Abstract：
:Local hemodynamics are an important factor in atherosclerosis, from the development of early lesions, to the assessment of stroke risk, to determining the ultimate fate of a mature plaque. Until recently, our understanding of arterial fluid dynamics and their relationship to atherosclerosis was limited by the use of idealized or averaged artery models. Recent advances in medical imaging, computerized image processing, and computational fluid dynamics (CFD) now make it possible to computationally reconstruct the time-varying, three-dimensional blood flow patterns in anatomically realistic models. In this paper we review progress, made largely within the last five years, towards the routine use of anatomically realistic CFD models, derived from in vivo medical imaging, to elucidate the role of local hemodynamics in the development and progression of atherosclerosis in large arteries. In addition to describing various image-based CFD studies carried out to date, we review the medical imaging and image processing techniques available to acquire the necessary geometric and functional boundary conditions. Issues related to accuracy, precision, and modeling assumptions are also discussed.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Steinman DAdoi
10.1114/1.1467679subject
Has Abstractpub_date
2002-04-01 00:00:00pages
483-97issue
4eissn
0090-6964issn
1573-9686journal_volume
30pub_type
杂志文章,评审abstract：:The local dilation of the infrarenal abdominal aorta, termed an abdominal aortic aneurysm (AAA), is often times asymptomatic and may eventually result in rupture-an event associated with a significant mortality rate. The estimation of in-vivo stresses within AAAs has been proposed as a useful tool to predict the likel...
journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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更新日期：2003-09-01 00:00:00
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journal_title：Annals of biomedical engineering
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更新日期：2002-09-01 00:00:00
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章,已发布勘误
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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