Abstract:
:We describe a model for the Compound Action Currents (CACs) and Compound Action Potentials (CAPs) produced by a peripheral nerve bundle in vitro. The Single Fiber Action Currents (SFACs) and the extracellular Single Fiber Action Potentials (SFAPs) are calculated using a generalized volume conduction model. Frequency-dependent conductivities, variations in the intracellular action potentials with recording temperature and axon conduction velocity, and the effects of axonal myelination are incorporated into the volume conduction calculation. We demonstrate how the propagation distance and the recording radius affect the simulated Compound Action Signals (CASs) of various nerve bundles. We also demonstrate how the frequency-dependent and -independent conductivities affect the CASs simulated by our model. For this simulation, some of the parameters for the nerve bundles and Conduction Velocity Distributions (CVDs) were obtained from the literature. In accompanying papers, we use the simulated CASs to investigate the effects of variations in the model parameters on the CVDs predicted by our inverse model.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Wijesinghe RS,Gielen FL,Wikswo JP Jrdoi
10.1007/BF02368460subject
Has Abstractpub_date
1991-01-01 00:00:00pages
43-72issue
1eissn
0090-6964issn
1573-9686journal_volume
19pub_type
杂志文章abstract::This paper presents an in vitro temperature mapping study of bovine cardiac tissue during radiofrequency ablation. The objectives were to: (i) develop a technique for measuring the spatial and temporal temperature distribution in the tissue and in the blood during ablation, and (ii) use the temperature measurements to...
journal_title:Annals of biomedical engineering
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pub_type: 杂志文章,评审
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journal_title:Annals of biomedical engineering
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