Abstract:
:In this paper, a novel cell stretcher design that mimics the real-time stretch of the heart wall is introduced. By culturing cells under stretched conditions that mimics the mechanical aspects of the native cardiac environment, better understanding on the role of biomechanical signaling on cell development can be achieved. The device utilizes a moving magnet linear actuator controlled through pulse-width modulated power combined with an automated closed loop feedback system for accurate generation of a designated mechanical stretch profile. The system's capability to stretch a cell culture membrane and accuracy of the designated frequency and waveform production for cyclic stretching were evaluated. Temperature and degradation assessments as well as a scalable design demonstrated the system's cell culture application for long term, in vitro studies.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Lau JJ,Wang RM,Black LD 3rddoi
10.1007/s10439-014-0976-xsubject
Has Abstractpub_date
2014-05-01 00:00:00pages
1062-73issue
5eissn
0090-6964issn
1573-9686journal_volume
42pub_type
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journal_title:Annals of biomedical engineering
pub_type: 杂志文章
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journal_title:Annals of biomedical engineering
pub_type: 临床试验,杂志文章
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journal_title:Annals of biomedical engineering
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journal_title:Annals of biomedical engineering
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journal_title:Annals of biomedical engineering
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journal_title:Annals of biomedical engineering
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journal_title:Annals of biomedical engineering
pub_type: 杂志文章,评审
doi:10.1023/b:abme.0000007789.99565.42
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journal_title:Annals of biomedical engineering
pub_type: 杂志文章
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journal_title:Annals of biomedical engineering
pub_type: 杂志文章
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journal_title:Annals of biomedical engineering
pub_type: 杂志文章
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journal_title:Annals of biomedical engineering
pub_type: 杂志文章
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journal_title:Annals of biomedical engineering
pub_type: 杂志文章
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更新日期:1995-09-01 00:00:00
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journal_title:Annals of biomedical engineering
pub_type: 杂志文章,评审
doi:10.1007/s10439-013-0902-7
更新日期:2014-02-01 00:00:00
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journal_title:Annals of biomedical engineering
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journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-009-9745-7
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journal_title:Annals of biomedical engineering
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journal_title:Annals of biomedical engineering
pub_type: 杂志文章
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journal_title:Annals of biomedical engineering
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doi:10.1007/s10439-014-0981-0
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journal_title:Annals of biomedical engineering
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