Abstract：
:Traditionally, measurement of pulmonary O2 uptake uses mass balance of N2 to correct for differences between inspired and expired volume (V) due to temperature (T) and relative humidity (RH). Often during anesthesia, N2 balance cannot be invoked due to high inspired O2 fraction (FIO2) or nonsteady state conditions. Then, O2 uptake per breath (VO2,br) must use assumed or measured T and RH differences between inspirate and expirate. This numerical analysis study examines how errors in inspired RH and T can affect VO2,br. Equations were developed to simulate a baseline metabolic and ventilatory condition. A unit error in inspired RH of 0.5 (during constant inspired T of 22 degrees C) caused percent errors in VO2,br of 5.6% during FIO2 = 0.2% and 28.8% during FIO2 of unity. Per(-57.6 x FIO2-0.115) VO2,br was given by (change in RH) (R2 > 0.999). Errors in inspired T (during constant inspired RH of 0.5) had similar effects on percent error in VO2,br( =-8.75 x FIO2-0.093) x (change in T) (R2 = 0.999). Because inspired VO2 is larger at higher FIO2 and because VO2,br is the difference between inspired and expired VO2, VO2,br is most affected by the inspired V error at the largest FIO2 . When tissue O2 consumption decreases relative to minute ventilation, T and RH errors have a greater effect on VO2 br because the error in inspired V affects a smaller VO2,br. At lower barometric pressure, RH errors affect VO2,br more because water vapor V occupies a larger fraction of inspired V. In summary, because inspired RH and T can vary significantly during anesthesia, a fast-response humidity and T sensor, combined with flow and FO2 measurements, are needed to allow accurate determination of VO2,br x VO2,br should become an important measure of metabolism and patient wellness during anesthesia.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Breen PHdoi
10.1114/1.1312184subject
Has Abstractpub_date
2000-09-01 00:00:00pages
1159-64issue
9eissn
0090-6964issn
1573-9686journal_volume
28pub_type
杂志文章abstract：:Wall Shear Stress (WSS) topological skeleton, composed by fixed points and the manifolds linking them, reflects the presence of blood flow features associated to adverse vascular response. However, the influence of WSS topological skeleton on vascular pathophysiology is still underexplored. This study aimed to identif...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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pub_type： 临床试验,杂志文章
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
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更新日期：2004-03-01 00:00:00
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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更新日期：1985-01-01 00:00:00
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02368054
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
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更新日期：1998-09-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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