00:00:00

abstract：:Functional electrical stimulation (FES) to lower extremity (LE) muscles is used by individuals post-stroke as an alternative to mechanical orthotic devices during gait or as a training modality during rehabilitation. Technological developments which improve the feasibility, accessibility and effectiveness of FES syste...

journal_title：Annals of biomedical engineering

authors： Kafri M,Laufer Y

更新日期：2015-02-01 00:00:00

abstract：:Rapid screening of biomarkers, with high specificity and accuracy, is critical for many point-of-care diagnostics. Microfluidics, the use of microscale channels to manipulate small liquid samples and carry reactions in parallel, offers tremendous opportunities to address fundamental questions in biology and provide a ...

journal_title：Annals of biomedical engineering

authors： Ng E,Chen K,Hang A,Syed A,Zhang JX

更新日期：2016-04-01 00:00:00

abstract：:Biologically active heart valves (tissue engineered and recellularized tissue-derived heart valves) have the potential to offer enhanced function when compared to current replacement value therapies since they can possibly remodel, and grow to meet the needs of the patient, and not require chronic medication. However,...

journal_title：Annals of biomedical engineering

authors： Hildebrand DK,Wu ZJ,Mayer JE Jr,Sacks MS

更新日期：2004-08-01 00:00:00

abstract：:Uncomplicated acute type B aortic dissections are usually treated medically, but they can become acutely complicated by rapid expansion, rupture and malperfusion syndromes and in the longer term by chronic dilatation and aortic aneurysm formation. The objective of this study is to use computational fluid dynamics reco...

journal_title：Annals of biomedical engineering

authors： Cheng Z,Wood NB,Gibbs RG,Xu XY

更新日期：2015-01-01 00:00:00

abstract：:Three animal models were evaluated in this study involving head impacts of the rat, including the Marmarou drop-weight and two momentum-exchange techniques. In series 1, 36 Wistar rats were hit on the side of the free-moving head using Marmarou's 450 g impact mass at 4.4, 5.4, and 6.3 m/s. Head acceleration was measur...

journal_title：Annals of biomedical engineering

authors： Viano DC,Hamberger A,Bolouri H,Säljö A

更新日期：2012-01-01 00:00:00

abstract：:Wall Shear Stress (WSS) topological skeleton, composed by fixed points and the manifolds linking them, reflects the presence of blood flow features associated to adverse vascular response. However, the influence of WSS topological skeleton on vascular pathophysiology is still underexplored. This study aimed to identif...

journal_title：Annals of biomedical engineering

authors： Morbiducci U,Mazzi V,Domanin M,De Nisco G,Vergara C,Steinman DA,Gallo D

更新日期：2020-12-01 00:00:00