Abstract：
:Cellular engineering applies the principles and methods of engineering to the problems of cell and molecular biology of both a basic and applied nature. As biomedical engineering has shifted from the organ and tissue level to the cellular and sub-cellular level, cellular engineering has emerged as a new area. A cornerstone of much of this activity is cell culture technology, i.e., the ability to grow living cells in the artificial environment of a laboratory. Cellular engineering includes the role of engineering in both basic cell biology research and in the making of products which use living cells, e.g., tissue engineering and bioprocess engineering. The former involves the use of living cells in the development of biological substitutes for the restoration or replacement of function, and the latter the use of living cells to manufacture a biochemical product, e.g., through the use of recombinant DNA technology. In fact, as biomedical engineering has expanded to include the cellular level, and bioprocess engineering has shifted in interest from microbial organisms to include mammalian cells, there are intellectual issues in which an interest is shared by these two formerly separate areas of engineering activity. Cellular engineering thus transcends the field of biomedical engineering.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Nerem RMdoi
10.1007/BF02367396subject
Has Abstractpub_date
1991-01-01 00:00:00pages
529-45issue
5eissn
0090-6964issn
1573-9686journal_volume
19pub_type
杂志文章,评审abstract：:Observing microscopic specimens is often useful in studies of cellular interaction with a vascular wall. We have developed an in vitro side-view flow chamber that permits observations from the side of the cell's contact with various adhesive surfaces under dynamic flow conditions. This side-view flow chamber consists ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02684196
更新日期：1997-05-01 00:00:00
abstract：:This study is aimed at refining our understanding of the role of vortex formation at mitral mechanical heart valve (MHV) closure and its association with the high intensity transient signals (HITS) seen in echocardiographic studies with MHV recipients. Previously reported numerical results described a twofold process ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-007-9293-y
更新日期：2007-07-01 00:00:00
abstract：:Newborns with single ventricle physiology are usually palliated with a multi-staged procedure. When cardiovascular complications e.g., collateral vessel formation occur during the inter-stage periods, further treatments are required. An 8-month-old patient, who underwent second stage (i.e., bi-directional Glenn, BDG) ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-014-1113-6
更新日期：2015-06-01 00:00:00
abstract：:Clinicians generally assume that Medical Compression Stockings (MCS) work by reducing vein luminal diameter and, in this way, help to prevent blood pooling. Conflicting results have been reported however in the case of lower leg deep veins which call into question this hypothesis. The purpose of this contribution is t...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-014-1121-6
更新日期：2015-02-01 00:00:00
abstract：:Continuous gradients exist at osteochondral interfaces, which may be engineered by applying spatially patterned gradients of biological cues. In the present study, a protein-loaded microsphere-based scaffold fabrication strategy was applied to achieve spatially and temporally controlled delivery of bioactive signals i...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-010-0028-0
更新日期：2010-06-01 00:00:00
abstract：:The manner in which energy from an explosion is transmitted into the brain is currently a highly debated topic within the blast injury community. This study was conducted to investigate the injury biomechanics causing blast-related neurotrauma in the rat. Biomechanical responses of the rat head under shock wave loadin...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-011-0343-0
更新日期：2011-10-01 00:00:00
abstract：:This is a personal historical essay on meanderings through the jungle of the microcirculatory swamp. Because one pretends that the wandering was purposefully exploratory, a few guideposts are placed at positions where one could discern blaze-marks from earlier wanderers, and the path cut a little wider along some of t...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1007/BF02363568
更新日期：1987-01-01 00:00:00
abstract：:The complexity of the coronary circulation especially in the deep layers largely evades experimental investigations. Hence, virtual/computational models depicting structure-function relation of the entire coronary vasculature including the deep layer are imperative. In order to interpret such anatomically based models...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-007-9278-x
更新日期：2007-05-01 00:00:00
abstract：:While considerable efforts have been expended to develop snore-driven markers for detecting obstructive sleep apnea (OSA), there is little emphasis on the relationship between the human upper airway (UA) dimensions and the attributes of snores. This paper aims to investigate the acoustical and perceptual impacts of ch...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-009-9745-7
更新日期：2009-09-01 00:00:00
abstract：:We examine the low-frequency limit of hearing of the mammalian ear through the analytical modelling of the natural frequency of the tympanic membrane. The resulting equation of the natural frequency of the modelled tympanic membrane is numerically verified against previous theoretical studies, and is statistically val...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-019-02356-4
更新日期：2020-01-01 00:00:00
abstract：:A progressive reduction in muscle fiber conduction velocity is typically observed during fatiguing muscle contraction. Although the exact causes of the conduction velocity decrease have not yet been fully established, increasing evidence suggests that changes in extracellular potassium concentration may be largely res...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-009-9756-4
更新日期：2009-10-01 00:00:00
abstract：:The traditional auscultatory technique and current methodologies for measuring human blood pressure are limited when used in situations where extreme vibration or acoustic noise is present. In this study, human subjects were used to establish the effectiveness of a novel adaptive blood pressure monitoring (ABPM) syste...
journal_title：Annals of biomedical engineering
pub_type： 临床试验,杂志文章
doi：10.1114/1.1481051
更新日期：2002-05-01 00:00:00
abstract：:Studying human cancer from a biomechanical perspective may contribute to pathogenesis understanding which leads to the malignancy. In this study, biomechanics of suspended and adhered breast cancer cells were investigated via the micropipette aspiration method with special emphasis on comparing the cell stiffness and ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-019-02284-3
更新日期：2019-08-01 00:00:00
abstract：:The purpose of this study is to measure the transmural pressure-cross sectional area relation of micro tubes (240 microns diameter) and to compare the measured perfusion pressure-flow relation with the pressure-flow relation calculated from the experimental pressure-cross sectional area relation. The microtubes are ma...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02368042
更新日期：1989-01-01 00:00:00
abstract：:An understanding of the mechanical deformation behavior of the liver under high strain rate loading conditions could aid in the development of vehicle safety measures to reduce the occurrence of blunt liver injury. The purpose of this study was to develop a constitutive model of the stress-strain behavior of the human...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-008-9555-3
更新日期：2008-11-01 00:00:00
abstract：:In this study, we introduce the fast wavelet transform as a method for characterizing maturational changes in electrocortical activity, respiratory activity, and blood pressure in fetal lambs in early (110-122 days), mid (123-135 days), and late (136-144 days) third trimester (term 145 days). Each recording was 2 hr i...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02584457
更新日期：1995-09-01 00:00:00
abstract：:We describe a model for the Compound Action Currents (CACs) and Compound Action Potentials (CAPs) produced by a peripheral nerve bundle in vitro. The Single Fiber Action Currents (SFACs) and the extracellular Single Fiber Action Potentials (SFAPs) are calculated using a generalized volume conduction model. Frequency-d...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02368460
更新日期：1991-01-01 00:00:00
abstract：:Induced pluripotent stem cell derived cardiomyocytes (iPSC-CM) provide a powerful platform for disease modeling and drug development in vitro. Traditionally, electrophysiological methods or fluorescent dyes (e.g. calcium) have been used in their functional characterization. Recently, video microscopy has enabled non-i...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-017-1933-2
更新日期：2018-01-01 00:00:00
abstract：:Dynamic occlusal loading during mastication is clinically relevant in the design and functional assessment of dental restorations and removable dentures, and in evaluating temporomandibular joint dysfunction. The aim of this study was to develop a modelling framework to evaluate subject-specific dynamic occlusal loadi...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-020-02688-6
更新日期：2021-01-06 00:00:00
abstract：:A coculture of endothelial cells (ECs) and smooth muscle cells (SMCs), which mimics cellular interactions appearing in vivo, has been performed in studies on the relationship between atherogenesis and fluid shear stress conditions. Although healthy arteries in vivo consist of contractile phenotype SMCs, cultured cells...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-011-0372-8
更新日期：2011-11-01 00:00:00
abstract：:This paper reviews the applications of accelerometers on the detection of physiological acoustic signals such as heart sounds, respiratory sounds, and gastrointestinal sounds. These acoustic signals contain a rich reservoir of vital physiological and pathological information. Accelerometer-based systems enable continu...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1007/s10439-014-1111-8
更新日期：2014-11-01 00:00:00
abstract：:Early intervention programs aim at improving cognitive and motor outcomes of preterm infants. Intensive custom-tailored training activities are usually accompanied by assessment procedures, which have shortcomings, such as subjectivity, complex setups, and need for structured environments. A novel sensorized system, c...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-016-1669-4
更新日期：2016-12-01 00:00:00
abstract：:Understanding the complex spatiotemporal dynamics of action potential propagation in the heart during arrhythmia is exceedingly difficult. This study applies nonlinear dynamics tools to simplify this task. Using the results of a simulation of an electrical induction of reentry in a sheet of myocardium represented as a...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.1581289
更新日期：2003-07-01 00:00:00
abstract：:Instrumentation systems for breath-to-breath analysis of respiratory gas exchange have been faulted by phase lags between various flow and composition signals and by difficulties in gathering and processing large amounts of data. The system described here represents an attempt to overcome these problems. Phase delays ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02367493
更新日期：1983-01-01 00:00:00
abstract：:Deep tissue injury (DTI) is a type of pressure ulcer in which tissue breakdown initiates at the bone-muscle interface under intact skin. Excessive deformation in the soft tissue, particularly around bony prominences, is believed to be one of the causes leading to the development of DTI. The main goal of this study was...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-012-0539-y
更新日期：2012-08-01 00:00:00
abstract：:Microscopic steps and crevices are inevitable features within prosthetic blood-contacting devices. This study aimed to elucidate the thrombogenicity of the associated microscopic flow features by studying the transport of fluorescent platelet-sized particles in a suspension of red blood cells (RBCs) flowing through a ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-008-9494-z
更新日期：2008-07-01 00:00:00
abstract：:The epidermal growth factor (EGF) is a growth factor with effects on many cell types and tissue. Morphometric and passive biomechanical properties were studied in isolated segments of the esophagus in 22 EGF-treated rats and 12 control rats. The rats were divided into groups with EGF treatment for 2, 4, 7, and 14 days...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.1575758
更新日期：2003-06-01 00:00:00
abstract：:Disease and injury perturb the balance of processes associated with inflammation and tissue remodeling, resulting in positive feedback loops, exacerbation of disease and compromised tissue repair. Conversely, under homeostatic healthy conditions, these processes are tightly regulated through the expansion and/or recru...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1007/s10439-014-1125-2
更新日期：2015-03-01 00:00:00
abstract：:The false vocal folds are believed to be components of the acoustic filter that is responsible for shaping the voice. However, the effects of false vocal folds on the vocal fold vibration and the glottal aerodynamic during phonation remain unclear. This effect has implications for computational modeling of phonation a...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-008-9630-9
更新日期：2009-03-01 00:00:00
abstract：:Dendritic cells (DCs) are crucial components of the immune response, strategically positioned as immune sentinels. Complex trafficking and accurate positioning of DCs are indispensable for both immunity and tolerance. This is particularly evident for their therapeutic application where an unmet clinical need exists fo...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1007/s10439-011-0448-5
更新日期：2012-04-01 00:00:00
